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From Technologies to Markets
© 2019
From Technologies to Markets
© 2019
Cameras for
Microscopy and
Next Generation
Sequencing
Market & Technology
Report 2019
Sample
2
MarjorieVillien,PhD
As a Technology & Market Analyst, Medical & Industrial Imaging, Marjorie Villien, PhD., is member of the Photonics & Sensing activities group at Yole
Développement (Yole). Marjorie contributes regularly to the development of imaging projects with a dedicated collection of market & technology reports as well as
custom consulting services in the medical and industrial fields. She regularly meets with leading imaging companies to identify and understand technology issues,
analyze market evolution and ensure the smart combination of technical innovation and industrial application. After spending two years at Harvard and prior to her
position at Yole, Marjorie served as a research scientist at INSERM and developed dedicated medical imaging expertise for the diagnosis and follow-up treatment of
Alzheimer’s disease, stroke and brain cancers. She presents to numerous international conferences throughout the year and has authored or co-authored 12
papers and 1 patent. Marjorie Villien graduated from Grenoble INP (France) and holds a PhD. in physics & medical imaging.
Email: villien@yole.fr
Loïc Michoud
As a Technology & Market Analyst,Artificial Intelligence (AI) & Imaging Technologies, Loic Michoud is involved in the development of technology &
market reports atYole Développement (Yole), within the Photonics & Sensing team. Loic studies and investigates innovative AI technologies for imaging
applications and related markets. Software and image processing are part of his technical background. Prior toYole, he was engaged in an internship at
the University of Michigan (MI, USA) where he developed relevant medical imaging expertise in image analysis and process digitization. Loic Michoud is
currently completing a bachelor degree at CPE Lyon (France). In parallel, he is studying a dedicated program focused on innovation management at EM
Lyon Business School (France).
Email: michoud@yole.fr
ABOUT THE AUTHORS
Biographies & contacts
Sebastien Clerc
Sébastien Clerc is a Technology & Market Analyst in Microfluidics, Sensing & Actuating at Yole Développement (Yole). As part of the Photonics & Sensing team,
Sébastien has authored a collection of market and technology reports dedicated to microfluidics and other micro-devices for both market segments: medical
(including diagnostics, pharmaceutical, biotechnology, drug delivery, medical devices) and industrial (including environment, agro-food). At the same time, he is
involved in custom projects such as strategic marketing, technology scouting and technology evaluation to help academic and industrial players in their innovation
processes. Thanks to his technology & market expertise, Sébastien has spoken in more than 20 industry conferences worldwide over the last 4 years. Sébastien
Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in Biomedical Technologies. He then completed
his academic studies with a Master’s degree in Innovation and Technology Management in the same institute.
Email: clerc@yole.fr Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
3
Accu-scope,Agilent technologies, ams,Amscope, amt,Andor,Anvajo,Artray,Aven, Basler, Baumer,
Bentham, BGI, Bio-Rad, Bruker, CEA, Cellmic, Centrillion technologies, Cnoptec, Cygnus, Dage-
mti,Danaher, Depixus, Dino-lite, Direct electron, Direct genomics, Emsis, Episenses, Euromex, Fein
optic, Fimm, Flir, Gatan, Genapsys, Genia, Gpixel, Greateyes, Hamamatsu, Hirox, Hitachi high-
technologies, Horiba, icfo, Illumina, Imec, imt, InSilixa, Intellectual ventures, Invenios, InView, Jenoptik,
Jeol, Kappa, Keyence, Kramer scientific, Labomed, Labsmith, Lasergen, Leica microsystems, Lissview,
Matrix vision, Meiji techno, Micralyne, Micronit, MicroscopeIT, Midiagnostics, Mitutoyo, Motic, Nabsys,
Nanotronics, Nikon, Novel optics, Nowdiagnostics, Olympus, Omano, Omax microscope, Omnivision,
ON semiconductor, Optika, Oxford Nanopore, Pacific Biosciences, Park systems, pax-it, PCO,
Phenomic.ai, Phograin, Photon focus, Photonis, Photron, Pixelink, Powerchip, Qiagen, QuantuMDx,
Raptor, Rigaku, Roswell biotechnologies, SeqLL, Sight,Silex microsystems, Sony, Spot imaging, Stanford
computer optics, Sunny optical technology, Swift,Teledyne,Thermo fisher,Thorlabs,TSMC,TVIPS,Witec,
Ximea, Zarbeco, Zeiss, and many more !
COMPANIES CITED IN THIS REPORT
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
240+ slides of market and technology analysis
Information gathered through direct discussions with players all along the supply chain
4
• Glossary 3
• Table of contents 4
• Report objectives 5
• Report scope 6
• Report methodology 7
• About the authors 8
• Companies cited in this report 9
• Yole Group’s related reports 10
• Executive summary 11
• Context 52
• Report scope
• Microscopy: historical perspective
• Next generation sequencing (NGS): context
• Market segmentation
• Market forecasts 65
• Segment descriptions
• Market data and forecasts 2018 - 2024 (value, units) at system level, by
segment
• Market data and forecasts 2018 - 2024 (value, units) at camera level, by
segment and technology
• Market data and forecasts 2018 - 2024 (value, units) at image sensor level, by
segment and technology
• Cameras and image sensors - average selling price evolution
• Roadmaps
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
TABLE OF CONTENTS
• Market trends 90
• Cameras for optical microscopy - market trends
• Cameras for electron microscopy - market trends
• Point-of-care microscopy - market trends
• High-end cameras in life sciences - market trends
• Per segment
• Technology and economic requirements, per application
• Market drivers
• Roadmaps, per segment
• Synthesis
• Supply chain and market share 145
• Ecosystem analysis
• Market share, at system and camera level
• M&A, collaborations, fundraising
• Supply chain analysis
• Business models
• Technology trends 173
• Technology description: cameras and image sensors
• Available commercial products and future product launches
• AI in microscopy
• Company profiles 213
• Conclusion 243
• Yole Développement presentation 246
5
• Provide an overview of the microscopy and NGS market at system, camera, and image sensor level,
along with an understanding of established and upcoming players, their technologies (and the
advantages/drawbacks), and how these will evolve in the coming years
• Present market data and forecasts at system, camera, and image sensor level, by segment (optical
microscopy, transmission electron microscopy, point-of-care microscopy, and NGS), in value ($) and
volume (units)
• Identify where the opportunities lie for different players along the supply chain, from materials
suppliers and foundries to camera manufacturers and system developers
• Discuss the different technologies used today (CCD, CMOS, sCMOS, TDI), as well as technological
trends like AI
REPORT OBJECTIVES
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6
SCOPE OFTHE REPORT
Yours needs are
out of the report’
scope?
Contact us for a custom:
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
Cameras for
microscopy and
next generation
sequencing
Microscopy
Cameras for
transmission
electron
microscopy (TEM)
Image sensors for
TEM
Cameras for
optical microscopy
Image sensors for
optical microscopy
Camera for point
of care (POC)
microscopy
Image sensors for
POC microscopy
Next generation
sequencing (NGS)
Cameras for NGS
instruments
Image sensors for
NGS instruments
Image sensors for
NGS consumables
7
METHODOLOGIES & DEFINITIONS
Market
Volume (in Munits)
ASP (in $)
Revenue (in $M)
Yole’s market forecast model is based on the matching of several sources:
Information
Aggregation
Preexisting
information
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
Report sample
9
Do not use a camera
THE 3 MAIN TYPES OF MICROSCOPES
Microscopy
Scanning
probe
microscope
Optical
microscope
Transmission
electron
microscope
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
Camera is a key element : focus of this report
10
Ernst Abbe defined the magnification limit of optical microscopes which is 0.2 µm. This is why viruses cannot
be studied through standard optical microscopes.
However, in 2014, Eric Betzig, Stefan W. Hell and William E. Moerner received the Nobel Prize in Chemistry
for their discovery of fluorescence microscopy. In theory, this new methodology has no limit size structure
limit and enables the study of nanoparticles.
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
MICROSCOPY
Magnification power
0,2 µm
11
NEXT GENERATION SEQUENCING
Applications
• Sequencing is mainly a research tool today, but has the potential to be used in many clinical and industrial applications
Diagnostics
Pandemic
control
Prenatal &
newborn
screening
Agriculture
Food safety
Bio-defense
Forensics
Environment
Wellness &
prevention
Data storage
Drug
development Reproductive
health
And more!
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
12Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
NEXT GENERATION SEQUENCING
Cost of sequencing
Since the introduction of next-generation sequencers,
DNA sequencing cost has decreased at an astounding
rate and outpacing Moore’s Law.
The $1,000 genome was reached in 2015 with the
release of Illumina’s HiSeq X Ten, and Illumina claims
that its new NovaSeq sequencers will drive sequencing
towards the $100 genome.
In the meantime, service providers using BGI’s
instrumentation are now proposing whole genome
sequencing at a price well below $1,000. BGI claims that
its new sequencer, the DNBSEQ-T7, can sequence a
genome for ~$500.
It appears the players engaged in this crazy race are still
far from crossing the finish line.
Source: www.genome.gov
13
The microscopy market is segmented into optical and electron microscopy. The optical microscopy field is subdivided into
optical microscopy (the traditional systems with high and low end cameras) and the point of care systems (on-chip cameras or
portable systems).
Same for the NGS field which is subdivided into NGS instruments (high-end cameras inside the instruments) and NGS
consumables (on-chip cameras).
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
CAMERAS FOR MICROSCOPY AND NGS
Market typology
Microscopy Next generation sequencing
Electron Photon
High-end cameras TEM
Optical
microscopy
NGS instruments
Low-end cameras
On-chip image sensor or
portable systems
POC
microscopy
NGS consumables
Optical systems
Domain
Detection
method
Scanning electron microscopy (SEM) is not included in this report
14
CAMERAS FOR MICROSCOPY AND NGS : MARKET OVERVIEW
Summary of
the camera for
NGS and
microscopy
market at the
system, camera
and image
sensor level
between 2018
and 2024
CAGR2018-2024: 2%
CAGR2018-2024: 3%
System
level
market
Camera
level
marketImage sensor
level market
CAGR2018-2024: 9%
15
System manufacturersSensor manufacturers Camera manufacturers
Optical microscopy,
most of them also integrated
Transmission electron microscopy
Transmission electron microscopy
Next generation sequencing
*Non-exhaustive list of companies
CAMERAS FOR MICROSCOPY AND NGS : MAIN PLAYERS
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
16
CAMERAS FOR NGS – TECHNOLOGY ROADMAP
2000 2010 2020
Automated sanger
sequencing
Next-generation optical sequencers
Optical consumables
4th generation:
CMOS image sensors integrated
on the consumables
2nd generation:
Optical detection using high-end
cameras inside the instruments
3rd generation:
Electrical detection integrated on
the consumables (CMOS sensors)
1st generation
2030
Instrument-free
sequencing
5th generation:
Instrument-free sequencing directly on consumables?
Opening a new market
opportunity for the
image sensor industry
Next-generation electrical
sequencers
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
17Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
MARKET FORECASTS
18Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
MARKET TRENDS
19Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
SUPPLY CHAIN AND MARKET SHARE
20Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
TECHNOLOGY TRENDS
21
Contact our
SalesTeam
for more
information
Point-of-NeedTesting:Application of
MicrofluidicTechnologies
Status of the CMOS Image Sensor Industry
2018
Next Generation Sequencing & DNA
Synthesis:Technology, Consumables
Manufacturing and MarketTrends 2019
CMOS Image Sensor Service – Imaging
Research
YOLE GROUP RELATED REPORTS & MONITORS
Yole Développement
Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
Why did we choose to discuss the technology
evolutionsinthemicroscopyandnext-generation
sequencing (NGS) market? Because this market
is undergoing enormous technological changes
that are opening new market opportunities for
the camera image sensors industry.
Cameras are key elements in the microscopy and
NGS space. Indeed, today most microscopes are
digital microscopes that use at least one (and
sometimes more) cameras. The main trend in
optical microscopy is to attain higher resolution,
as well as faster acquisition and higher sensitivity
for quicker and better diagnostics, and real-
time imaging of living organisms. CCD is the
main image sensor technology used today,
but sCMOS is gaining market share due to an
increasing need for high-speed image acquisition.
However, this trend towards better imaging is
counterbalanced by another trend – one that
leans towards portability and use of microscopy
at the point of care. These systems are sleeker
and cheaper, and deliver microscopy results
directly to the caregiver.
This is also the case for NGS. Two very
different trends are discernable: one towards
higher throughput with very expensive, bulky
equipment; and another that is lower throughput,
with cheaper equipment offering lower footprint
and wide availability. Take for example Illumina,
the optical NGS market leader with more than
80% market share: Illumina has a diverse product
portfolio of very high-end systems, but recently
launched a more affordable, lower-throughput
system - the iSeq100. This follows the trend
towards commoditization of NGS. The iSeq100
does not integrate optical systems in the
instrument anymore, but uses a disposable image
sensor directly inside the flow cell, which is a
game-changer in the NGS market! Indeed, this
makes the instrument much more affordable,
enabling Illumina to place more systems and
therefore sell more consumables, which they
can make cheaper because of increased volumes.
