This document provides guidance on evaluating chemicals and authoring safety data sheets for OSHA Hazard Communication 2012 requirements. It outlines 12 steps to determine hazard classifications, exposure risks, physical/chemical properties, toxicology information, transportation requirements, and applicable regulations for chemical mixtures by searching numerous online resources and databases.

1. CHEMICAL EVALUATION AND SAFETY ASSESSMENT FOR
OSHA HAZCOM 2012 SAFETY DATA SHEETS AUTHORING
Theodore M. Amet
Regulatory Research Analyst
A. MIXTURE/PREPARATION
Ordered Steps:
1. Hazards Determination (Physical, Health and Safety)
Table 1. Reactivity Prediction (Compatibility)
Composition/Information on Ingredients
CAMEO Chemicals:http://www.cameochemicals.noaa.gov/
• Build a list of chemicals
• Predict reactivity
• Extract pertinent information on chemical substances:
(Exposure/First Aid, Fire Hazards, Accidental Release and Containment,
Physical Data, Transportation Classification, Regulatory Information, etc.)
Table 2. Chemical Evaluation (Environment, Health and Safety)
Information on Chemical Substances
TSCA: http://www.epa.gov/enviro/facts/tsca/tsca_search.html
Substance Registry Services (SRS) Advanced Search:
http://iaspub.epa.gov/sor_internet/registry/substreg/searchandretrieve/advancedsearch/search.do
ChemSub Online:http://chemsub.online.fr/
ESIS (European chemical Substances Information System): http://esis.jrc.ec.europa.eu/ /
http://esis.jrc.ec.europa.eu/index.php?PGM=cla
ECHA (European Chemical Agency): http://www.echa.europa.eu/
• Obtain Hazard, Risk and Safety Information
Table 3. Toxicological Information on Substances
Toxicological Information Resources
• IARC: http://www.iarc.fr/
• NTP: http://ntp.niehs.nih.gov/
• OSHA: http://www.osha.gov/dts/chemicalsampling/toc/toc_chemsamp.html
• ACGIH: http://www.acgih.org/home.htm
• TOXNET: http://toxnet.nlm.nih.gov/
• HSDB: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
http://sis.nlm.nih.gov/enviro/hsdbchemicalslist.html
• ASTDR: http://www.atsdr.cdc.gov/
• ACToR: http://actor.epa.gov/actor/faces/ACToRHome.jsp
• CROETWeb: http://www.croetweb.com/
• NPIC: http://npic.orst.edu/
• California Proposition 65: http://www.oehha.ca.gov/prop65.html
Links: http://meso.spawar.navy.mil/Links/toxicology.html
Carcinogens Table: http://publicsafety.tufts.edu/ehs/files/carcinogens.pdf
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2. 2. GHS Label Elements Determination
GHS Hazard Communication Pictograms Assignment
• GHS Konverter: http://ghs-konverter.de/ghs/konverter/index.htm
3. Exposure, Symptoms, Adverse Effects and First Aid Measures
Information on Hazardous Chemicals
• Haz-Map: http://hazmap.nlm.nih.gov/index.php
• Haz-Map Database: http://www.haz-map.com/refernc.htm#NAERG
• CAMEO Chemicals: http://www.cameochemicals.noaa.gov/
• Chemical Safety: http://www.cdc.gov/niosh/topics/chemical-safety/
• Emergency Response Card: https://erplan.net/eplan/home.htm
• First Responders: http://www.cdc.gov/niosh/docs/2008-115/
• NIOSH: http://www.cdc.gov/niosh/
• 2012 Emergency Response Guide Book: http://phmsa.dot.gov/hazmat/library/erg
4. Fire-Fighting Measures
Hazard Class Fire Fighting Measures
• CAMEO Chemicals: http://www.cameochemicals.noaa.gov/
• 2012 Emergency Response Guide Book: http://phmsa.dot.gov/hazmat/library/erg
• Emergency Response Card: https://erplan.net/eplan/home.htm
5. Spillage and Disposal
Spillage and Disposal
• CAMEO Chemicals: http://www.cameochemicals.noaa.gov/
• 2012 Emergency Response Guide Book: http://phmsa.dot.gov/hazmat/library/erg
• Emergency Response Card: https://erplan.net/eplan/home.htm
