Amyloid plaques

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Adonis Sfera, MD

Quick Reminder of Amyloid formation and anti-amyloid drugs.

Gesundheit & Medizin Business Unterhaltung & Humor

Amyloid Plaques

PHYSIOLOGICAL PATHWAY: Alpha
Secretase

PATHOLOGICAL PATHWAY: Beta
Secretase

Beta Secretase Inhibitors
• Merck: MK-8931
• Lilly: LY450139

Severe adverse
Effects: cancer

Gamma Secretase Inhibitors
• Merck: MK-8931
• Eisai: E 2609
• Lilly: LY2886721
In clinical trials

Monoclonal Antibodies against Abeta
42
*Solanezumab (Lilly)
*Bepaneuzumaub (Pfizer) - failed

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Amyloid plaques

1. Amyloid Plaques

2. PHYSIOLOGICAL PATHWAY: Alpha Secretase

3. PATHOLOGICAL PATHWAY: Beta Secretase

4. Beta Secretase Inhibitors • Merck: MK-8931 • Lilly: LY450139 Severe adverse Effects: cancer

5. Gamma Secretase Inhibitors • Merck: MK-8931 • Eisai: E 2609 • Lilly: LY2886721 In clinical trials

6. Monoclonal Antibodies against Abeta 42 *Solanezumab (Lilly) *Bepaneuzumaub (Pfizer) - failed