This trend is also seen with BGI, Illumina’s
Chinese competitor, which recently announced
a benchtop NGS system based on CMOS chips.
A broader trend is artificial intelligence (AI),
which is upending the microscopy hardware
ecosystem because deep learning could enable
not only ultra-high resolution at lower hardware
cost, but also automation.
This report describes the technology evolutions
in the microscopy and NGS field, and the effect
these developments will have on the market and
ecosystem.
CAMERAS FOR MICROSCOPY AND NEXT-GENERATION
SEQUENCING 2019
Market & Technology Report - November 2019
MOVING TOWARD DISPOSABLE IMAGE SENSORS FOR NEXT-GENERATION
SEQUENCING AND POINT-OF-CARE MICROSCOPY
Disposable image sensors: a revolution for microscopy and next-generation sequencing.
(Yole Développement, November 2019)
21st
century technology roadmap for next-generation sequencing
KEY FEATURES
•	Historical perspective and synergies
with other markets
•	Market data and forecasts
at system, camera, and image
sensor level, by segment (optical
microscopy, transmission electron
microscopy (TEM), point-of-
care microscopy, NGS) and
technology(CCD, CMOS, sCMOS,
TDI), in value (US$) and volume
(units)
•	Technology penetration and market
trends, per segment
•	Supply chain analysis with market
share, at system level and camera
level
•	Technology landscape, evolutions,
and roadmaps
2000 2010 2020
Automated sanger
sequencing
Next-generation optical sequencers
Optical consumables
4th generation:
CMOS image sensors integrated
on the consumables
2nd generation:
Optical detection using high-end
cameras inside the instruments
Next-generation
electrical sequencers
3rd generation:
Electrical detection integrated on
the consumables (CMOS sensors)
1st generation
2030
Instrument-free
sequencing
5th generation:
Instrument-free sequencing directly on consumables?
Opening a new market
opportunity for the
image sensor industry
THOUGH EACH MARKET SEGMENT HAS DIFFERENT DYNAMICS, THE
OVERALL IMAGE SENSOR MARKET FOR MICROSCOPY AND NGS WILL
SHOW IMPRESSIVE GROWTH, WITH A CAGR2018-2024
OF 18% (IN VOLUME)
At system level, the global microscopy and NGS
market represented $4.1B in 2018. The biggest
market segment was optical microscopy ($2.5B
in 2018). Cameras for microscopy and NGS
represented $367M, and is expected to reach
$446M in 2024 at a CAGR of 3.3%. Meanwhile,
CAMERAS FOR MICROSCOPY AND NEXT-GENERATION SEQUENCING 2019
A STRUCTURED ECOSYSTEM WITH COLLABORATIONS AT DIFFERENT LEVELS OF
THE SUPPLY CHAIN BETWEEN IMAGE SENSOR, CAMERA, AND SYSTEM-LEVEL PLAYERS
The $1,000 genome barrier was broken about five
years ago, and we are now heading towards the
$100 genome thanks to higher throughput and faster
equipment. The ultimate goal is to reach as low as $10
per genome, and semiconductor technologies are
key enablers for NGS affordability. The race towards
sequencing inexpensiveness and commoditization is
a tremendous opportunity for the semiconductor
industry, because volumes will explode.
Specific to ecosystem, microscopy and NGS is a
structured market with a few key players. At system
level, the major players in optical microscopy are
Olympus, Nikon, Zeiss, and Leica Microsystems.
Combined, they hold more than 80% of optical
microscopy market share. The transmission electron
microscopy (TEM) main players are Jeol, Thermo
Fisher Scientific, and Hitachi High-Technologies, and
the optical NGS main players are Illumina, Pacific
Biosciences, and BGI. At camera level, the market
is also well structured, with integrated players like
Olympus and Zeiss, and specialized camera players
such as Teledyne, Sony, Hamamatsu, and Andor. In
the TEM market the main camera players are Gatan
and Thermo Fisher, which is integrated. The key
image sensor providers for microscopy and NGS
are Sony, ON Semiconductor, Hamamatsu, Gpixel,
Omnivision, and ams.
Recent mergers and acquisitions of microscope
manufacturers are aimed at finding expertise in the
field of data management and software (ex: Zeiss
acquiring gom in 2019; Olympus acquiring Image
Stream Medical in 2017). This trends follows the
parallel development of deep learning algorithms in
this field.
image sensors for microscopy and NGS achieved
$31M in 2018. This rather small market should
enjoy rapid growth (CAGR2018-2024
in value: 9%, and
in volume: 18%), an improvement driven mostly
by the arrival of image sensors-on-consumables in
NGS.
The image sensor market for microscopy is
divided into four different categories, each having
a different maturity level. For example, optical
and transmission electron microscopy is a mature
marketwithalowCAGR.Point-of-caremicroscopy
was a very small, emerging market in 2018, but is
poised for fast growth. Image sensors embedded
in cameras for high-end NGS systems is a declining
market due to the trend toward cheaper systems
with less cameras. The image sensors market for
NGS consumables is booming. This new business
model implies the creation of products where
the image sensor is disposable, equating to a very
low average selling price (compared to the image
sensors previously used in microscopy and NGS
systems) and very high volume.
This report describes the 2018 market and offers
forecasts for the period 2018 - 2024 at system,
camera, and image sensor level. The hypothesis
behind these forecasts and the roadmaps leading
to these assumptions are also described.
Cameras for microscopy and next-generation sequencing market:
2018 - 2024 forecast
(Yole Développement, November 2019)
2018 2024
$4,130M $4,654M
$367M $446M
$31M $51M
CAGR2018-2024: 3%
CAGR2018-2024: 2%
CAGR2018-2024: 9%
System
level
market
Camera
level
market
Image sensor
level market
Cameras for microscopy and next-generation sequencing: players ecosystem*
(Yole Développement, November 2019)
System manufacturersSensor manufacturers Camera manufacturers
Optical microscopy,
most of them also integrated
Transmission electron microscopy
Next generation sequencing
*Non-exhaustive list of companies
Transmission electron microscopy
COMPANIES CITED IN THE REPORT (non exhaustive list)
Accu-scope, Agilent Technologies, ams, Amscope, amt, Andor, Anvajo, Artray, Aven, Basler, Baumer,
Bentham, BGI, Bio-Rad, Bruker, CEA, Cellmic, Centrillion Technologies, Cnoptec, Cygnus, Dage-
mti,Danaher, Depixus, Dino-lite, Direct Electron, Direct Genomics, Emsis, Episenses, Euromex,
Fein Optic, Fimm, Flir, Gatan, Genapsys, Genia, Gpixel, Greateyes, Hamamatsu, Hirox, Hitachi
High-Technologies, Horiba, icfo, Illumina, Imec, imt, InSilixa, Intellectual Ventures, Invenios, InView,
Jenoptik,Jeol,Kappa,Keyence,KramerScientific,Labomed,Labsmith,Lasergen,LeicaMicrosystems,
Lissview, Matrix Vision, Meiji Techno, Micralyne, Micronit, MicroscopeIT, Midiagnostics, Mitutoyo,
Motic, Nabsys, Nanotronics, Nikon, Novel Optics, Nowdiagnostics, Olympus, Omano, Omax
Microscope, Omnivision, ON Semiconductor, Optika, Oxford Nanopore, Pacific Biosciences, Park
Systems, pax-it, PCO, Phenomic.ai, Phograin, Photon Focus, Photonis, Photron, Pixelink, Powerchip,
Qiagen, QuantuMDx, Raptor, Rigaku, Roswell Biotechnologies, SeqLL, Sight,Silex Microsystems,
Sony, Spot Imaging, Stanford Computer Optics, Sunny Optical Technology, Swift, Teledyne, Thermo
Fisher, Thorlabs, TSMC, TVIPS, Witec, Ximea, Zarbeco, Zeiss, and many more…
MARKET  TECHNOLOGY REPORT

Report objectives	 5
Report scope	 6
Companies cited in this report	 9
Executive summary	 11
Context	52
 Microscopy: historical perspective
 Next generation sequencing (NGS): context
 Market segmentation
Market forecasts	 65
 Segment descriptions
 Market data and forecasts 2018 - 2024
(value, units) at system level, by segment
 Market data and forecasts 2018 - 2024
(value, units) at camera level, by segment
and technology
 Market data and forecasts 2018 - 2024
(value, units) at image sensor level, by
segment and technology
 Cameras and image sensors - Average
selling price evolution
 Roadmaps 	
Market trends 	 90
	 Optical microscopy - Market trends
 Transmission electron microscopy - Market
trends
 Point-of-care microscopy - Market trends		
 Next generation sequencing - Market
trends	
- Per segment
- Technology and economic requirements,
per application
- Market drivers
- Roadmaps, per segment
- Synthesis
Supply chain and market share	 145
 Ecosystem analysis
 Market share, at system and camera level
 MA, collaborations, fundraising
 Supply chain analysis
 Business models
Technology trends	 173
 Technology description: cameras and image
sensors
 Available commercial products and future
product launches
 AI in microscopy
Conclusion	 243
Yole Développement presentation	 246
TABLE OF CONTENTS (complete content on i-Micronews.com)
• Next Generation Sequencing  DNA
Synthesis: Technology, Consumables
Manufacturing and Market Trends 2019
• Status of the CMOS Image Sensor Industry
2018
• CMOS Image Sensor Service – Imaging
Research
• Point-of-Need Testing: Application of
Microfluidic Technologies
Find all our reports on www.i-micronews.com
RELATED REPORTS AND MONITORS
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AUTHORS
As a Technology  Market Analyst, Medical
 Industrial Imaging, Marjorie Villien,
PhD., is member of the Photonics  Sensing
activities group at Yole Développement
(Yole). Marjorie contributes regularly to
the development of imaging projects with a
dedicated collection of market  technology
reportsaswellascustomconsultingservicesin
the medical and industrial fields. She regularly
meets with leading imaging companies to
identify and understand technology issues,
analyze market evolution and ensure the
smart combination of technical innovation
and industrial application. Marjorie Villien
graduated from Grenoble INP (France) and
holds a PhD. in physics  medical imaging.
REPORT OBJECTIVES
•	Provide an overview of the microscopy and NGS market at system, camera, and image sensor
level, along with an understanding of established and upcoming players, their technologies (and
the advantages/drawbacks), and how these will evolve in the coming years
•	Present market data and forecasts at system, camera, and image sensor level, by segment (optical
microscopy, transmission electron microscopy, point-of-care microscopy, and NGS), in value ($)
and volume (units)
•	Identify where the opportunities lie for different players along the supply chain, from materials
suppliers and foundries to camera manufacturers and system developers
•	Discuss the different technologies used today (CCD, CMOS, sCMOS, TDI), as well as
technological trends like artificial intelligence
As a Technology  Market Analyst, Artificial
Intelligence (AI)  Imaging Technologies, Loic
Michoud is involved in the development
of technology  market reports at Yole
Développement (Yole), within the Photonics
 Sensing team. Loic studies and investigates
innovative AI technologies for imaging
applications and related markets. Software
and image processing are part of his technical
background. Loic Michoud is currently
completing a bachelor degree at CPE Lyon
(France). In parallel, he is studying a dedicated
program focused on innovation management
at EM Lyon Business School (France).
Sébastien Clerc is a Technology  Market
Analyst in Microfluidics, Sensing  Actuating
at Yole Développement (Yole). As part of
the Photonics  Sensing team, Sébastien
has authored a collection of market and
technology reports dedicated to microfluidics
and other micro-devices for the medical
market segment mainly. At the same time,
he is involved in custom projects such as
strategic marketing, technology scouting and
technology evaluation to help academic and
industrial players in their innovation processes.
Sébastien Clerc graduated from Grenoble
Institute of Technology (Grenoble INP -
Grenoble, France) with a Master’s degree in
Biomedical Technologies. He then completed
his academic studies with a Master’s degree
in Innovation and Technology Management in
the same institute.
In this report, Yole Développement’s analysts
identify the key players leading the market,
analyze the supply chain, and discuss the
technology’s evolution and its influence on
ecosystem changes.
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+886 979 336 809 – wang@yole.fr
• Korea - Peter OK:
+82 10 4089 0233 – peter.ok@yole.fr
• Specific inquiries: +33 472 830 180 – info@yole.fr
(1)
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The present document is valid 24 months after its publishing date:
November 6, 2019
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Founded in 1998, Yole Développement (Yole) has grown to become a group of companies providing marketing, technology and strategy consulting, media and
corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications using
silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 120 collaborators worldwide covering MEMS and image
sensors, Compound semiconductors, RF Electronics, Solid-state lighting, Displays, Software, Optoelectronics, Microfluidics  Medical, Advanced Packaging,
Manufacturing, Power Electronics, Batteries  Energy Management and Memory.
The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting,
PISEO, KnowMade and Blumorpho, supports industrial companies, investors and RD organizations worldwide to help them understand markets and follow
technology trends to grow their business.
