Access Pharmaceuticals' presentation on MuGard. It has been found recently in tests that Mugard is a great preventative for oral mucositis, a debilitating side effect of many patients that undergo radiation and chemo therapy.

1. Prescribing information is available at this meeting

3. Over 90% of patients receiving radiotherapy will develop some degree of oral mucositis (OM)1

4. Up to 43% will present with severe oral mucositis1

5. Up to 40% of patients receiving chemotherapy will develop OM2Mucositis is a significant health issue in patients receivingradiotherapy/chemotherapy The severity of oral mucositis varies with type of chemotherapy, radiationdose and schedule Trotti, A., L. A. Bellm, et al. (2003). "Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review." Radiother Oncol 66(3): 253-62 Karthaus, M., C. Rosenthal, et al. (1999). "Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis - are there new strategies?" Bone Marrow Transplant 24(10): 1095-108. Prescribing information is available at this meeting

6. Signs and symptoms include1 Erythema Ulceration Pain –sometimes severe Inability tochew, swallow or speak Patient risk affected by1 Chemotherapy intensity of treatmentconcurrent radiationmethotrexate Radiation target areatotal dosetreatment time Poor dentition ill fitting prosthetic appliances dentures sharp or fractured teeth BMI - extremely low or high Medication related poor salivary gland function Prior episode of mucositis Schattner MD. Oral mucositis is often underrecognized and undertreated. Highlights of the 13th Annual Conference National Comprehensive Cancer Network. March 2008. Elsevier.Downloaded from www.nccn.org Dec 2000 Prescribing information is available at this meeting Mucositis is a significant health issue in patients receivingradiotherapy/chemotherapy

7. Oral mucositis - has a profound impact on patient’s health “…patients with OM [oral mucositis] are fourfold more likely to have unplanned breaks in radiation therapy and more than three timesas likely to be hospitalized…”1 International guidelines recommend preventive strategies2 “Use of a preventive oral care regimen should be part of routine supportive care along with a therapeutic oral care regimen if mucositis develops”2 Vera-Llonch, M., G. Oster, et al. (2006). "Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma." Cancer 106(2): 329-36 Keefe, D. M., M. M. Schubert, et al. (2007). "Updated clinical practice guidelines for the prevention and treatment of mucositis." Cancer 109(5): 820-31. Prescribing information is available at this meeting

8. Introducing MuGard MuGard is an innovative mucoadhesive oral rinse which forms a protective hydrogel coating over the oral mucosa1 MuGard is indicated for the prevention and management of the lesions and symptoms of oral mucositis1 MuGard is the first ready-to-use mouth rinse Carbomerhomopolymer A, polysorbate 60, glycerin, benzyl alcohol, citric acid, sodium saccharin, potassium hydroxyde, phosphoric acid, purified water Viscous ready-to-use liquid, supplied in 250ml glass bottle MuGard Instructions for Use. Prescribing information is available at this meeting

9. Mucositis Severity - Patient Analysis Start MuGard when you start therapy 42% of MuGardgroup did notdevelopsignificantmucositiscompared withonly 7% in thecontrol group1 80% 70% MuGard Standard Care 60% 50% 40% 30% 20% 10% 0% None Mild Moderate Severe OMAS score range2 ≤ 0.56 0.56 and ≤ 0.78 > 0.78 and ≤ 1.11 > 1.11 Baud CM, Colon LE, Gerberich J, Nowotnik DP, Howell SB Protection from Radiation-Induced Oral Mucositis by MuGard™ Oral Rinse - A Clinical Study and in silico Analysis. Poster at The 18th International Symposium of the Multinational Association of Supportive Care in Cancer in Toronto, June 22-24, 2006. Sonis et al. Validation of a New Scoring System for the Assessment of Clinical Trial Research of Oral Mucositis Induced by Radiation or Chemotherapy. Cancer; 1999;85:2103-2113 Prescribing information is available at this meeting

10. MuGard significantly reduces the severity of oral mucositis 2.0 1.8 1.6 1.4 1.2 1.0 0.8 0.6 0.4 0.2 0 OMAS vs. Time - Dataset 2 Mean + SEM Mean mucositisscores lower forpatients usingMuGard than forsimilar patients onstandard care1 Standard Care MuGard 15 17 11 13 9 5 7 1 3 Oral Mucositis Assessment Scale (OMAS)2 Ulceration 0 = no lesion 1 = < 1 cm2 2 = 1 cm2 – 3 cm2 3 = > 3 cm2 Erythema 0 = none 1 = not severe 2 = severe Baud CM, Colon LE, Gerberich J, Nowotnik DP, Howell SB Protection from Radiation-Induced Oral Mucositis by MuGard™ Oral Rinse - A Clinical Study and in silico Analysis. Poster at The 18th International Symposium of the Multinational Association of Supportive Care in Cancer in Toronto, June 22-24, 2006. Sonis et al. Validation of a New Scoring System for the Assessment of Clinical Trial Research of Oral Mucositis Induced by Radiation or Chemotherapy. Cancer; 1999;85:2103-2113 Prescribing information is available at this meeting

12. No case of overdose has been reported Treatment should be initiated at the beginning of radiation therapy or chemotherapy, even before the signs and symptoms of mucositis are evident Prescribing information is available at this meeting

13. Prescribing information is available at this meeting Easy to manage, easy to take

15. Mean mucositis scores lower for patients using MuGard than for standard care3MuGard has no known adverse interactions with medicinal or other products4 MuGard is the first ready-to-use mouth rinse Rubenstein, E. B., D. E. Peterson, et al. (2004). "Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis." Cancer 100(9 Suppl): 2026-46. Keefe, D. M., M. M. Schubert, et al. (2007). "Updated clinical practice guidelines for the prevention and treatment of mucositis." Cancer 109(5): 820-31. Baud CM, Colon LE, Gerberich J, Nowotnik DP, Howell SB (2006)Protection from Radiation-Induced Oral Mucositis by MuGard™ Oral Rinse - A Clinical Study and in silico Analysis.Poster at The 18th International Symposium of the Multinational Association of Supportive Care in Cancer in Toronto, June 22-24, 2006. MuGard Instructions for Use. Prescribing information is available at this meeting