animal handling rat and mice gavage needle handling of mice and rats oral drug administration acute oral toxicity glp clinical observations topical application freund's complete adjuvant intradermal injection buehler test guinea pig maximisation test handling of guinea pig skin sensitisation oecd 406 oecd 425 up-and-down procedure udp acute class method oecd 423 eschar edema erythema handling of rabbit grading of skin acute dermal corrosion acute dermal irritation oecd 404 life sciences rabbit study eye corrosion oecd 405 acute eye irritation oecd 402 dermal toxicity acute pre-clinical drug administration rodents and non rodents pharmaceutical biotechnology toxicology oecd
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