The BioMEMS market is expected to grow rapidly, from $1.9B in 2012 to $6.6B in 2018! Microsystems integration is fast becoming a key added-value for system manufacturers. THE BIOMEMS MARKET WILL ALMOST TRIPLE IN SIZE OVER THE NEXT FIVE YEARS, WITH MOBILE CARE APPLICATIONS CONTRIBUTING SIGNIFICANTLY TO THIS IMPRESSIVE GROWTH! Microsystem devices have become increasingly visible in the Healthcare market by serving as solutions adapted to the requirements of various applications. The usefulness of these devices is two-fold: for one, they improve medical device performance for the patient; and secondly, they offer competitive advantages to system manufacturers. For example, the introduction of accelerometers in pacemakers has revolutionized the treatment of cardiac diseases. The Microsystem technologies market for Healthcare applications looks promising, and should reach $6.6B by 2018. Yole Développement has followed this market’s innovations and key players for the last several years, and based on an accurate analysis of the market’s last three years, this new report consolidates market data for 2010-2012 and provides forecasts for 2012-2018. The devices considered in the BioMEMS 2013 report are: - Pressure sensors - Silicon microphones - Accelerometers - Gyroscopes - Optical MEMS and Image sensors - Microfluidic chips - Microdispensers for drug delivery - Flow meters - Infrared temperature sensors - Emerging MEMS (RFID, strain sensors, energy harvesting) For each of the above, the report provides a market description, the main device and system manufacturers, current market data, and forecasts. Additionally, main technological trends are reviewed. REGULATION OVERVIEW The regulation particulars for medical device development, included organisms and process overview, are described for five different regions: Europe, North America, Japan, China and India. This section is particularly important for Microsystem device and systems manufacturers. The report objectives are as follows: - Provide a robust analysis of the Micro Devices used to develop innovative solutions for Healthcare applications. - Compare Yole Développement’s previous forecast with current market data and draw conclusions. - Deliver the following information for each device category: market insights, main device manufacturers and system integrators, and main trends. - Describe the market drivers per application group. More information on the report at http://www.i-micronews.com/reports/BIOMEMS/4/345/

1. BIOMEMS
Microsystem Device Market for Healthcare Applications
SAMPLE
Overview of the technical & economic requirements
for Healthcare Applications
February 2013
Le Quartz - 75 cours Emile Zola - 69100 LYON-Villeurbanne
Tel: +33 472 83 01 80 - Fax: +33 472 83 01 83
Web: www.yole.fr

2. Table of Contents
Executive Summary – p7
BIOMEMS 2013 Report – p28
1. Introduction– p29
2. The Microsystems Market for Healthcare Applications– p46
3. Market Forecast in $M– p65
4. Market Forecast in Munits– p79
5. Applications of Microsystems and BioMEMS in Healthcare– p91
6. Microsystems & BioMEMS Current Products– p109
• Pressure sensors
• Silicon microphones
• Accelerometers
• Gyroscopes
• Optical MEMS and Image sensors
• Microfluidic chips
• Microdispensers for drug delivery
• Flow meters
• Infrared temperature sensors
• Emerging MEMS (RFID, Strain sensors, Energy Harvesting
• Others Biological Sensors for Cell Phone
7. BioMEMS Activities in China– p217
8. Regulation Aspects for medical device development– p251
9. Summary and conclusions– p266
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3. Objectives of the Report
• The report is divided in 9 main sections:
– Comparison between previous forecast & real market data
– The microsystem market for Healthcare applications
– BioMEMS Market Forecast in $M
– BioMEMS Market Forecast in M units
– Microsystem and BioMEMS applications in healthcare
– Current Microsystem & BioMEMS products
• Pressure sensors
• Silicon microphones
• Accelerometers
• Gyroscopes
• Optical MEMS and Image sensors
• Microfluidic chips
• Microdispensers for drug delivery
• Flow meters
• Infrared temperature sensors
• Emerging MEMS (RFID, Strain sensors, Energy Harvesting)
• Others Biological Sensors for Cell Phone
– BioMEMS activities in China
– Regulation Aspects for medical device development
– Conclusions
• It enables you to:
– Understand the Healthcare market and define your strategy to address it
– Get an overview of the technologies and the trends for the coming years
– Understand the real added value of Microsystems and Semiconductors to the healthcare industry
– Understand the main regulatory requirements (FDA, CE…)
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4. Microsystems and BioMEMS in this Report
• Microeletromechanical systems, or
MEMS, are integrated microdevices or
• Medical Devices produced re-using systems that combine electrical and
semiconductor manufacturing processes mechanical components, fabricated
using integrated circuit compatible
batch –processing techniques, and vary
in size from micrometers to millimeters.
These systems merge computation with
sensing and actuation.
