Muhammad Adeel Pharmacist G.C University Faisalabad

1. Calcium Gluconate

2. Contents
• Introduction
• Synonyms
• Formula
• Properties
• Preparation
• Pharmacological Properties
• Therapeutic Applications
• Side Effects
• Drug Interactions
• Contraindications

3. Introduction of Calcium Gluconate
• Anhydrous Compound
• Mineral Supplement
• Essential Body Electrolyte
• Muscle and Nerve Integrity
• Also Essential for
Muscle Contraction
Cardiac Functions
Coagulation of the Blood

4. Synonyms of Calcium Gluconate
•Calcium D-gluconate
•Calcium salt of Gluconic acid
•Gluconic Acid hemi-calcium salt

5. Formula of Calcium Gluconate
Chemical Formula = C12H22CaO14
Structural Formula =

6. Properties of Calcium Gluconate
•Solubility = Slowly in H2O, Insoluble in
organic solvent and alcohol.
•Natue = Inorganic and Mildly acidic
•Appearnce = Powder and granules.
•Odour = Odorless

7. Preparation of Calcium Gluconate
Oxidation of Glucose to Gluconic acid
In the presence of calcium..

8. Pharmacological Properties of Calcium
Glucoante
•Plays role in physiology of organism and cell.
•Pivotal role in signal transduction pathway.
•Acts as 2nd messenger in neurotransmitter
release of neurons and contraction of all muscle
cell types.
•Many enzymes require calcium ions as a
cofactor. Notable example is blood clotting
cascade.

9. Pharmacological Properties of Calcium
Gluconate
•Extracellular calcium is important for
maintaining potential difference across excitable
cell membranes as well as bone formation.
•Calcium is absorbed from the small intestine by
active transport and passive diffusion.
•It crosses placenta and enters in breast milk.

10. Therapeutic Applications of Calcium
Gluconate
• Hypocalcemia:
• Related to Hypothyroidism.
• Magnesium Sulphate Overdose:
• Hydrofluoric acid Burns:
• Calcium gluconate reacts with hydrofluoric acid to form insoluble,
nontoxic calcium fluoride.

11. Therapeutic Applications of Calcium
Gluconate
• Hyperkalemia:
• Black Widow spider bites:
• As an anti-dot
• Muscle Cramping:

12. Side Effects of Calcium Gluconate
• Nausea, Constipation, Stomach upset
• Rapid I.V may cause hypercalcemia which can result in
vasodilation, cardiac arrhythmias, decreased Blood Pressure
and bradycardia.
• I.M may lead to local necrosis and abscess formation.

13. Drug Interactions of Calcium Gluconate
• Digoxin
• Antacids or other calcium supplements.
• Vitamin-D supplement.
• Doxycycline.
• Tetracycline.

14. Contraindications of Calcium Gluconate
• Hypercalcemia
• Ventricular Fibrillation.
• Kidney Problem