Women are as unique as their fingerprints, inside and outside. It is this fundamental premise that prompted Marla Ahlgrimm R. Ph. nearly 30 years ago to develop her revolutionary approach to helping women balance their unique hormone fingerprint, bioidentically, one woman at a time, with The Restore® Program. Learn why and how in this presentation.

1. Healthcare as individual as you!

5. And Also a Concern of the Present

30. Estrogen Molecules Equilin Estrone Estradiol

33. Progesterone: Natural vs. Synthetic Medroxyprogesterone acetate mutes beneficial effects of estradiol on HDL cholesterol Medroxyprogesterone Progesterone

48. Daily Hormonal Changes Testosterone pg/ml Saliva Time 5 am 0 5 10 15 20 25 30 35 40 9 am 12 pm 4 pm 10 pm 45

49. Monthly Hormonal Changes

50. Yearly Hormonal Changes DHEA and Testosterone Ranges of Women Saliva Hormone pg/ml Age (years) 20-29 DHEA Testosterone 30-39 40-49 50-59 60-69 70-79 80-89 0 25 50 75 100 125 150 175 200

60. Bone Remodeling Process Fragments of excavated bone collagen are released into body fluids 3 Bone Formation - Osteoblasts deposit new collagen to fill excavated pits 4 When resorption and formation are in balance, there is no net change in bone mass Bone Resorption - Osteoclasts excavate small pits in bone 2 1

61. A Decrease in NTx in Response to HT Indicates Gain in Bone Mass Mean NTx values throughout the study Mean percent change in BMD from baseline Chesnut et al., Am J Med. 1997;102:29-37. 40 20 0 1 3 6 12 0 1 2 3 BMD NTx Months Baseline 60 38

62. Case Study: 52-year-old female Hysterectomy w/o ovaries: Premarin 1.25 mg/1 daily Normal Initial Saliva Range Test Estradiol 0.2 - 5.0 pg/ml 1.60 pg/ml Progesterone 0.01 - 0.5 ng/ml 0.08 ng/ml Testosterone 5 - 21 pg/ml 7.70 pg/ml DHEA 40 - 150 pg/ml 126.00 pg/ml Cortisol 5 - 15 ng/ml (AM) 4.0 0 ng/ml (AM) Urine - NTx < 38 nM BCE 53.70 nM BCE Rx: Bi Est 2.5 mg capsule 2x daily Fosamax 10 mg daily

63. Case study: 52-year-old female (follow-up) Hysterectomy w/o ovaries: Premarin 1.25 mg/1 daily Normal Initial 3 Mos. Saliva Range Test Later Estradiol 0.2 - 5.0 pg/ml 1.60 pg/ml 4.2 pg/ml Progesterone 0.01 - 0.5 ng/ml 0.08 ng/ml Testosterone 5 - 21 pg/ml 7 .70 pg/ml DHEA 40 - 150 pg/ml 26.00 pg/ml Cortisol 5 5- 15 ng/ml (AM) 4.00 ng/ml (AM) Urine - NTx < 38 nM BCE 53.7 nM BCE 19.8 nMBCE Rx: Bi Est 2.5 mg capsule 2x daily Fosamax 10 mg daily

64. Urine Testing is Most Beneficial When Used in Combination With BMD ***Urine testing does not diagnose osteoporosis but is measures the rate of bone loss CHOLESTEROL MONITORING (measured in Practitioner’s Office)

69. Hormone Profile Each woman’s hormonal profile is as unique as a fingerprint!

70. WHERE NATURAL HORMONE THERAPY BEGAN

77. Women’s Health America, Inc.

78. The HRT Solution by Marla Ahlgrimm, R. Ph.

82. Restore ® : Changing Health Care “ One Unique Woman at a Time”

83. Specialized Pharmacy Services