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Immuno-Oncology Report, September 2016
Tracxn
World’s Largest Startup Research Platform
2
Immuno-Oncology Report, September 20163
Contents
Topic Page No.
Scope of Report 05
Entrepreneur Activity 07
Investment Trend 09
Who is Investing 17
Exit Outlook - IPO, Acquisitions 21
Sub Sector Analysis 24
Interesting Companies 42
Company List 49
Team 154
Immuno-Oncology Report, September 20164
Illustrative Sectors We Track
ENTERPRISE
INFRASTRUCTURE
TECH
SECURITY
STORAGE
NETWORKING
MOBILITY
IT OPS
CLOUD INFRASTRUCTURE
API MANAGEMENT
BIGDATA INFRASTRUCTURE
INTERNET OF THINGS
3D PRINTING
HEALTH
EDUCATION
BIOPHARMA
DIAGNOSTICS
MEDICAL DEVICES
HEALTHCARE ANALYTICS
FITNESS AND WELLNESS
HEALTH IT
CONSUMER HEALTHTECH
MOBILE HEALTH
EDUCATION IT
SELF LEARNING
ENTERPRISE
APPLICATIONS
MOBILE
SAAS
MOBILE-FIRST ENT. APPS
INTELLIGENT ENT. APPS
OPEN SOURCE
RETAIL TECH
MARKETING TECH
STEALTH MODE
VERTICAL SAAS
MOBILE COMMERCE
MOBILE PAYMENTS
CONSUMER
FINTECH
MARKETPLACES
SUBSCRIPTION COMM.
UBER FOR X
INTERNET FIRST BRANDS
FOOD TECH
GROCERY TECH
TRAVEL
GAMING
BITCOIN
PAYMENTS
Immuno-Oncology Report, September 20165
Sector Overview
Scope of report
The report contains companies which are developing therapeutics to suppress or activate immune system for the treatment of
cancer. This includes all the companies which are developing antibodies, small molecules, vaccines, viral and adoptive cell
therapies for cancer. The report excludes big pharma companies, contract services providers and platform companies.
For funding, this report only includes venture capital/ private equity funding rounds and excludes debt financing and
grants/prize money.
The scope of this report includes equity as well as debt funding received by the companies.
5
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
6
Immuno-Oncology Report, September 2016
25
20
24
27
22
37
8
0
8
16
24
32
40
2010 2011 2012 2013 2014 2015 2016
NumberofCompanies
7
YoY – Number of companies founded
BeiGene Panacela Labs ADC Therapeutics Juno Therapeutics Corvus Pharmaceuticals Gritstone Oncology Hengrui Therapeutics
PsiOxus Therapeutics TG Therapeutics Armo BioSciences Jounce Therapeutics Unum Therapeutics Autolus Cell Design Labs
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
8
8
Immuno-Oncology Report, September 20169
YoY – Number of Rounds and Total Funding
Note: The funding includes debt rounds also.
$0.5B
$0.7B
$1.2B
$0.7B $0.7B
$1.6B
$2.2B
$4.1B
$1.7B
25
72
101
74 73
100
133
129
79
0
28
56
84
112
140
0.0
0.9
1.8
2.7
3.6
4.5
2008 2009 2010 2011 2012 2013 2014 2015 2016
NumberofRounds
FundingAmount(inBillions)
Funding Amount Number of Rounds
Immuno-Oncology Report, September 201610
YoY – Number of Rounds by Stage
Immuno-Oncology Report, September 201611
YoY – Funding by Stage
Immuno-Oncology Report, September 201612
Average Ticket Size – Early Stage
Immuno-Oncology Report, September 201613
Top investments in last one year
Immuno-Oncology Report, September 201614
Top investments in last one year
Immuno-Oncology Report, September 201615
Funnel view of Sector
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
6
16
Immuno-Oncology Report, September 201617
Most Active Investors in Sector
29
21
20 20
15
14 14 14
13
12
0
7
14
21
28
35
Orbimed MPM Capital Alta Partners Novo A/S Novartis
Venture Fund
5AM Ventures KPCB Versant Ventures SV
Life Sciences
Sofinnova
Ventures
TotalNumberofRounds
Alpine Immune
Sciences
Oncorus Allakos Corvus Pharmaceuticals Adicet Bio Ideaya Biosciences Cell Design Labs Gritstone Oncology Delenex
Checkmate
Pharmaceuticals
Armo BioSciences
Amphivena
Therapeutics
Kite Pharma Allakos IFM Therapeutics Igenica Zai Lab Nouscom NKT Therapeutics NextCure
Immuno-Oncology Report, September 201618
Where are Top Investors investing
Immuno-Oncology Report, September 201619
Top Investor by Stage of Entry
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
0
20
Immuno-Oncology Report, September 201621
Top IPOs in last three years
Immuno-Oncology Report, September 201622
Major Acquisitions in last one year
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
3
23
Immuno-Oncology Report, September 201624
September 2016Tracxn BlueBox : Immuno-Oncology
400+ companies in the sector, 343 funded in last 5 years, over $5.7B invested in 2015-16
Immuno-Oncology Report, September 201625
Top Business Models by Funding
$6.5B
$1.5B $1.5B
$1.1B
$536M $425M $264M $131M
0
1400
2800
4200
5600
7000
Antibody Adoptive Cell Therapy Vaccine Suite Oncolytic Virus Small Molecule Cytokines Others
TotalFundingAmount(inMillions)
# Cos. 174 30 95 31 28 20 7 16
Avg. Age 2005.8 2009.5 2005.7 2006.8 2007.9 2008.8 2002.9 2005.8
Stemcentrx NantKwest CureVac Immatics BioVex Syndax IRX Therapeutics Iconic Therapeutics
Symphogen Juno Therapeutics Argos Therapeutics BeiGene PsiOxus Therapeutics VentiRx Armo BioSciences Molecular Templates
Immuno-Oncology Report, September 2016
Antibody – Business Model Description
26
Immuno-Oncology Report, September 201627
Antibody – Entrepreneur Activity and Investment
Trend
Immuno-Oncology Report, September 201628
Antibody – Most Funded Companies
Immuno-Oncology Report, September 2016
Adoptive Cell Therapy – Business Model
Description
29
Immuno-Oncology Report, September 201630
Adoptive Cell Therapy – Entrepreneur Activity and
