p21 mechanism slide

•

1 gefällt mir•707 views

The slide shows the cellular stress response leading to growth arrest as explained by the induction of the universal cell cycle inhibitor p21(WAF1) by the tumor suppressor p53.

Gesundheit & Medizin

G1

M

S

G2

R

p53

Direct p21 transcription

Inactive CDK

T

P

T-loop

ATP

161

14

CDK

PSTAIRE

NH2

T

Y

15

p21

G1 Arrest

Cell cycle arrest mediated by p53 target p21 (WAF1)

DNA damage

El-Deiry et al., Cell 75:817, 1993
5,934 citations
as of 4-13
The most highly
cited original
MS in Cell

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