6. Storage and Isolation
Storage and Isolation
• CAMEO Chemicals: http://www.cameochemicals.noaa.gov/
• IPCS: http://inchem.org/
http://www.who.int/ipcs/en/#
7. Substance Workplace Exposure Limits
Occupational Exposure Limits
• OSHA Chemical Sampling Information:
http://www.osha.gov/dts/chemicalsampling/toc/toc_chemsamp.html
• CAMEO Chemicals: http://www.cameochemicals.noaa.gov/
• Haz-Map: http://hazmap.nlm.nih.gov/index.php
• International Chemical Safety Card: http://www.cdc.gov/niosh/ipcs/icstart.html
http://www.cdc.gov/niosh/ipcs/ipcscard.html
8. Physical and Chemical Dangers
Physical and Chemical Properties
• QC Data Sheet and Certificate of Analysis
9. Stability and Reactivity
Stability and Reactivity
• CAMEO Chemicals: http://www.cameochemicals.noaa.gov/
• Incompatibility Charts:
http://www.uos.harvard.edu/ehs/environmental/EPAChemicalCompatibilityChart.pdf
• http://www.google.com/search?q=chemical+incompatibility+chart&hl=en&prmd=imvns&tbm=isch&tbo=u&s
ource=univ&sa=X&ei=_HiIUOT4KoOOygGiloCgDg&ved=0CCAQsAQ&biw=1280&bih=640
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3. 10. Toxicological Data
Toxicological Profile Information
• Product toxicology data; or
• Substance data (Step 1, Table 3)
11. Transportation
Transportation Information
• See Safety Data Sheet Authoring Guide
http://www.slideshare.net/TOXICOGENOMICS
• Hazardous Materials Table (49 CFR § 172.101):
http://www.setonresourcecenter.com/transportation/49CFR/172_101tb.pdf
12. Regulatory Information Lookup:
California Proposition 65:
http://www.oehha.ca.gov/prop65.html
CAMEO Chemicals:
http://www.cameochemicals.noaa.gov/
Clean Air Act:
http://www.thecre.com/fedlaw/legal14air/contents.htm
http://www.epa.gov/air/caa/
http://www.epa.gov/lawsregs/laws/caa.html
Clean Air Act, Section 112 (Hazardous Air Pollutants)
http://scorecard.goodguide.com/chemical-groups/one-list.tcl?short_list_name=hap (HAPs)
http://www.epa.gov/ttn/atw/112g/112gpg.html
http://www.law.cornell.edu/uscode/text/42/7412
http://www.scdhec.gov/environment/baq/112r/
40 CFR Part 61 - National Emission Standards for Hazardous Air Pollutants (NESHAPS):
http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&tpl=/ecfrbrowse/Title40/40cfr61_main_02.tpl
http://www.law.cornell.edu/cfr/text/40/61
http://www.tceq.state.tx.us/permitting/air/rules/federal/61/61hmpg.html
Collecting and Assessing Information on Chemicals
http://www.epa.gov/oppt/existingchemicals/pubs/collectinfo.html
Emergency Planning and Community Right-To-Know Act (EPCRA):
http://www.epa.gov/oecaagct/lcra.html
http://www.epa.gov/oem/content/epcra/epcra_storage.htm (EPCRA Sections 311-312)
http://www.gecap.org/tghtml/epcra2pg.html
http://oecscomply.com/index.html
EPA Envirofacts
http://www.epa.gov/enviro/index.html
EPA’s Existing Chemicals:
http://www.epa.gov/oppt/existingchemicals/index.html
http://www.epa.gov/oppt/existingchemicals/
http://www.epa.gov/oppt/existingchemicals/pubs/findinfo.html (Finding Public Information on Chemicals)
EPA’s Substance Registry Services:
http://iaspub.epa.gov/sor_internet/registry/substreg/searchandretrieve/advancedsearch/search.do
Toxic Release Inventory:
http://www.epa.gov/TRI/
http://www.epa.gov/enviro/facts/tri/ez.html
http://www.epa.gov/tri/trichemicals/ (SARA 313)
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4. TSCA Chemical CAS Number Lookup:
http://www.epa.gov/emefdata/TSCA.lookup_window?v_type=N&v_field=fac_value
TSCA Chemical Name Lookup:
http://www.epa.gov/emefdata/TSCA.lookup_window?v_type=C&v_field=fac_value
Note: For training purposes only! Use at your own risk.
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