Investment Trend
Immuno-Oncology Report, September 201631
Adoptive Cell Therapy – Most Funded Companies
Immuno-Oncology Report, September 201632
Vaccine – Business Model Description
32
Immuno-Oncology Report, September 201633
Vaccine – Entrepreneur Activity and Investment
Trend
Immuno-Oncology Report, September 201634
Adoptive Cell Therapy – Most Funded Companies
Immuno-Oncology Report, September 201635
Suite – Business Model Description
35
Immuno-Oncology Report, September 201636
Suite – Entrepreneur Activity and Investment
Trend
Immuno-Oncology Report, September 201637
Suite – Most Funded Companies
Immuno-Oncology Report, September 201638
Oncolytic Virus – Business Model Description
38
Immuno-Oncology Report, September 201639
Oncolytic Virus – Entrepreneur Activity and
Investment Trend
Immuno-Oncology Report, September 201640
Oncolytic Virus – Most Funded Companies
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
41
Immuno-Oncology Report, September 201642
Interesting Unfunded Companies
Company Overview Business Model
immunophotonics.com
Aurora Biopharma
(2016, Miami)
CAR T cell based immunotherapies for solid cancers. Adoptive Cell Therapy > T Cell
batubiologics.com
Chestnut Pharmaceuticals
(2015, Toronto)
Developing novel therapeutics for metastatic cancers employing a comprehensive
approach to reverse the metastatic state of tumor cells.
Antibody > Tumor-targeting
affinicon.com
AR Pharma
(2015, Woburn)
Monoclonal antibody to treat B-cell chronic lymphocytic leukemia Antibody > Suite
AngioClast
(2015, Cambridge (UK))
Developing antibody drug conjugate for treatment of Glioblastoma multiforme.
Antibody > Tumor-targeting >
Antibody Drug Conjugates
GO Therapeutics
(2013, Cambridge (US))
Developing tumor-specific antibodies for cancer immunotherapy based on cancer
glycoproteome.
Antibody > Tumor-targeting
Curated list of companies by the sector analyst are defined as Interesting
Immuno-Oncology Report, September 201643
Interesting Seed Companies
Immuno-Oncology Report, September 201644
Interesting Series A Companies
Immuno-Oncology Report, September 201645
Interesting Series B Companies
Immuno-Oncology Report, September 201646
Interesting Late Stage Companies
Immuno-Oncology Report, September 201647
Top Funded Deadpooled Companies
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
4848
Immuno-Oncology Report, September 201649
Immuno-Oncology – Company List
COVERS THE FOLLOWING SECTORS
Small
Molecule
Cytokines Antibody Vaccine
Oncolytic
Virus
Adoptive Cell
Therapy
Others Suite
Immuno-Oncology Report, September 201650
Small Molecule (1/6)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Company Details Funding Investors
Immunosuppressive Pathway
Inhibitors
Syndax [Waltham, 2005]: Syndax is a late-stage biopharmaceutical company developing entinostat as a
combination therapy in multiple cancer indications with an initial focus on tumors that have shown
sensitivity to immunotherapy, including lung cancer, melanoma and triple negative breast cancer. Entinostat
(phase3, breast cancer), its lead drug candidate is an oral, small molecule that has direct effects on both
cancer cells and immune regulatory cells, potentially enhancing the body's immune response to tumors.
$158.65M
Fidelity Investments, Orbimed, Avalon
Ventures, MPM Capital, Domain
Associates, Pappas Ventures, Forward
Ventures, Tavistock Group, Jennison
Associates, Arrowpoint Partners,
RusnanoMedInvest, Delos Capital,
EcoR1, Pappas Capital
Immunosuppressive Pathway
Inhibitors
Flexus Biosciences [San Carlos, 2013]: Flexus Biosciences focuses on small-molecule cancer
immunotherapies: IDO & TDO Inhibitors (Immune Response Checkpoint Modulators) that target regulatory T
cells. The company utilizes immunology techniques to identify Agents for Reversal of Tumor
Immunosuppression (ARTIS). Flexus has a proprietary IDO/TDO discovery program which includes its IDO-
selective, IDO/TDO dual and TDO-selective compound libraries. Cancer cells use IDO and TDO pathways to
suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of
malignant cells. The company has been acquired by Bristol-Myers Squibb on Feb 2015 ($800M upfront and
$450M in milestone payments).
$47M
KPCB, The Column Group, Celgene,
The Column Group
Immunosuppressive Pathway
Inhibitors
Ideaya Biosciences [San Francisco, 2015]: Ideaya Biosciences is an oncology-focused company committed to
the discovery of personalized synthetic lethality medicines targeting DNA damage and repair for genetically
defined patient populations and immuno-oncology therapies targeting the tumor microenvironment.
Synthetic lethality is a phenomenon where the independent loss-of-function of two different genes have no
significant effects on cell growth and viability, but when combined results in robust cell death. It will focus
on novel synthetic lethal interactions for genetically defined patient populations, exploiting inherent tumor
susceptibilities en-route to discovery and development of small-molecule agents to treat major human
cancers. It also focusses on modulating DNA repair to augment response to immunotherapy. In addition,
drug discovery programs will target pathways known to produce an immune suppressed tumor
microenvironment, enabling tumors to escape recognition by the host immune system.
