Medical innovation calls for new models for collaborations that facilitates, government, academia and industry. Barriers to research and ultimate commercialization will be lowered by bringing best practices from industry and academic settings. Hippocrates platform facilitates early drug development extending from basic research to drug invention and commercialization significantly saving time and money. The platform is designed in such way to facilitate collaboration amongst stakeholders as well as taking advantage of the vast resources currently available on the web to generate and aggregate content based on the needs of the research of the end-user.

2. KTs Vision on Drug Development
• Medical innovation calls for new models for collaborations that
facilitates, government, academia and industry.
• Barriers to research and ultimate commercialization will be lowered
by bringing best practices from industry and academic settings.
• Hippocrates platform facilitates early drug development extending
from basic research to drug invention and commercialization
significantly saving time and money.
• The platform is designed in such way to facilitate collaboration
amongst stakeholders as well as taking advantage of the vast
resources currently available on the web to generate and
aggregate content based on the needs of the research of the end-
user.

3. Phase
III
Phase
II
Phase
I
Discover Define Develop Demonstrate
Drug Discovery Preclinical Clinical Trials
Regulatory
Review
Scale-up to
Manufacture
Post Marketing
Surveillance
Approved
New
Medicine
6 – 7 Years3 – 6 Years 0.5 – 2 Years Indefinite
Number of Patients / Subjects
20-100 100-500 1000-5000
• Development Stage Companies
• Universities
• Life-Science Incubators
• Laboratories
• Contract Research Organisations
• Clinical Trial Service Firms • CMOs
• Packagers
• Formulators
• API Manufacturers
• Health
Services
Pre-Discovery

4. Phase
III
Phase
II
Phase
I
Discover Define Develop DemonstratePre-Discovery
Drug Discovery Preclinical Clinical Trials
Regulatory
Review
Scale-up to
Manufacture
Post Marketing
Surveillance
Approved
New
Medicine
6 – 7 Years3 – 6 Years 0.5 – 2 Years Indefinite
Number of Patients / Subjects
20-100 100-500 1000-5000
• Development Stage Companies
• Universities
• Life-Science Incubators
• Laboratories
• Contract Research Organisations
• Clinical Trial Service Firms • CMOs
• Packagers
• Formulators
• API Manufacturers
• Health
Services

5. Phase
III
Phase
II
Phase
I
Discover Define Develop Demonstrate
Drug Discovery Preclinical Clinical Trials
Regulatory
Review
Scale-up to
Manufacture
Post Marketing
Surveillance
Approved
New
Medicine
6 – 7 Years3 – 6 Years 0.5 – 2 Years Indefinite
Number of Patients / Subjects
20-100 100-500 1000-5000
• Development Stage Companies
• Universities
• Life-Science Incubators
• Laboratories
• Contract Research Organisations
• Clinical Trial Service Firms • CMOs
• Packagers
• Formulators
• API Manufacturers
• Health
Services
Pre-Discovery

6. Pre-Discovery Phase
The Need…
• A clear understanding of the disease on a
molecular level
• Access to studies showing associations
between biological mutations and disease
states
• A good understanding of the underlying
causes and pathways of a disease may lead to
a biological target for a potential new medicine
Hippocrates platform…
• Provides users with access to the latest open
access medical and market information
• The content provided is appropriately
annotated with semantically driven
mechanisms so as to provide users with
maximum associations as well as rich
metadata.
• The competency matching features of the
platform combined with the collaborative
services allow scientists from both industry
and academia to collaborate in a secure
environment

7. Pre-Discovery Phase
Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data

8. Pre-Discovery Phase
Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Centralized Access to
More than 500 Medical
Databases

9. Pre-Discovery Phase
Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Check the DBs
of Hippocrates
Check the Architecture
of the Aggregator
of Hippocrates

10. Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Pre-Discovery Phase
A: Access Medicine, ACP Smart Medicine & AHFS Drug Essentials, Ageline ( Ebscohost), AGRICOLA (Ebsco), AgrisAIDS, InfoALFRED: ALlele FRequency Database, Alt-HealthWatch, AltBib (TOXNET), Altweb, American Indian
Health (NLM), American Psychological Association (APA) eBook Collection, American Speech-Language-Hearing Association Journals, Amirsys Imaging Reference Center, AnatomyTV (Stat!Ref), Annuals Reviews, Arctic Health
(NLM), ARUP Consult, Asian American Health (NLM), Assembly Archive
B: Bandoli, er, BankIt, Bates Guide to Physical Examination, Bioethics Information Resources (NLM), BioLINCC, Bioline International, Biological Abstracts see BIOSIS Previews, Biological Sciences Collection (ProQuest),
BioMedCentral, Biomedical Reference Collection: Basic, BioOne, BioSample, BIOSIS Previews (via ISI Web of Knowledge), BioSystems, Biotechnology Information & Databases (NCBI), BLAST (NCBI), BMI Research (formerly
Business Monitor International), Bookshelf (NCBI), Business Source Premier (Ebsco)
C:CABI eBook Packages, Cancer Information (NLM), Cancer.gov, Catalog of Federal Domestic Assistance, CCRIS (TOXNET), CenterWatch, Centre for Reviews & Dissemination, CRD Databases, CER Queries (Comparative
Effectiveness Research from NLM), CFR, the Code of Federal Regulations (FDsys), Chemical Abstracts (via SciFinder), Chemical Information (NLM), Chemical Structure Lookup Service (CSLS), ChemIDplus, CHEMINDEX,
ChemInfo, CHEMnetBASE, Chemoinformatics Tools and User Services, NCI/CADD, Chemotherapy Resources (via Facts & Comparisons®), ChemSpider, Child Welfare Information Gateway, CINAHL, CiteSeerX, CitingMedicine
(NLM), Clinical Alerts, ClinicalKey, ClinicalTrials.gov, ClinVar, CloneDB (formerly Clone Registry), Cochrane Library, Code of Federal Regulations, CFR (FDsys), Coffee Break (NLM), CogNet, Common Chemistry, Comparative
Toxicogenomics Database (CTD), Compendex ARCHIVE (EI), Computational Resources from NCBI Structure Group, Computer Source, Computing Reviews, Conference Papers Index, Congressional Bills (FDsys), Congressional
Publications (ProQuest), Consensus CDS (CCDS), Conserved Domains Database (CDD), CQ Researcher, CRC Handbook of Chemistry & Physics, Credo Reference, CRISP - see NIH RePorter
D: Daily Med (NLM)DARE (Database of Abstracts of Reviews of Effects)DART, Developmental and Reproductive Toxicology Database (TOXNET)Database of Expressed Sequence Tags (dbEST)Database of Genotype and
Phenotype (dbGaP)Database of Major Histocompatibility Complex (dbMHC)Database of Single Nucleotide Polymorphisms (dbSNP)Deseret NewsDietary Supplements Labels DatabaseDIRLINE (archived)Disaster
InformationDissertations & Theses: Full TextDOE/OSTI E-print network, Domains & Structures (NCBI), Drug Facts and Comparisons® (via Facts & Comparisons®)Drug Information Portal (NLM)Drug Interaction Facts® (via Facts &
Comparisons®)DrugBankDynaMed
E: e-MoleculesE-Print NetworkebraryEBSCO eBooksEbscohost Web Databases.Education Full Text + ERICeFacts - see Facts & Comparisons®eJournals for University of UtahEmbaseeMedicineEncyclopedia
BritannicaEncyclopedia of LifeEndNote Web / EndNote OnlineEngineering VillageEnvironmental Health and Toxicology InformationEpigenomicsEpocrates OnlineERIC (Ebscohost)ERIC (U.S. Dept. of Education)Ethnic NewsWatch
F:Facts & Comparisons®Faculty of 1000 / F1000PrimeFamily & Society Studies WorldwideFDsysFedBizOppsFederal Register (FDsys)Films on DemandFirstsearch Databases (OCLC)Foundation DirectoryFunding (SciVal)

11. Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Pre-Discovery Phase
G GenBankGenderWatchGeneGene Expression Omnibus (GEO) DatabaseGene Expression Omnibus (GEO) DataSetsGene Expression Omnibus (GEO) ProfilesGene Expression Omnibus (GEO) ProfilesGENE-TOX (Genetic
Toxicology DataBank)GeneCardsgenenames.orgGenetic & Rare Diseases Information Center (GARD)Genetic Testing Registry (GTR) [replaces GeneTests]Genetics Home ReferenceGenome (NCBI)Genome ProjectGenome
Reference Consortium (GRC)GitHubGoodman & Gilman's Pharmacologic Basis of TherapeuticsGoogleScholarGPO Access see FDsysGreenfile
H HazMapHEAL: Health Education Assets LibraryHealth Data Standards and Privacy (NLM)Health HotlinesHealth Services and Sciences Research Resources (HSRR)Health Services Research & Health Care TechnologyHealth
Services Research Projects (HSRProj)Health Services Technology Assessment Texts (HSTAT)healthfinderHealthy People 2020 Structured Evidence QueriesHistorical Statistics of the United StatesHistory of Medicine (NLM)HIV
InSiteHIV/AIDS Information (NLM)HomoloGeneHouseholdProductsHSDB (NLM)HSR Information Central (NLM)HSTAT, Health Services/Technology Assessment Text
I IBIS-PHImages from the History of Medicine (NLM)Index Catalogue (NLM)Influenza Virus Resource (NLM(Integrated Risk Information System (IRIS)International Atomic Energy AgencyInternational Clinical Trials Registry Platform
(ICTRP) Search Portal (WHO)International Toxicity Estimates for Risk (ITER)IR - the Institutional Repository of the University of UtahIRIS (TOXNET)ITER
J Journals Database (NLM)
L LactMed - Drugs and Lactation DatabaseLibrary CatalogLibrary of Congress CatalogLILACS - Latin American and Caribbean Health SciencesList of Serials Indexed for Online UsersLIVERTOXLocatorPlus®
M Malaria Research ResourcesMAUDE - Manufacturer and User Facility Device Experience (FDA)MedGenMedical Home PortalMedical Subject Headings, MeSHMEDLINE PubMed
(NLM)MEDLINE(EBSCOhost)MedlinePlusMedlinePlus en español (Spanish language version)MedscapeMedscape Drug ReferenceMeSH BrowserMeSH DatabaseMolecular BiologyMSDS, Material Safety Data Sheets
N National Guideline ClearinghouseNative Health DatabasesNCBINCBI Databases and Tools.NCBI Resource GuideNCCAM is now NCCIHNCCIH - National Center for Complementary and Integrative HealthNetting the
EvidenceNewspaper Source PlusNIH Manuscript Submission System (NIHMS)NIH Public AccessNIH RePorterNIHSeniorHealthNLM CatalogNLM GatewayNLM LocatorPlusNLM Technical BulletinNLM's Databases & Electronic
ResourcesNLM's Specialized Information ServicesNOVEL:The Neuro-Ophthalmology Virtual Education LibraryNucleotide
O Occupational Outlook HandbookOLDMEDLINE (subset in PubMed)OMIA (Online Mendelian Inheritance in Animals)OMIM (Online Mendelian Inheritance in Man®)OncologySTATOnline Books PageOrphanetOTSeeker
P Patent SearchPDQ® - NCI's Comprehensive Cancer DatabasePEDro: Physiotherapy Evidence DatabasePhytochemical and Ethnobotanical Databases, Dr. Duke'sPILOTSPLANTS DatabasePLoS (Public Library of
Science)POPLINEPopSetProbeProfiles in Science®Project GutenbergProQuest Databases - Health and MedicineProteinProteinLoungePubChemPubCrawlerPubGetPublic Health PartnersPubMedPubMed BookshelfPubMed
Central®PubMed Clinical QueriesPubMed HealthPubMed Special Queries

12. Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Pre-Discovery Phase
Q Quick Health Data Online
R Radiation Event Medical Management System (REMM)Rare Diseases: Genetic & Rare Diseases Information Center (GARD)Regional Business NewsResearch GuidesRetraction WatchRetrovirus Resources (NCBI)RNA
Modification DatabaseRoMEO (SHERPA)RxNorm
S Salt Lake TribuneSciELO - Scientific Electronic Library OnlineScience.govSHERPA / RoMEOSpace Life Sciences (PubMed)Special Queries - PubMedSpecialized Information Services (NLM)Statistical Abstracts of the United
States (U.S. Census Bureau)Structure
T TaxonomyTaxonomy BrowserTHOMASToolKit (NCBI)Tox TownToxicology & Environmental Health Information TOXLINE TOXMAPToxMysteryTOXNET® - Toxicology Data NetworkTRITripTurning the Pages
U U Scholar WorksU.S. CodeU.S. Patent & Trademark OfficeUMLS® - Unified Medical Language System® UniGene University of Utah Institutional RepositoryUniversity of Utah's Digital CollectionsUSA
TodayUSA.govUSA.govUSpaceUSPTO Patent DatabasesUtah CollectionsUtah's IBIS-PHUtah's Online Library
V Virtual Health Library (VHL)Visible Human ProjectVisualDX
W WebPath: The Internet Pathology Laboratory for Medical EducationWebVisionWho Named It?WHOLISWISER® (Wireless Information System for Emergency Responders)Women's Health.govWorldCat

13. Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Pre-Discovery Phase
Already Integrated DBs New DBs (to be integrated)
Crawlers
Hip-Base
DataSourcesLayer
Term Dictionaries
Semi- Automatic Annotation Mechanisms
Centralized Access to
More than 500
Medical Databases

14. Pre-Discovery Phase
Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
Hip-Base
User
Hippocrates
platform UI
KOS modelling tool
Annotation Tools
Annotation Types
Public ontologies e.g.
Linked Data
Domain specific
ontologies
Text based
resources
Graphical
elements
Elements with
text and images
Search features

15. Pre-Discovery Phase
Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data
User
Hippocrates
Authentication
Mechanism
(HAM)
Hip-Base
Academic / Scientific Profile
Professional Profile

16. Pre-Discovery Phase
Collaboration
Competency
Matching
Semantically
Driven
Infrastructure
Access to
data

17. Phase
III
Phase
II
Phase
I
Discover Define Develop Demonstrate
Drug Discovery Preclinical Clinical Trials
Regulatory
Review
Scale-up to
Manufacture
Post Marketing
Surveillance
Approved
New
Medicine
6 – 7 Years3 – 6 Years 0.5 – 2 Years Indefinite
Number of Patients / Subjects
20-100 100-500 1000-5000
• Development Stage Companies
• Universities
• Life-Science Incubators
• Laboratories
• Contract Research Organisations
• Clinical Trial Service Firms • CMOs
• Packagers
• Formulators
• API Manufacturers
• Health
Services
Pre-Discovery

18. Drug-Discovery Phase
The Need…
• Find promising leads for a drug candidate
• Search for a lead compound (organic or other
drug molecule)
• Mechanisms and methods to allow
researchers to test hundreds of thousands of
compounds against the target to identify those
that might have good potential.
Hippocrates platform…
• Provides users with access to the latest open
access medical and market information.
• Correlate current research with past /
recorded data using the crawlers and
annotation mechanisms of the platform.
• The content provided is appropriately
annotated with semantically driven
mechanisms so as to provide users with
maximum associations as well as rich
metadata.
• The modular architecture of the platform
allows for maximum integration to the
systems used by the researchers.

19. Analytics
and Lessons
Learned
Testing
Recording
Mechanisms
Semantically
Driven
Infrastructure
Access to
data
Drug-Discovery Phase
Already Integrated DBs New DBs (to be integrated)
Crawlers
Hip-Base
DataSourcesLayer
Term Dictionaries
Semi- Automatic Annotation Mechanisms

20. Drug-Discovery Phase
Analytics
and Lessons
Learned
Testing
Recording
Mechanisms
Semantically
Driven
Infrastructure
Access to
data
Hip-Base
User
Hippocrates
platform UI
KOS modelling tool
Annotation Tools
Annotation Types
Public ontologies e.g.
Linked Data
Domain specific
ontologies
Text based
resources
Graphical
elements
Elements with
text and images
Search features

21. Drug-Discovery Phase
Analytics
and Lessons
Learned
Testing
Recording
Mechanisms
Semantically
Driven
Infrastructure
Access to
data
Hip-Base
User
Hippocrates
platform UI
End-Users
testing
infrastructure
Hip Semantic infrastructure
Hip-Recording Mechanisms

