People Unlimited, Presentation 01-09-15, Final "Lucifer would also appear to have a central role in the origin of humanity, and in the origin of death. It is thought that Lucifer brought about physical procreation through a primeval sexual act with Cheva (Eve). With procreation came death; but of course without death there is no change, no evolution. Thus the opening of the gate of death, the act of "sinking into matter," was a necessary step to link man to the current whereby Paradise can again be gained. But this time humanity will do it consciously and of its own will, and thus gain eternal life and wisdom. Then man will have truly become his own god - which is the path of Saturn." ―S. Flowers "And the Lord said, My spirit shall not always strive with man, for that he also is flesh: yet his days shall be an hundred and twenty years." ―Genesis 6:3 "And they are going to live longer than the oldest man among all peoples, the ones that the holy books talk about." ―John of Jerusalem

1. 1
Curing Aging
Is Aging a Disease?
Can it be Cured?
Theoretical Maximum Lifespan
125 Years
1. Carnes, BA et al., Biogerontology 4:13-45 (2003)
2. Hayflick, L., J Gerontol A Biol Sci Med Sci 59:B573-B578 (2004)
3. Weon, BM & Je JH., Biogerontology 10:65-71 (2009)

2. 2
Before We Add
Years to Life
We Must Add
Life to Years
130 Year Old
Runs 7 minute Mile
Aging Has been Cured
And, Aging is a Disease!
Is Aging
Necessary?

3. 3
Human Reproductive Cells
 Better Sewage Systems
 Vaccines
 Refrigeration
 Exercise
 Cleaner Water
 Better Diets
 Antibiotics
 Better Care of our Teeth
 Blood Pressure Medicine
 Coronary Artery By-pass Surgery
 Cholesterol Medications
 Chemo & Radiation Therapy
 Anti-Oxidants
 Anti-Smoking Crusade
 Better Working Conditions
 Controlled Indoor Environment
 Eye Glasses
 Pasteurization
But, Are We Just Creating Sick Old People?
Health & Life Extenders
47.3 to 78.0 Years Since 1900
 Stem Cells
 Gene Regulation
 Mitochondria
 SENS
 Brain Uploading
 Nanomedicine
 Telomeres
 Cryonics
 What Else?
 (Michael West – Biotime)
 (Bryant Villeponteau – Genescient Corp.)
 (Rafal Smigrodzki – Gencia Corp.)
 (Aubrey de Grey – SENS Foundation)
 (Anders Sandberg/Ralph Merkle/Hans Moravec)
 (Robert Freitas/Ralph Merkle)
 (Bill Andrews – Sierra Sciences)
 (Greg Fahy – 21st Century Medicine)
 (Who? – Where?)
We Need Them All!
Efforts Underway to Cure Aging
Theories on Why We Age
 Disposable Soma Theory – We just temporarily house our Genes.
 Oxidative Stress Theory – Free radicals cause damage to cells.
 Vital Substance Theory – A vital substance is limiting.
 Genetic Mutation Theory – Accumulation of mutations cause aging.
 Reproductive Exhaustion Theory – After reproduction we die rapidly.
 Aging by Design Theory – Aging is programmed.
 Mitochondrial Dysfunction Theory – Altered Mitochondria.
 The Neuroendrocrine Theory – Changes in hormone regulation.
 Wear and Tear Theory – Self explanatory
 The Rate of Living Theory – Similar to the Vital Substance Theory
 The Waste Product Accumulation Theory – Self explanatory
 The Cross-Linking Theory – Proteins such as collagen crosslink.
 The Immune System Theory – Decreased immune function.
 Errors and Repairs Theory – Inaccurate repair of damage.
 The Order to Disorder Theory – Decreased maintenance of order.
 Telomere Theory of Aging – Telomere length controls aging.
They’re all True!
Aging1
Aging2
Multiple
Sticks of
Dynamite
Aging3
Aging1
Aging2
Which Stick
of Dynamite
has the
Shortest
Fuse?
Aging3

4. 4
Telomeres The Problem
Telomere
Shortening
Disease
Bad Things
Happen When
Telomeres
Get Short!
Telomere

5. 5
Sierra Sciences, LLC

6. 6
Congratulations
Elizabeth Blackburn, Carol Greider, and Jack Szostak
2009 Nobel Prize in Medicine!
The Bad Things
Some People are Born with Short
Telomeres
Progeria
Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20.
Short Telomere
Disease

