World Best Technology Showcase 2009

1. Thomas Martinuzzo
Project Leader, Sciences and Engineering
thomas.martinuzzo@univalor.ca
MrSUB: The
“Fantastic
Voyage” Image: Bluejacketsfoundation.org
A revolutionary tool
for fighting cancer
Presented by Sylvain Martel, Eng., Ph.D.
sylvain.martel@polymtl.ca

2. The real fact…
• We can send a robot precisely to a targeted location far
away on the surface of planet Mars… But we cannot
send therapeutic agents directly to a tumor located just a
fingertip distance deep in the human body…
• This is why today’s solutions often rely on chemotherapy
where large doses of toxic drugs are injected in patients,
leading to secondary toxicity that could be avoided by
navigating smaller doses of therapeutics using the most
direct and effective routes using MR-SUB

3. The MR-SUB
proposition
• Bringing the evolution of tools for cancer therapy one
step forward by integrating engineering and computer
technology with nanomedicine by upgrading clinical
Magnetic Resonance Imaging (MRI) systems as
powerful drug delivery platforms.

4. What MR-SUB brings
A technology that
1 can deliver
therapeutics directly
A library of micro-
carriers to bring
2 therapeutics through
the vascular network
3
Worldwide
recognized
expertise and
proof-of-
concepts
4 HOPE…

5. Synopsys and market
opportunity
• The treatment of cancer is one of the most challenging
tasks of modern medicine as toxicity remains a critical
issue.
• The U.S. market for cancer therapy products and
services is forecasted to reach $27 billion by 2009.
• The platform MR-SUB also addresses the interventional
radiology industry (1.5 billion dollars market - expected
to grow at a CAGR of 6% from 2006 to 2013 to reach
$2.5 billion in 2013)
• Typical end-users include hospitals (about 170 000
worldwide in 2012), outpatient surgery centers, private
clinics and university based research centers.

6. Overview
• The technology:
– Proof-of-concept done in large animal models proving that the
MR-SUB technology enables untethered entities to reach targets
inaccessible to modern interventional tools such as the catheter
– Years and several million $ in R&D funded from a number of
research grants
• Intellectual property:
– US (11/145,007) and CA Patent Applications - “Method and
system for propelling and controlling displacement of a
microrobot in a blood vessel” - US patent application
(11/993,320) – “Mr-Tracking based on magnetic signature
selective excitation”- New applications (non-provisional US) in
progress

7. Our goal with the MR-
SUB technology
• Some 40 years after the movie
“Fantastic Voyage”, we have
shown that science-fiction can
now become a reality with MR-
SUB
• To make this technology
accessible, Univalor is presently
seeking management and
funding to propel the MR-SUB
platform to product launch

8. MrSUB: The “Fantastic
Voyage”
• Contacts:
– Thomas Martinuzzo
thomas.martinuzzo@univalor.ca
– Sylvain Martel
sylvain.martel@polymtl.ca –
Inventor
– Booth # 402
100,000 km of blood vessels – 100,000 km of MR-SUB opportunities in each patient