Marketing slide presentation

1. ROLE OF
METFORMIN AND
GLIMIPIRIDE
IN
DIABETES
BY – ABHIJEET KUMAR

2. Diabetes Mellitus
 Metabolic disorder characterized by chronic or
persistant hyperglycemia.
 Associated with abnormal carbohydrate, fat
and protein metabolism.
 Major types
a) Type 1 DM (IDDM)
b) Type 2 DM (NIDDM)
c) Gestational Diabetes

3.  Type 1 DM must be managed by insulin
injections.
 Type 2 DM may be treated with medications
with or without insulin.
 Other treatment options
Life style modification
Diet and Exercise
Pharmacological therapy

4. Diabetic Complications

7. Management of Type-2 DM
 Oral Hypoglycemic agents :
Decreases glucose level by direct stimulation
on insulin secretion.
Eg; Sulfonylurea derivatives
1st Gen : Tolbutamide, Chlorpropamide.
2nd Gen : Glibenclamide, Glipizide, Gliclazide,
Glimepride.

8.  Anti-hyperglycemic agents :
a) Sensitizers- improves insulin sensitivity.
Eg; Bigunides - Metformin
Glitazones – Rosiglitazone, Pioglitazone
b) Alpha-Glicosidase inhibitor- delaying glucose
absorption. Eg; Acarbose, Voglibose.
c) DPP 4 enzyme inhibitor- extend the action of
insulin and supress glucagon release. Eg;
Sitagliptin, Saxagliptin.

9. Metformin – Glimipiride Market
 The Rs 4,500 crore anti-diabetic market is
growing annually at 20%, with the glimepiride
and metformin combination molecule
contributing 1/4th of sales.
 Widely-prescribed anti-diabetic drugs
(glimepiride plus metformin) clocked sales of
Rs 105 crore, in May 2014.
 The anti-diabetic sub-class, a combination of
glimepiride and metformin, registered a growth
of 34.4% in May 2014.

10. Top leaders of Glimepiride
 Amaryl – Sanofi
 Zoryl – Intas
 Glimy – Dr.Reddys
 GP – USV
 Euglim – Zydus
 Glimulin – Glenmark
 Glypride – Sun

11. Ordain Presents

12. Top leaders of Metformin
 Glyciphage – Franco Ind
 Glycomet – USV
 Obimet – Abbott
 Riomet – Ranbaxy
 Gliconorm – Lupin
 Xmet – Glenmark
 Cetapin XR – Aventis

13. Ordain Presents

14. Various Combination available
 Metformin starting dose is 500mg b.i.d or
850mg o.d with meals and maximum dose is
2550mg per day.
 Glimepiride 1mg + Metformin 500mg
 Glimepiride 2mg + Metformin 500mg
 Glimepiride 0.5 mg + Metformin 1000mg
Triple drug combinations;
(Glimepiride 1&2mg + Pioglitazone 15mg +
Metformin HCl 500mg)

15. Top leaders
 Glycomet GP – USV
 Gemer – Sun
 Glimaday – Wokhardt
 Zoryl M – Intas
 Gluconorm G – Lupin

16. Ordain Presents

17. End Note
"While metformin is the best drug to treat
diabetes, combination therapy with glimepiride
is required in most cases sooner or later. In
India, this combination is most commonly-used
since it is cheap and effective. Because of
unabated diabetes increasing use of this
combined therapy is understandable", says Dr
Anoop Misra, director of Delhi-based Fortis-
CDOC hospital for diabetes.