granulomatous mastitis

1. Patient details
• Female 36 years
• Hospital No: 1654839
• Biopsy no: 372/2020
• Clinical Diagnosis : Chronic granulomatous lesion - ? TB
• Nature of Specimen : Left breast lumpectomy
• h/o previous biopsies done : Tru cut biopsies (outside)
1. Tru cut biopsy – No evidence of malignancy (July 2019)
2. Tru cut biopsy – Chronic suppurative granulomatous lesion
(September 2019)

2. GROSS
• Received lumpectomy specimen
ⓜ 8.5 x 5 x 3 cm
• Cut sections showed
• Cystic areas
 largest ⓜ 2.5 x 2 x 3 cm.
 smallest ⓜ 1.5 x 1 x 3 cm.
• Multiple irregular pale white
areas.
• Pale white areas with nodules
 pale white areas ⓜ 0.8 x 0.5cm
 nodules
 largest ⓜ 0.8 x 0.5cm
 smallest ⓜ 0.5 x 0.4cm
372/2020

3. MICROSCOPY
Dense lobulocentric inflammation
10x

4. MICROSCOPY
Lobulocentric granulomatous inflammation comprising of epithelioid histiocytes, multinucleated
giant cells, lymphocytes, plasma cells and neutrophils forming microabscesses
10x
40x

5. MICROSCOPY
10x
Foci of foreign body seen with foreign body giant cell reaction

6. MICROSCOPY
Foci of foreign body seen with foreign body giant cell reaction
40x 40x

7. MICROSCOPY
Proliferation of glandular and stromal elements.
4x

8. MICROSCOPY
Glands appear elongated, distorted and compressed by the proliferating stroma.
Few glands are cystically dilated with open lumina surrounded by the proliferating stroma.
10x4x

9. MICROSCOPY
4x
10x
Areas of microcysts surrounded by areas of fibrosis in the stroma

10. IMPRESSION
• Granulomatous mastitis with additional
features of fibroadematous changes and
foreign body giant cell reaction