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- 1. “Memory in Aging with and without Parkinson’s Disease” Speaker: Tazrina Alrazi (PhD student at the PCAN Lab) University of Calgary Cumming School of Medicine Clinical Neuroscience Department
- 6. Epidemiology of Parkinson’s Disease • Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the world • In North America, the prevalence of PD is 107-187 per 100,000 population • The most alarming non-motor PD complication is dementia (PDD)
- 7. Epidemiology of Parkinson’s Disease Dementia • PDD can affect up to 50% of patients 10 years after diagnosis and over 80% by 20 years • Dementia risk is almost six times higher in PD patients than in age-matched healthy controls • Severely affects quality of life, independent activities of daily living, and interpersonal relationships
- 8. Mild Cognitive Impairment (MCI) Normal Cognition Mild Cognitive Impairment Dementia: -Alzheimer’s dementia -Lewy body dementia -Frontotemporal dementia -Parkinson’s dementia -Vascular dementia
- 9. Mild Cognitive Impairment (MCI) MCI encompasses all 5 cognitive domains Executive functions Attention Visuo-spatial and visuo-perceptual functions Language Memory
- 10. Epidemiology of Mild Cognitive Impairment in Parkinson’s Disease • 26.7% (range 18.9–38.2%) of non-demented PD patients have PD-MCI • Janvin et al. found 62% of PD-MCI patients converted to PDD over a 4-year period
- 13. Pathophysiology of Cognitive Impairment in PD
- 14. Associative Memory Associative memory tasks demand high efficiency of the medial temporal lobe
- 15. Associative Memory Task •FAST (FACE ASSOCIATED SCENE TASK)
- 16. Our Volunteers (Study Groups) Participants: Parkinson’s disease, no mild cognitive impairment PD (non-MCI) (35) Parkinson’s disease with mild cognitive impairment PD-MCI (65) Mild cognitive impairment, no Parkinson’s disease MCI (non-PD-MCI) (65) Healthy Controls (age-matched to patients) HC (35)
- 19. Importance of This Research Pioneering research
- 21. Lets Test Memory
- 23. Do you like the pair?
- 24. Unsure
- 25. Unsure
- 27. Do you recall seeing these pictures?
- 29. Together
- 32. GREAT JOB!!!!!
Hinweis der Redaktion
- James Parkinson Born in april
- You say: Pd is a Neurodegenerative disorder characterized by motor and non motor symptoms. Loss of dopaminergic substantia nigra neurons are principally responsible for the motor deficits. Etiology for non motor symptoms are still not clear. Motor features are cardinally resting tremor, rigidity, brady kinesia but one of the most important non motor feature of pd is loss of cognition (most but nt all pd patients get it) :…..motor features are which are asymmetrical in origin and presentation. Non motor features among others are cognitive decline in the 5 identified domains namely…… Just act…don’t write
- Mayeux R1, Marder K, Cote LJ, Denaro J, Hemenegildo N, Mejia H, Tang MX, Lantigua R, Wilder D, Gurland B, et al. The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988-1993. m J Epidemiol. 1995 Oct 15;142(8):820-7. 3. Williams-Gray CH, Mason SL, Evans JR, Foltynie T, BrayneC, Robbins TW, & Barker RA (2013) The CamPaIGN study of Parkinson’s disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry, 84, 1258-1264. 4. Hely MA, Reid WG, Adena MA, Halliday GM, & Morris JG (2008) The Sydney multicenter study of Parkinson’s disease: The inevitability of dementia at 20 years. Mov Disord, 23, 837-844. 2. Zhang ZX1, Román GC. Worldwide occurrence of Parkinson's disease: an updated review. Neuroepidemiology.1993;12(4):195-208.
- 4. Hely MA, Reid WG, Adena MA, Halliday GM, & Morris JG (2008) The Sydney multicenter study of Parkinson’s disease: The inevitability of dementia at 20 years. Mov Disord, 23, 837-844. 2. Zhang ZX1, Román GC. Worldwide occurrence of Parkinson's disease: an updated review. Neuroepidemiology.1993;12(4):195-208
- MCI is conceived as an intermediary stage between normal cognition and dementia. (because a few ppl goes back to normal may b due to improper diagnosis at the first place). Initially this was proposed and very well studied as prodromal AD, but it was not well studied in PD. Now it is well accepted in PD. There was no clinical criteria until 2011, when mds task force recommended litvan to plan clinical guideline for mci in pd and later in 2012 litvan and collegues made the clinical criteria with level 1 and 2. level 1 is clinical diagnosis and moca and mmse. Level 2 includes all the neuropsychologcal assessments. However, recent post-mortem studies suggest that between 30 and 45% of PD patients with dementia also meet neuropathological diagnostic criteria for AD [8]. With such a high proportion of demented PD patients with concurrent AD, it would be valuable, from a therapeutic standpoint, to identify those with AD earlier. In the context of the present proposal we will be able to follow longitudinally different groups of PD patients and compare them to non-PD amnestic MCI patients who are at risk of developing a medio-temporal lobe dementia such as AD.
- Single, non-memory domain MCI (69%) VS SINGLE DOMAIN, A MCI (40%)= It bypasses my hippocampus because that’s mostky related to memeory and if more non amnestics convert to dementia, that goes against my hypothesis of MTL involvement. But this is not consistent and it varies a lot. Many of the multi domain will convert to dementia…….our study looks more stuff than just MTL. Litvan I, Aarsland D, Adler CH, Goldman JG, Kulisevsky J, Mollenhauer B, et al. MDS Task Force on mild cognitive impairment in Parkinson's disease: Critical review of PD-MCI. Mov Disord. 2011;26:1814–24. Janvin CC, Larsen JP, Aarsland D, Hugdahl K. Subtypes of mild cognitive impairment in Parkinson’s disease: progression to dementia. Mov Disord. 2006; 21:1343–1349. [PubMed:
- This is the classic two pathway for cognitive decline proposed so far well accepted. My task mostly will focus on the posterior cortical pathways. And mildly frontal. Dementia: A general term for a decline in mental ability severe enough to interfere with daily life. Williams gray 2009 paper: 5 year longitudinal study:Figure 3 Schematic representation of hypothesized aetiological pathways leading to cognitive dysfunction in early Parkinson’s disease and their relationship to the development of dementia 5 years later. ‘Frontal executive’ impairments in early disease appear to be a consequence of a hyperdopaminergic state in the prefrontal cortex, which is in turn modulated by COMT genotype and dopaminergic medication. These deficits are not associated with subsequent global cognitive decline and dementia over 5 years of follow-up. In contrast, it seems that early deficits on more posterior cortically based cognitive tasks, which do develop into subsequent dementia, do not have a dopaminergic basis. Rather, this work supports the hypothesis that they reflect Lewy body deposition in posterior cortical areas, which is in turn influenced by MAPT genotype and the ageing process; PD = Parkinson’s disease. This diagram is a review by Williams gray in 2014. Most of PD patients develops dementia (PDD) in advanced stages of disease, but it affects over 80% of those with 20 years of disease[1] and a considerable number of them already shows cognitive deficits in the early stage so severe enough to be diagnosed as dementia. AD ASSOCIATION
- Dennis NA, Turney IC, Webb CE, Overman AA. The effects of item familiarity on the neural correlates of successful associative memory encoding. Cogn Affect Beha Neurosci. 2015 Dec;15(4):889-900. doi: 10.3758/s13415-015-0359-2.PMID: 25939781.
- What do u mean by each version: 32 encoding pair is full 16 encoding pair is mini version
- Litvan 2016 paper: ad mci vs pd mci
- Encoding pairs