7. 7
Progeria
Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20.
Short Telomere
Disease
Life Expectancy - 20 Years
Progeria
Mech Ageing Dev. 2009 Jun;130(6):377-83. Epub 2009 Mar 20.
Short Telomere
Disease
Life Expectancy - 20 Years
Preventing Telomere Shortening
Could Cure These Kids!
Bad Things
Happen When
Telomeres
Get Short!
Telomere Shortening Diseases
• Cardiovascular
• Cancer
• COPD
• Degenerative Disc Disease
• Alzheimer’s
• Osteoarthritis
• RheumatoidArthritis
• Osteoporosis
• General Immunity
• Skin Aging
• Macular Degeneration
• Liver Cirrhosis
• Muscular Dystrophy
• Cell & Tissue Transplants
• AIDS
• Progeria
• Dyskeratosis Congenita
• Idiopathic Pulmonary Fibrosis
• Cri du Chat syndrome
• Down’s Syndrome
• Fanconi’s Anemia
• Tuberous Sclerosis
• Werner’s Syndrome
• And, Aging Itself???????
Pubmed
http://www.ncbi.nlm.nih.gov/pubmed
Publications in Medicine
published in
Scientifically Peer Reviewed Journals
Search for
Telomere AND <Disease of Interest>

8. 8
Basal Level
Telomere
Shortening

9. 9
Accelerated
Telomere
Shortening
Preventing
Accelerated Telomere Shortening
 Exercise
January
February
March
April
May
June
July
August
September
October
November
December
Molly & Taylor’s
Run From Anywhere
5K Events
January
February
March
April
May
June
July
August
September
October
November
December
Molly & Taylor’s
Run From Anywhere
5K Events
www.DesertSkyAdventures.com
www.RunFromAnywhere.com
Preventing
Accelerated Telomere Shortening
 Exercise
 Anti-Oxidants
 Omega 3’s
 Vitamin D3
Isagenix
Ageless Essentials

10. 10
Preventing
Accelerated Telomere Shortening
 Exercise
 Anti-Oxidants
 Omega 3’s
 Vitamin D3
 Don’t Smoke
 Don’t be Obese
Isagenix
Cleanse for Life
Preventing
Accelerated Telomere Shortening
 Exercise
 Anti-Oxidants
 Omega 3’s
 Vitamin D3
 Don’t Smoke
 Don’t be Obese
 Reduce Stress
Isagenix
Ionix Supreme
Preventing
Accelerated Telomere Shortening
 Exercise
 Anti-Oxidants
 Omega 3’s
 Vitamin D3
 Don’t Smoke
 Don’t be Obese
 Reduce Stress
 Reduce Depression
 Reduce Pessimism
 Be Happy!
These Are Things You Can Do NOW!
But, Telomeres
Will Still Shorten

11. 11
Basal Level
Telomere
Shortening
The Solution
in Reproductive Cells!
Aging Doesn’t OccurTelomeres Don’t Shorten Telomerase
Telomere
Telomerase
United States Inventor of the Year
(Second Place)

12. 12
Telomerase
Telomere
is the Enzyme
that Lengthens the
What Happens if Telomerase is
Produced in All Cells?

13. 13
ABC News
Diane Sawyer
Can’t do this in Humans Yet
Sierra Sciences
Reno, Nevada
The Plan
Reproductive Cells Produce
Telomerase
Telomerase GeneRegulatory
Element
Our Strategy

14. 14
The Gene is Repressed in All
Other Cells
Telomerase GeneRegulatory
Element
Repressor
Telomerase GeneRegulatory
Element
Discover Telomerase Inducers
Sierra Sciences, LLC
TAM-818
High Throughput Screening
 Screened over 300,000 compounds
 Identified 900+ Hits, 39 Families
• Random Compounds 5%
• Medicinal Chemistry
• Further Modified for Saftey and
Bioavailability
• Clinical Studies Completed 2014
Normal
Shortening
No
Shortening100%
0%
5%
16%
16%
Licensed to
Rewind Youth
Potency
Telomerase Score
Rewind Youth Clinical Studies
Skin Cream with TAM-818

15. 15
Rewind Youth Clinical Studies
Skin Cream with TAM-818
defytime
with TAM-818
www.defytimeserum.com
1Truth818
with TAM-818
www.1truth.com.au
Distributors Needed
Contact Rewind Youth
All royalties received by
Sierra Sciences go to research!
www.rewindyouth.com
Human Aging Reversed!
 Screened over 300,000 compounds
 Identified 900+ Hits, 39 Families
• Random Compounds 5%
• Medicinal Chemistry
• Further Modified for Saftey and
Bioavailability
• Clinical Studies Completed 2014
• One More Year 100%
High Throughput Screening
Normal
Shortening
No
Shortening100%
0%
16%
16%
Potency
Telomerase Score
+
Human Aging Stopped!
Projections
Funding From Royalties
by Mid-2015
Drug that Reverses Human Aging
by Mid-2016

16. 16
>10,000 Natural Products
37 Hits
IsaGenesis
All royalties received by
Sierra Sciences go to research!
The Future of Telomere Biology
 Pharmaceutical and Natural Products
 Stem Cell Products
 Skin and Hair Care Products
 Pet Products
 Gene Therapy
 Improved Diagnostics
 Cancer Therapies
 Water and Energy Drinks
 Pet Cloning
Telomere Basics
Curing Aging
To Learn More
Available at
Amazon.com
All royalties received by Sierra
Sciences go to research!
The Power of Telomeres

17. 17
Thank you!
www.cure-aging-or-die-trying.com
Questions?