CONSULTING AND ANALYSIS
• Market data  research, marketing analysis
• Technology analysis
• Strategy consulting
• Reverse engineering  costing
• Patent analysis
• Design and characterization of innovative optical systems
• Financial services (due diligence, MA with our partner)
More information on www.yole.fr
MEDIA  EVENTS
• i-Micronews.com website, application  related e-newsletter
• Communication  webcast services
• Events: TechDays, forums…
More information on www.i-Micronews.com
REPORTS
• Market  technology reports
• Patent investigation and patent infringement risk analysis
• Structure, process and cost analysis and teardowns
• Cost simulation tool
More information on www.i-micronews.com/reports
CONTACTS
For more information about :
• Consulting  Financial Services: Jean-Christophe Eloy (eloy@yole.fr)
• Reports  Monitors: David Jourdan (jourdan@yole.fr)  Fayçal Khamassi
(khamassi@yole.fr)
• Marketing  Communication: Camille Veyrier (veyrier@yole.fr)
• Public Relations: Sandrine Leroy (leroy@yole.fr)
© 2019
Yole Développement
From Technologies to Market
Source: Wikimedia Commons
23©2019 | www.yole.fr | About Yole Développement
YOLE DEVELOPPEMENT – FIELDS OF EXPERTISE WITHIN 3 MAIN DOMAINS
Semiconductor  Software
o Semiconductor Packaging and Substrates
o Semiconductor Manufacturing
o Memory
o Computing and Software
Power  Wireless
o RF Devices  Technologies
o Compound Semiconductors  Emerging
Materials
o Power Electronics
o Batteries  Energy Management
Photonics  Sensing
o Photonics
o Lighting
o Imaging
o Sensing  Actuating
o Display
About Yole Développement | www.yole.fr | ©2019
24©2019 | www.yole.fr | About Yole Développement
4 BUSINESS MODELS
o Consulting and Analysis
• Market data  research,
marketing analysis
• Technology analysis
• Strategy consulting
• Reverse engineering  costing
• Patent analysis
• Design and characterization
of innovative optical systems
• Financial services (due
diligence, MA with our
partner)
www.yole.fr
o Syndicated reports
• Market  technology reports
• Patent investigation and patent
infringement risk analysis
• Teardowns  reverse costing
analysis
• Cost simulation tool
www.i-Micronews.com/reports o Media
• i-Micronews.com website and
application
• i-Micronews e-newsletter
• Communication  webcast
services
• Events:TechDays, forums,…
www.i-Micronews.com
o Monitors
• Monthly and quarterly update
• Excel database covering supply,
demand, and technology
• Price, market, demand and
production forecasts
• Supplier market shares
www.i-Micronews.com/reports
About Yole Développement | www.yole.fr | ©2019
25©2019 | www.yole.fr | About Yole Développement
6 COMPANIES TO SERVEYOUR BUSINESS
Due diligence
www.yole.fr
Manufacturing costs analysis
Teardown and reverse engineering
Cost simulation tools
www.systemplus.fr
Market, technology and strategy
consulting
www.yole.fr
IP analysis
Patent assessment
www.knowmade.fr
Innovation and business maker
www.bmorpho.com
Design and characterization of
innovative optical systems
www.piseo.fr
Yole Group of Companies
About Yole Développement | www.yole.fr | ©2019
26
OUR GLOBAL ACTIVITY
30%of our business
40%of our business
30%of our business
Greater
China office
Yole Japan
HQ in Lyon
Nantes
Paris
Nice
Vénissieux
Yole Deutschland
Frankfurt
Hsinchu
Tokyo
Yole Korea
Seoul
Palo Alto
Yole Inc.
Cornelius
About Yole Développement | www.yole.fr | ©2019
27©2019 | www.yole.fr | About Yole Développement
ANALYSIS SERVICES - CONTENT COMPARISON
High
Technology
and Market
Report
Leadership
Meeting
QA
Service
Depth of the analysis
Breadthoftheanalysis
Meet the
Analyst
Custom
Analysis
High
Low
About Yole Développement | www.yole.fr | ©2019
28©2019 | www.yole.fr | About Yole Développement
SERVING THE ENTIRE SUPPLY CHAIN
Our analysts
provide
market
analysis,
technology
evaluation,
and business
plans along
the entire
supply chain
Integrators, end-
users and software
developers
Device manufacturers
Suppliers: material,
equipment, OSAT, foundries…
Financial investors, RD centers
About Yole Développement | www.yole.fr | ©2019
29©2019 | www.yole.fr | About Yole Développement
SERVING MULTIPLE INDUSTRIAL FIELDS
We work
across
multiples
industries to
understand
the impact of
More-than-
Moore
technologies
from device
to system
From A to Z…
Transportation
makers
Mobile phone
and
consumer
electronics
Automotive
Medical
systems
Industrial
and defense
Energy
management
About Yole Développement | www.yole.fr | ©2019
30
o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now
provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as
intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports,
10 new monitors and 120 teardowns. Combining respective expertise and methodologies from the three companies, they cover:
o If you are looking for:
• An analysis of your product market and technology
• A review of how your competitors are evolving
• An understanding of your manufacturing and production costs
• An understanding of your industry’s technology roadmap and related IPs
• A clear view supply chain evolution
Our reports and monitors are for you!
o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information,
identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’s
landscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the main
players of their industries and realized more than 5,000 interviews per year.
WHAT TO EXPECT IN 2019?
In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also building
on and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software and
hardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Last but not least,
System Plus Consulting is developing its teardowns service providing 120+ offers related to phones, smart home, wearables and connected devices. Discover our 2019
program right now, and ensure you get a true vision of the industry. Stay tuned!
REPORTS COLLECTION
www.i-Micronews.com
• MEMS  Sensors
• RF devices  technologies
• Medical technologies
• Semiconductor Manufacturing
• Advanced packaging
• Memory
• Batteries and energy management
• Power electronics
• Compound semiconductors
• Solid state lighting
• Displays
• Software
• Imaging
• Photonics
About Yole Développement | www.yole.fr | ©2019
31
OUR 2019 REPORTS COLLECTION (1/4)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
Market –Technology – Strategy – byYole Développement
Yole Développement (Yole) offers market reports including quantitative market forecasts,
technology trends, company strategy evaluation and indepth application analyses. Yole will
publish more than 55 reports in 2019, with our partner PISEO contributing to some of
the lighting reports.
Reverse Costing® – Structure, Process and Cost Analysis – by
System Plus Consulting
The Reverse Costing® report developed by System Plus Consulting provides full
teardowns, including detailed photos, precise measurements, material analyses,
manufacturing process flows, supply chain evaluations, manufacturing cost analyses and
selling price estimations. The reports listed below are comparisons of several analyzed
components from System Plus Consulting. More reports are however available, and over
60 reports will be released in 2019.The complete list is available at www.systemplus.fr.
Patent Reports – by KnowMade
More than describing the status of the IP situation, these analyses provide a missing link
between patented technologies and market, technological and business trends. They offer
an understanding of the competitive landscape and technology developments from a
patent perspective. They include key insights into key IP players, key patents and future
technology trends. For 2019 KnowMade will release over 15 reports.
The markets targeted are :
• Mobile  Consumer
• Automotive Transportation
• Medical
• Industrial
• Telecom  Infrastructure
• Defense  Aerospace
• Linked reports are dealing with the same topic to provide
• a more detailed analysis.
About Yole Développement | www.yole.fr | ©2019
32
OUR 2019 REPORTS COLLECTION (1/5)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
MEMS  SENSORS
o MARKET ANDTECHNOLOGY REPORT
• Status of the MEMS Industry 2019 - Update
• Status of the Audio Industry 2019 - New
• Uncooled Infrared Imagers and Detectors 2019 – Update
• Consumer Biometrics:Technologies and MarketTrends 2018
• MEMS Pressure Sensor Market and Technologies 2018
• Gas  Particle Sensors 2018
o STRUCTURE, PROCESS  COST REPORT
• MEMS  Sensors Comparison 2019
• MEMS Pressure Sensor Comparison 2018
• Particle Sensors Comparison 2019
• Miniaturized Gas Sensors Comparison 2018
o PATENT REPORT
• MEMS Foundry Business Portfolio 2019 - New
• Miniaturized Gas Sensors 2019 - New
PHOTONIC AND OPTOELECTRONICS
o MARKET ANDTECHNOLOGY REPORT
• Silicon Photonics and Photonic Integrated Circuits 2019
• LiDARs for Automotive and Industrial Applications 2019 - Update
o PATENT REPORT
• Silicon Photonics for Data Centers: Optical Transceiver 2019 - New
• LiDAR for Automotive 2018
RF DEVICES ANDTECHNOLOGIES
o MARKET ANDTECHNOLOGY REPORT
• RF GaN Market:Applications, Players,Technology,
and Substrates 2019 - Update
• 5G’s Impact on RF Front-End Module and Connectivity
for Cell Phones 2019 – Update
• 5G Impact on Telecom Infrastructure 2019 - New
• Radar and Wireless for Automotive: Market and Technology
Trends 2019 - Update
• Passive  Active Antenna Systems for Telecom
Infrastructure 2019 - New
• RF Standards and Technologies for Connected Objects 2018
o STRUCTURE, PROCESS  COST REPORT
• RF Front-End Module Comparison 2019 - Update
• Automotive Radar RF Chipset Comparison 2018
o PATENT REPORT
• Antenna for 5G Wireless Communications 2019 - New
• RF Front End Modules for Cellphones 2018
• RF Filter for 5G Wireless Communications: Materials and Technologies 2019
• RF GaN 2019 – Patent Landscape Analysis
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
33
OUR 2019 REPORTS COLLECTION (2/5)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
IMAGING
o MARKET ANDTECHNOLOGY REPORT
• Status of the CIS Industry 2019:Technology
and Foundry Business - Update
• Imaging for Automotive 2019 - Update
• Neuromorphic Sensing and Computing 2019 - Update
• Status of the Camera Module Industry 2019 - Focus on
Wafer Level Optics – Update
• 3D Imaging  Sensing 2018
• MachineVision for Industry and Automation 2018
• Sensors for RoboticVehicles 2018
o STRUCTURE, PROCESS  COST REPORT
• Compact Camera Modules Comparison 2019
• CMOS Image Sensors Comparison 2019
o PATENT REPORT
• Facial  Gesture Recognition Technlogies in Mobile Devices 2019 - New
• Apple iPhone X Proximity Sensor  Flood Illuminator 2018
MEDICAL IMAGING AND BIOPHOTONICS
o MARKET ANDTECHNOLOGY REPORT
• X-Ray Detectors for Medical, Industrial
and Security Applications 2019- New
• Microscopy Life Science Cameras: Market and Technology Analysis 2019
• Ultrasound technologies for Medical, Industrial
and Consumer Applications 2018
o PATENT REPORT
• Optical Coherence Tomography Medical Imaging 2018
MICROFLUIDICS
o MARKET ANDTECHNOLOGY REPORT
• Status of the Microfluidics Industry 2019 - Update
• Next Generation Sequencing  DNA Synthesis - Technology,
Consumables Manufacturing and MarketTrends 2019 - New
• Organs-on-chips Market and Technology Landscape 2019 - Update
• Point-of-Need Testing Application of MicrofluidicTechnologies 2018
• Liquid Biopsy: from Isolation to Downstream Applications 2018
• Chinese Microfluidics Industry 2018
o PATENT REPORT
• Microfluidic ManufacturingTechnologies 2019 – New
• Nanopore Sequencing 2019 - New
INKJET AND ACCURATE DISPENSING
o MARKET ANDTECHNOLOGY REPORT
• Inkjet Printheads - Dispensing Technologies
 Market Landscape 2019 - Update
• Emerging PrintingTechnologies
for Microsystem Manufacturing 2019 - New
• Piezoelectric Devices from Bulk to Thin Film 2019 - New
• Inkjet Functional and Additive Manufacturing for Electronics 2018
o STRUCTURE, PROCESS  COST REPORT
