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1. From Technologies to Market
Liquid Biopsy:
From Isolation
to Downstream
Applications 2018
Sample
2018

2. 2
LIST OF COMPANIES MENTIONED IN THIS REPORT
©2018 | www.yole.fr | Liquid Biopsy: From Isolation to Downstream Applications 2018 | Sample
Abbott,AdnaGen, Agilent Technologies, Amazon,Amgen, Angle, ApoCell, Assurex Health, AstraZeneca,Axon Dx,
BD, Beckman Coulter, BGI, Biocartis, Biocept, Biodesix, BioFluidica, Bio-Rad, Bioview, Bristol Myers Squibb,
Cambridge Consultants, CellMax Life, CellSearch, Celsee, Circulogix, Cirina, Clearbridge BioMedics, Clinical
Genomics, Cogent, Creatv MicroTech, Cynvenio Biosystems, CytoLumina, CytoTrack, DiaDx, Diagnologix, Epic
Sciences, Epigenomics, Exact Sciences, ExosomeDx, FivePrime, Fluxion Biosciences, Foundation Medicine,
Foxgene, Freenome, GE Healthcare, Genapsys, Gendia, Genomic Health, Gilupi, GnuBio, Grail, Greiner Bio-One,
Guardant Health, HP, IBM Watson, iCellate, IKOTECH, Illumina, IncellDx, Inivata, Janssen Pharmaceuticals,
Johnson & Johnson, LifeArc, Livzon, Menarini Silicon Biosystems, Merck, Microsoft, Mikro Biyosistemler, Miltenyi
Biotec, Myriad Generics, Nabsys, NanoLite Systems, Nanostring, Natera, Noblegen, Novartis, Oncocyte, Oxford
Nanopore Technologies, Pacific Biosciences, Pathway Genomics, Personal Genome Diagnostics, Pfizer, Predicine,
Qiagen, RareCells Diagnostics, RareCyte, Roche, SBI, ScreenCell, Sigma Aldrich, Simfo, Sividon Diagnostics, SRI
Biosciences, StemCell Technologies, Stratec, Streck, Sysmex, TeloVision, Thermo Fisher Scientific, thinXXS,
Trovagene,Veracyte,Vitatex,Vortex Biosciences, Zomedica…
and many more!
210+ slides of market and technology analysis
Information gathered through direct discussions with players all along the supply chain

3. 3
Biographies & contacts
ABOUT THE AUTHORS
Dr. MarjorieVillien
Sébastien Clerc
• Sébastien Clerc is a Medical Technologies Analyst at Yole Développement, the "More than Moore" market research and strategy consulting company.
After graduating from Grenoble Institute of Technology with a Master’s degree in Biomedical Technologies, he completed his training with a Master’s
of Innovation and Technology Management, during which he oversaw strategy and marketing.
• Email: clerc@yole.fr
• As a Technology & Market Analyst, Dr. Marjorie Villien works in the Microfluidic & Medical Technologies (MedTech) business unit at Yole
Développement, the "More than Moore" market research and strategy consulting company. She is a daily contributor to the development of
MedTech activities, with a dedicated collection of market & technology reports as well as custom consulting projects. After spending two years at
Harvard, Dr. Villien served as a research scientist at INSERM in the field of MRI & PET imaging. She has spoken at numerous international
conferences and has authored or co-authored 11 papers and one patent. Dr. Villien graduated from Grenoble INP and holds a PhD in Physics &
Medical Imaging.
• Email: villien@yole.fr
Asma Siari
• As a Technology & Market Analyst in the Medical Technologies (MedTech) business unit at Yole Développement (Yole), Asma Siari is involved in the
development of technology & market reports as well as the production of custom consulting projects. After a Master’s degree in Biotechnologies,
Diagnostic Therapeutics & Management, Asma serves as Research Assistant at the Moores Cancer Center (San Diego, CA). She is a coauthor in two
scientific publications published in the Molecular Cancer Research Journal. In addition to her mission at Yole, Asma is graduated with an Advanced
Master’s degree in International Strategy & Marketing BtoB (EM Lyon Business School, France).
• Email: siari@yole.fr

4. 4
REPORT CONTENT
• Explain what liquid biopsy is, why it is used, and the characteristics of each biomarker (ctDNA,
CTC, exosomes)
• Market analysis of M&A, collaborations, fundraisings, and business models
• Technical and biological requirements, product examples, key players, market share, and technology
trends
• Market overview and forecasts at service and device levels, for ctDNA and CTC applications
• Overview of the market’s main players and the technologies involved, including company profiles
• Focus on downstream analysis and identification of the main technologies used for liquid biopsy
• Supply chain analysis

5. 5
WHO SHOULD BE INTERESTED BY THIS REPORT?
o Biotechnology & Pharmaceutical Companies:
• To understand what is the state of the art of liquid
biopsy technologies
• To identify the different players across the supply chain
• To understand behavior evolution and identify new
business models
• To identify competitors and targets for collaborations
or M&A
o Equipment & Material suppliers:
• To understand the technical evolution of ctDNA, CTC
and exosome solutions involved in the detection and
isolation process
• To identify business opportunities and prospects
o R&D players:
• To understand challenges linked to the use of liquid
biopsy systems
• Address the right market with the right technology
o Industrial & service companies:
• Grasp which solutions could bring operational benefits
o Medical devices outsourcing companies:
• To have a broad overview of all applications & markets
• To identify new Liquid biopsy markets
• To monitor and benchmark potential competitors
• To understand behaviors evolution
o Microfluidic foundries and device makers:
• Grasp technical requirements, depending on the
application
• Target business opportunities and prospects
o Financial & Strategic investors:
• To understand the potential of liquid biopsy in the
consumer and healthcare industries
• To know the latest moves within the industry
• To get a list of players and their activities in the field of
diagnostic using liquid biopsy
o Healthcare & governmental organizations:
• Evaluate the benefits of using non invasive testing
• Pinpoint relevant companies