MCNC 1996
• Bio-Medical Microstructured products
made out of Glass, silicon, polymer,
ceramic or metal
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5. Companies Cited in this Report
Abbott, Akustika, Analog Devices, Baxter, Becton Dickinson (BD), Bluechiip, Boehringer
Ingelheim Microparts, Boston Scientific, Caliper Life Science, CapitalBio, Cepheid,
CleveMed, Dalsa, Debiotech, Dolomite, e2v, ELA Medical, Endevco, Excelitas, Fluidigm,
Freescale, GE Sensing, Given Imaging, Golden Elephant of XinXiang, Hamamatsu,
Handylab (BD), Heimann, Honeywell, HSG-IMIT, Huiqin, IMEC, IMS-chips, Insound Medical,
Integrated Sensing Systems, Intuitive Surgical, Invenios, KarlStorz, Knowles Acoustics,
Kodak, Lepu Medical Group, LifeTechnologies, Magnotec, MEAS, Medspray, Medtronic,
Melexis, Micralyne, Microfluidic Chipshop, Microlife, Micron, Micronit, Nanopass, NeuroIZ,
Nicera, Olympus, Omron, Oticon, Philips, Phonak, QINMING Medical, Respitronix, Roche,
Sensimed, SensorDynamics, Shanghai BioChip, Shanghai HealthDigital, Shanghai YuLong
BioTech, Shanxi LifeGen, Sony, St Jude Medical, STMicroelectronics, TDK EPCOS,
Terumo,Texas Instrument, Landwind, ThinXXS, Tianjin BioChip Corp, TNO, Trixel, Tronic’s
Microsystems, United Gene, VTI, Widex, Yongsheng, YUYUE Medical Equipment…
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6. Markets Considered in This Report
Life sciences
Pharmaceutical In Vitro Diagnostics Medical Devices Medical Home Care
Biological test Medical equipment Prescribed Medical
Drug discovery and
development and development and devices and services
commercialization
commercialization commercialization for home care
$855B 2011 $65.3B 2011 $267B 2011 $69B 2011
CAGR 11: 5% CAGR 11: ~8% CAGR 11: 6% CAGR 11: 9%
Source IMS Health, VFA
BioMEMS contribution: BioMEMS BioMEMS
BioMEMS contribution:
$674M contribution: $521M contribution: $52M
$317M Source Yole estimation Source Yole estimation Source Yole estimation
Agrofood Environment
control control R&D spending around Wide range of products.
R&D spending ~17% of . process • water 8% of sales Excludes consumer health
annual turnover control, monitoring,
source PhRma source Eucomed and sport products
traceability, • homeland
… security,…
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7. What as changed since 2010?
• This report provides last updated market data for each device category explored.
• The microfluidic device market has been validated against reported sales data of
approximately 150 players. We estimate that these players cover 95% of the total
market. This resulted in adjustments of the forecasts.
• We have gone a step further in our forecasts with the split of general application
into more detailed ones. For example, “Blood Pressure applications” became
separated into “blood monitoring disposable” and “blood monitoring equipment”.
• The regulation aspects have been updated as news regulations are in the pipeline
for European Market access.
• Specific case studies have been added to deeply treat two hot topics: Microfluidic
chip and retinal implant.
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8. What as changed since 2010?
• Microsystem devices and BioMEMS are applied in the pharmaceutical research, the
In-vitro diagnostics and the medical device sectors.
• We noticed a clear trend towards the development of technologies for patient
monitoring outside the hospital and consumer health.
• Although the “home care” market is a subsection of the medical market, we choose
to address this segment separately in this report as it is a high growth market.
• This document only addresses the market of “Medical Home Care”, that we define
as “prescribed home care medical devices”. Consumer, over the counter products,
and sport/fitness equipment does not fall under the scope of this analysis.
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9. Microsystem Devices for Healthcare Applications
2011 & 2018 market in M$
7000
BioMEMS and Microsystems for Life Science Market in $M
6000
5000
CAGR2013-2018=24%
4000
3000
2000
1000
0
2011 2012 2013 2014 2015 2016 2017 2018
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10. Markets Trends & Drivers
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11. Global Miniaturization roadmap
Anywhere Care
Medical requirements
Only for chronic diseases
Home Care Quality and for medical safety reasons
Miniaturization and integration level
Point of care of Life Implantable
•Pacemakers
Mobility •Neurostimulators
Wearable •ECG
•Coclear implants
Ease of use •Glucose monitoring •...
Near Patient •Kidney dialysis
•Theranostics
Hospital and Portable •Activity monitoring
Lab Care •Patient monitoring
•IVD
•Smart pills
•Point of care
•...
•Infusion and drug
delivery
•Respiratory monitoring
•...
Benchtop
•Anesthesia
• ventilators
•medical monitoring
•...
Time
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12. Three specific case studies
Retina Implant
Retina Implant – Subretinal Implant
Courtesy of Retina Implant
Microfluidic chips
Alere
PIMATM CD4 analyzer
OJ-bio’s
SAW Biosensors
Micro sensors connected to smartphone
The report includes three specific focus:
Retina implant, microfluidics chips and sensors connected to smartphone
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13. More information, please contact
Benjamin Roussel, PhD
Technology & Market Analyst
Microfluidics & Medical Technologies
Email : benjamin.roussel@yole.fr – Skype : broussel_yole
Phone : +33 472 83 01 04
Le Quartz, 75 Cours Emile Zola – 69100 Villeurbanne
Lyon – FRANCE
www.yole.fr – www.i-micronews.com
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14. Yole activities in MedTech
Market Consulting
Research services
Market research,
Reports & Technology & Strategy
database
Media business
News feed / Magazines /
Webcasts
www.yole.fr
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15. MedTech reports from YOLE
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