• Piezoelectric Materials from Bulk to Thin Film Comparison 2019
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
34
OUR 2019 REPORTS COLLECTION (3/5)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
BIOMEMS  MEDICAL MICROSYSTEMS
o MARKET ANDTECHNOLOGY REPORT
• Medical Wearables: Market  Technology Analysis 2019 - New
• Neurotechnologies and Brain Computer Interface 2018
• BioMEMS  Non-Invasive Sensors: Microsystems for Life Sciences
 Healthcare 2018
o PATENT REPORT
• 3D Cell Printing 2019 - New
• CirculatingTumor Cells Isolation 2019 - New
SOFTWARE AND COMPUTING
o MARKET ANDTECHNOLOGY REPORT
• Artificial Intelligence Computing For Automotive 2019 - New
• Artificial Intelligence Computing for Consumer 2019 - Update
• Image Signal Processor andVision Processor Market
and Technology Trends 2019
• xPU (Processing Units) for Cryptocurrency, Blockchain, HPC
and Gaming 2019 – New
• Artificial Intelligence for Medical Imaging 2019 - New
o PATENT REPORT
• Artificial Intelligence for Medical Diagnostics - New
MEMORY
o MARKET ANDTECHNOLOGY REPORT
• Status of the Memory Industry 2019 - New
• MRAM Technology and Business 2019 - New
• Emerging NonVolatile Memory 2018
o STRUCTURE, PROCESS  COST REPORT
• Memory Comparison 2019
o PATENT REPORT
• Magnetoresistive Random-Access Memory (MRAM) 2019 - New
• 3D Non-Volatile Memory 2018
ADVANCED PACKAGING
o MARKET ANDTECHNOLOGY REPORT
• Fan Out PackagingTechnologies and MarketTrends 2019 - Update
• 2.5D/3D TSV  Wafer-Level Stacking:Technology
 Market Updates 2019- Update
• Advanced RF SiP for Cellphones 2019 - Update
• Status of the Advanced Packaging Industry 2019 - Update
• Status of the Advanced Substrates 2019 - Update
• Automotive Packaging Market  Technology Trends 2019 - New
• Trends in Automotive Packaging 2018
• Thin-Film Integrated Passive Devices 2018
• Die Attach Equipment Trends 2019 en Semiconductor
Manufacturing - New
o STRUCTURE, PROCESS  COST REPORT
• Advanced RF SiP for Cellphones Comparison 2019
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
35
OUR 2019 REPORTS COLLECTION (4/5)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
SEMICONDUCTOR MANUFACTURING
o MARKET ANDTECHNOLOGY REPORT
• Nano-Imprint Technology Trends for Semiconductor
Applications 2019 - New
• Equipment and Materials for Fan Out Packaging 2019 - Update
• Equipment for More than Moore:Thin Film Deposition
 Etching 2019 - New
• Wafer Starts for More Than Moore Applications 2018
• Polymeric Materials atWafer-Level
for Advanced Packaging 2018
• Bonding and Lithography Equipment Market
for More than Moore Devices 2018
o STRUCTURE, PROCESS  COST REPORT
• Wafer Bonding Comparison 2018
o PATENT REPORT
• Hybrid Bonding for 3D Stack 2019 – New
SOLID STATE LIGHTING
o MARKET ANDTECHNOLOGY REPORT
• Status of the Solid-State Lighting Source Industry 2019- New
• Edge Emitting Lasers (EELS) 2019 - New
• Light Shaping Technologies 2019 – New
• Automotive Advanced Front Lighting Systems 2019 - New
• VCSELs – Market and Technology Trends 2019 - Update
• IR LEDs and Laser Diodes – Technology,Applications,
and Industry Trends 2018
• Automotive Lighting 2018:Technology, Industry and MarketTrends
• UV LEDs - Technology, Manufacturing and ApplicationTrends 2018
• LiFi:Technology, Industry and MarketTrends 2018
o STRUCTURE, PROCESS  COST REPORT
• VCSEL Comparison 2019
o PATENT REPORT
• VCSELs 2018
DISPLAY
o MARKET ANDTECHNOLOGY REPORT
• Next Generation 3D Displays 2019 - New
• Next Generation Human Machine Interaction (HMI)in Displays 2019 - New
• MicroLED Displays 2019 - Update
• MiniLED 2019 - Update
• Next Generation TV Panels: NewTechnologies, Features and
Market Impact 2019
• Displays  OpticalVision Systems forVR,AR  MR 2018
o PATENT REPORT
• MicroLED Displays : Intellectual Property Landscape 2018
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
36
OUR 2019 REPORTS COLLECTION (5/5)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
POWER ELECTRONICS
o MARKET ANDTECHNOLOGY REPORT
• Power SiC: Materials, Devices and Applications 2019 - Update
• Power Electronics for EV/HEV and e-mobility:
Market, Innovations and Trends 2019 - Update
• Status of the Power Electronics Industry 2019 - Update
• Discrete Power Packaging : Material Market
and Technology Trends 2019 - New
• Status of the Power ICs Industry 2019 - Update
• Status of the Inverter Industry 2019 - Update
• Status of the Power Module Packaging Industry 2019 - Update
• Wireless Charging Market Expectations
and Technology Trends 2018
• Power GaN 2018: Epitaxy, Devices,Applications
and Technology Trends
o STRUCTURE, PROCESS  COST REPORT
• Automotive Power Module Packaging Comparison 2018
• GaN-on-Silicon Transistor Comparison 2019
• SiC Transistor Comparison 2019
o PATENT REPORT
• Power SiC : Materials, Devices and Modules 2019 - New
• Power GaN : Materials, Devices and Modules 2019 – Update
BATTERY  ENERGY MANAGEMENT
o MARKET ANDTECHNOLOGY REPORT
• Status of the Rechargeable Li-ion Battery Industry 2019 - New
o PATENT REPORT
• Battery Energy Density Increase: Materials
and EmergingTechnologies 2019 - New
• Solid-State Batteries 2019 - New
• Status of the Battery Patents 2018
COMPOUND SEMI.
o MARKET ANDTECHNOLOGY REPORT
• Emerging Semiconductor Substrates:
Market  Technology Trends 2019- New
• InP Wafer and Epiwafer Market - Photonic and
RF Applications 2019- New
• GaAsWafer and Epiwafer Market: RF, Photonics,
LED and PV Applications 2018
o PATENT REPORT
• GaN-on-Silicon Substrate: Materials, Devices
and Applications 2019 - Update
BIOTECHNOLOGIES
o MARKET ANDTECHNOLOGY REPORT
• CRISPR-Cas9 Technology: From Lab to Industries 2018
o PATENT REPORT
• Personalized Medicine 2019 – New
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
37
OUR 2019 MONITORS COLLECTION (1/2)
Get the most updated overview of your market to monitor your strategy
Yole Développement, System Plus Consulting and KnowMade, all part of the Yole Group of Companies, are launching a collection of 10 monitors in 2019. The monitors aim to
provide updated market, technology and patent data as well dedicated quarterly analyses of the evolution in your industry over the previous 12 months. Furthermore, you can
benefit from direct access to the analyst for an on-demand QA and discussion session regarding trend analyses, forecasts and breaking news.
Topics covered will be compact camera modules (CCMs), advanced packaging, compound semiconductors, microfluidics, batteries, RF and memory.
MARKET MONITOR byYole Développement
A FULL PACKAGE:
The monitors will provide the evolution of the market in units, wafer area and revenues.
They will also offer insights into what is driving the business and a close look at what is
happening will also be covered in it.
The following deliverables will be included in the monitors:
• An Excel database with all historical and forecast data
• A PDF slide deck with graphs and comments/analyses covering the expected
evolutions
o ADVANCED PACKAGING – NEW
This monitor will provide the evolution of the advanced packaging platforms. It will
cover Fan-Out Wafer Level Packaging (WLP), Fan-Out Panel Level Packaging (PLP),
Wafer-Level Chip Scale Packaging (WLCSP), Flip Chip packaging platforms, and 2.5D
and 3D Through Silicon Via (TSV) integration. Frequency: Quarterly, starting from Q4
2019
o COMPOUND SEMI. – NEW
This monitor will describe how the compound semiconductor industry is evolving. It
will offer a close look at GaAs, InP, SiC, GaN and other compounds of interest
providing wafer volumes, revenues, application breakdowns and momentum.
Frequency: Quarterly, starting from Q 2019
o CMOS IMAGE SENSORS – NEW
This monitor will provide the evolution of the imaging industry, with a close look at
image sensor, camera module, lens and VCM. Volumes, revenues and momentum of
companies like Sony, Samsung, Omnivision and OnSemi will thus be analysed.
Frequency: Quarterly, starting from Q3 2019
o MEMORY – UPDATE
For the memory industry you can have access to a quaterly monitor, as well as an
additional service, a monthly pricing. Both services can be bought seprately:
• DRAM Service: Including a quarterly monitor and monthly pricing.
• NAND Service: Including a quarterly monitor and monthly pricing.
REVERSETECHNOLOGY MONITOR by System Plus Consulting
o SMARTPHONES – NEW
To stay updated on the latest components, packaging and silicon chip choices of the smartphone makers, System Plus Consulting has created its first Smartphone Reverse
Technology monitor. This year, get access to the packaging and silicon content database of at least 20 different flagship smartphones – more than five per quarter. Starting at the
beginning of 2020, the monitor will include an Excel database report for each phone and a quarterly comparison.
About Yole Développement | www.yole.fr | ©2019
38
OUR 2019 MONITORS COLLECTION (2/2)
Get the most updated overview of your market to monitor your strategy
PATENT MONITOR by KnowMade
A FULL PACKAGE:
Starting at the beginning of the year, the KnowMade monitors include the following
deliverables:
• An Excel file including the monthly IP database of:
• New patent applications
• Newly granted patents
• Expired or abandoned patents
• Transfer of IP rights through re-assignment and licensing
• Patent litigation and opposition
• Quarterly report including a PDF slide deck with the key facts  figures of the
quarter: IP trends over the three last months, with a close look to key IP players and
key patented technologies.
o GaN for Power  RF Electronics
Wafers and epiwafers, GaN-on-SiC, silicon, sapphire or diamond, semiconductor
devices such as transistors, and diodes, devices and applications including converters,
rectifiers, switches, amplifiers, filters, and Monolothic Microwave Integrated Circuits
(MMICs), packaging, modules and systems.
o GaN for Optoelectronics  Photonics
Wafers and epiwafers, GaN-on-sapphire, SiC or silicon; semiconductor devices such
as LEDs and lasers; and applications including lighting, display, visible communication,
photonics, packaging, modules and systems.
o Li-ion Batteries
Anodes made of lithium metal, silicon, and lithium titanate (LTO); cathodes made of
Lithium Iron Phosphate (LFP), Nickel-Manganese-Cobalt (NMC), Lithium Nickel
Cobalt Aluminium Oxide (NCA), Lithium Nickel Metal Dioxide (LiNiMO2), Lithium
Metal Phosphate (LiMPO4), and Lithium Metal Tetroxide (LiMO4); electrolytes
including liquid, polymer/gel, and solid inorganics; ceramic and other separators;
battery cells including thin film/microbattery, flexible, cylindrical and prismatic; and
battery packs and systems.
o Post Li-ion Batteries
Battery technologies including redox-flow batteries, sodium-ion, lithiumsulfur, lithium-
air, and magnesium-ion, and their supply chains, including electrodes, electrolytes,
battery cells and battery packs/systems.
o Solid-State Batteries
Supply chain including electrodes, battery cells, battery packs/systems and
electrolytes, including polymer, inorganic and inorganic/polymer, inorganic materials,
including argyrodites, LIthium Super Ionic CONductor, (LISICONs), Thio-LISICONs,
sulfide glasses, oxide glasses, perovskites, anti-perovskites and garnets.
o RF Acoustic Wave Filters
Including Surface Acoustic Wave (SAW), Temperature Compensated (TC)- SAW, Bulk
Acoustic Wave- Free-standing Bulk Acoustic Resonator (BAWFBAR), BAW-Solidly-
Mounted Resonator (BAW-SMR), and Packaging.
o RF Power Amplifiers
Including Low Noise Amplifiers, Doherty Amplifiers, Packaging, and Millimeter-Wave
technology.
o RF Front-End Modules
o Microfluidics
From components to chips and systems, including all applications.
About Yole Développement | www.yole.fr | ©2019
39
I-MICRONEWS MEDIA
To meet the growing demand for market,
technological and business information,
i-Micronews Media integrates several tools
able to reach each individual contact within its
network.