6. 6
TABLE OF CONTENTS
• Executive Summary 9
• Introduction 50
• What is liquid biopsy?
• What can we learn from Liquid Biopsy?
• Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA)
• Report scope
• Liquid Biopsy Market Analysis 64
• Applications and drivers
• Cancer prevalence
• Liquid biopsy ecosystem
• Mergers and acquisitions/collaborations
• Fundraising analysis
• Market data and forecasts 2017 - 2023
• Business models
• Regulations status
• Roadmaps
• Circulating Tumor DNA and Exosomes 89
• Introduction to ctDNA and exosome technologies in liquid biopsy
• Workflow for detection of ctDNA and exosomes in cancer patients
• Main players and market share
• Market data and forecasts 2017 – 2023
• Supply chain analysis
• Company profiles
• Circulating Tumor Cells 132
• Introduction to CTCs
• CTCs - analysis workflows in liquid biopsy
• CTCs - enrichments and isolation methods
• Workflow coverage for the main CTC players
• Main players and players map
• Market data and forecasts 2017 – 2023
• Supply chain analysis
• Company profiles
• Downstream Analysis 184
• Overview of analytical approaches for liquid biopsy
• Main technologies and requirements
• Focus on next-generation sequencing: main players and applications
• Focus on polymerase chain reaction and beaming technology - main players
and applications
• Company profiles
• General Conclusions 208

7. 7
LIQUID BIOPSY
Definition
The
advantages of
liquid biopsy
• Liquid biopsy hold the hopes of answering the needs for a
less invasive procedure that could give a better picture of
the cancer diagnosis, treatment or recurrence.
• Tissue biopsy are more invasive hence only provide a
snapshot of the disease as it can’t be easily repeated.
• But maybe the greatest limitation to tissue based biopsy
techniques is that sampling of a single tumor may not
capture all of the mutations present.
• Liquid biopsy allows for real-time, serial and longitudinal
monitoring during cancer therapy.
• It also provides a more comprehensive view of the tumor’s
biomarkers. http://liquid-biopsy.gene-quantification.info/

8. 8
LIQUID BIOPSY
What is analyzed?
Analyses of
circulating tumor
cells (CTC),
circulating tumor
DNA (ctDNA),
and tumor-
derived
extracellular
vesicles can
enable tumor
characterization
by minimally
invasive means
Liquid biopsy
Circulating tumor cells (CTCs) Circulating tumor DNA (ctDNA)
Extracellular vesicles (EVs)

9. 9
LIQUID BIOPSY
Liquid biopsy in the care pathway of cancer patients
• According to the National Institutes of Health’s clinical trials database, clinicaltrials.gov, over 250 trials are currently studying the
use of liquid biopsies in cancer detection, identification, or treatment in the USA only.
• Liquid biopsy can be used at various stage in the care pathway of cancer patients from screening, to monitoring of treatments
and understanding drug resistance mechanisms.
• What’s needed to make a difference in patients’ lives is clinical evidence of sensitivity, selectivity, and efficacy.
Screening for
Early Detection
Profiling
Cancer
Developing
Personalized
Treatment
Monitoring
Treatment
Assessing
Possible
Recurrence
Detect cancer earlier to
start treatment earlier
Identify people at risk for
developing cancer
Understand molecular
mechanisms associated
with this patient
Choose and develop a
tailored treatment
Monitor treatment’s
efficiency along with
drug resistance
Screening for disease
recurrence

10. 10
LIQUID BIOPSY
Scope of the report
• We decided to focus our report on cancer liquid biopsy as the other applications are quite different in term of
market dynamics and players.
• We focused our reports on ctDNA, CTCs and exosomes analysis as protein analysis for liquid biopsy are more
in a research stage today.
• In our market analysis we focused on companies developing liquid biopsy kits, instruments and service.
In the report Not in the report
Applications Cancer
Others (noninvasive prenatal testing,
etc.)
Biomarkers ctDNA, CTCs, exosomes Proteins
Market analysis
Companies developing liquid biopsy kits,
instruments and services