22. Drug-Discovery Phase
Hip-Base
User
Hippocrates
platform UI
End-Users
testing
infrastructure
Hip Semantic infrastructure
Hip-Recording Mechanisms
Hip-Aggregator
Lessons
Learned
Analytics
and Lessons
Learned
Testing
Recording
Mechanisms
Semantically
Driven
Infrastructure
Access to
data

23. Phase
III
Phase
II
Phase
I
Discover Define Develop Demonstrate
Drug Discovery Preclinical Clinical Trials
Regulatory
Review
Scale-up to
Manufacture
Post Marketing
Surveillance
Approved
New
Medicine
6 – 7 Years3 – 6 Years 0.5 – 2 Years Indefinite
Number of Patients / Subjects
20-100 100-500 1000-5000
• Development Stage Companies
• Universities
• Life-Science Incubators
• Laboratories
• Contract Research Organisations
• Clinical Trial Service Firms • CMOs
• Packagers
• Formulators
• API Manufacturers
• Health
Services
Pre-Discovery

24. The Need…
• Minimal access to historical data on general health and/or
disease pathology
• Too resource intensive and too expensive business models
• Animal testing in the research-based pharmaceutical
industry has been reduced in recent years both for ethical
and cost reasons
Hippocrates platform…
Hippocrates platform integrates to the existing pre-
clinical infrastructure of the end-user acting
complementary significantly enhancing the research
infrastructure providing:
• Access to historical data and on-going research
through the Hip-aggregator.
• Targeted resource management through the
competency matching service.
• Access to Patenting services through APIs that
connect to EPO and USPTO
• Recording and history mechanisms connected to
the lessons learned database and the Hip-Base
Pre-clinical Testing
On average, only one in every 5,000 compounds that
enters drug discovery to the stage of preclinical
development becomes an approved drug
Ezekiel J. Emanuel. "The Solution to Drug Prices". New York Times

25. Preclinical Testing
Patenting
Analytics
and Lessons
Learned
Knowledge
Management
Hip-Base
Semantic
Indexing
Component
Semantic
Search
Component
Semantic
Search
Results
Set of Filtering
Options
Prioritization of
Results
Text
Images
Semantic Editing
Component
Set of Semantic
Models
Existing
Models
User Defined
Models
Semantic
Annotation
Component
Auto
Suggestions
User Defined
Text
Annotation
Image
Annotation

26. Preclinical Testing
Patenting
Analytics
and Lessons
Learned
Knowledge
Management
Hip-Base
User
Hippocrates
platform UI
End-Users
testing
infrastructure
Hip Semantic infrastructure
Hip-Recording Mechanisms
Hip-Aggregator
Lessons
Learned

27. Preclinical Testing
Patenting
Analytics
and Lessons
Learned
Knowledge
Management
• A patent is a set of exclusive rights granted by a state to an inventor for a
limited time (Usually 20 years from the filing date) in exchange for public
disclosure of an invention.
Prevent Others from commercially exploiting the Invention
• Patents are “prosecuted” by Patent Examiner and rejected or Granted
• Invisible for 18 months from filing.
• When published it becomes Prior Art and enters the Public Domain
• A granted patent application must include one or more Claims that define
the Invention
• Patents should demonstrate:
• Novelty,
• Usefulness
• Non-obviousness by someone skilled in the Art
• European Patent Office: https://www.epo.org/searching/free/espacenet.html
• Patents are filed and Paid Country by Country and need to be translated
• Patents are subject to Renewal Fees to keep the patent in force
• (USA Fees due 3½, 7½ and 11½ years after grant of the patent, UK yearly
after year 4).
Hippocrates
platform UI
Hip-Base
Lessons
Learned

28. Hippocrates USPs
• Hippocrates platform covers the entire spectrum of the lifecycle of drug discovery
and pre-clinical testing. It’s QA and project management modules will assist in
monitoring the clinical trial organisations.
• Its modular architecture allows for maximum integration re-using and/or integrating
where requested the existing technologies that end-users are familiar with. This
reduces both costs on licensing as well as training time.
• The advanced semi-automatic and generative mechanisms of the platform aim to
saves time to the researcher and funds to the pharmaceuticals allowing them to
focus the funds to more complicated and funds/demanding research