Pres 9 Kueppers

1. A ToolBox of techniques for analytical Process Control in pharmaceutical industry Stephan Küppers Schering AG, VT, Müllerstrasse 170-78 13342 Berlin, Germany

4. Raman Chemometrics LC IR MS Sensors UV-VIS TOOLS FIA

6. Data evaluation

7. SAW-Sensor in plant

8. Specifications for P-HPLC Validation: performed according to ICH-guidelines T. Wessa, S. Küppers, M. Rapp; J. Reibel, Sensors and Acutators B, 70 (2000) 203-213

9. Monitoring of Grignard-reaction (MIR) + R-Br + Mg O 2 Mg R Br O O

10. Reaction monitoring using MIR K. Lovis, N. Dantan, U. Tilstam, W. Frenzel S. Küppers; Analytica Conference, München 11.-14.4.2000

12. Cis/Trans Calcinol

14. using a GC/MS time axis in sec.!

15. FIA for water determination Methanol Methanol KF-Lösung 660 cm/ 0.5 mm 200 cm/ 0.5 mm Detektor Inj.-Ventil N. Dantan, W. Frenzel, S. Küppers, Talanta, 52 (2000) 101-109

16. LOD´s and LOQ´s of water using KF-FIA N. Dantan, S. Kröning, W. Frenzel, S. Küppers; Analytica Chimica Acta, 420 (2000) 133-142

17. FIA with photoisomerisation

18. FIA with photoisomerisation Hexan Mischung 300 cm/ 0.5 mm Detektor Inj.-Ventil Probe Inj.-Ventil Diethylphat. Inj.-Ventil HPLC, 1µl LC-Pumpe Säule Spherisorb SI Hexan/EE 96/4 Anthracen Diethylphtalat CIS TRANS

19. spectra Cis/Trans 220 240 260 280 300 320 340 360 0.0 0.5 1.0 1.5 2.0 2.5 Gemisch AU nm ?

20. Cis/Trans lab-data Software : SIMCA, Method : PLS, 6 Components