11. 11
INTRODUCTION TO LIQUID BIOPSY

12. 12
LIQUID BIOPSY MARKET ANALYSIS

13. 13
CIRCULATING TUMOR DNA AND EXOSOMES

14. 14
CIRCULATING TUMOR CELL

15. 15
DOWNSTREAM ANALYSIS

16. 16
RELATED REPORTS

17. Cancer is a rising concern in modern society.
Numerous drivers contribute to the increase of
cancer cases, such as ageing of the population,
lifestyle, and environment. According to the World
Health Organization, cancer is responsible for one
in six deaths worldwide, and one in two people are
likely to develop cancer in their lifetime. Cancer
cells are cells whose genes have mutated; in order
to understand each cancer’s mechanisms and
determine the appropriate treatment, these tumors
require analysis. Traditional biopsy methods involve
obtaining a piece of the tumor through invasive
surgery. However, these procedures are expensive
and exhausting for the patient, and cannot be
reproduced regularly in order to monitor a cancer’s
evolution and treatment efficiency over time.
However, it is now possible to avoid such invasive
procedures thanks to a “liquid biopsy”. Indeed, it
is possible to collect a simple blood draw in which
relevant biomarkers can provide useful information
about the patient’s cancer. In particular, a number
of companies are developing technologies to
collect, isolate, and analyze circulating tumor
DNA (ctDNA: DNA molecules shed by cancerous
cells) and circulating tumor cells (CTCs: tumor
cells shed from the original tumor) that spread
into the bloodstream. Thanks to these tools, it is
possible to not only diagnose cancer uninvasively,
but also to understand the molecular mechanisms
associated with each patient, choose and develop
a tailored treatment, monitor the treatment’s
efficiency (along with drug resistance), and screen
for disease recurrence. Some companies are even
working on screening for early detection, although
this is a more long-term application.
Liquid biopsy thus has the potential to assist
at every stage of cancer care, saving lives and
cutting healthcare costs. The opportunity is huge,
and the associated market is already large and
growing extremely fast. According to this Yole
Développement report, the liquid biopsy market
will grow from $1.7B in 2017 at a CAGR2017-2023
of 29%, reaching $7.8B by 2023. This includes
hardware (systems and devices) and reagent kit
sales, along with service revenue, for CTC and
ctDNA applications.
LIQUID BIOPSY: FROM ISOLATION TO DOWNSTREAM
APPLICATIONS 2018
Market & Technology report - June 2018
LIQUID BIOPSY: A POWERFUL EMERGING TOOL FOR CANCER CARE, AND
A HUGE BUSINESS OPPORTUNITY
How will liquid biopsy change cancer care?
KEY FEATURES
• Introduction to liquid biopsy
testing, definitions, and why it is
used
• Market analysis of mergers and
acquisitions, collaborations,
fundraisings and business models
• Technical and biological
requirements, product examples,
key players, market share, and
technology trends
• Market overview and forecasts at
both service and device levels, for
circulating tumor DNA (ctDNA:
DNA molecules shed by cancerous
cells) and for circulating tumor cells
(CTCs: tumor cells shed from the
original tumor) applications
• Overview of the market’s main
players and the technologies
involved, including company
profiles
• Focus on downstream analysis
and identification of the main
technologies used for liquid biopsy
• Supply chain analysis
(Yole Développement, June 2018)
Liquid biopsy: a game-changer in cancer care
WHY LIQUID BIOPSY?
WHAT IS ANALYZED IN LIQUID
BIOPSY?
WHAT QUESTIONS COULD
LIQUID BIOPSY ANSWER?
vs
Circulating Tumor
Cells (CTCs)
Exosomes
Circulating Tumor
DNA(ctDNA)
Early detection
and diagnosis
Personalized
treatment
Monitoring
treatment
Assessing
recurrence
Standard
Biopsy
Liquid Biopsy
Invasive Minimally invasive
Localized sampling
of tissue
Comprehensive
tissue profile
Time intensive Quick
Some associated
pain and risk
for the patient
Minimal pain
and risk for
the patient
AN IMPRESSIVE RANGE OF COMPANIES AND BUSINESS MODELS
Studying mutations in cancer cells’ DNA is not
an easy task, and requires many different tools
and skills. From the enrichment and analysis
of biomarkers to the bioinformatics analysis of
mutation profiles, the path is long and many players
are involved. This report confirms the role of each
player at each level of the supply chain, explains
who is specialized in which step, and details where
the value lies and how the development of liquid
biopsy is boosting downstream analysis equipment
markets like sequencing and digital PCR. The
difference and complementarity of ctDNA and
CTCs is also described, and Yole Développement’s
analysts explain why CTC has yet to attract
significant funding, and how the situation may now
change thanks to recent findings.
Indeed, ctDNA companies have raised more than
$3.7B since 2010, while CTC companies have only
raised around $280M. In terms of revenue, the split

18. LIQUID BIOPSY: FROM ISOLATION TO DOWNSTREAM APPLICATIONS 2018
TECHNOLOGICAL BREAKTHROUGHS ARE DRIVEN BY MICROFLUIDIC TECHNOLOGY
Many steps in the liquid biopsy workflow have been
made possible thanks to microfluidic technologies.
From isolation to downstream analysis, microfluidic
devices are involved everywhere. A major part of CTC
enrichment and isolation systems relies on microfluidic
devices that enable separation of CTCs from other
blood cells, using their physical properties such as
size, shape, deformability, and dielectric properties.
Important companies such as Angle plc, Celsee,
Clearbridge Biomedics, and Vortex Biosciences rely
on microfluidics. These microfluidic methods work
for a wide range of cells and enable high throughput
capture at a low cost. Moreover, downstream analysis
solutions also rely on microfluidic technologies in
numerous cases: DNA sequencers from Illumina, Ion
Torrent, and others use microfluidic flow cells, and
other technologies like droplet digital PCR from Bio-
Rad, Stilla Technologies, and RainDance (acquired by
Bio-Rad) are also microfluidic technologies.
All of these state-of-the-art technologies are enabled
by innovative microfluidic hardware and allow more
complex analyses to be performed, thus contributing to
concrete improvements in cancer care. In this report,
Yole Développement focuses on these microfluidic
technologiesateveryleveloftheliquidbiopsy workflow.
is also unbalanced in favor of ctDNA companies. This
is primarily due to business models: most ctDNA
companies offer testing services in their Clinical
Laboratory Improvement Amendments (CLIA)
labs, performing tests developed in-house which do
not require Food and Drug Administration (FDA)
clearance. Moreover, DNA is easier to transport and
store than live cells, which is another advantage for
ctDNA. On the contrary, most CTC companies are
developing instruments that are directly sold to end-
users, along with the associated consumables.
However, most of these instruments for CTC
isolation are still for research use only because the
FDA requires more evidence of the benefits derived
from analyzing CTCs in patients’ survival rate, before
approving them for clinical use. This explains, at least
partially, why CTC companies are lagging behind in
terms of revenue. Thankfully, this situation may soon
change thanks to advances in technology and to the
increasing number of published works proving the
clinical value of CTC analysis: in fact, a complete live cell
can carry much more information than a DNA strand.
Immuno-enrichment
methods (antibody labeling)
Physical properties
Positive and/or negative
immuno-enrichment
Size, shape, deformability
(filtration, inertial focusing…)
Dielectric properties
Enrichment-free
Direct
imaging
Immunomagnetic separation,
fluorescence detection
Usually microfluidic chip /
microstructures / microfilters
Dielectrophoresis
(DEP) based CTC
enrichment
Fluorescence staining of glass
slides
Centrifugation + fluorescence
staining of glass slides
Enrichment-free / density-
based separation
Non-exhaustive list of companies, * CTC: circulating tumor cell
Density-based enrichment
Density gradient
centrifugation + fluorescence
staining of glass slides
Liquid biopsy market ecosystem for 2017
(Yole Développement, June 2018)
Indirect liquid
biopsy market:
downstream
analysis companies
ctDNA**
andexosomes
companies
CTC* companies
Liquid
biopsy
market
* CTC: circulating tumor cell
** ctDNA: circulating tumor DNA
Non-exhaustive list of companies
Liquid biopsy market: technologies for CTC* workflows
(Yole Développement, June 2018)

