Pattern Diagnostics, an integral part of PRECISION MEDICINE

1. InnVentis
Pattern Diagnostics
&
Precision MedicineToward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New
Taxonomy of Disease Committee on a Framework for Development a New Taxonomy of Disease;
National Research Council
Preparing for Precision Medicine World Economic Forum November 2012
The precision medicine revolution: Targeted treatment zeros in on disease; GE Look ahead 2013
R&D Ecosystem of the Future 2011:
By 2020, four out of every five drugs launched will be Precision Medicine drugs.
Precision Medicine © Dr. Thomas Wilckens, InnVentis

2. InnVentis
Precision Medicine - Paradigm Shift
Symptom-based Cohort-based Algorithm-based
Yesterday
Intuition
Medicine
Today
Evidence-based
Medicine
Tomorrow
Precision
Medicine
DATAACTIONS
Application of rules, algorithms and reference databases enables
ACTIONABLE clinical decision support & PRECISE/EFFICIENT care
Reference
Databases
(Rules &
Algorithms)
Personal
Molecular
Profiles
(PMP, multi-omics)
Molecular
Imaging
Non-molecular content
(waveforms)
Precision
Medicine
(prevention,
diagnosis, treatment)
Mobile
Information
Communication
Technologies
Big Data
Analytics
Precision Medicine © Dr. Thomas Wilckens, InnVentis

3. InnVentis
PRECISION MEDICINE:
Integrating multi-omics, clinical and real world data
Eric Topol, CELL,Volume 157, Issue 1, 27 March 2014, Pages 241–253
‘‘omic’’ Latin suffix ‘‘ome’’ = mass or many.
Creation of topological maps
of health/disease

4. InnVentis
Convergence of diagnostics with Big-Data & AI:
Multi-omics create Personal Molecular Profile, PMP
Genome
25.000 genes
Proteome
1 million
Metabolome
> 6000 SM
Microbiom
1-3 % of
body mass
Existing knowledge ?
Precision Medicine © Dr. Thomas Wilckens, InnVentis
Big DATA
Pattern Discovery
Reference Database
Machine learning
Algorithms
Personal
Molecular
Profile

5. InnVentis
Pattern discovery & machine learning:
All human senses use this principle
Pattern recognition:
• Hearing (Music, Voices,…)
• Odors
• Taste
• Vision
• ……….
Precision Medicine © Dr. Thomas Wilckens, InnVentis

6. InnVentis
Patter recognition is an archaic principle
Application of pattern discovery to identify hidden disturbances
Pattern diagnostics:
• Host defence and immunity
• Enables greater flexibility
• Follows evolutionary principles
• Artificial Immune Systems in
Computing, Fraud analysis etc.
Precision Medicine © Dr. Thomas Wilckens, InnVentis

7. InnVentis
Disease is a cuckoo‘s egg
Application of Pattern discovery to identify hidden disturbances
Pattern recognition algorithm reveals how birds evolve individual egg pattern signatures Nature
Communications 2014/5, Article number: 4117
Pattern diagnostics:
• Invented by nature
• Enables dynamic differentiation
• Appreciates individuality
Precision Medicine © Dr. Thomas Wilckens, InnVentis

8. InnVentis
Pattern diagnostics:
• Dynamic models
• Identifies „minor“ changes
• Flexible viewpoints
The tools are there:
Facebooks deep learning face recognition
Precision Medicine © Dr. Thomas Wilckens, InnVentis

9. InnVentis
Pattern-diagnostics:
• Is independent from baselines
• Reveals “hidden” disturbances
• The more data the better the analysis;
i.e. precise patter recognition from
“different angles”
• Machine learning recognizes
“fragments” of a pattern
Molecular patterns are like memorable „skylines“
Pattern discovery, Machine Learning in Precision Medicine:
Pattern-diagnostics enables flexible, precise diagnostics
Precision Medicine © Dr. Thomas Wilckens, InnVentis

10. InnVentis
child
Pattern diagnostics:
• Lifetime monitoring
• Prevention
• Early intervention
• What‘s needed? DATA
Patterns are dynamic and flexible:
Personal molecular pattern evolution over time
adult
Precision Medicine © Dr. Thomas Wilckens, InnVentis

11. InnVentis
Detecting criminal organizations in mobile phone networks.
Expert Systems with Applications 41(13):5733-5750, 2014
Disrupting biomedical R&D:
Machine learning, pattern discovery and algorithm-based analytics
Paradigm shift:
• Social networks are like biological
organisms
• There are tools to analyze social
networks – user friendly
• Detecting pathologies with
machine learning and algorithms
in real-time: the future of
diagnostics
Precision Medicine © Dr. Thomas Wilckens, InnVentis

12. InnVentis
POC: Classification for childhood arthritis with pattern recognition:
Relationship between the clusters and ILAR subtypes
The biological basis for clinical heterogeneity in childhood arthritis.
Arthritis Rheumatol. 2014 Sep 8
Pattern diagnostics:
• ILAR knows 6 (clinical) groups
• 152 and 102 patients
• Multiple molecular analytes
• New: 11 molecular clusters
Precision Medicine © Dr. Thomas Wilckens, InnVentis

13. InnVentis
 Fully automated pattern discovery and classification
 Resulting predictive model has an overall accuracy of 92.4%
 In cross-validation, 88.4% of never before seen individuals could be assigned the correct class
Pattern discovery & machine learning
Facilitating Big DATA management & analytics
Data of 1209 metabolites from 132 patients assigned to three groups:
Healthy controls, low risk patients and high risk patients.
InnVentis‘solution reduceds
the time for analysis from:
1day to 1min
Scalable for Big DATA
Precision Medicine © Dr. Thomas Wilckens, InnVentis

14. InnVentis
New data and standardized processes (SOP)
Essential prerequisites for success and value creation:
Nature 03 April 2013
If a job is worth doing, it is
worth doing twice
Researchers and funding
agencies need to put a premium
on ensuring that results are
reproducible
Garbage in
Garbage out
Precision Medicine © Dr. Thomas Wilckens, InnVentis
How much existing „knowledge“ can be used, how?

15. InnVentis
Standards and SOPs on the horizon to secure value today?
The case for vertically integrated lean and fast pilot projects
Launch of a Transformative Health Care Initiative:
The National Biomarker Development Alliance (NBDA) 1/2014
Problems with scientific research
How science goes wrong
Scientific research has changed
the world. Now it needs to
change itself 10/2013
A sea of standards for omics
data: sink or swim?
JD Tenenbaum et. al. Am Med Inform Assoc, 09/2013
SOPs
=
Value
Precision Medicine © Dr. Thomas Wilckens, InnVentis
Establishing data bases and algorithms
requires highest comparability, validity & reliability

16. InnVentisChallenges:
Pros should pave the way
Most biomarker discovery still takes place in
government-funded university laboratories that
are ill equipped to undertake the myriad
procedures required for stringent biomarker
profiling on the scale required to achieve
the evidence needed to attract larger
investment in clinical trials.
National Biomarker Development Alliance 9/2014
Precision Medicine © Dr. Thomas Wilckens, InnVentis

17. InnVentis
Precision Medicine & Big DATA
Thomas.Wilckens@InnVentis.com
InnVentis
enabling
PRECISION MEDICINE
Disclaimer:
This presentation is for educational purposes only.
No copyright violations are intended.
Distribution, also in part, for commercial purpose is illigal
Precision Medicine © Dr. Thomas Wilckens, InnVentis