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Innovative Drug
      Delivery Device
           Solutions

      Ramin Mojdeh, Ph.D.
  Executive Vice President and
     Chief Operating Officer


UBS Specialty Pharma Conference
           May 2011
Cautionary Note Regarding Forward-Looking Statements


This presentation contains forward looking statements under the
safe harbor provisions of the US securities laws. These forward-
looking statements are based on management’s beliefs and
assumptions and on information currently available to our
management. Our management believes that these forward-
looking statements are reasonable as and when made. However
you should not place undue reliance on any such forward looking
statements as these are subject to risks and uncertainties. Please
refer to our press release and our SEC filings for more information
regarding the use of forward looking statements.




                                                                      2
Introducing Unilife




Emerging global leader in innovative drug delivery device solutions
Enable and enhance delivery of drugs by pharmaceutical customers
Rapidly expanding pipeline being driven by customer needs
Unifill – world’s only prefilled platform with integrated safety
NASDAQ listed (UNIS) with state-of-the-art facility in York, PA

                                                                      3
Attractive Market Trends and Opportunity
$30B Injectable drug delivery device market in 2015, 12.3% CAGR
Large macromolecule composition of pharmaceutical pipeline
Safety legislation and sharps management
Devices drive patient acceptance, preference and adherence
Emerging healthcare needs of aging global population
Rising global healthcare standards creating strong market potential
Improved outcomes and economics with use of unit-dose and ready to
administer formats
Trend to patients self-administration of injectable drugs
Patent cliff - 30 biologics with $51B sales expire by 2015

                                                                      4
Strategic Focus




Innovative device solutions for commercial drugs/biosimilars
    Integrated proprietary primary drug delivery devices with value-add features
Target and address emerging unmet needs for pipeline drugs
    Pharmaceutical collaborations – specialized devices for novel drugs
Target high-end of market for differentiated devices, high margins
    Strategic sourcing of components
    In-house manufacturing and final assembly
                                                                             5
Customer-Driven Technology Pipeline
Technology pipeline developed in partnership with customers
Directly responding to emerging customer needs including:
   Integrated primary drug delivery devices with value-add features and
   customization
   Advanced syringe systems with integrated safety and transfer mechanisms
   Dry drug reconstitution and delivery technologies
   Large-volume viscous drugs delivery technologies
   Targeted organ delivery devices
   Multi-chamber proprietary primary containers and delivery systems
   Reusable and disposable self administration device technologies

Technology portfolio can be leveraged to develop customized
device concepts according to specific customer needs
                                                                          6
Unifill – The Leading Edge of Our Portfolio
World’s first and only prefilled syringes with integrated safety




Now in production
Controlled retraction into barrel
Needle locked after use for convenient, compact disposal
                                                               7
Unifill as a Game Changer
    2.5B Units Annually                                  Primary drug delivery
                                                         device with integrated
                                                         safety
           Ancillary
      +     safety
            needle                             Unifill   Direct substitute for
                                              Platform
                                                         current prefill and safety
Standard               Current                           prefill syringes
 Prefill               Safety
Syringe                Syringe
                                   Direct
                                 Substitute              Powerful brand
                                                         differentiation

           Ancillary
                                                         Streamlines fill-finish
      +     safety
            Device
                                                         and packaging process
                                                         Optimal protection
Standard               Current
 Prefill               Safety
Syringe                Syringe
                                                                                  8
Success in the Face of a Big Challenge




Technology solves a technical challenge most thought impossible
Sanofi invested $40MM for access rights to Unifill
Ready for initial shipment in July – well ahead of original
schedule
Current capacity of 60MM units, planned 150MM unit line
extension

                                                              9
New Paradigm in Drug-Device Development
                    Clinical Development (phase I, II, III)   Approval   Sales

         Patient
  requirements
            Drug
industrialization
  requirements
    Customized
 delivery device



          Devices customized to specific requirements of drugs and target
          patients
          Collaboration with drug companies from clinical development
          through commercial sales
          Unique devices increasingly used to differentiate brands,
          optimize product lifecycles and enhance patient care
                                                                            10
Summary

Unilife - emerging global leader in innovative drug delivery devices
Injectable drug delivery device market is attractive and growing fast
Innovative, differentiated devices for pipeline drugs and biosimilars
Developing rich portfolio of technologies driven by customer need
Unifill: the 1st and only prefill syringe system with integrated safety
The new drug-device paradigm is to target pipeline drugs to develop
total system solutions for the pharmaceutical partner
Launch with Unifill, then drive growth with successive introductions
of innovative, differentiated devices