We will ensure your company benefits from
this
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Cameras for Microscopy and Next-Generation Sequencing 2019 report by Yole Développement

  • 1. From Technologies to Markets © 2019 From Technologies to Markets © 2019 Cameras for Microscopy and Next Generation Sequencing Market & Technology Report 2019 Sample
  • 2. 2 MarjorieVillien,PhD As a Technology & Market Analyst, Medical & Industrial Imaging, Marjorie Villien, PhD., is member of the Photonics & Sensing activities group at Yole Développement (Yole). Marjorie contributes regularly to the development of imaging projects with a dedicated collection of market & technology reports as well as custom consulting services in the medical and industrial fields. She regularly meets with leading imaging companies to identify and understand technology issues, analyze market evolution and ensure the smart combination of technical innovation and industrial application. After spending two years at Harvard and prior to her position at Yole, Marjorie served as a research scientist at INSERM and developed dedicated medical imaging expertise for the diagnosis and follow-up treatment of Alzheimer’s disease, stroke and brain cancers. She presents to numerous international conferences throughout the year and has authored or co-authored 12 papers and 1 patent. Marjorie Villien graduated from Grenoble INP (France) and holds a PhD. in physics & medical imaging. Email: villien@yole.fr Loïc Michoud As a Technology & Market Analyst,Artificial Intelligence (AI) & Imaging Technologies, Loic Michoud is involved in the development of technology & market reports atYole Développement (Yole), within the Photonics & Sensing team. Loic studies and investigates innovative AI technologies for imaging applications and related markets. Software and image processing are part of his technical background. Prior toYole, he was engaged in an internship at the University of Michigan (MI, USA) where he developed relevant medical imaging expertise in image analysis and process digitization. Loic Michoud is currently completing a bachelor degree at CPE Lyon (France). In parallel, he is studying a dedicated program focused on innovation management at EM Lyon Business School (France). Email: michoud@yole.fr ABOUT THE AUTHORS Biographies & contacts Sebastien Clerc Sébastien Clerc is a Technology & Market Analyst in Microfluidics, Sensing & Actuating at Yole Développement (Yole). As part of the Photonics & Sensing team, Sébastien has authored a collection of market and technology reports dedicated to microfluidics and other micro-devices for both market segments: medical (including diagnostics, pharmaceutical, biotechnology, drug delivery, medical devices) and industrial (including environment, agro-food). At the same time, he is involved in custom projects such as strategic marketing, technology scouting and technology evaluation to help academic and industrial players in their innovation processes. Thanks to his technology & market expertise, Sébastien has spoken in more than 20 industry conferences worldwide over the last 4 years. Sébastien Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in Biomedical Technologies. He then completed his academic studies with a Master’s degree in Innovation and Technology Management in the same institute. Email: clerc@yole.fr Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 3. 3 Accu-scope,Agilent technologies, ams,Amscope, amt,Andor,Anvajo,Artray,Aven, Basler, Baumer, Bentham, BGI, Bio-Rad, Bruker, CEA, Cellmic, Centrillion technologies, Cnoptec, Cygnus, Dage- mti,Danaher, Depixus, Dino-lite, Direct electron, Direct genomics, Emsis, Episenses, Euromex, Fein optic, Fimm, Flir, Gatan, Genapsys, Genia, Gpixel, Greateyes, Hamamatsu, Hirox, Hitachi high- technologies, Horiba, icfo, Illumina, Imec, imt, InSilixa, Intellectual ventures, Invenios, InView, Jenoptik, Jeol, Kappa, Keyence, Kramer scientific, Labomed, Labsmith, Lasergen, Leica microsystems, Lissview, Matrix vision, Meiji techno, Micralyne, Micronit, MicroscopeIT, Midiagnostics, Mitutoyo, Motic, Nabsys, Nanotronics, Nikon, Novel optics, Nowdiagnostics, Olympus, Omano, Omax microscope, Omnivision, ON semiconductor, Optika, Oxford Nanopore, Pacific Biosciences, Park systems, pax-it, PCO, Phenomic.ai, Phograin, Photon focus, Photonis, Photron, Pixelink, Powerchip, Qiagen, QuantuMDx, Raptor, Rigaku, Roswell biotechnologies, SeqLL, Sight,Silex microsystems, Sony, Spot imaging, Stanford computer optics, Sunny optical technology, Swift,Teledyne,Thermo fisher,Thorlabs,TSMC,TVIPS,Witec, Ximea, Zarbeco, Zeiss, and many more ! COMPANIES CITED IN THIS REPORT Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 240+ slides of market and technology analysis Information gathered through direct discussions with players all along the supply chain
  • 4. 4 • Glossary 3 • Table of contents 4 • Report objectives 5 • Report scope 6 • Report methodology 7 • About the authors 8 • Companies cited in this report 9 • Yole Group’s related reports 10 • Executive summary 11 • Context 52 • Report scope • Microscopy: historical perspective • Next generation sequencing (NGS): context • Market segmentation • Market forecasts 65 • Segment descriptions • Market data and forecasts 2018 - 2024 (value, units) at system level, by segment • Market data and forecasts 2018 - 2024 (value, units) at camera level, by segment and technology • Market data and forecasts 2018 - 2024 (value, units) at image sensor level, by segment and technology • Cameras and image sensors - average selling price evolution • Roadmaps Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 TABLE OF CONTENTS • Market trends 90 • Cameras for optical microscopy - market trends • Cameras for electron microscopy - market trends • Point-of-care microscopy - market trends • High-end cameras in life sciences - market trends • Per segment • Technology and economic requirements, per application • Market drivers • Roadmaps, per segment • Synthesis • Supply chain and market share 145 • Ecosystem analysis • Market share, at system and camera level • M&A, collaborations, fundraising • Supply chain analysis • Business models • Technology trends 173 • Technology description: cameras and image sensors • Available commercial products and future product launches • AI in microscopy • Company profiles 213 • Conclusion 243 • Yole Développement presentation 246
  • 5. 5 • Provide an overview of the microscopy and NGS market at system, camera, and image sensor level, along with an understanding of established and upcoming players, their technologies (and the advantages/drawbacks), and how these will evolve in the coming years • Present market data and forecasts at system, camera, and image sensor level, by segment (optical microscopy, transmission electron microscopy, point-of-care microscopy, and NGS), in value ($) and volume (units) • Identify where the opportunities lie for different players along the supply chain, from materials suppliers and foundries to camera manufacturers and system developers • Discuss the different technologies used today (CCD, CMOS, sCMOS, TDI), as well as technological trends like AI REPORT OBJECTIVES Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 6. 6 SCOPE OFTHE REPORT Yours needs are out of the report’ scope? Contact us for a custom: Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 Cameras for microscopy and next generation sequencing Microscopy Cameras for transmission electron microscopy (TEM) Image sensors for TEM Cameras for optical microscopy Image sensors for optical microscopy Camera for point of care (POC) microscopy Image sensors for POC microscopy Next generation sequencing (NGS) Cameras for NGS instruments Image sensors for NGS instruments Image sensors for NGS consumables
  • 7. 7 METHODOLOGIES & DEFINITIONS Market Volume (in Munits) ASP (in $) Revenue (in $M) Yole’s market forecast model is based on the matching of several sources: Information Aggregation Preexisting information Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 9. 9 Do not use a camera THE 3 MAIN TYPES OF MICROSCOPES Microscopy Scanning probe microscope Optical microscope Transmission electron microscope Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 Camera is a key element : focus of this report
  • 10. 10 Ernst Abbe defined the magnification limit of optical microscopes which is 0.2 µm. This is why viruses cannot be studied through standard optical microscopes. However, in 2014, Eric Betzig, Stefan W. Hell and William E. Moerner received the Nobel Prize in Chemistry for their discovery of fluorescence microscopy. In theory, this new methodology has no limit size structure limit and enables the study of nanoparticles. Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 MICROSCOPY Magnification power 0,2 µm
  • 11. 11 NEXT GENERATION SEQUENCING Applications • Sequencing is mainly a research tool today, but has the potential to be used in many clinical and industrial applications Diagnostics Pandemic control Prenatal & newborn screening Agriculture Food safety Bio-defense Forensics Environment Wellness & prevention Data storage Drug development Reproductive health And more! Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 12. 12Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 NEXT GENERATION SEQUENCING Cost of sequencing Since the introduction of next-generation sequencers, DNA sequencing cost has decreased at an astounding rate and outpacing Moore’s Law. The $1,000 genome was reached in 2015 with the release of Illumina’s HiSeq X Ten, and Illumina claims that its new NovaSeq sequencers will drive sequencing towards the $100 genome. In the meantime, service providers using BGI’s instrumentation are now proposing whole genome sequencing at a price well below $1,000. BGI claims that its new sequencer, the DNBSEQ-T7, can sequence a genome for ~$500. It appears the players engaged in this crazy race are still far from crossing the finish line. Source: www.genome.gov
  • 13. 13 The microscopy market is segmented into optical and electron microscopy. The optical microscopy field is subdivided into optical microscopy (the traditional systems with high and low end cameras) and the point of care systems (on-chip cameras or portable systems). Same for the NGS field which is subdivided into NGS instruments (high-end cameras inside the instruments) and NGS consumables (on-chip cameras). Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 CAMERAS FOR MICROSCOPY AND NGS Market typology Microscopy Next generation sequencing Electron Photon High-end cameras TEM Optical microscopy NGS instruments Low-end cameras On-chip image sensor or portable systems POC microscopy NGS consumables Optical systems Domain Detection method Scanning electron microscopy (SEM) is not included in this report
  • 14. 14 CAMERAS FOR MICROSCOPY AND NGS : MARKET OVERVIEW Summary of the camera for NGS and microscopy market at the system, camera and image sensor level between 2018 and 2024 CAGR2018-2024: 2% CAGR2018-2024: 3% System level market Camera level marketImage sensor level market CAGR2018-2024: 9%
  • 15. 15 System manufacturersSensor manufacturers Camera manufacturers Optical microscopy, most of them also integrated Transmission electron microscopy Transmission electron microscopy Next generation sequencing *Non-exhaustive list of companies CAMERAS FOR MICROSCOPY AND NGS : MAIN PLAYERS Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 16. 16 CAMERAS FOR NGS – TECHNOLOGY ROADMAP 2000 2010 2020 Automated sanger sequencing Next-generation optical sequencers Optical consumables 4th generation: CMOS image sensors integrated on the consumables 2nd generation: Optical detection using high-end cameras inside the instruments 3rd generation: Electrical detection integrated on the consumables (CMOS sensors) 1st generation 2030 Instrument-free sequencing 5th generation: Instrument-free sequencing directly on consumables? Opening a new market opportunity for the image sensor industry Next-generation electrical sequencers Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 17. 17Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 MARKET FORECASTS
  • 18. 18Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 MARKET TRENDS
  • 19. 19Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 SUPPLY CHAIN AND MARKET SHARE
  • 20. 20Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019 TECHNOLOGY TRENDS
  • 21. 21 Contact our SalesTeam for more information Point-of-NeedTesting:Application of MicrofluidicTechnologies Status of the CMOS Image Sensor Industry 2018 Next Generation Sequencing & DNA Synthesis:Technology, Consumables Manufacturing and MarketTrends 2019 CMOS Image Sensor Service – Imaging Research YOLE GROUP RELATED REPORTS & MONITORS Yole Développement Cameras for Microscopy and Next-Generation Sequencing | Sample | www.yole.fr | ©2019
