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Cal polypoPreliminary studies of preparation of ferrite nanoparticles and the hyperthermia property in simulated tissuesmona ubm-nanoparticles-2-13-14
1. Sophia Chan, Eric Duong, Yong X. Gan
Department of Mechanical Engineering
California State Polytechnic University Pomona
February 13, 2014
2. ⢠Understand the theory and fabrication of nanoparticles
⢠How nanoparticles are applied to cancer treatment
3. ⢠Research was first done to understand how nanoparticles are
used in cancer treatment
⢠How did the heat generated by nanoparticles aid cancer
treatment
4. ⢠Chemotherapy
- Necrosis Factor Alpha (TNF) are attached to gold
nanoparticles with Thiol-derivatized Polyethylene Glycol
⢠Heat Generation
- Absorbtion of infrared light from a laser produces heat
generation in the nanoshells
⢠Combination (Chemotherapy and Heat Generation)
- Nanoparticles act as a drug carrier while a laser
produces heat generation
5. ⢠Also known as magnetic nanoparticles
⢠Exhibits valuable physical and chemical characteristics that can
be used in numerous applications in biomedicine
-
Cell seperation
Drug delivery
Magnetic Resonance Imaging (MRI)
Hyperthermia
6. ⢠Magnetic nanoparticles are first mixed within a carrier
fluid(medicine)
⢠Direct injection or tumor specific antibody targeting is then
applied to target the tumor
⢠Using various instruments, the tumor is then exposed to an
alternating magnetic field to generate heat by magnetic
relaxation mechanisms
9. ⢠Making the Solution
⢠95% Ethylene glycol
⢠1% Ammonium flouride
⢠4% Deionized water
⢠Power supply
⢠Kept at 12 Volts
⢠Process time
⢠24-48 hours
10. ⢠Takes too long
⢠Very little nanoparticles made
⢠Wastes electricity, since it needed more than12V of power to
excite the electrons of the iron rod
⢠Solution will get old, so constant of changing is required
⢠Since if the solution works best and fastest when it is fresh
11. ⢠Iron (III) nitrate
nanahydrate
⢠potassium hydroxide
12. ⢠Preparing the solution
⢠Iron (III) nitrate nanahydrate, ACS, 98.0-101.0%
⢠Potassium hydroxide (P5958-250G) 2%
⢠Solution precipitates
⢠Iron oxide (Fe2O3/FeO/Fe3O4)
13. ⢠Put the solution in the
centrifuge machine
⢠To separate the precipitate
with solution
⢠Collecting the precipitate
and letting it dry
⢠The dried precipitate is the
nanoparticles used for
experiment
14.
15.
16.
17.
18. ⢠Trying to prove that MNP in different quantities can reach high
temperatures in less time
⢠Procedure
⢠Heat one sample at a time
⢠In a time interval of 1 second
⢠Take temperature reading
⢠Let it set cool to the initial temperature
⢠Repeat same above steps for the consecutive second
23. ⢠MNP has a unique magnetic property
⢠Heating Mechanism
⢠No specific proof of how it works
⢠There are 3 assumptions
⢠The initial assumption for heating mechanism is the susceptibility loss.
⢠The other heating mechanism that starts to be activated is the
hysteresis loss
⢠Viscous heating or magnetic stirring
24. ⢠Time is always the most golden factor for cancer treatment
⢠Electromagnetic waves were to excite the magnetic
nanoparticles
⢠To force them through the phase of the delay in the relaxation
of the magnetic moment through either the rotation within the
particle or the rotation of the particle itself
⢠Different losses that goes through that blocks off magnetic
nanoparticles and the moments that cannot switch were the
reasons behind the generation of heat was beneficial
25. ⢠NSF Grant No. CMMI-1333044
⢠CAFA Faculty Development Grant
⢠Cal Poly Pomona 2013-2014 RSCA Program