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1. Definition it is a conditions characterized by idiopathic chronic
inflammation of bowel.
. Inflammation limited to mucosal layer of colon.
Full thickness inflammation involving any part of the Gl
tract from mouth to anus)
4. EPIDEMIOLO
GY
It can affect any part of GIT from mouth to anus.
most common in North America and Northern
Europe with annual incidence of 8 per 100 000.
Prevalence of around 145 per 100 000 in UK.
most commonly diagnosed between the ages of 25
and 40 years.
especially prevalent 3 to 5 times higher in the
ashkenazi Jews.
6. AETIOLOGY
gut mucosa and the normal gut bacteria becomes deranged,
Genetic. 10% first deg relatives.50% in monozygotic twins.
NOD2/CARD15 genes .
Environmental . jews
Infection.mycobacterium DNA.M Johne’s disease of cattle.
Smoking increase risk three fold.cessationeffect equal to
medicine.
diet high in refined foodstuff.
sanitation esp in children in childhood.
7. PATHOGENESIS
increased gut mucosal permeability with ncreased
passage of luminal antigens. an abnormal immune-
mediated response to colonisation of the gut .
induce a cell-mediated inflammatory response
release of proinflammatory cytokines
a defect in suppressor T-cells function.
10. CLINICAL FEATURES
post prandial colicky pain.
• Anorexia, Nausea ,vomiting,
• intermittent Fever,wight loss
• appendicitis
• tender mass inRIF
• intestinal obstruction.
• local or diffuse Peritonitis.
• gall stones
• mild prolong Diarrhea.
• blood in stool.
• anemia,Weight loss common
• fulminant colitis
11. Gut perforation
Enterocutaneous fistula.interloop,ileovesical,rectovaginal
fistulaileosigmoid fistula-profuse diarrhoea.
Periana skin bluish. abscesses and
fistulae,Incontinence,watering-can perineum.
Rectal bleeding Growth failure
‘Metastatic’ CD can occur in the vagina and/or
skin with nodular ulcers,
Malnutrition, vitamin deficiencies
14. PATHOLOGY
terminal ileum is most commonly (65%) alone or with colon
Colitis alone upto a one-third
perianal lesions up to 50–75% cases. 25% per cent of
patients
with small bowel disease, but in 75% of patients with Crohn’s
colitis.
characterized by skip lesions, adhesions & fistulas between
gut loops.
cobblestone appearance on endoscopy and contrast studies.
fat wrapping of inflamed part of bowel.
15. PATHOLOGY
•areas of normal mucosa in between areas of inflammation
ulcerations WITH mucopurulent exudate..
AREA OF STRICTURING AND PRESTENOTIC DILATATIONS.
• NC l Granuloma in 60%.most common in anorectal disease.
• Submucosal or subserosal lymphoid aggregates.
Fissure,fistula,abscess formation
16. Clinical Features
Clinical Feature Ulcerative Colitis Crohn's
Inflammation Superficial,
continuous
Full thickness, patchy
Mucosal Ulcers
Superficial Deep, linear
Involvement Rectum, colon mouth to anus
Extra-intestinal Yes Yes
Fistulas No Yes
Symptoms Bloody diarrhea, Diarrhea, pain, weight loss
27. MEDICAL TREATMENT
1-CORTICOSTEROID
moderate to severe disease,RAPID remission in
70–80% of cases .
short courses only,Not used for maintenance.
Prednisone (40-60 mg/day) acute episode.
Budesonide ileal or right-side colonic disease
usually replaced with immunomodulatory agents
adrenal suppression.
28. MEDICAL TREATMENT
2-ASA AGENTS
Mesalamine. small bowel
Mesalazine Asacol,Pentasa
Olsalazine (5-ASA dimer cleaves in colon)
limited efficacy in small bowel CD
29. MEDICAL TREATMENT
3-immunosuppressive agents .
AZATHIOPURINE-6MP used for CURRENTLY
STD maintenance therapy,Inhibit cell-mediated
responses
TPMT activity TEST, myelosuppression
Cyclosporine 80% remission.
30. MEDICAL TREATMENT.
4-MONOCLONAL ANTIBODIES
currently widely used for induction and maintenance.
also appear to be effective treatments for perianal disease
early and aggressive THERAPY at high risk for early RECURRENCE.
Suppress cell mediated immunity,
1ST Gen MAB. Infliximab. TNF BLOCKER.ESP pediatric CD.
2ND-Gen MAB adalimumab. TNF-α blocker. SC 1-2 WKLY
3-RD GEN MAB. integrin Ab. vedulizumab and etrolizumab
binds α4β7 and α4β1 receptors .ptevent WBCs
migration at site inflammation.
COSTLY,,MALIG
Contraindications Active infection, tuberculosis ,history of malignancy
31. MEDICAL TREATMENT
Antibiotics. metronidazole peripheral neuropathy,
ciprofloxacin Achilles tendinitis and tendon rupture ESP
IN PERIANAL
Antidiarrheal Agents. Loperamide,diphenoxylate.
Bile acid sequestrants .cholestyramine, colestipol
Anticholinergic agents.dicyclomine,hyoscyamine,
propantheline
33. SURGERY IN CD
70% of patients with CD will require a bowel
resection in the first decade
fundamental principle is to preserve healthy gut and
to maintain adequate function
34. INDICATIONS OF SURGERY IN CD
recurrent intestinal obstruction.
persistent or massive acute bleeding.
perforation of the bowel.
failure of medical therapy.
steroid dependent disease.
intestinal fistula.
perianal disease (abscess, fistula, stenosis).
malignant change.
35. OPERATIONS DONE FOR CD
Strictureplasty
Ileocaecal resection
Segmental resection
Proctectomy and proctocolectomy.
Colectomy and ileorectal anastomosis
Subtotal colectomy and ileostomy
Temporary loop ileostomy.
36. INDICATIONS OF DELAYED
ANASTOMOSIS OR ILEOSTOMY
Intra-abdominal septic compli_x0002_cations are more
common if
current high-dose steroid therapy (≥10mg prednisolone
for ≥4 weeks before surgery);
current preoperative monoclonal antibody therapy;
preoperative significant weight loss (>10% premorbid
weight).
pre-existing abdominal sepsis (notably abscess or fistula);
serum albumin <32 g/L.