$46M
Canaan Partners, Celgene, 5AM
Ventures, Alexandria Real Estate
Equities, NIBR, WuXi Healthcare
Ventures
Immuno-Oncology Report, September 201651
Small Molecule (2/6)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Company Details Funding Investors
Immunosuppressive Pathway
Inhibitors
NewLink Genetics [Ames, 1999]: NewLink Genetics is discovering and developing novel immuno-oncology
product candidates using its checkpoint inhibitor platform. The company is developing IDO pathway
inhibitors for the treatment of cancer. The indoleamine 2,3-dioxygenase (IDO) pathway regulates immune
response by suppressing T-cell function and enabling local tumor immune escape. It is developing two IDO
pathway inhibitors—GDC-0919 (in partnership with Genentech) and indoximod. Indoximod is being
developed in combination with antibodies and chemotherapy for the treatment of breast cancer (Phase 2),
pancreatic cancer (Phase 2), glioblastoma (Phase 2), melanoma (Phase 2).
$24.5M
Iowa Capital Management, Ames
Economic Development Commission
Immunosuppressive Pathway
Inhibitors
Confluence Life Sciences [St. Louis, 2010]: Confluence Life Sciences (CLS) is a drug discovery and early
development company which is focusing on developing kinase inhibitors using its proprietary technology. Its
platform KINect claims to accelerate the identification of drug candidates targeting active-site cysteine-
containing kinases. The platform has a thiol-directed chemical library of protein kinase inhibitors which has
been utilized in multiple drug discovery programs. Its internal development pipeline has programs for cancer
immunotherapy and autoimmune diseases (IL-2 Inducible T-Cell Kinase (ITK) / Tyrosine-protein Kinase
inhibitors). It is also developing programs for inflammation and cancer externally in partnership with other
pharmacy companies.
$12.81M
BioGenerator, Helix Funds, Missouri
Technology, Mercury Fund, Epidarex
Capital, St Louis Arch Angels
Immunosuppressive Pathway
Inhibitors
TPP Global Development [Edinburgh, 2008]: IOmet (previously named TPP) is a UK-based preclinical-stage
drug development company focused on cancer immunotherapy and metabolism. IOmet has a
comprehensive pipeline of IDO, TDO and dual-acting IDO/TDO inhibitors and novel GLUT1 inhibitors. IOmet
is pursuing a number of other undisclosed cancer immunotherapy and cancer metabolism targets, in
addition to a GLUT9 inhibitor program for the treatment of gout. Effective January 11, 2016, IOmet Pharma
is a wholly owned subsidiary of Merck & Co., Inc.
$12.2M Scottish Enterprise
Immunosuppressive Pathway
Inhibitors
Xios Therapeutics [Boston, 2015]: Xios Therapeutics is a biotechnology company focussed on developing
small molecule therapies for cancer. It is developing drugs which are capable of preventing tumors from
evading the immune system and targets the immuno-oncology pathways and mechanisms which can be the
potential therapeutic target for cancer treatment.
$6M Sutter Hill Ventures
Immuno-Oncology Report, September 201652
Small Molecule (3/6)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Company Details Funding Investors
Immunosuppressive Pathway
Inhibitors
Partikula [Miami, 2013]: Partikula is focused on developing novel mitochondrial-targeted therapeutics for
oncology using its chemical engineering technologies. It is developing programs which affect the proteins
present in and around mitochondria. Its portfolio candidates include KULA 18 and KULA 19 which inhibits
pyruvate dehydrogenase kinase (PDK) and Hexokinase respectively; KULA-200, a small peptide targeted to
inhibit the anti-apoptotic protein Bcl-2; KULA-300 cancer chemotherapeutics and KULA-101, a tumor
Microenvironment Modifier (TMEM) for cancer immunotherapy. It is planning to begin clinical studies of its
lead programs in late 2016.
$5.7M 2M Companies
Immunosuppressive Pathway
Inhibitors
ImmunoMet Therapeutics [Houston, 2015]: ImmunoMet Therapeutics (a spinoff of HanAll Biopharma) is a
development-stage biotechnology company developing oncology products with a focus on cancer
metabolism and immuno-oncology. Its novel technology is designed to disrupt cancer cell growth and
enhance anti-cancer immunity and may be used in a broad range of difficult-to-treat cancers. Its lead cancer
metabolism compound, IM156, an OXPHOS inhibitor, for the treatment of glioblastoma (brain cancer) is
expected to enter Phase 1 clinical development in the second half of 2016.
$5.2M Mirae Asset
Immunosuppressive Pathway
Inhibitors
Aminex Therapeutics [Kenmore, 2009]: Aminex Therapeutics is developing cancer immunotherapies. The
company is developing a class of immunotherapies known as suppressor class modulators. Its lead candidate
reduces polyamine uptake in cancer cells, which in turn leads to reduction in the number of myeloid-
derived suppressor cells. As a result, the innate immune system can then be triggered to attack cancer cells.
Its lead candidate AMX-513 consists of two drugs, an FDA approved polyamine synthesis inhibitor (DFMO,
difluoromethylornithine) and a novel potent polyamine uptake, or transport, inhibitor (AMXT 1501).
$4M
Immunosuppressive Pathway
Inhibitors
Oncofactor [Seattle, 2011]: Oncofactor develops cancer therapeutics that disrupt signaling pathways
between tumors and the immune system. The company is developing an oncology platform to identify and
target immune modulating proteins deferentially expressed by cancer cells. The company claims that
targeting these oncofactors will reveal cancer to the host immune system and permit clearance by native
immunity.