19. MARKET TECHNOLOGY REPORT
COMPANIES CITED IN THE REPORT (non exhaustive list)
Abbott, AdnaGen, Agilent Technologies, Amazon, Amgen, Angle, ApoCell, Assurex Health,
AstraZeneca, Axon Dx, BD, Beckman Coulter, BGI, Biocartis, Biocept, Biodesix, BioFluidica, Bio-Rad,
Bioview, Bristol Myers Squibb, Cambridge Consultants, CellMax Life, CellSearch, Celsee, Circulogix,
Cirina, Clearbridge BioMedics, Clinical Genomics, Cogent, Creativ MicroTech, Cynvenio, CytoLumina,
CytoTrack, DiaDx, Diagnologix, Epic Sciences, Epigenomics, Exact Sciences, ExosomeDx, FivePrime,
Fluxion, Foundation Medicine, Freenome, GE Healthcare, Genapsys, Gendia, Genomic Health, Gilupi,
GnuBio, Grail, Greiner Bio-One, Guardant Health, HP, IBM Watson, iCellate, IKOTECH, Illumina,
IncellDx, Inivata, Janssen Pharmaceuticals, Johnson Johnson, Life Technologies, LifeArc, Livzon,
Menarini Silicon Biosystems, Merck, Microsoft, Mikro Biyosistemler, Miltenyi Biotec, Myriad, Nabsys,
Nanostring, Natera, Noblegen, Novartis, Oncocyte, Oxford Nanopore, Pacific Biosciences, Pathway
Genomics, Personal Genome Diagnostics, Pfizer, Predicine, Qiagen, RareCells, Roche, SBI, ScreenCell,
Sigma Aldrich, Simfo, Sividon Diagnostics, SRI Biosciences, StemCell Technologies, Stratec, Streck,
Sysmex, TeloVision, Thermo Fisher, Thermo Fisher Scientific, ThinXXS, Trovagene, Veracyte, Vitatex,
Vortex Biosciences, Zomedica,… and many more
Executive summary 9
Introduction 50
What is liquid biopsy?
What can we learn from liquid biopsy?
Circulating Tumor Cells (CTCs) and circulating
tumor DNA (ctDNA)
Scope of the report
Liquid biopsy market analysis 64
Applications and drivers
Cancer prevalence
Liquid biopsy ecosystem
Mergers and acquisitions/Collaborations
Fundraising analysis
Market data and forecasts 2017-2023
Business models
Regulations status
Roadmaps
Circulating tumor DNA and exosomes 89
Introduction to ctDNA and exosomes
technologies in liquid biopsy
Workflow for detection of ctDNA and
exosomes in cancer patients
Main players and market share
Market data and forecasts 2017–2023
Supply chain analysis
Company profiles
Circulating tumor cell 132
Overview of analytical approaches for liquid
biopsy
Main technologies and requirements
Focus on next generation sequencing : main
players and applications
Focus on polymerase chain reaction and
beaming technology: main players and
applications
Company profiles
Downstream analysis 184
Introduction to CTCs
CTCs analysis workflows in liquid biopsy
CTCs enrichments and isolation methods
Workflow coverage for the main CTCs players
Main players and players map
Market data and forecasts 2017–2023
Supply chain analysis
Company profiles
General conclusions 208
TABLE OF CONTENTS (complete content on i-Micronews.com)
OBJECTIVES OF THE REPORT
• Explain what liquid biopsy is, why it is used, and the characteristics of each biomarker (ctDNA,
CTC, exosomes)
• Show what constitutes “state-of-the-art” is today and what is expected for tomorrow, and
understand the positive and negative impacts on the adoption of liquid biopsy for clinical use
• Provide a players overview at each supply chain level, from enrichment and isolation to
downstream analysis, for CTC and ctDNA applications
• Provide a list and analysis of fundraisings and MA
• Provide an analysis of the business models used in the liquid biopsy field
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AUTHORS
Sébastien Clerc worksasaTechnologies
Market Analyst, Microfluidics Medical
Technologies. Sébastien authored a
collection of market and technology reports
dedicated to topics such as microfluidics,
point-of-care and more. In parallel, he is
daily involved in custom projects. Thanks
to its technology market expertise,
Sébastien has spoken in more than 10
industry conferences worldwide over the
last 2 years. Sébastien Clerc is graduated
from Grenoble Institute of Technology
(Grenoble INP - Grenoble, France) with a
Master degree in Biomedical Technologies.
Then he completed his cursus with a Master
degree in Innovation and Technology
Management in the same institute.
As a Technology Market Analyst,
Biotechnologies Molecular Innovations,
Asma Siari is involved in the development
of technology market reports as well as
custom consulting projects. After a Master’s
degree in Biotechnologies, Diagnostic
Therapeutics Management, Asma served
as Research Assistant at the Moores Cancer
Center (San Diego, CA). She is a coauthor
in two scientific publications. Asma Siari
is graduated with an Advanced Master’s
degree in International Strategy Marketing
BtoB from EM Lyon Business School (Lyon,
France).
As a Technology Market Analyst,
Medical Imaging Biophotonics, Dr.
Marjorie Villien is a daily contributor
to the development of medical technologies
activities with a dedicated collection of
market technology reports as well as
custom consulting projects. After spending
two years at Harvard, Marjorie served
as a research scientist at INSERM in the
field of medical imaging. She has spoken
in numerous international conferences and
has authored or co-authored 11 papers and
1 patent. Marjorie Villien is graduated from
Grenoble INP (Grenoble, France) and holds
a PhD in physics medical imaging.
Dr. Marjorie Villien, Asma Siari and Sébastien Clerc,
all part of the Life Sciences Healthcare division at
Yole Développement co-authored the Liquid Biopsy:
From Isolation To Downstream Applications report:
Find more
details about
this report here:

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infringement risk analysis
• Teardowns reverse costing
analysis
• Cost simulation tool
www.i-Micronews.com/reports
o Media
• i-Micronews.com website
• @Micronews e-newsletter
• Communication webcast
services
• Events:TechDays,forums,…
www.i-Micronews.com

24. 4©2018 | www.yole.fr | About Yole Développement
6 COMPANIES TO SERVEYOUR BUSINESS
Due diligence
www.yole.fr
Manufacturing costs analysis
Teardown and reverse engineering
Cost simulation tools
www.systemplus.fr
Market,technology and strategy
consulting
www.yole.fr
IP analysis
Patent assessment
www.knowmade.fr
Innovation and business maker
www.bmorpho.com
Design and characterization of
innovative optical systems
www.piseo.fr
Yole Group of Companies

25. 5©2018 | www.yole.fr | About Yole Développement
OUR GLOBAL ACTIVITY
30%of our business
40%of our business
30%of our business
Greater
China office
Yole Japan
HQ in Lyon
Nantes
Paris
Nice
Vénissieux
Europe office
Frankfurt
Hsinchu
Tokyo
Yole Inc.
Phoenix
Yole Korea
Seoul
Palo Alto

26. 6©2018 | www.yole.fr | About Yole Développement
ANALYSIS SERVICES - CONTENT COMPARISON
Technology
and Market
Report
Leadership
Meeting
QA
Service
Depth of the analysis
Breadthoftheanalysis
Meet the
Analyst
Custom
Analysis
High
High
Low

27. 7©2018 | www.yole.fr | About Yole Développement
SERVINGTHE ENTIRE SUPPLY CHAIN
Our analysts
provide
market
analysis,
technology
evaluation,
and business
plans along
the entire
supply chain
Integrators,end-
users and software
developpers
Device manufacturers
Suppliers:material,equipment,
OSAT,foundries…
Financial investors,RD centers

28. 8©2018 | www.yole.fr | About Yole Développement
SERVING MULTIPLE INDUSTRIAL FIELDS
We work
across
multiples
industries to
understand
the impact of
More-than-
Moore
technologies
from device
to system
FromA to Z…
Transportation
makers
Mobile phone
and
consumer
electronics
Automotive
Medical
systems
Industrial
and defense
Energy
management

29. 9©2018 | www.yole.fr | About Yole Développement
o Yole Développement, System Plus Consulting, KnowMade and PISEO, all part of Yole Group of Companies, keep on increasing their collaboration to offer, in 2018, a
collection of 150+ reports. Combining respective expertise and methodologies from the 4 companies, the reports aim to provide market technology analysis, patent
investigation and patent infringement risk analysis, teardowns reverse costing analysis.They cover:
o You are looking for:
• An analysis of your product market
• A review of your competitors evolution
• An understanding of your manufacturing and production costs
• An understanding of your industry technology roadmap and related IPs
• A clear view on the evolution of the supply chain…
Our reports are for you!
The combined team of 60+ experts (PhDs, MBAs, industry veterans…) from Yole Développement, System Plus Consulting, KnowMade and PISEO, collect information,
identify the trends, the challenges, the emerging markets, the competitive environments and turn it into results to give you a complete picture of your industry
landscape.
In the past 20 years, we worked on more than 1 700 projects, interacting with technology professionals and high level opinion makers from the main players of the
industry.
o In 2018, Yole Group of Companies plan to publish +150 reports.Gain full benefit from our Bundled Offer and receive at least a 36% discount.
REPORTS COLLECTION
www.i-Micronews.com
• MEMS Sensors
• RF devices technologies
• Imaging
• Medical technologies (MedTech)
• Photonics
• Advanced packaging
• Manufacturing
• Advanced substrates
• Power electronics
• Batteries and energy management
• Compound semiconductors
• Solid state lighting
• Displays
• Software
• Memory