  • 22. Why did we choose to discuss the technology evolutionsinthemicroscopyandnext-generation sequencing (NGS) market? Because this market is undergoing enormous technological changes that are opening new market opportunities for the camera image sensors industry. Cameras are key elements in the microscopy and NGS space. Indeed, today most microscopes are digital microscopes that use at least one (and sometimes more) cameras. The main trend in optical microscopy is to attain higher resolution, as well as faster acquisition and higher sensitivity for quicker and better diagnostics, and real- time imaging of living organisms. CCD is the main image sensor technology used today, but sCMOS is gaining market share due to an increasing need for high-speed image acquisition. However, this trend towards better imaging is counterbalanced by another trend – one that leans towards portability and use of microscopy at the point of care. These systems are sleeker and cheaper, and deliver microscopy results directly to the caregiver. This is also the case for NGS. Two very different trends are discernable: one towards higher throughput with very expensive, bulky equipment; and another that is lower throughput, with cheaper equipment offering lower footprint and wide availability. Take for example Illumina, the optical NGS market leader with more than 80% market share: Illumina has a diverse product portfolio of very high-end systems, but recently launched a more affordable, lower-throughput system - the iSeq100. This follows the trend towards commoditization of NGS. The iSeq100 does not integrate optical systems in the instrument anymore, but uses a disposable image sensor directly inside the flow cell, which is a game-changer in the NGS market! Indeed, this makes the instrument much more affordable, enabling Illumina to place more systems and therefore sell more consumables, which they can make cheaper because of increased volumes. This trend is also seen with BGI, Illumina’s Chinese competitor, which recently announced a benchtop NGS system based on CMOS chips. A broader trend is artificial intelligence (AI), which is upending the microscopy hardware ecosystem because deep learning could enable not only ultra-high resolution at lower hardware cost, but also automation. This report describes the technology evolutions in the microscopy and NGS field, and the effect these developments will have on the market and ecosystem. CAMERAS FOR MICROSCOPY AND NEXT-GENERATION SEQUENCING 2019 Market & Technology Report - November 2019 MOVING TOWARD DISPOSABLE IMAGE SENSORS FOR NEXT-GENERATION SEQUENCING AND POINT-OF-CARE MICROSCOPY Disposable image sensors: a revolution for microscopy and next-generation sequencing. (Yole Développement, November 2019) 21st century technology roadmap for next-generation sequencing KEY FEATURES • Historical perspective and synergies with other markets • Market data and forecasts at system, camera, and image sensor level, by segment (optical microscopy, transmission electron microscopy (TEM), point-of- care microscopy, NGS) and technology(CCD, CMOS, sCMOS, TDI), in value (US$) and volume (units) • Technology penetration and market trends, per segment • Supply chain analysis with market share, at system level and camera level • Technology landscape, evolutions, and roadmaps 2000 2010 2020 Automated sanger sequencing Next-generation optical sequencers Optical consumables 4th generation: CMOS image sensors integrated on the consumables 2nd generation: Optical detection using high-end cameras inside the instruments Next-generation electrical sequencers 3rd generation: Electrical detection integrated on the consumables (CMOS sensors) 1st generation 2030 Instrument-free sequencing 5th generation: Instrument-free sequencing directly on consumables? Opening a new market opportunity for the image sensor industry THOUGH EACH MARKET SEGMENT HAS DIFFERENT DYNAMICS, THE OVERALL IMAGE SENSOR MARKET FOR MICROSCOPY AND NGS WILL SHOW IMPRESSIVE GROWTH, WITH A CAGR2018-2024 OF 18% (IN VOLUME) At system level, the global microscopy and NGS market represented $4.1B in 2018. The biggest market segment was optical microscopy ($2.5B in 2018). Cameras for microscopy and NGS represented $367M, and is expected to reach $446M in 2024 at a CAGR of 3.3%. Meanwhile,
  • 23. CAMERAS FOR MICROSCOPY AND NEXT-GENERATION SEQUENCING 2019 A STRUCTURED ECOSYSTEM WITH COLLABORATIONS AT DIFFERENT LEVELS OF THE SUPPLY CHAIN BETWEEN IMAGE SENSOR, CAMERA, AND SYSTEM-LEVEL PLAYERS The $1,000 genome barrier was broken about five years ago, and we are now heading towards the $100 genome thanks to higher throughput and faster equipment. The ultimate goal is to reach as low as $10 per genome, and semiconductor technologies are key enablers for NGS affordability. The race towards sequencing inexpensiveness and commoditization is a tremendous opportunity for the semiconductor industry, because volumes will explode. Specific to ecosystem, microscopy and NGS is a structured market with a few key players. At system level, the major players in optical microscopy are Olympus, Nikon, Zeiss, and Leica Microsystems. Combined, they hold more than 80% of optical microscopy market share. The transmission electron microscopy (TEM) main players are Jeol, Thermo Fisher Scientific, and Hitachi High-Technologies, and the optical NGS main players are Illumina, Pacific Biosciences, and BGI. At camera level, the market is also well structured, with integrated players like Olympus and Zeiss, and specialized camera players such as Teledyne, Sony, Hamamatsu, and Andor. In the TEM market the main camera players are Gatan and Thermo Fisher, which is integrated. The key image sensor providers for microscopy and NGS are Sony, ON Semiconductor, Hamamatsu, Gpixel, Omnivision, and ams. Recent mergers and acquisitions of microscope manufacturers are aimed at finding expertise in the field of data management and software (ex: Zeiss acquiring gom in 2019; Olympus acquiring Image Stream Medical in 2017). This trends follows the parallel development of deep learning algorithms in this field. image sensors for microscopy and NGS achieved $31M in 2018. This rather small market should enjoy rapid growth (CAGR2018-2024 in value: 9%, and in volume: 18%), an improvement driven mostly by the arrival of image sensors-on-consumables in NGS. The image sensor market for microscopy is divided into four different categories, each having a different maturity level. For example, optical and transmission electron microscopy is a mature marketwithalowCAGR.Point-of-caremicroscopy was a very small, emerging market in 2018, but is poised for fast growth. Image sensors embedded in cameras for high-end NGS systems is a declining market due to the trend toward cheaper systems with less cameras. The image sensors market for NGS consumables is booming. This new business model implies the creation of products where the image sensor is disposable, equating to a very low average selling price (compared to the image sensors previously used in microscopy and NGS systems) and very high volume. This report describes the 2018 market and offers forecasts for the period 2018 - 2024 at system, camera, and image sensor level. The hypothesis behind these forecasts and the roadmaps leading to these assumptions are also described. Cameras for microscopy and next-generation sequencing market: 2018 - 2024 forecast (Yole Développement, November 2019) 2018 2024 $4,130M $4,654M $367M $446M $31M $51M CAGR2018-2024: 3% CAGR2018-2024: 2% CAGR2018-2024: 9% System level market Camera level market Image sensor level market Cameras for microscopy and next-generation sequencing: players ecosystem* (Yole Développement, November 2019) System manufacturersSensor manufacturers Camera manufacturers Optical microscopy, most of them also integrated Transmission electron microscopy Next generation sequencing *Non-exhaustive list of companies Transmission electron microscopy
  • 24. COMPANIES CITED IN THE REPORT (non exhaustive list) Accu-scope, Agilent Technologies, ams, Amscope, amt, Andor, Anvajo, Artray, Aven, Basler, Baumer, Bentham, BGI, Bio-Rad, Bruker, CEA, Cellmic, Centrillion Technologies, Cnoptec, Cygnus, Dage- mti,Danaher, Depixus, Dino-lite, Direct Electron, Direct Genomics, Emsis, Episenses, Euromex, Fein Optic, Fimm, Flir, Gatan, Genapsys, Genia, Gpixel, Greateyes, Hamamatsu, Hirox, Hitachi High-Technologies, Horiba, icfo, Illumina, Imec, imt, InSilixa, Intellectual Ventures, Invenios, InView, Jenoptik,Jeol,Kappa,Keyence,KramerScientific,Labomed,Labsmith,Lasergen,LeicaMicrosystems, Lissview, Matrix Vision, Meiji Techno, Micralyne, Micronit, MicroscopeIT, Midiagnostics, Mitutoyo, Motic, Nabsys, Nanotronics, Nikon, Novel Optics, Nowdiagnostics, Olympus, Omano, Omax Microscope, Omnivision, ON Semiconductor, Optika, Oxford Nanopore, Pacific Biosciences, Park Systems, pax-it, PCO, Phenomic.ai, Phograin, Photon Focus, Photonis, Photron, Pixelink, Powerchip, Qiagen, QuantuMDx, Raptor, Rigaku, Roswell Biotechnologies, SeqLL, Sight,Silex Microsystems, Sony, Spot Imaging, Stanford Computer Optics, Sunny Optical Technology, Swift, Teledyne, Thermo Fisher, Thorlabs, TSMC, TVIPS, Witec, Ximea, Zarbeco, Zeiss, and many more… MARKET TECHNOLOGY REPORT Report objectives 5 Report scope 6 Companies cited in this report 9 Executive summary 11 Context 52 Microscopy: historical perspective Next generation sequencing (NGS): context Market segmentation Market forecasts 65 Segment descriptions Market data and forecasts 2018 - 2024 (value, units) at system level, by segment Market data and forecasts 2018 - 2024 (value, units) at camera level, by segment and technology Market data and forecasts 2018 - 2024 (value, units) at image sensor level, by segment and technology Cameras and image sensors - Average selling price evolution Roadmaps Market trends 90 Optical microscopy - Market trends Transmission electron microscopy - Market trends Point-of-care microscopy - Market trends Next generation sequencing - Market trends - Per segment - Technology and economic requirements, per application - Market drivers - Roadmaps, per segment - Synthesis Supply chain and market share 145 Ecosystem analysis Market share, at system and camera level MA, collaborations, fundraising Supply chain analysis Business models Technology trends 173 Technology description: cameras and image sensors Available commercial products and future product launches AI in microscopy Conclusion 243 Yole Développement presentation 246 TABLE OF CONTENTS (complete content on i-Micronews.com) • Next Generation Sequencing DNA Synthesis: Technology, Consumables Manufacturing and Market Trends 2019 • Status of the CMOS Image Sensor Industry 2018 • CMOS Image Sensor Service – Imaging Research • Point-of-Need Testing: Application of Microfluidic Technologies Find all our reports on www.i-micronews.com RELATED REPORTS AND MONITORS Benefit from our Bundle Annual Subscription offers and access our analyses at the best available price and with great advantages AUTHORS As a Technology Market Analyst, Medical Industrial Imaging, Marjorie Villien, PhD., is member of the Photonics Sensing activities group at Yole Développement (Yole). Marjorie contributes regularly to the development of imaging projects with a dedicated collection of market technology reportsaswellascustomconsultingservicesin the medical and industrial fields. She regularly meets with leading imaging companies to identify and understand technology issues, analyze market evolution and ensure the smart combination of technical innovation and industrial application. Marjorie Villien graduated from Grenoble INP (France) and holds a PhD. in physics medical imaging. REPORT OBJECTIVES • Provide an overview of the microscopy and NGS market at system, camera, and image sensor level, along with an understanding of established and upcoming players, their technologies (and the advantages/drawbacks), and how these will evolve in the coming years • Present market data and forecasts at system, camera, and image sensor level, by segment (optical microscopy, transmission electron microscopy, point-of-care microscopy, and NGS), in value ($) and volume (units) • Identify where the opportunities lie for different players along the supply chain, from materials suppliers and foundries to camera manufacturers and system developers • Discuss the different technologies used today (CCD, CMOS, sCMOS, TDI), as well as technological trends like artificial intelligence As a Technology Market Analyst, Artificial Intelligence (AI) Imaging Technologies, Loic Michoud is involved in the development of technology market reports at Yole Développement (Yole), within the Photonics Sensing team. Loic studies and investigates innovative AI technologies for imaging applications and related markets. Software and image processing are part of his technical background. Loic Michoud is currently completing a bachelor degree at CPE Lyon (France). In parallel, he is studying a dedicated program focused on innovation management at EM Lyon Business School (France). Sébastien Clerc is a Technology Market Analyst in Microfluidics, Sensing Actuating at Yole Développement (Yole). As part of the Photonics Sensing team, Sébastien has authored a collection of market and technology reports dedicated to microfluidics and other micro-devices for the medical market segment mainly. At the same time, he is involved in custom projects such as strategic marketing, technology scouting and technology evaluation to help academic and industrial players in their innovation processes. Sébastien Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in Biomedical Technologies. He then completed his academic studies with a Master’s degree in Innovation and Technology Management in the same institute. In this report, Yole Développement’s analysts identify the key players leading the market, analyze the supply chain, and discuss the technology’s evolution and its influence on ecosystem changes.