$3.1M
OVP Venture Partners, ARCH Venture
Partners, Alexandria Real Estate
Equities, Accelerator, Washington
Research Foundation, Amgen
Immuno-Oncology Report, September 201653
Small Molecule (4/6)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201654
Small Molecule (5/6)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201655
Small Molecule (6/6)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201656
Cytokines (1/2)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201657
Cytokines (2/2)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201658
Antibody (1/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201659
Antibody (2/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201660
Antibody (3/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201661
Antibody (4/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201662
Antibody (5/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201663
Antibody (6/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201664
Antibody (7/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201665
Antibody (8/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201666
Antibody (9/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201667
Antibody (10/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201668
Antibody (11/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201669
Antibody (12/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201670
Antibody (13/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201671
Antibody (14/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201672
Antibody (15/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201673
Antibody (16/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201674
Antibody (17/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201675
Antibody (18/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201676
Antibody (19/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201677
Antibody (20/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201678
Antibody (21/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201679
Antibody (22/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201680
Antibody (23/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201681
Antibody (24/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201682
Antibody (25/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201683
Antibody (26/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201684
Antibody (27/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201685
Antibody (28/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201686
Antibody (29/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201687
Antibody (30/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201688
Antibody (31/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201689
Antibody (32/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201690
Antibody (33/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201691
Antibody (34/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201692
Antibody (35/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201693
Antibody (36/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201694
Antibody (37/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201695
Antibody (38/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201696
Antibody (39/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201697
Antibody (40/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201698
Antibody (41/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 201699
Antibody (42/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016100
Antibody (43/43)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016101
Vaccine (1/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016102
Vaccine (2/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016103
Vaccine (3/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016104
Vaccine (4/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016105
Vaccine (5/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016106
Vaccine (6/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016107
Vaccine (7/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016108
Vaccine (8/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016109
Vaccine (9/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016110
Vaccine (10/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016111
Vaccine (11/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016112
Vaccine (12/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016113
Vaccine (13/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016114
Vaccine (14/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016115
Vaccine (15/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016116
Vaccine (16/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016117
Vaccine (17/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016118
Vaccine (18/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016119
Vaccine (19/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016120
Vaccine (20/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016121
Vaccine (21/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016122
Vaccine (22/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016123
Vaccine (23/23)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016124
Oncolytic Virus (1/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016125
Oncolytic Virus (2/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016126
Oncolytic Virus (3/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016127
Oncolytic Virus (4/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016128
Oncolytic Virus (5/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016129
Oncolytic Virus (6/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016130
Oncolytic Virus (7/7)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016131
Adoptive Cell Therapy (1/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016132
Adoptive Cell Therapy (2/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016133
Adoptive Cell Therapy (3/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016134
Adoptive Cell Therapy (4/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016135
Adoptive Cell Therapy (5/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016136
Adoptive Cell Therapy (6/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016137
Adoptive Cell Therapy (7/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016138
Adoptive Cell Therapy (8/8)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016139
Others (1/5)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016140
Others (2/5)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016141
Others (3/5)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016142
Others (4/5)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016143
Others (5/5)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016144
Suite (1/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016145
Suite (2/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016146
Suite (3/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016147
Suite (4/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016148
Suite (5/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016149