30. 10©2018 | www.yole.fr | About Yole Développement
OUR 2018 REPORTS COLLECTION (1/4)
MEMS SENSORS
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Status of the MEMS Industry 2018 – Update
− Silicon Photonics 2018 – Update
− Consumer Biometrics: Hardware Software 2018 – Update
− Inkjet Functional and Additive Manufacturing for Electronics 2018
− Fingerprint Sensor Applications and Technologies – Consumer Market Focus 2017
− Sensors and Sensing Modules for Smart Homes and Buildings 2017
− Acoustic MEMS and Audio Solutions 2017
− MEMS Sensors for Automotive Market Technology Trends 2017
− High End Inertial Sensors 2017
− Magnetic Sensor 2017
o REVERSE COSTING® – STRUCTURE, PROCESS COST REPORT
– by System Plus Consulting
− Piezo MEMS 2018 *
o PATENT ANALYSES – by KnowMade
− MEMS Microphone – Patent Landscape Analysis
− Knowles MEMS Microphones in Apple iPhone 7 Plus – Patent-to-Product
Mapping 2017
o LINKED REPORTS – by Yole Développement, System Plus Consulting and KnowMade
− MEMS Pressure Sensor 2018 – Market Technology Report
− MEMS Pressure Sensor Comparison 2018 – Structure, Process Cost Report
− Gas Particles 2018 – Market Technology Report
− Gas Particles Comparison 2018 – Structure, Process Cost Report
− LiDARs for Automotive and Industrial Applications 2018 – Market
Technology Report
− LiDAR for Automotive 2018 – Patent Landscape Analysis
− MEMS Packaging 2017 – Market Technology Report
− MEMS Packaging Comparison 2017 – Structure, Process Cost Report
RF DEVICES ANDTECHNOLOGIES
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Wireless technologies (Radar, V2X) for Automotive 2018
− RF Standards and Technologies for Connected Objects 2018
− RF Photonic Components Technologies for 5G Infrastructure2018
o REVERSE COSTING® – STRUCTURE, PROCESS COST REPORT– by System
Plus Consulting
− Automotive Radar Comparison 2018
o PATENT ANALYSES – by KnowMade
− RF Acoustic Wave Filters 2017 – Patent Landscape Analysis
o LINKED REPORTS – by Yole Développement, System Plus Consulting andKnowMade
− 5G impact on RF Front End Modules and Connectivity for Cellphones 2018 – Market
Technology Report – Update
− RF Front-End Module Comparison 2018 – Structure, Process Cost Report
− RF Front End Modules for Cellphones 2018 – Patent Landscape Analysis
− Advanced RF System-in-Package for Cellphones 2018 – Market Technology
Report – Update*
− Advanced RF SiPs for Cell Phones Comparison 2017 – Structure, Process
Cost Report
− RF GaN Market: Applications, Players, Technology, and Substrates 2018-2023
Market Technology Report – Update
− RF GaN Comparison 2018* – Structure, Process Cost Report
− RF GaN 2018 – Patent Landscape Analysis
SOFTWARE
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Consumer Biometrics: Sensors Software 2018 – Update
− Processing Hardware and Software for AI 2018 - Vol. 1 2
− From Image Processing to Deep Learning, Introduction to Hardware and Software
Update : 2017 version still available / *To be confirmed

31. 11©2018 | www.yole.fr | About Yole Développement
OUR 2018 REPORTS COLLECTION (2/4)
IMAGING OPTOELECTRONICS
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Status of the Compact Camera Module and Wafer Level Optics
− Industry 2018 – Update
− 3D Imaging and Sensing 2018 – Update
− Sensors for Robotic Vehicles 2018
− Machine Vision for Industry and Automation 2018
− Imagers and Detectors for Security and Smart Buildings 2018
− Uncooled Infrared Imagers 2017
o PATENT ANALYSES – by KnowMade
− iPhone X Dot Projector – Patent-to-Product Mapping
o LINKED REPORTS – by Yole Développement, System Plus Consulting and KnowMade
− Status of the CMOS Image Sensor Industry 2018 – Market Technology Report -
Update
− CMOS Image Sensor Comparison 2018 – Structure, Process Cost Report
− CMOS Image Sensors Monitor 2018* – Quaterly Update**
− Camera Module 2017 – Market Technology Report
− Compact Camera Module Comparison 2018 – Structure, Process Cost Report
− LiDARs for Automotive and Industrial Applications 2018 – Market Technology
Report
− LiDAR for Automotive 2018 – Patent Landscape Analysis
ADVANCED PACKAGING
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Status of Advanced Packaging Industry 2018 – Update
− Status of Advanced Substrates 2018: Embedded Die andInterconnects,
Substrate Like PCB Trends
− 3D TSV and Monolithic Business Update 2018 – Update
− Power Modules Packaging 2018 – Update
− Discrete Power Packaging 2018 – Update*
− Status of Panel Level Packaging 2018
− Trends in Automotive Packaging 2018
− Hardware and Software for AI 2018 - Vol. 1 2
− Integrated Passive Devices (IPD) 2018
− Thin-Film Integrated Passive Devices 2018
− Memory Packaging Market and Technology Report 2018 – Update*
o PATENT ANALYSES – by KnowMade
− Hybrid Bonding for 3D Stack – Patent Landscape Analysis
o LINKED REPORTS– by Yole Développement and System Plus Consulting
− Advanced RF System-in-Package for Cellphones 2018 – Market Technology Report -
Update*
− Advanced RF SiPs for Cell Phones Comparison 2017 – Structure, Process
Cost Report
− Fan-Out Packaging 2018 – Market Technology Report – Update*
− Fan-Out Packaging Comparison 2018* – Structure, Process Cost Report
MANUFACTURING
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Wafer Starts for More Than Moore Applications 2018
− Equipment for More than Moore: Technology Market Trends
for Lithography Bonding/Debonding 2018
− Polymeric Materials for wafer-level Advanced Packaging 2018
− Laser Technologies for Semiconductor Manufacturing 2017
− Glass Substrate Manufacturing in the Semiconductor Field 2017
− Equipment and Materials for Fan-Out Packaging 2017
− Equipment and Materials for 3D TSV Applications 2017
o LINKED REPORTS – by Yole Développement and System Plus Consulting
− Equipment for More than Moore: Technology Market Trends for
Lithography Bonding/Debonding 2018 – Market Technology Report
− Wafer Bonding Comparison2018 – Structure, Process Cost Report
Update : 2017 version still available / *To be confirmed