  • 25. ORDER FORM Cameras for Microscopy and Next-Generation Sequencing 2019 SHIPPING CONTACT First Name: Email: Last Name: Phone: PAYMENT BY CREDIT CARD Visa Mastercard Amex Name of the Card Holder: Credit Card Number: Card Verification Value (3 digits except AMEX: 4 digits): Expiration date: BY BANK TRANSFER BANK INFO: HSBC, 1 place de la Bourse, F-69002 Lyon, France, Bank code: 30056, Branch code: 00170 Account No: 0170 200 1565  87, SWIFT or BIC code: CCFRFRPP, IBAN: FR76 3005 6001 7001 7020 0156 587 RETURN ORDER BY • MAIL: YOLE DÉVELOPPEMENT, Le Quartz, 75 Cours Emile Zola, 69100 Villeurbanne/Lyon - France SALES CONTACTS • Western US Canada - Steve Laferriere: + 1 310 600-8267 – laferriere@yole.fr • Eastern US Canada - Chris Youman: +1 919 607 9839 – chris.youman@yole.fr • Europe RoW - Lizzie Levenez: + 49 15 123 544 182 – levenez@yole.fr • Japan Rest of Asia - Takashi Onozawa: +81-80-4371-4887 – onozawa@yole.fr • Greater China - Mavis Wang: +886 979 336 809 – wang@yole.fr • Korea - Peter OK: +82 10 4089 0233 – peter.ok@yole.fr • Specific inquiries: +33 472 830 180 – info@yole.fr (1) Our Terms and Conditions of Sale are available at www.yole.fr/Terms_and_Conditions_of_Sale.aspx The present document is valid 24 months after its publishing date: November 6, 2019 / ABOUT YOLE DEVELOPPEMENT BILL TO Name (Mr/Ms/Dr/Pr): Job Title: Company: Address: City: State: Postcode/Zip: Country*: *VAT ID Number for EU members: Tel: Email: Date: PRODUCT ORDER - Ref YD19049 Please enter my order for above named report: One user license*: Euro 5,990 Multi user license: Euro 6,490 - The report will be ready for delivery from November 18, 2019 - For price in dollars, please use the day’s exchange rate. All reports are delivered electronically at payment reception. For French customers, add 20% for VAT I hereby accept Yole Développement’s Terms and Conditions of Sale(1) Signature: *One user license means only one person at the company can use the report. Founded in 1998, Yole Développement (Yole) has grown to become a group of companies providing marketing, technology and strategy consulting, media and corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications using silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 120 collaborators worldwide covering MEMS and image sensors, Compound semiconductors, RF Electronics, Solid-state lighting, Displays, Software, Optoelectronics, Microfluidics Medical, Advanced Packaging, Manufacturing, Power Electronics, Batteries Energy Management and Memory. The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting, PISEO, KnowMade and Blumorpho, supports industrial companies, investors and RD organizations worldwide to help them understand markets and follow technology trends to grow their business. CONSULTING AND ANALYSIS • Market data research, marketing analysis • Technology analysis • Strategy consulting • Reverse engineering costing • Patent analysis • Design and characterization of innovative optical systems • Financial services (due diligence, MA with our partner) More information on www.yole.fr MEDIA EVENTS • i-Micronews.com website, application related e-newsletter • Communication webcast services • Events: TechDays, forums… More information on www.i-Micronews.com REPORTS • Market technology reports • Patent investigation and patent infringement risk analysis • Structure, process and cost analysis and teardowns • Cost simulation tool More information on www.i-micronews.com/reports CONTACTS For more information about : • Consulting Financial Services: Jean-Christophe Eloy (eloy@yole.fr) • Reports Monitors: David Jourdan (jourdan@yole.fr) Fayçal Khamassi (khamassi@yole.fr) • Marketing Communication: Camille Veyrier (veyrier@yole.fr) • Public Relations: Sandrine Leroy (leroy@yole.fr)
  • 26. © 2019 Yole Développement From Technologies to Market Source: Wikimedia Commons
  • 27. 23©2019 | www.yole.fr | About Yole Développement YOLE DEVELOPPEMENT – FIELDS OF EXPERTISE WITHIN 3 MAIN DOMAINS Semiconductor Software o Semiconductor Packaging and Substrates o Semiconductor Manufacturing o Memory o Computing and Software Power Wireless o RF Devices Technologies o Compound Semiconductors Emerging Materials o Power Electronics o Batteries Energy Management Photonics Sensing o Photonics o Lighting o Imaging o Sensing Actuating o Display About Yole Développement | www.yole.fr | ©2019
  • 28. 24©2019 | www.yole.fr | About Yole Développement 4 BUSINESS MODELS o Consulting and Analysis • Market data research, marketing analysis • Technology analysis • Strategy consulting • Reverse engineering costing • Patent analysis • Design and characterization of innovative optical systems • Financial services (due diligence, MA with our partner) www.yole.fr o Syndicated reports • Market technology reports • Patent investigation and patent infringement risk analysis • Teardowns reverse costing analysis • Cost simulation tool www.i-Micronews.com/reports o Media • i-Micronews.com website and application • i-Micronews e-newsletter • Communication webcast services • Events:TechDays, forums,… www.i-Micronews.com o Monitors • Monthly and quarterly update • Excel database covering supply, demand, and technology • Price, market, demand and production forecasts • Supplier market shares www.i-Micronews.com/reports About Yole Développement | www.yole.fr | ©2019
  • 29. 25©2019 | www.yole.fr | About Yole Développement 6 COMPANIES TO SERVEYOUR BUSINESS Due diligence www.yole.fr Manufacturing costs analysis Teardown and reverse engineering Cost simulation tools www.systemplus.fr Market, technology and strategy consulting www.yole.fr IP analysis Patent assessment www.knowmade.fr Innovation and business maker www.bmorpho.com Design and characterization of innovative optical systems www.piseo.fr Yole Group of Companies About Yole Développement | www.yole.fr | ©2019
  • 30. 26 OUR GLOBAL ACTIVITY 30%of our business 40%of our business 30%of our business Greater China office Yole Japan HQ in Lyon Nantes Paris Nice Vénissieux Yole Deutschland Frankfurt Hsinchu Tokyo Yole Korea Seoul Palo Alto Yole Inc. Cornelius About Yole Développement | www.yole.fr | ©2019
  • 31. 27©2019 | www.yole.fr | About Yole Développement ANALYSIS SERVICES - CONTENT COMPARISON High Technology and Market Report Leadership Meeting QA Service Depth of the analysis Breadthoftheanalysis Meet the Analyst Custom Analysis High Low About Yole Développement | www.yole.fr | ©2019
  • 32. 28©2019 | www.yole.fr | About Yole Développement SERVING THE ENTIRE SUPPLY CHAIN Our analysts provide market analysis, technology evaluation, and business plans along the entire supply chain Integrators, end- users and software developers Device manufacturers Suppliers: material, equipment, OSAT, foundries… Financial investors, RD centers About Yole Développement | www.yole.fr | ©2019
  • 33. 29©2019 | www.yole.fr | About Yole Développement SERVING MULTIPLE INDUSTRIAL FIELDS We work across multiples industries to understand the impact of More-than- Moore technologies from device to system From A to Z… Transportation makers Mobile phone and consumer electronics Automotive Medical systems Industrial and defense Energy management About Yole Développement | www.yole.fr | ©2019
  • 34. 30 o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports, 10 new monitors and 120 teardowns. Combining respective expertise and methodologies from the three companies, they cover: o If you are looking for: • An analysis of your product market and technology • A review of how your competitors are evolving • An understanding of your manufacturing and production costs • An understanding of your industry’s technology roadmap and related IPs • A clear view supply chain evolution Our reports and monitors are for you! o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information, identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’s landscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the main players of their industries and realized more than 5,000 interviews per year. WHAT TO EXPECT IN 2019? In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also building on and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software and hardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Last but not least, System Plus Consulting is developing its teardowns service providing 120+ offers related to phones, smart home, wearables and connected devices. Discover our 2019 program right now, and ensure you get a true vision of the industry. Stay tuned! REPORTS COLLECTION www.i-Micronews.com • MEMS Sensors • RF devices technologies • Medical technologies • Semiconductor Manufacturing • Advanced packaging • Memory • Batteries and energy management • Power electronics • Compound semiconductors • Solid state lighting • Displays • Software • Imaging • Photonics About Yole Développement | www.yole.fr | ©2019
  • 35. 31 OUR 2019 REPORTS COLLECTION (1/4) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape Market –Technology – Strategy – byYole Développement Yole Développement (Yole) offers market reports including quantitative market forecasts, technology trends, company strategy evaluation and indepth application analyses. Yole will publish more than 55 reports in 2019, with our partner PISEO contributing to some of the lighting reports. Reverse Costing® – Structure, Process and Cost Analysis – by System Plus Consulting The Reverse Costing® report developed by System Plus Consulting provides full teardowns, including detailed photos, precise measurements, material analyses, manufacturing process flows, supply chain evaluations, manufacturing cost analyses and selling price estimations. The reports listed below are comparisons of several analyzed components from System Plus Consulting. More reports are however available, and over 60 reports will be released in 2019.The complete list is available at www.systemplus.fr. Patent Reports – by KnowMade More than describing the status of the IP situation, these analyses provide a missing link between patented technologies and market, technological and business trends. They offer an understanding of the competitive landscape and technology developments from a patent perspective. They include key insights into key IP players, key patents and future technology trends. For 2019 KnowMade will release over 15 reports. The markets targeted are : • Mobile Consumer • Automotive Transportation • Medical • Industrial • Telecom Infrastructure • Defense Aerospace • Linked reports are dealing with the same topic to provide • a more detailed analysis. About Yole Développement | www.yole.fr | ©2019
  • 36. 32 OUR 2019 REPORTS COLLECTION (1/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape MEMS SENSORS o MARKET ANDTECHNOLOGY REPORT • Status of the MEMS Industry 2019 - Update • Status of the Audio Industry 2019 - New • Uncooled Infrared Imagers and Detectors 2019 – Update • Consumer Biometrics:Technologies and MarketTrends 2018 • MEMS Pressure Sensor Market and Technologies 2018 • Gas Particle Sensors 2018 o STRUCTURE, PROCESS COST REPORT • MEMS Sensors Comparison 2019 • MEMS Pressure Sensor Comparison 2018 • Particle Sensors Comparison 2019 • Miniaturized Gas Sensors Comparison 2018 o PATENT REPORT • MEMS Foundry Business Portfolio 2019 - New • Miniaturized Gas Sensors 2019 - New PHOTONIC AND OPTOELECTRONICS o MARKET ANDTECHNOLOGY REPORT • Silicon Photonics and Photonic Integrated Circuits 2019 • LiDARs for Automotive and Industrial Applications 2019 - Update o PATENT REPORT • Silicon Photonics for Data Centers: Optical Transceiver 2019 - New • LiDAR for Automotive 2018 RF DEVICES ANDTECHNOLOGIES o MARKET ANDTECHNOLOGY REPORT • RF GaN Market:Applications, Players,Technology, and Substrates 2019 - Update • 5G’s Impact on RF Front-End Module and Connectivity for Cell Phones 2019 – Update • 5G Impact on Telecom Infrastructure 2019 - New • Radar and Wireless for Automotive: Market and Technology Trends 2019 - Update • Passive Active Antenna Systems for Telecom Infrastructure 2019 - New • RF Standards and Technologies for Connected Objects 2018 o STRUCTURE, PROCESS COST REPORT • RF Front-End Module Comparison 2019 - Update • Automotive Radar RF Chipset Comparison 2018 o PATENT REPORT • Antenna for 5G Wireless Communications 2019 - New • RF Front End Modules for Cellphones 2018 • RF Filter for 5G Wireless Communications: Materials and Technologies 2019 • RF GaN 2019 – Patent Landscape Analysis Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
  • 37. 33 OUR 2019 REPORTS COLLECTION (2/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape IMAGING o MARKET ANDTECHNOLOGY REPORT • Status of the CIS Industry 2019:Technology and Foundry Business - Update • Imaging for Automotive 2019 - Update • Neuromorphic Sensing and Computing 2019 - Update • Status of the Camera Module Industry 2019 - Focus on Wafer Level Optics – Update • 3D Imaging Sensing 2018 • MachineVision for Industry and Automation 2018 • Sensors for RoboticVehicles 2018 o STRUCTURE, PROCESS COST REPORT • Compact Camera Modules Comparison 2019 • CMOS Image Sensors Comparison 2019 o PATENT REPORT • Facial Gesture Recognition Technlogies in Mobile Devices 2019 - New • Apple iPhone X Proximity Sensor Flood Illuminator 2018 MEDICAL IMAGING AND BIOPHOTONICS o MARKET ANDTECHNOLOGY REPORT • X-Ray Detectors for Medical, Industrial and Security Applications 2019- New • Microscopy Life Science Cameras: Market and Technology Analysis 2019 • Ultrasound technologies for Medical, Industrial and Consumer Applications 2018 o PATENT REPORT • Optical Coherence Tomography Medical Imaging 2018 MICROFLUIDICS o MARKET ANDTECHNOLOGY REPORT • Status of the Microfluidics Industry 2019 - Update • Next Generation Sequencing DNA Synthesis - Technology, Consumables Manufacturing and MarketTrends 2019 - New • Organs-on-chips Market and Technology Landscape 2019 - Update • Point-of-Need Testing Application of MicrofluidicTechnologies 2018 • Liquid Biopsy: from Isolation to Downstream Applications 2018 • Chinese Microfluidics Industry 2018 o PATENT REPORT • Microfluidic ManufacturingTechnologies 2019 – New • Nanopore Sequencing 2019 - New INKJET AND ACCURATE DISPENSING o MARKET ANDTECHNOLOGY REPORT • Inkjet Printheads - Dispensing Technologies Market Landscape 2019 - Update • Emerging PrintingTechnologies for Microsystem Manufacturing 2019 - New • Piezoelectric Devices from Bulk to Thin Film 2019 - New • Inkjet Functional and Additive Manufacturing for Electronics 2018 o STRUCTURE, PROCESS COST REPORT • Piezoelectric Materials from Bulk to Thin Film Comparison 2019 Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