Suite (6/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016150
Suite (7/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016151
Suite (8/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016152
Suite (9/9)
Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
Immuno-Oncology Report, September 2016
Scope of Report
Entrepreneur Activity
Investment Trend
Who is Investing
Exit Outlook - IPO, Acquisitions
Sub Sector Analysis
Interesting Companies
Company List
Team
153
Immuno-Oncology Report, September 2016154
Team
154
Shubham Garg
Analyst, BioPharma
Vikash Peesapati
Lead Analyst, Life Sciences

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Tracxn Research — Immuno-Oncology Landscape, September 2016

  • 1.
  • 2. Immuno-Oncology Report, September 2016 Tracxn World’s Largest Startup Research Platform 2
  • 3. Immuno-Oncology Report, September 20163 Contents Topic Page No. Scope of Report 05 Entrepreneur Activity 07 Investment Trend 09 Who is Investing 17 Exit Outlook - IPO, Acquisitions 21 Sub Sector Analysis 24 Interesting Companies 42 Company List 49 Team 154
  • 4. Immuno-Oncology Report, September 20164 Illustrative Sectors We Track ENTERPRISE INFRASTRUCTURE TECH SECURITY STORAGE NETWORKING MOBILITY IT OPS CLOUD INFRASTRUCTURE API MANAGEMENT BIGDATA INFRASTRUCTURE INTERNET OF THINGS 3D PRINTING HEALTH EDUCATION BIOPHARMA DIAGNOSTICS MEDICAL DEVICES HEALTHCARE ANALYTICS FITNESS AND WELLNESS HEALTH IT CONSUMER HEALTHTECH MOBILE HEALTH EDUCATION IT SELF LEARNING ENTERPRISE APPLICATIONS MOBILE SAAS MOBILE-FIRST ENT. APPS INTELLIGENT ENT. APPS OPEN SOURCE RETAIL TECH MARKETING TECH STEALTH MODE VERTICAL SAAS MOBILE COMMERCE MOBILE PAYMENTS CONSUMER FINTECH MARKETPLACES SUBSCRIPTION COMM. UBER FOR X INTERNET FIRST BRANDS FOOD TECH GROCERY TECH TRAVEL GAMING BITCOIN PAYMENTS
  • 5. Immuno-Oncology Report, September 20165 Sector Overview Scope of report The report contains companies which are developing therapeutics to suppress or activate immune system for the treatment of cancer. This includes all the companies which are developing antibodies, small molecules, vaccines, viral and adoptive cell therapies for cancer. The report excludes big pharma companies, contract services providers and platform companies. For funding, this report only includes venture capital/ private equity funding rounds and excludes debt financing and grants/prize money. The scope of this report includes equity as well as debt funding received by the companies. 5
  • 6. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 6
  • 7. Immuno-Oncology Report, September 2016 25 20 24 27 22 37 8 0 8 16 24 32 40 2010 2011 2012 2013 2014 2015 2016 NumberofCompanies 7 YoY – Number of companies founded BeiGene Panacela Labs ADC Therapeutics Juno Therapeutics Corvus Pharmaceuticals Gritstone Oncology Hengrui Therapeutics PsiOxus Therapeutics TG Therapeutics Armo BioSciences Jounce Therapeutics Unum Therapeutics Autolus Cell Design Labs
  • 8. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 8 8
  • 9. Immuno-Oncology Report, September 20169 YoY – Number of Rounds and Total Funding Note: The funding includes debt rounds also. $0.5B $0.7B $1.2B $0.7B $0.7B $1.6B $2.2B $4.1B $1.7B 25 72 101 74 73 100 133 129 79 0 28 56 84 112 140 0.0 0.9 1.8 2.7 3.6 4.5 2008 2009 2010 2011 2012 2013 2014 2015 2016 NumberofRounds FundingAmount(inBillions) Funding Amount Number of Rounds
  • 10. Immuno-Oncology Report, September 201610 YoY – Number of Rounds by Stage
  • 11. Immuno-Oncology Report, September 201611 YoY – Funding by Stage
  • 12. Immuno-Oncology Report, September 201612 Average Ticket Size – Early Stage
  • 13. Immuno-Oncology Report, September 201613 Top investments in last one year
  • 14. Immuno-Oncology Report, September 201614 Top investments in last one year
  • 15. Immuno-Oncology Report, September 201615 Funnel view of Sector
  • 16. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 6 16
  • 17. Immuno-Oncology Report, September 201617 Most Active Investors in Sector 29 21 20 20 15 14 14 14 13 12 0 7 14 21 28 35 Orbimed MPM Capital Alta Partners Novo A/S Novartis Venture Fund 5AM Ventures KPCB Versant Ventures SV Life Sciences Sofinnova Ventures TotalNumberofRounds Alpine Immune Sciences Oncorus Allakos Corvus Pharmaceuticals Adicet Bio Ideaya Biosciences Cell Design Labs Gritstone Oncology Delenex Checkmate Pharmaceuticals Armo BioSciences Amphivena Therapeutics Kite Pharma Allakos IFM Therapeutics Igenica Zai Lab Nouscom NKT Therapeutics NextCure
  • 18. Immuno-Oncology Report, September 201618 Where are Top Investors investing
  • 19. Immuno-Oncology Report, September 201619 Top Investor by Stage of Entry
  • 20. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 0 20
  • 21. Immuno-Oncology Report, September 201621 Top IPOs in last three years
  • 22. Immuno-Oncology Report, September 201622 Major Acquisitions in last one year
  • 23. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 3 23
  • 24. Immuno-Oncology Report, September 201624 September 2016Tracxn BlueBox : Immuno-Oncology 400+ companies in the sector, 343 funded in last 5 years, over $5.7B invested in 2015-16
  • 25. Immuno-Oncology Report, September 201625 Top Business Models by Funding $6.5B $1.5B $1.5B $1.1B $536M $425M $264M $131M 0 1400 2800 4200 5600 7000 Antibody Adoptive Cell Therapy Vaccine Suite Oncolytic Virus Small Molecule Cytokines Others TotalFundingAmount(inMillions) # Cos. 174 30 95 31 28 20 7 16 Avg. Age 2005.8 2009.5 2005.7 2006.8 2007.9 2008.8 2002.9 2005.8 Stemcentrx NantKwest CureVac Immatics BioVex Syndax IRX Therapeutics Iconic Therapeutics Symphogen Juno Therapeutics Argos Therapeutics BeiGene PsiOxus Therapeutics VentiRx Armo BioSciences Molecular Templates
  • 26. Immuno-Oncology Report, September 2016 Antibody – Business Model Description 26
  • 27. Immuno-Oncology Report, September 201627 Antibody – Entrepreneur Activity and Investment Trend
  • 28. Immuno-Oncology Report, September 201628 Antibody – Most Funded Companies
  • 29. Immuno-Oncology Report, September 2016 Adoptive Cell Therapy – Business Model Description 29
  • 30. Immuno-Oncology Report, September 201630 Adoptive Cell Therapy – Entrepreneur Activity and Investment Trend
  • 31. Immuno-Oncology Report, September 201631 Adoptive Cell Therapy – Most Funded Companies
  • 32. Immuno-Oncology Report, September 201632 Vaccine – Business Model Description 32
  • 33. Immuno-Oncology Report, September 201633 Vaccine – Entrepreneur Activity and Investment Trend
  • 34. Immuno-Oncology Report, September 201634 Adoptive Cell Therapy – Most Funded Companies
  • 35. Immuno-Oncology Report, September 201635 Suite – Business Model Description 35
  • 36. Immuno-Oncology Report, September 201636 Suite – Entrepreneur Activity and Investment Trend
  • 37. Immuno-Oncology Report, September 201637 Suite – Most Funded Companies
  • 38. Immuno-Oncology Report, September 201638 Oncolytic Virus – Business Model Description 38
  • 39. Immuno-Oncology Report, September 201639 Oncolytic Virus – Entrepreneur Activity and Investment Trend
  • 40. Immuno-Oncology Report, September 201640 Oncolytic Virus – Most Funded Companies
  • 41. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 41
