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The NCBO Annotator and Enrichment Analysis with the 
Human Disease Ontology 
Trish Whetzel, Paea LePendu, Ray Fergerson, Mark Musen, Nigam Shah 
Stanford University, Stanford, CA 
250+ Biomedical Ontologies 
• Create clean lexicons 
• Normalize via mappings 
• Aggregate via hierarchies 
1 
Pattern Analysis 
1.04–million patients 
• Use temporal ordering 
NCBO Annotator Workflow 
2.8–million terms 
9.5–million clinical notes 
• Adds negation detection 
• Processes 1–million notes per hour 
2 
Patient t0 t1 … tn 
Acknowledgements 
The National Center for Biomedical Ontology is one of the National Centers for 
Biomedical Computing supported by the NHGRI, the NHLBI, and the NIH Common 
Fund under grant U54-HG004028. 
1 A,B,X B,X,Y … A,X 
2 B,X,Z C,Z … B,C 
3 A,C,Y B,Z … X 
Drug Safety Off-label Drug Use 
3 
Enrichment Analysis 
For more information on the NCBO, visit http://www.bioontology.org 
or email support@bioontology.org

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NCBO Annotator Enriches Clinical Notes with Human Disease Ontology Terms

  • 1. The NCBO Annotator and Enrichment Analysis with the Human Disease Ontology Trish Whetzel, Paea LePendu, Ray Fergerson, Mark Musen, Nigam Shah Stanford University, Stanford, CA 250+ Biomedical Ontologies • Create clean lexicons • Normalize via mappings • Aggregate via hierarchies 1 Pattern Analysis 1.04–million patients • Use temporal ordering NCBO Annotator Workflow 2.8–million terms 9.5–million clinical notes • Adds negation detection • Processes 1–million notes per hour 2 Patient t0 t1 … tn Acknowledgements The National Center for Biomedical Ontology is one of the National Centers for Biomedical Computing supported by the NHGRI, the NHLBI, and the NIH Common Fund under grant U54-HG004028. 1 A,B,X B,X,Y … A,X 2 B,X,Z C,Z … B,C 3 A,C,Y B,Z … X Drug Safety Off-label Drug Use 3 Enrichment Analysis For more information on the NCBO, visit http://www.bioontology.org or email support@bioontology.org