pediatrics seminar

1. Entamoeba histolytica

2. E.Histolytica fits in the category of . . . . ?
Nomenclature?
What is amebiasis?

3. E. Histolytica infections
90% by non-pathogenic 10% only by
strains pathogenic ones
10%
90% subclinical symptomatic
infection

4. Route of infection
“ORAL”
Mode of infection
ingestion of contaminated food or
water with CYSTS

5. Clinical Features of Amebiasis
Amebic Colitis 
Fulminating Enterocolitis 
Ameboma 
Amebic Liver Abscess 

6. Amebic Colitis
Weight loss
( failure to thrive)
Diarrhea with:
“blood” or
“mucous” or both
Diarrhea in Amebic colitis can be:
Mild, frequent, severe

7. Cysts colonize the epithelial surface of the colon
(most frequently in the cecum & ascending colon)
What is dysentery?
inflammatory disorder of the colon, that results in severe
diarrhea containing mucus and/or blood in the feces with
abdominal pain.
When it develops?
Once amebae attach to the colonic epithelium

8. “intestinal amoebiasis”
Incubation period: 2 weeks to many years!
Most cases are asymptomatic.
Course of the disease:
Chronic course with abdominal pains (right lower
quadrant), two or more unformed
stools / day.
*Simulate acute appendicitis* WHY?

9. Cont’d
Systemic manifestation of fever or lethargy?
Flask shaped ulcers!
Examination of ulcer edge >>> no inflammatory
cells! WHY?
>>> hematogenous trophozoites

10. Complications of amebic colitis
Anemias
(iron deficiency, or Megaloblastic)
Megacolon
Mortality