  • 42. Immuno-Oncology Report, September 201642 Interesting Unfunded Companies Company Overview Business Model immunophotonics.com Aurora Biopharma (2016, Miami) CAR T cell based immunotherapies for solid cancers. Adoptive Cell Therapy > T Cell batubiologics.com Chestnut Pharmaceuticals (2015, Toronto) Developing novel therapeutics for metastatic cancers employing a comprehensive approach to reverse the metastatic state of tumor cells. Antibody > Tumor-targeting affinicon.com AR Pharma (2015, Woburn) Monoclonal antibody to treat B-cell chronic lymphocytic leukemia Antibody > Suite AngioClast (2015, Cambridge (UK)) Developing antibody drug conjugate for treatment of Glioblastoma multiforme. Antibody > Tumor-targeting > Antibody Drug Conjugates GO Therapeutics (2013, Cambridge (US)) Developing tumor-specific antibodies for cancer immunotherapy based on cancer glycoproteome. Antibody > Tumor-targeting Curated list of companies by the sector analyst are defined as Interesting
  • 43. Immuno-Oncology Report, September 201643 Interesting Seed Companies
  • 44. Immuno-Oncology Report, September 201644 Interesting Series A Companies
  • 45. Immuno-Oncology Report, September 201645 Interesting Series B Companies
  • 46. Immuno-Oncology Report, September 201646 Interesting Late Stage Companies
  • 47. Immuno-Oncology Report, September 201647 Top Funded Deadpooled Companies
  • 48. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 4848
  • 49. Immuno-Oncology Report, September 201649 Immuno-Oncology – Company List COVERS THE FOLLOWING SECTORS Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 50. Immuno-Oncology Report, September 201650 Small Molecule (1/6) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite Company Details Funding Investors Immunosuppressive Pathway Inhibitors Syndax [Waltham, 2005]: Syndax is a late-stage biopharmaceutical company developing entinostat as a combination therapy in multiple cancer indications with an initial focus on tumors that have shown sensitivity to immunotherapy, including lung cancer, melanoma and triple negative breast cancer. Entinostat (phase3, breast cancer), its lead drug candidate is an oral, small molecule that has direct effects on both cancer cells and immune regulatory cells, potentially enhancing the body's immune response to tumors. $158.65M Fidelity Investments, Orbimed, Avalon Ventures, MPM Capital, Domain Associates, Pappas Ventures, Forward Ventures, Tavistock Group, Jennison Associates, Arrowpoint Partners, RusnanoMedInvest, Delos Capital, EcoR1, Pappas Capital Immunosuppressive Pathway Inhibitors Flexus Biosciences [San Carlos, 2013]: Flexus Biosciences focuses on small-molecule cancer immunotherapies: IDO & TDO Inhibitors (Immune Response Checkpoint Modulators) that target regulatory T cells. The company utilizes immunology techniques to identify Agents for Reversal of Tumor Immunosuppression (ARTIS). Flexus has a proprietary IDO/TDO discovery program which includes its IDO- selective, IDO/TDO dual and TDO-selective compound libraries. Cancer cells use IDO and TDO pathways to suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells. The company has been acquired by Bristol-Myers Squibb on Feb 2015 ($800M upfront and $450M in milestone payments). $47M KPCB, The Column Group, Celgene, The Column Group Immunosuppressive Pathway Inhibitors Ideaya Biosciences [San Francisco, 2015]: Ideaya Biosciences is an oncology-focused company committed to the discovery of personalized synthetic lethality medicines targeting DNA damage and repair for genetically defined patient populations and immuno-oncology therapies targeting the tumor microenvironment. Synthetic lethality is a phenomenon where the independent loss-of-function of two different genes have no significant effects on cell growth and viability, but when combined results in robust cell death. It will focus on novel synthetic lethal interactions for genetically defined patient populations, exploiting inherent tumor susceptibilities en-route to discovery and development of small-molecule agents to treat major human cancers. It also focusses on modulating DNA repair to augment response to immunotherapy. In addition, drug discovery programs will target pathways known to produce an immune suppressed tumor microenvironment, enabling tumors to escape recognition by the host immune system. $46M Canaan Partners, Celgene, 5AM Ventures, Alexandria Real Estate Equities, NIBR, WuXi Healthcare Ventures
  • 51. Immuno-Oncology Report, September 201651 Small Molecule (2/6) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite Company Details Funding Investors Immunosuppressive Pathway Inhibitors NewLink Genetics [Ames, 1999]: NewLink Genetics is discovering and developing novel immuno-oncology product candidates using its checkpoint inhibitor platform. The company is developing IDO pathway inhibitors for the treatment of cancer. The indoleamine 2,3-dioxygenase (IDO) pathway regulates immune response by suppressing T-cell function and enabling local tumor immune escape. It is developing two IDO pathway inhibitors—GDC-0919 (in partnership with Genentech) and indoximod. Indoximod is being developed in combination with antibodies and chemotherapy for the treatment of breast cancer (Phase 2), pancreatic cancer (Phase 2), glioblastoma (Phase 2), melanoma (Phase 2). $24.5M Iowa Capital Management, Ames Economic Development Commission Immunosuppressive Pathway Inhibitors Confluence Life Sciences [St. Louis, 2010]: Confluence Life Sciences (CLS) is a drug discovery and early development company which is focusing on developing kinase inhibitors using its proprietary technology. Its platform KINect claims to accelerate the identification of drug candidates targeting active-site cysteine- containing kinases. The platform has a thiol-directed chemical library of protein kinase inhibitors which has been utilized in multiple drug discovery programs. Its internal development pipeline has programs for cancer immunotherapy and autoimmune diseases (IL-2 Inducible T-Cell Kinase (ITK) / Tyrosine-protein Kinase inhibitors). It is also developing programs for inflammation and cancer externally in partnership with other pharmacy companies. $12.81M BioGenerator, Helix Funds, Missouri Technology, Mercury Fund, Epidarex Capital, St Louis Arch Angels Immunosuppressive Pathway Inhibitors TPP Global Development [Edinburgh, 2008]: IOmet (previously named TPP) is a UK-based preclinical-stage drug development company focused on cancer immunotherapy and metabolism. IOmet has a comprehensive pipeline of IDO, TDO and dual-acting IDO/TDO inhibitors and novel GLUT1 inhibitors. IOmet is pursuing a number of other undisclosed cancer immunotherapy and cancer metabolism targets, in addition to a GLUT9 inhibitor program for the treatment of gout. Effective January 11, 2016, IOmet Pharma is a wholly owned subsidiary of Merck & Co., Inc. $12.2M Scottish Enterprise Immunosuppressive Pathway Inhibitors Xios Therapeutics [Boston, 2015]: Xios Therapeutics is a biotechnology company focussed on developing small molecule therapies for cancer. It is developing drugs which are capable of preventing tumors from evading the immune system and targets the immuno-oncology pathways and mechanisms which can be the potential therapeutic target for cancer treatment. $6M Sutter Hill Ventures
