Presentation by Yves Fromes, MD, PhD

1. Preparing for Precision Medicine:
Aging Research
Sarcopenia: a multifactorial disease
Yves Fromes, MD, PhD

2. Boiled down to its essence, precision medicine describes
the ability to tailor therapies to a patient's individual
needs by examining their particular genome, physiology,
and environment.
Personalized Health Care is P4 / Systems Medicine

3. Precision medicine
◦ P4 medicine is the clinical face of systems medicine
◦ P4 medicine will make blood a diagnostic window for
viewing health and disease for the individual
◦ P4 medicine will integrate multiple parameters in
assessing the individual patient
◦ P4 medicine will provide new approaches to drug target
discovery
◦ P4 medicine will drive profound economic, policy and
social changes

4. The path to adoption of precision medicine requires
access to large-scale, well-designed, and
standardized electronic health records or precision
medicine platforms
to connect the clinical features, with imaging, biomarkers,
and the omics fields.
AToolbox
for Precision Medicine

5. Sarcopenia
an age-related decline in muscle mass and
function, is one of the most important
health problems in elderly with a high rate
of adverse outcomes.
Increasing health problem in Western
societies

6. Sarcopenia
degenerative loss of skeletal muscle mass and strength
related with aging
◦ Highly prevalent in a population older than 65 years old
◦ Leading to poor outcomes (functional decline and related
consequences)
◦ No clear understanding of the pathophysiology, its origin, risk
factors
Sarcopenia is not a single disease
◦ Therefore personalized approaches are necessary for the most
effective treatment.
◦ There are ways to improve quality of life and health span, and to
maintain as much strength for as long as possible.

7. Diagnosis
Clinical assessment
◦ No single pathophysiological hypothesis
◦ Systems biomedicine approach
Early diagnosis can prevent some adverse
outcomes
◦ Functional evaluation and NMR examination
a multiparametric approach
large volumes of data sets
Individualized treatments lead to lower costs,
fewer side effects, and better outcomes

8. Long-term monitoring
Sarcopenia is a chronic condition
Non-invasive tracking of multiple functional
parameters
◦ Biosensors
◦ Wearable sensors
Patient participation
Digitalization
Big data management
Multiscale integration from tissue to organism