                                                                     11

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Innovative Drug Delivery Device Solutions for Pharmaceutical Customers

  • 1. Innovative Drug Delivery Device Solutions Ramin Mojdeh, Ph.D. Executive Vice President and Chief Operating Officer UBS Specialty Pharma Conference May 2011
  • 2. Cautionary Note Regarding Forward-Looking Statements This presentation contains forward looking statements under the safe harbor provisions of the US securities laws. These forward- looking statements are based on management’s beliefs and assumptions and on information currently available to our management. Our management believes that these forward- looking statements are reasonable as and when made. However you should not place undue reliance on any such forward looking statements as these are subject to risks and uncertainties. Please refer to our press release and our SEC filings for more information regarding the use of forward looking statements. 2
  • 3. Introducing Unilife Emerging global leader in innovative drug delivery device solutions Enable and enhance delivery of drugs by pharmaceutical customers Rapidly expanding pipeline being driven by customer needs Unifill – world’s only prefilled platform with integrated safety NASDAQ listed (UNIS) with state-of-the-art facility in York, PA 3
  • 4. Attractive Market Trends and Opportunity $30B Injectable drug delivery device market in 2015, 12.3% CAGR Large macromolecule composition of pharmaceutical pipeline Safety legislation and sharps management Devices drive patient acceptance, preference and adherence Emerging healthcare needs of aging global population Rising global healthcare standards creating strong market potential Improved outcomes and economics with use of unit-dose and ready to administer formats Trend to patients self-administration of injectable drugs Patent cliff - 30 biologics with $51B sales expire by 2015 4
  • 5. Strategic Focus Innovative device solutions for commercial drugs/biosimilars Integrated proprietary primary drug delivery devices with value-add features Target and address emerging unmet needs for pipeline drugs Pharmaceutical collaborations – specialized devices for novel drugs Target high-end of market for differentiated devices, high margins Strategic sourcing of components In-house manufacturing and final assembly 5
  • 6. Customer-Driven Technology Pipeline Technology pipeline developed in partnership with customers Directly responding to emerging customer needs including: Integrated primary drug delivery devices with value-add features and customization Advanced syringe systems with integrated safety and transfer mechanisms Dry drug reconstitution and delivery technologies Large-volume viscous drugs delivery technologies Targeted organ delivery devices Multi-chamber proprietary primary containers and delivery systems Reusable and disposable self administration device technologies Technology portfolio can be leveraged to develop customized device concepts according to specific customer needs 6
  • 7. Unifill – The Leading Edge of Our Portfolio World’s first and only prefilled syringes with integrated safety Now in production Controlled retraction into barrel Needle locked after use for convenient, compact disposal 7
  • 8. Unifill as a Game Changer 2.5B Units Annually Primary drug delivery device with integrated safety Ancillary + safety needle Unifill Direct substitute for Platform current prefill and safety Standard Current prefill syringes Prefill Safety Syringe Syringe Direct Substitute Powerful brand differentiation Ancillary Streamlines fill-finish + safety Device and packaging process Optimal protection Standard Current Prefill Safety Syringe Syringe 8
  • 9. Success in the Face of a Big Challenge Technology solves a technical challenge most thought impossible Sanofi invested $40MM for access rights to Unifill Ready for initial shipment in July – well ahead of original schedule Current capacity of 60MM units, planned 150MM unit line extension 9
  • 10. New Paradigm in Drug-Device Development Clinical Development (phase I, II, III) Approval Sales Patient requirements Drug industrialization requirements Customized delivery device Devices customized to specific requirements of drugs and target patients Collaboration with drug companies from clinical development through commercial sales Unique devices increasingly used to differentiate brands, optimize product lifecycles and enhance patient care 10
  • 11. Summary Unilife - emerging global leader in innovative drug delivery devices Injectable drug delivery device market is attractive and growing fast Innovative, differentiated devices for pipeline drugs and biosimilars Developing rich portfolio of technologies driven by customer need Unifill: the 1st and only prefill syringe system with integrated safety The new drug-device paradigm is to target pipeline drugs to develop total system solutions for the pharmaceutical partner Launch with Unifill, then drive growth with successive introductions of innovative, differentiated devices 11