  • 52. Immuno-Oncology Report, September 201652 Small Molecule (3/6) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite Company Details Funding Investors Immunosuppressive Pathway Inhibitors Partikula [Miami, 2013]: Partikula is focused on developing novel mitochondrial-targeted therapeutics for oncology using its chemical engineering technologies. It is developing programs which affect the proteins present in and around mitochondria. Its portfolio candidates include KULA 18 and KULA 19 which inhibits pyruvate dehydrogenase kinase (PDK) and Hexokinase respectively; KULA-200, a small peptide targeted to inhibit the anti-apoptotic protein Bcl-2; KULA-300 cancer chemotherapeutics and KULA-101, a tumor Microenvironment Modifier (TMEM) for cancer immunotherapy. It is planning to begin clinical studies of its lead programs in late 2016. $5.7M 2M Companies Immunosuppressive Pathway Inhibitors ImmunoMet Therapeutics [Houston, 2015]: ImmunoMet Therapeutics (a spinoff of HanAll Biopharma) is a development-stage biotechnology company developing oncology products with a focus on cancer metabolism and immuno-oncology. Its novel technology is designed to disrupt cancer cell growth and enhance anti-cancer immunity and may be used in a broad range of difficult-to-treat cancers. Its lead cancer metabolism compound, IM156, an OXPHOS inhibitor, for the treatment of glioblastoma (brain cancer) is expected to enter Phase 1 clinical development in the second half of 2016. $5.2M Mirae Asset Immunosuppressive Pathway Inhibitors Aminex Therapeutics [Kenmore, 2009]: Aminex Therapeutics is developing cancer immunotherapies. The company is developing a class of immunotherapies known as suppressor class modulators. Its lead candidate reduces polyamine uptake in cancer cells, which in turn leads to reduction in the number of myeloid- derived suppressor cells. As a result, the innate immune system can then be triggered to attack cancer cells. Its lead candidate AMX-513 consists of two drugs, an FDA approved polyamine synthesis inhibitor (DFMO, difluoromethylornithine) and a novel potent polyamine uptake, or transport, inhibitor (AMXT 1501). $4M Immunosuppressive Pathway Inhibitors Oncofactor [Seattle, 2011]: Oncofactor develops cancer therapeutics that disrupt signaling pathways between tumors and the immune system. The company is developing an oncology platform to identify and target immune modulating proteins deferentially expressed by cancer cells. The company claims that targeting these oncofactors will reveal cancer to the host immune system and permit clearance by native immunity. $3.1M OVP Venture Partners, ARCH Venture Partners, Alexandria Real Estate Equities, Accelerator, Washington Research Foundation, Amgen
  • 53. Immuno-Oncology Report, September 201653 Small Molecule (4/6) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 54. Immuno-Oncology Report, September 201654 Small Molecule (5/6) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 55. Immuno-Oncology Report, September 201655 Small Molecule (6/6) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 56. Immuno-Oncology Report, September 201656 Cytokines (1/2) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 57. Immuno-Oncology Report, September 201657 Cytokines (2/2) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 58. Immuno-Oncology Report, September 201658 Antibody (1/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 59. Immuno-Oncology Report, September 201659 Antibody (2/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 60. Immuno-Oncology Report, September 201660 Antibody (3/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 61. Immuno-Oncology Report, September 201661 Antibody (4/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 62. Immuno-Oncology Report, September 201662 Antibody (5/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 63. Immuno-Oncology Report, September 201663 Antibody (6/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 64. Immuno-Oncology Report, September 201664 Antibody (7/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 65. Immuno-Oncology Report, September 201665 Antibody (8/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 66. Immuno-Oncology Report, September 201666 Antibody (9/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 67. Immuno-Oncology Report, September 201667 Antibody (10/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 68. Immuno-Oncology Report, September 201668 Antibody (11/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 69. Immuno-Oncology Report, September 201669 Antibody (12/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 70. Immuno-Oncology Report, September 201670 Antibody (13/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 71. Immuno-Oncology Report, September 201671 Antibody (14/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 72. Immuno-Oncology Report, September 201672 Antibody (15/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 73. Immuno-Oncology Report, September 201673 Antibody (16/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 74. Immuno-Oncology Report, September 201674 Antibody (17/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 75. Immuno-Oncology Report, September 201675 Antibody (18/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 76. Immuno-Oncology Report, September 201676 Antibody (19/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 77. Immuno-Oncology Report, September 201677 Antibody (20/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 78. Immuno-Oncology Report, September 201678 Antibody (21/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 79. Immuno-Oncology Report, September 201679 Antibody (22/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 80. Immuno-Oncology Report, September 201680 Antibody (23/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 81. Immuno-Oncology Report, September 201681 Antibody (24/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 82. Immuno-Oncology Report, September 201682 Antibody (25/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 83. Immuno-Oncology Report, September 201683 Antibody (26/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 84. Immuno-Oncology Report, September 201684 Antibody (27/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 85. Immuno-Oncology Report, September 201685 Antibody (28/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 86. Immuno-Oncology Report, September 201686 Antibody (29/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 87. Immuno-Oncology Report, September 201687 Antibody (30/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 88. Immuno-Oncology Report, September 201688 Antibody (31/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 89. Immuno-Oncology Report, September 201689 Antibody (32/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 90. Immuno-Oncology Report, September 201690 Antibody (33/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 91. Immuno-Oncology Report, September 201691 Antibody (34/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 92. Immuno-Oncology Report, September 201692 Antibody (35/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 