32. 12©2018 | www.yole.fr | About Yole Développement
OUR 2018 REPORTS COLLECTION (3/4)
MEMORY
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Emerging Non Volatile Memory 2018 – Update
− Memory Packaging Market and Technology Report 2018 – Update*
o QUARTERLY UPDATE – by Yole Développement**
− Memory Market Monitor 2018 (NAND DRAM)
o MONTHLY UPDATE – by Yole Développement**
− Memory Pricing Monitor 2018 (NAND DRAM)
o REVERSE ENGINEERING COSTING REVIEW – by System Plus Consulting
− DRAM Technology Cost Review 2018
− NAND Memory Technology Cost Review 2018
o PATENT ANALYSES – by KnowMade
− 3D Non-Volatile Memories – Patent Landscape
COMPOUND SEMICONDUCTORS
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Status of Compound Semiconductor Industry 2018*
− GaAs Materials, Devices and Applications 2018
− InP Materials, Devices and Applications 2018
− Bulk GaN Substrate Market 2017
o LINKED REPORTS – by Yole Développement, System Plus Consulting and KnowMade
− Power SiC 2018: Materials, Devices, and Applications – Market Technology
Report – Update
− SiC Transistor Comparison 2018 – Structure, Process Cost Report
− Power SiC 2018 – Patent Landscape Analysis
− Power GaN 2018: Materials, Devices, and Applications – Market Technology Report
– Update
− GaN-on-Silicon Transistor Comparison 2018 – Structure, Process Cost Report
− Status of the GaN IP – Patent Watch 2018 Patent Activity 2017
− RF GaN Market: Applications, Players, Technology, and Substrates 2018-2023
– Market Technology Report – Update
− RF GaN – Patent Landscape Analysis
POWER ELECTRONICS
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Status of Power Electronics Industry 2018 – Update
− Discrete Power Packaging 2018 – Update*
− Power Electronics for Electric Vehicles 2018 – Update
− Integrated Passive Devices (IPD) 2018
− Wireless Charging Market Expectations and Technology Trends 2018
− Thermal Management Technology and Market Perspectives in Power
− Electronics and LEDs 2017
− Gate Driver 2017
− Power MOSFET 2017
− IGBT 2017
− Market Opportunities for Thermal Management Components in
Smartphones 2017
o LINKED REPORTS – by Yole Développement, System Plus Consulting
and KnowMade
− Power Modules Packaging 2018 – Market Technology Report – Update
− Automotive Power Module Packaging Comparison2018 – Structure,
Process Cost Report
− Power ICs Market Monitor 2018 – Quaterly Update**
− Power ICs Market Comparison 2018* – Structure, Process Cost Report
BATTERY AND ENERGY MANAGEMENT
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Li-ion Battery Packs for Automotive and Stationary Storage Applications 2018 –
Update
o PATENT ANALYSES – by KnowMade
− Status of the Battery Patents – Patent Watch 2018 Patent Activity 2017
o LINKED REPORTS – by Yole Développement and KnowMade
− Solid State Electrolyte Battery 2018 – Market Technology Report
− Solid-State Batteries 2018 – Patent Landscape Analysis
Update : 2017 version still available / *To be confirmed / ** Can not be selected within an Annual Subscription offer

33. 13©2018 | www.yole.fr | About Yole Développement
OUR 2018 REPORTS COLLECTION (4/4)
SOLID STATE LIGHTING
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− IR LEDs and Lasers 2018: Technology, Industry and Market Trends – Update
− Automotive Lighting 2018: Technology, Industry and Market Trends – Update
− UV LEDs 2018: Technology, Industry and Market Trends – Update
− LiFi: Technology, Industry and Market Trends
− LED Lighting Module Technology, Industry and Market Trends 2017
− CSP LED Lighting Modules
− Phosphors Quantum Dots 2017 - LED Downconverters for Lighting Displays
− Horticultural Lighting 2017
o LINKED REPORTS – by Yole Développement and System Plus Consulting
− VCSELs 2018: Technology, Industry and Market Trends – Market Technology
Report
− VCSELs Comparison 2018 – Structure, Process Cost Report
DISPLAYS
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− Quantum Dots and Wide Color Gamut Display Technologies 2018 – Update
− Displays and Optical Vision Systems for VR/AR/MR 2018
− MicroLED Displays 2018 – Market Technology Report – Update
o PATENT ANALYSES – by KnowMade
− MicroLED Display – Patent Landscape Analysis
MEDTECH
o MARKET AND TECHNOLOGY REPORT – by Yole Développement
− BioMEMS Non Invasive Emerging Biosensors: Microsystems for Medical
− Applications 2018 – Update
− Point-of-Need Testing Application of Microfluidic Technologies 2018 – Update
− Neurotechnologies and Brain Computer Interface 2018
− CRISPR-Cas9 Technology: From Lab to Industries 2018
− Ultrasound technologies for Medical, Industrial and Consumer 2018
− Inkjet Functional and Additive Manufacturing for Electronics 2018
− Liquid Biopsy: from Isolation to Downstream Applications 2018
− Chinese Microfluidics Industry 2018
− Scientific Cameras for the Life Sciences Analytical Instrumentation
Laboratory Markets 2018*
− Artificial Organ Technology and Market 2017
− Connected Medical Devices Market and Business Models 2017
− Status of the Microfluidics Industry 2017
− Organs-On-Chips 2017
− Solid-State Medical Imaging 2017
− Medical Robotics Market Technology Analysis 2017
o PATENT ANALYSES – by KnowMade
− Microfluidic IC Cooling – Patent Landscape
− Circulating Tumor Cell Isolation – Patent Landscape
− OCT Medical Imaging – Patent Landscape
− Pumps for Microfluidic Devices – Patent Landscape 2017
− Microfluidic Technologies for Diagnostic Applications– Patent Landscape 2017
− FLUIDIGM – Patent Portfolio Analysis 2017
− Consumer Physics SCiO Molecular Sensor – Patent-to-Product Mapping 2017
o LINKED REPORTS – by Yole Développement, System Plus Consulting and KnowMade
− Organs-On-Chips 2017 – Market Technology Report
− Organ-on-a-Chip– Patent Landscape Analysis
Update : 2017 version still available / *To be confirmed

