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AN AUTO-PERFUSING UMBILICAL CORD BLOOD COLLECTION INSTRUMENT.ppt

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AN AUTO-PERFUSING UMBILICAL CORD BLOOD COLLECTION INSTRUMENT.ppt

  1. 1. AN AUTO-PERFUSING UMBILICAL CORD BLOOD COLLECTION INSTRUMENT
  2. 2.  Contents  Introduction  Why this advancement in the field of ‘Biomedical Instrumentation ‘?  UCB Collection Instrument  Systems in UCB collection Instrument  Two Fraction UCB collection  Applications  Conclusion
  3. 3.  Introduction  An Automated Blood collection Instrument comprises of Mechanical ,electronic and Control components.  UCB from the placenta provides a rich source of highly proliferative cells for many clinical uses as it contains rich Hematopoietic Stem Cells (HSCs) .  Current collection of UCB uses a syringe to extract blood from placenta.  An Automated UCB collection instrument to
  4. 4. Why this advancement in the field of ‘Biomedical Instrumentation ‘? As an ex-utero approach, the challenges to be addressed during the collection process will include: (1) Limited time window for further collection. (2) Need to stay robust of cross contamination from maternal blood. (3) Replication of a uterus compression force on the placenta. (4) In Ex-Utero,infusion of saline back into the placenta will dislodge the cells
  5. 5. Ex-Utero
  6. 6.  UCB Collection Instrument Functionally, it comprises the following systems: • Placenta handling system. • Controlled air chamber. • Auto-perfusion system. • Time window widening system. • Open-architecture control system.
  7. 7.  Placenta Handling System Main parts of the system : • Air tight lid • Placenta Bowl • Supporting Legs • Base
  8. 8.  Parts Of The System
  9. 9.  Controlled Air Chamber The lid houses the interfaces to three standard ports which are connected to • Proportional Valve • Solenoid valve • An Analog Pressure Sensor
  10. 10. • The air pressure variation in the chamber will be converted to a patterned force profile acting on the maternal surface of the placenta via a pressure membrane as shown in Fig.
  11. 11. Finite Element Analysis(FEA)
  12. 12.  Auto-Perfusing System • Enables perfusion automatically. • Consist of catheter and three valves. • A catheter is inserted into a vein on the umbilical cord. • Other end of the catheter a three-way valve is connected.
  13. 13.  Time -Widening Window System  A two-pronged approach is adopted.  A vibrator, rendering a low frequency vibration of about 2 Hz.  Secondly, the exposed end of the cord can be rapidly cooled to a low temperature once it is cut.
  14. 14.  Open –Architecture Control System  Needed for all components to work together as one unified instrument.  A standalone embedded control system is employed based on the National Instrument (NI) single board solution sbRIO-9632 .
  15. 15. The I/O interface from the board to the other components is depicted in fig below :
  16. 16.  Two-fraction UCB collection  Synchronous operations with current procedures of code blood banks along with autoperfusion is also possible.
  17. 17. The flowchart of the overall automated procedure is shown in fig
  18. 18.  Conclusion  An automated and self-perfusing instrument enables the more efficient and extensive harvesting of HCS.  Can be used for the pediatric and adult treatment.  Instrument maximizes the explusion of cord blood.  a stand-alone system to retrieve cord blood in a one stage collection
  19. 19.  References :  Bishop RH, editor. Learning with LabVIEW 2009. New Jersey: Prentice Hall 2009.  Karargyris A, Bourbakis N. Detection of small bowel polyps and ulcers in wireless capsule endoscopy videos. IEEE Transactions on Biomedical Engineering 2011;58(10):2777– 86.  Johnson GW, Jennings R, editors. LabVIEW gaphical pogramming. New York: McGraw-Hill Professional; 2001  Garbe S, Buttgereit A, Schurmann S, Friedrich O. Automated multiscale morphometry of muscle disease from second harmonic generation microscopy using tensor-based image processing. IEEE Transactions on Biomedical Engineering 2012;59(1):39–44.  Gyllensten IC, Bonomi AG. Identifying types of physical

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