93. Immuno-Oncology Report, September 201693 Antibody (36/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 94. Immuno-Oncology Report, September 201694 Antibody (37/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 95. Immuno-Oncology Report, September 201695 Antibody (38/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 96. Immuno-Oncology Report, September 201696 Antibody (39/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 97. Immuno-Oncology Report, September 201697 Antibody (40/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 98. Immuno-Oncology Report, September 201698 Antibody (41/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 99. Immuno-Oncology Report, September 201699 Antibody (42/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 100. Immuno-Oncology Report, September 2016100 Antibody (43/43) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 101. Immuno-Oncology Report, September 2016101 Vaccine (1/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 102. Immuno-Oncology Report, September 2016102 Vaccine (2/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 103. Immuno-Oncology Report, September 2016103 Vaccine (3/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 104. Immuno-Oncology Report, September 2016104 Vaccine (4/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 105. Immuno-Oncology Report, September 2016105 Vaccine (5/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 106. Immuno-Oncology Report, September 2016106 Vaccine (6/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 107. Immuno-Oncology Report, September 2016107 Vaccine (7/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 108. Immuno-Oncology Report, September 2016108 Vaccine (8/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 109. Immuno-Oncology Report, September 2016109 Vaccine (9/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 110. Immuno-Oncology Report, September 2016110 Vaccine (10/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 111. Immuno-Oncology Report, September 2016111 Vaccine (11/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 112. Immuno-Oncology Report, September 2016112 Vaccine (12/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 113. Immuno-Oncology Report, September 2016113 Vaccine (13/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 114. Immuno-Oncology Report, September 2016114 Vaccine (14/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 115. Immuno-Oncology Report, September 2016115 Vaccine (15/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 116. Immuno-Oncology Report, September 2016116 Vaccine (16/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 117. Immuno-Oncology Report, September 2016117 Vaccine (17/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 118. Immuno-Oncology Report, September 2016118 Vaccine (18/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 119. Immuno-Oncology Report, September 2016119 Vaccine (19/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 120. Immuno-Oncology Report, September 2016120 Vaccine (20/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 121. Immuno-Oncology Report, September 2016121 Vaccine (21/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 122. Immuno-Oncology Report, September 2016122 Vaccine (22/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 123. Immuno-Oncology Report, September 2016123 Vaccine (23/23) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 124. Immuno-Oncology Report, September 2016124 Oncolytic Virus (1/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 125. Immuno-Oncology Report, September 2016125 Oncolytic Virus (2/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 126. Immuno-Oncology Report, September 2016126 Oncolytic Virus (3/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 127. Immuno-Oncology Report, September 2016127 Oncolytic Virus (4/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 128. Immuno-Oncology Report, September 2016128 Oncolytic Virus (5/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 129. Immuno-Oncology Report, September 2016129 Oncolytic Virus (6/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 130. Immuno-Oncology Report, September 2016130 Oncolytic Virus (7/7) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 131. Immuno-Oncology Report, September 2016131 Adoptive Cell Therapy (1/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 132. Immuno-Oncology Report, September 2016132 Adoptive Cell Therapy (2/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 133. Immuno-Oncology Report, September 2016133 Adoptive Cell Therapy (3/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 134. Immuno-Oncology Report, September 2016134 Adoptive Cell Therapy (4/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 135. Immuno-Oncology Report, September 2016135 Adoptive Cell Therapy (5/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 136. Immuno-Oncology Report, September 2016136 Adoptive Cell Therapy (6/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 137. Immuno-Oncology Report, September 2016137 Adoptive Cell Therapy (7/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 138. Immuno-Oncology Report, September 2016138 Adoptive Cell Therapy (8/8) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 139. Immuno-Oncology Report, September 2016139 Others (1/5) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 140. Immuno-Oncology Report, September 2016140 Others (2/5) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 141. Immuno-Oncology Report, September 2016141 Others (3/5) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 142. Immuno-Oncology Report, September 2016142 Others (4/5) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 143. Immuno-Oncology Report, September 2016143 Others (5/5) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 144. Immuno-Oncology Report, September 2016144 Suite (1/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 145. Immuno-Oncology Report, September 2016145 Suite (2/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 146. Immuno-Oncology Report, September 2016146 Suite (3/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 147. Immuno-Oncology Report, September 2016147 Suite (4/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 148. Immuno-Oncology Report, September 2016148 Suite (5/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 149. Immuno-Oncology Report, September 2016149 Suite (6/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 150. Immuno-Oncology Report, September 2016150 Suite (7/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 151. Immuno-Oncology Report, September 2016151 Suite (8/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 152. Immuno-Oncology Report, September 2016152 Suite (9/9) Small Molecule Cytokines Antibody Vaccine Oncolytic Virus Adoptive Cell Therapy Others Suite
  • 153. Immuno-Oncology Report, September 2016 Scope of Report Entrepreneur Activity Investment Trend Who is Investing Exit Outlook - IPO, Acquisitions Sub Sector Analysis Interesting Companies Company List Team 153
  • 154. Immuno-Oncology Report, September 2016154 Team 154 Shubham Garg Analyst, BioPharma Vikash Peesapati Lead Analyst, Life Sciences