NCBO Annotator Enriches Clinical Notes with Human Disease Ontology Terms
1. The NCBO Annotator and Enrichment Analysis with the
Human Disease Ontology
Trish Whetzel, Paea LePendu, Ray Fergerson, Mark Musen, Nigam Shah
Stanford University, Stanford, CA
250+ Biomedical Ontologies
• Create clean lexicons
• Normalize via mappings
• Aggregate via hierarchies
1
Pattern Analysis
1.04–million patients
• Use temporal ordering
NCBO Annotator Workflow
2.8–million terms
9.5–million clinical notes
• Adds negation detection
• Processes 1–million notes per hour
2
Patient t0 t1 … tn
Acknowledgements
The National Center for Biomedical Ontology is one of the National Centers for
Biomedical Computing supported by the NHGRI, the NHLBI, and the NIH Common
Fund under grant U54-HG004028.
1 A,B,X B,X,Y … A,X
2 B,X,Z C,Z … B,C
3 A,C,Y B,Z … X
Drug Safety Off-label Drug Use
3
Enrichment Analysis
For more information on the NCBO, visit http://www.bioontology.org
or email support@bioontology.org