34. 14©2018 | www.yole.fr | About Yole Développement
OUR 2017 PUBLISHED REPORTS LIST (3/3)
OUR PARTNERS’ REPORTS
PATENT ANALYSES – by KnowMade
− Wireless Charging Patent LandscapeAnalysis
− RF Acoustic Wave Filters Patent LandscapeAnalysis
− NMC Lithium-Ion Batteries Patent LandscapeAnalysis
− Pumps for Microfluidic Devices Patent Landscape
− III-N PatentWatch
− FLUIDIGM Patent Portfolio Analysis
− Knowles MEMS Microphones in Apple iPhone 7 Plus Patent-to-Product Mapping 2017
− Consumer Physics SCiO Molecular Sensor Patent-to-Product Mapping
− Patent Licensing Companies in the Semiconductor Market - Patent Litigation Risk and Potential Targets
− Microfluidic Technologies for Diagnostic Applications Patent Landscape
TEARDOWN REVERSE COSTING – by System Plus Consulting
More than 60 teardowns and reverse costing analysis and cost simulation tools published in 2017
MORE INFORMATION
o All the published reports from theYole Group of Companies are available on our website www.i-Micronews.com.
o Ask for our Bundle Subscription offers: With our bundle offer, you choose the number of reports you are interested in and select the related offer. You then haveup
to 12 months to select the required reports from the Yole Développement, System Plus Consulting and KnowMade offering. Pay once and receive the reports
automatically (multi-user format). Contact your sales team according to your location (see the last slide).

35. 15©2018 | www.yole.fr | About Yole Développement
MICRONEWS MEDIA
o About Micronews Media
To meet the growing demand for market,
technological and business information,
Micronews Media integrates several tools able
to reach each individual contact within its
network.We will ensure you benefit from this.
ON L IN E ON SITE IN PERSON
@Micronews e-newsletter
i-Micronews.com
i-Micronewsjp.com
FreeFullPDF.com
Events Webcasts
Unique, cost-effective ways
to reach global audiences.
Online display advertising
campaigns are great strategies
for improving your
product/brand visibility.They
are also an efficient way to
adapt with the demands of the
times and to evolve an effective
marketing plan and strategy.
Brand visibility,networking
opportunities
Today's technology makes it
easy for us to communicate
regularly, quickly,and
inexpensively – but when
understanding each other is
critical, there is no substitute
for meeting in-person.Events
are the best way to exchange
ideas with your customers,
partners, prospects while
increasing your brand/product
visibility.
Targeted audience
involvement equals clear,
concise perception of your
company’s message.
Webcasts are a smart,
innovative way of
communicating to a wider
targeted audience.Webcasts
create very useful,dynamic
reference material for
attendees and also for
absentees, thanks to the
recording technology.
Benefit from the i-Micronews.com
traffic generated by the 11,200+
monthly unique visitors, the
10,500+ weekly readers of
@Micronew se-newsletter
Several key events planned for
2018 on different topics to
attract 120 attendees on average
Gain new leads for your business
from an average of 340
registrants per webcast
Contact: Camille Veyrier (veyrier@yole.fr),Marketing Communication Project Manager

36. 16©2018 | www.yole.fr | About Yole Développement
CONTACT INFORMATION
o CONSULTINGANDSPECIFICANALYSIS,REPORT
BUSINESS
• North America:
• Steve LaFerriere, Senior Sales Director for Western US
Canada
Email: laferriere@yole.fr – + 1 310 600-8267
• Troy Blanchette, Senior Sales Director for Eastern US
Canada
Email: troy.blanchette@yole.fr – +1 704 859-0453
• Japan Rest ofAsia:
• Takashi Onozawa, General Manager,Asia Business
Development (Korea, Singapore, India ROA)
Email: onozawa@yole.fr - +81 34405-9204
• Miho Othake, Account Manager (Japan)
Email: ohtake@yole.fr - +81 3 4405 9204
• Itsuyo Oshiba, Account Manager (Japan)
Email: oshiba@yole.fr - +81-80-3577-3042
• Greater China: MavisWang, Director of Greater China Business
Development
Email: wang@yole.fr - +886 979 336 809
• Europe: Lizzie Levenez,EMEA Business Development Manager
Email: levenez@yole.fr - +49 15 123 544 182
• RoW: Jean-Christophe Eloy,CEO President,Yole Développement
Email eloy@yole.fr - +33 4 72 83 01 80
o FINANCIAL SERVICES (in partnershipwithWoodside
CapitalPartners)
• Jean-Christophe Eloy,CEO President
Email: eloy@yole.fr - +33 4 72 83 01 80
• Ivan Donaldson,VP of Financial Market Development
Email: ivan.donaldson@yole.fr - +1 208 850 3914
o GENERAL
• Public Relations: leroy@yole.fr - +33 4 72 83 01 89
• Email: info@yole.fr - +33 4 72 83 01 80
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