  • 38. 34 OUR 2019 REPORTS COLLECTION (3/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape BIOMEMS MEDICAL MICROSYSTEMS o MARKET ANDTECHNOLOGY REPORT • Medical Wearables: Market Technology Analysis 2019 - New • Neurotechnologies and Brain Computer Interface 2018 • BioMEMS Non-Invasive Sensors: Microsystems for Life Sciences Healthcare 2018 o PATENT REPORT • 3D Cell Printing 2019 - New • CirculatingTumor Cells Isolation 2019 - New SOFTWARE AND COMPUTING o MARKET ANDTECHNOLOGY REPORT • Artificial Intelligence Computing For Automotive 2019 - New • Artificial Intelligence Computing for Consumer 2019 - Update • Image Signal Processor andVision Processor Market and Technology Trends 2019 • xPU (Processing Units) for Cryptocurrency, Blockchain, HPC and Gaming 2019 – New • Artificial Intelligence for Medical Imaging 2019 - New o PATENT REPORT • Artificial Intelligence for Medical Diagnostics - New MEMORY o MARKET ANDTECHNOLOGY REPORT • Status of the Memory Industry 2019 - New • MRAM Technology and Business 2019 - New • Emerging NonVolatile Memory 2018 o STRUCTURE, PROCESS COST REPORT • Memory Comparison 2019 o PATENT REPORT • Magnetoresistive Random-Access Memory (MRAM) 2019 - New • 3D Non-Volatile Memory 2018 ADVANCED PACKAGING o MARKET ANDTECHNOLOGY REPORT • Fan Out PackagingTechnologies and MarketTrends 2019 - Update • 2.5D/3D TSV Wafer-Level Stacking:Technology Market Updates 2019- Update • Advanced RF SiP for Cellphones 2019 - Update • Status of the Advanced Packaging Industry 2019 - Update • Status of the Advanced Substrates 2019 - Update • Automotive Packaging Market Technology Trends 2019 - New • Trends in Automotive Packaging 2018 • Thin-Film Integrated Passive Devices 2018 • Die Attach Equipment Trends 2019 en Semiconductor Manufacturing - New o STRUCTURE, PROCESS COST REPORT • Advanced RF SiP for Cellphones Comparison 2019 Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
  • 39. 35 OUR 2019 REPORTS COLLECTION (4/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape SEMICONDUCTOR MANUFACTURING o MARKET ANDTECHNOLOGY REPORT • Nano-Imprint Technology Trends for Semiconductor Applications 2019 - New • Equipment and Materials for Fan Out Packaging 2019 - Update • Equipment for More than Moore:Thin Film Deposition Etching 2019 - New • Wafer Starts for More Than Moore Applications 2018 • Polymeric Materials atWafer-Level for Advanced Packaging 2018 • Bonding and Lithography Equipment Market for More than Moore Devices 2018 o STRUCTURE, PROCESS COST REPORT • Wafer Bonding Comparison 2018 o PATENT REPORT • Hybrid Bonding for 3D Stack 2019 – New SOLID STATE LIGHTING o MARKET ANDTECHNOLOGY REPORT • Status of the Solid-State Lighting Source Industry 2019- New • Edge Emitting Lasers (EELS) 2019 - New • Light Shaping Technologies 2019 – New • Automotive Advanced Front Lighting Systems 2019 - New • VCSELs – Market and Technology Trends 2019 - Update • IR LEDs and Laser Diodes – Technology,Applications, and Industry Trends 2018 • Automotive Lighting 2018:Technology, Industry and MarketTrends • UV LEDs - Technology, Manufacturing and ApplicationTrends 2018 • LiFi:Technology, Industry and MarketTrends 2018 o STRUCTURE, PROCESS COST REPORT • VCSEL Comparison 2019 o PATENT REPORT • VCSELs 2018 DISPLAY o MARKET ANDTECHNOLOGY REPORT • Next Generation 3D Displays 2019 - New • Next Generation Human Machine Interaction (HMI)in Displays 2019 - New • MicroLED Displays 2019 - Update • MiniLED 2019 - Update • Next Generation TV Panels: NewTechnologies, Features and Market Impact 2019 • Displays OpticalVision Systems forVR,AR MR 2018 o PATENT REPORT • MicroLED Displays : Intellectual Property Landscape 2018 Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
  • 40. 36 OUR 2019 REPORTS COLLECTION (5/5) 18 fields of excellence combined with six markets to provide a complete picture of your industry landscape POWER ELECTRONICS o MARKET ANDTECHNOLOGY REPORT • Power SiC: Materials, Devices and Applications 2019 - Update • Power Electronics for EV/HEV and e-mobility: Market, Innovations and Trends 2019 - Update • Status of the Power Electronics Industry 2019 - Update • Discrete Power Packaging : Material Market and Technology Trends 2019 - New • Status of the Power ICs Industry 2019 - Update • Status of the Inverter Industry 2019 - Update • Status of the Power Module Packaging Industry 2019 - Update • Wireless Charging Market Expectations and Technology Trends 2018 • Power GaN 2018: Epitaxy, Devices,Applications and Technology Trends o STRUCTURE, PROCESS COST REPORT • Automotive Power Module Packaging Comparison 2018 • GaN-on-Silicon Transistor Comparison 2019 • SiC Transistor Comparison 2019 o PATENT REPORT • Power SiC : Materials, Devices and Modules 2019 - New • Power GaN : Materials, Devices and Modules 2019 – Update BATTERY ENERGY MANAGEMENT o MARKET ANDTECHNOLOGY REPORT • Status of the Rechargeable Li-ion Battery Industry 2019 - New o PATENT REPORT • Battery Energy Density Increase: Materials and EmergingTechnologies 2019 - New • Solid-State Batteries 2019 - New • Status of the Battery Patents 2018 COMPOUND SEMI. o MARKET ANDTECHNOLOGY REPORT • Emerging Semiconductor Substrates: Market Technology Trends 2019- New • InP Wafer and Epiwafer Market - Photonic and RF Applications 2019- New • GaAsWafer and Epiwafer Market: RF, Photonics, LED and PV Applications 2018 o PATENT REPORT • GaN-on-Silicon Substrate: Materials, Devices and Applications 2019 - Update BIOTECHNOLOGIES o MARKET ANDTECHNOLOGY REPORT • CRISPR-Cas9 Technology: From Lab to Industries 2018 o PATENT REPORT • Personalized Medicine 2019 – New Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019
  • 41. 37 OUR 2019 MONITORS COLLECTION (1/2) Get the most updated overview of your market to monitor your strategy Yole Développement, System Plus Consulting and KnowMade, all part of the Yole Group of Companies, are launching a collection of 10 monitors in 2019. The monitors aim to provide updated market, technology and patent data as well dedicated quarterly analyses of the evolution in your industry over the previous 12 months. Furthermore, you can benefit from direct access to the analyst for an on-demand QA and discussion session regarding trend analyses, forecasts and breaking news. Topics covered will be compact camera modules (CCMs), advanced packaging, compound semiconductors, microfluidics, batteries, RF and memory. MARKET MONITOR byYole Développement A FULL PACKAGE: The monitors will provide the evolution of the market in units, wafer area and revenues. They will also offer insights into what is driving the business and a close look at what is happening will also be covered in it. The following deliverables will be included in the monitors: • An Excel database with all historical and forecast data • A PDF slide deck with graphs and comments/analyses covering the expected evolutions o ADVANCED PACKAGING – NEW This monitor will provide the evolution of the advanced packaging platforms. It will cover Fan-Out Wafer Level Packaging (WLP), Fan-Out Panel Level Packaging (PLP), Wafer-Level Chip Scale Packaging (WLCSP), Flip Chip packaging platforms, and 2.5D and 3D Through Silicon Via (TSV) integration. Frequency: Quarterly, starting from Q4 2019 o COMPOUND SEMI. – NEW This monitor will describe how the compound semiconductor industry is evolving. It will offer a close look at GaAs, InP, SiC, GaN and other compounds of interest providing wafer volumes, revenues, application breakdowns and momentum. Frequency: Quarterly, starting from Q 2019 o CMOS IMAGE SENSORS – NEW This monitor will provide the evolution of the imaging industry, with a close look at image sensor, camera module, lens and VCM. Volumes, revenues and momentum of companies like Sony, Samsung, Omnivision and OnSemi will thus be analysed. Frequency: Quarterly, starting from Q3 2019 o MEMORY – UPDATE For the memory industry you can have access to a quaterly monitor, as well as an additional service, a monthly pricing. Both services can be bought seprately: • DRAM Service: Including a quarterly monitor and monthly pricing. • NAND Service: Including a quarterly monitor and monthly pricing. REVERSETECHNOLOGY MONITOR by System Plus Consulting o SMARTPHONES – NEW To stay updated on the latest components, packaging and silicon chip choices of the smartphone makers, System Plus Consulting has created its first Smartphone Reverse Technology monitor. This year, get access to the packaging and silicon content database of at least 20 different flagship smartphones – more than five per quarter. Starting at the beginning of 2020, the monitor will include an Excel database report for each phone and a quarterly comparison. About Yole Développement | www.yole.fr | ©2019
  • 42. 38 OUR 2019 MONITORS COLLECTION (2/2) Get the most updated overview of your market to monitor your strategy PATENT MONITOR by KnowMade A FULL PACKAGE: Starting at the beginning of the year, the KnowMade monitors include the following deliverables: • An Excel file including the monthly IP database of: • New patent applications • Newly granted patents • Expired or abandoned patents • Transfer of IP rights through re-assignment and licensing • Patent litigation and opposition • Quarterly report including a PDF slide deck with the key facts figures of the quarter: IP trends over the three last months, with a close look to key IP players and key patented technologies. o GaN for Power RF Electronics Wafers and epiwafers, GaN-on-SiC, silicon, sapphire or diamond, semiconductor devices such as transistors, and diodes, devices and applications including converters, rectifiers, switches, amplifiers, filters, and Monolothic Microwave Integrated Circuits (MMICs), packaging, modules and systems. o GaN for Optoelectronics Photonics Wafers and epiwafers, GaN-on-sapphire, SiC or silicon; semiconductor devices such as LEDs and lasers; and applications including lighting, display, visible communication, photonics, packaging, modules and systems. o Li-ion Batteries Anodes made of lithium metal, silicon, and lithium titanate (LTO); cathodes made of Lithium Iron Phosphate (LFP), Nickel-Manganese-Cobalt (NMC), Lithium Nickel Cobalt Aluminium Oxide (NCA), Lithium Nickel Metal Dioxide (LiNiMO2), Lithium Metal Phosphate (LiMPO4), and Lithium Metal Tetroxide (LiMO4); electrolytes including liquid, polymer/gel, and solid inorganics; ceramic and other separators; battery cells including thin film/microbattery, flexible, cylindrical and prismatic; and battery packs and systems. o Post Li-ion Batteries Battery technologies including redox-flow batteries, sodium-ion, lithiumsulfur, lithium- air, and magnesium-ion, and their supply chains, including electrodes, electrolytes, battery cells and battery packs/systems. o Solid-State Batteries Supply chain including electrodes, battery cells, battery packs/systems and electrolytes, including polymer, inorganic and inorganic/polymer, inorganic materials, including argyrodites, LIthium Super Ionic CONductor, (LISICONs), Thio-LISICONs, sulfide glasses, oxide glasses, perovskites, anti-perovskites and garnets. o RF Acoustic Wave Filters Including Surface Acoustic Wave (SAW), Temperature Compensated (TC)- SAW, Bulk Acoustic Wave- Free-standing Bulk Acoustic Resonator (BAWFBAR), BAW-Solidly- Mounted Resonator (BAW-SMR), and Packaging. o RF Power Amplifiers Including Low Noise Amplifiers, Doherty Amplifiers, Packaging, and Millimeter-Wave technology. o RF Front-End Modules o Microfluidics From components to chips and systems, including all applications. About Yole Développement | www.yole.fr | ©2019
  • 43. 39 I-MICRONEWS MEDIA To meet the growing demand for market, technological and business information, i-Micronews Media integrates several tools able to reach each individual contact within its network. We will ensure your company benefits from this ONLINE ONSITE INPERSON i-Micronews e-newsletter i-Micronews.com FreeFullPDF.com Events Webcasts Unique, cost-effective ways to reach global audiences. Online display advertising campaigns are great strategies for improving your product/brand visibility.They are also an efficient way to adapt with the demands of the times and to evolve an effective marketing plan and strategy. Brand visibility, networking opportunities Today's technology makes it easy for us to communicate regularly, quickly, and inexpensively – but when understanding each other is critical, there is no substitute for meeting in-person. Events are the best way to exchange ideas with your customers, partners, prospects while increasing your brand/product visibility. Targeted audience involvement equals clear, concise perception of your company’s message. Webcasts are a smart, innovative way of communicating to a wider targeted audience.Webcasts create very useful, dynamic reference material for attendees and also for absentees, thanks to the recording technology. #15,800+ monthly unique visitors on i-Micronews.com #10,900+ weekly readers of i-Micronews e-newsletter #110 attendees on average #7+ key events planned for 2019 on different topics #380 registrants per webcast on average to gain new leads for your business Contact: CamilleVeyrier (veyrier@yole.fr), Marketing Communication Director About Yole Développement | www.yole.fr | ©2019
  • 44. 40 CONTACT INFORMATION o CONSULTING AND SPECIFICANALYSIS, REPORT BUSINESS • North America: • Steve LaFerriere, Senior Sales Director forWestern US Canada Email: laferriere@yole.fr – + 1 310 600-8267 • ChrisYouman, Senior Sales Director for Eastern US Canada Email: chris.youman@yole.fr – +1 919 607 9839 • Japan Rest of Asia: • Takashi Onozawa, General Manager,Asia Business Development (India ROA) Email: onozawa@yole.fr - +81 34405-9204 • Miho Ohtake, Account Manager (Japan) Email: ohtake@yole.fr - +81 3 4405 9204 • Itsuyo Oshiba, Account Manager (Japan Singapore) Email: oshiba@yole.fr - +81-80-3577-3042 • Korea: Peter Ok, Business Development Director Email: peter.ok@yole.fr - +82 10 4089 0233 • Greater China: Mavis Wang, Director of Greater China Business Development Email: wang@yole.fr - +886 979 336 809 • Europe: Lizzie Levenez, EMEA Business Development Manager Email: levenez@yole.fr - +49 15 123 544 182 • RoW: Jean-Christophe Eloy, CEO President,Yole Développement Email eloy@yole.fr - +33 4 72 83 01 80 o FINANCIAL SERVICES (in partnership withWoodside Capital Partners) • Jean-Christophe Eloy, CEO President Email: eloy@yole.fr - +33 4 72 83 01 80 • Ivan Donaldson,VP of Financial Market Development Email: ivan.donaldson@yole.fr - +1 208 850 3914 o CUSTOM PROJECT SERVICES • Jérome Azémar,Technical Project Development Director Email: azemar@yole.fr - +33 6 27 68 69 33 o GENERAL • CamilleVeyrier, Director, Marketing Communication Email: veyrier@yole.fr - +33 472 83 01 01 • Sandrine Leroy, Director, Public Relations Email: leroy@yole.fr - +33 4 72 83 01 89 / +33 6 33 11 61 55 • Email: info@yole.fr - +33 4 72 83 01 80 Follow us on About Yole Développement | www.yole.fr | ©2019