AppTrim® is a medical food manufactured in a cGMP certified facility in the United States, that is specially formulated to manage the increased nutritional requirements of obesity. AppTrim provides the specific amino acids and nutrients required by the body to stimulate the production of key neurotransmitters responsible for controlling appetite, hunger and satiety. AppTrim is clinically proven to reduce appetite, carbohydrate cravings and weight when used in addition to a daily exercise and nutrition plan

1. AppTrim®
For the dietary
management of
obesity.

2. Providing Patients with a Safer & More
Effective Way to Manage Obesity

3. 03
AppTrim®
A Healthy Way to Manage Obesity
u
Patented Technology
Ingredient technology that
improves the uptake and
conversion of amino acids
to neurotransmitters.
Decreased Appetite
Improving amino acid
levels can help control
hunger and cravings.
Safe & Effective
Clinically proven ingredients
that are Generally
Recognized as Safe.
Amino Acids
The fuel the nervous
system needs to
communicate efficiently.
Improve BMI
Decreasing the daily
caloric intake can help
decrease BMI.
Order Today
To register an online ordering
account please visit:
www.medicalfoodorders.com

4. 04
AppTrim®
Decreased Appetite in Double-Blind Study
3.52
3.323.32
3.28
3.15
3.2
3.25
3.3
3.35
3.4
3.45
3.5
3.55
AppTrim Placebo
AppetiteIndex
Baseline Six Weeks
In one double-blind, placebo controlled study*, patients taking AppTrim twice daily
for six weeks experienced a significant reduction in appetite when compared to
placebo.
* Targeted Medical Pharma; P-105 study; A double-blind placebo controlled trial on the effect of AppTrim on Appetite Suppression and Obesity Management; 2011

5. 05
AppTrim®
Reduction of Body Weight at 6 Weeks
Placebo AppTrim
In one double-blind, placebo controlled study*, weight loss occurred gradually over a 6 week
period in the AppTrim group compared to placebo. Losses averaged 0.5-1 lb/week, consistent
with a healthy rate of weight loss.
* Targeted Medical Pharma; P-105 study; A double-blind placebo controlled trial on the effect of AppTrim on Appetite Suppression and Obesity Management; 2011
-4.5
-4
-3.5
-3
-2.5
-2
-1.5
-1
-0.5
0
Baseline Week 2 Week 4 Week 6
WeightLoss(lbs)

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The Distinct Amino Acid Requirements of Obesity
Connecting Nutrition to Medicine
Recent studies focusing on amino acids and neurotransmitters have consistently revealed disruption of
normal amino acid metabolism in obese, insulin-resistant states and Type 2 diabetes.*
*Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH, “Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-diabetic and
Type 2 Diabetic Obese African-American Women” PLoS ONE 2010;5:e15234

7. 07
AppTrim®
Amino Acid Requirements of Obesity
Neurotransmitters are prevalent in the stomach and act as
important mediators of hunger and satiety. They are
responsible for conveying information to regions of the brain
that regulate energy balance.* Imbalance of certain
neurotransmitters will impact weight regulation, appetite and
satiety.
Neurotransmitters and their amino acid precursors control
appetite, satiety, and carbohydrate cravings. Obese patients
often lack appropriate levels of amino acids and
neurotransmitters that are responsible for controlling
appetite, satiety and carbohydrate cravings.**
Increasing the availability of certain amino acids is critical to
increasing neurotransmitter production, helping to control
appetite and regulate body weight more effectively.
*Bray, GA “Medical treatment of obesity: the past, the present and the future” Best Pract. Res
Clin Gastroenterol. 2014 Aug; 28 (4): 665-84
**Wurtman RJ, Wurtman, JJ “Brain Serotonin, carbohydrate-craving, obesity and depression”
Obesity Research Nov 1995 vol 3, Issue S4 pg 477S-480S

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As a medical food, AppTrim addresses specific amino acid deficiencies associated with obesity. Addressing the increased
amino acid requirements of obesity can help coordinate communication between the brain, stomach and nervous system
helping to reduce appetite quicker and for a longer period of time. AppTrim is an important part of an Obesity management
program and is a safe and effective tool for reducing appetite, BMI and managing obesity.
Amino Acids and Appetite
Control Appetite and Satiety with Targeted Nutrition
Amino acids and neurotransmitters,
particularly serotonin and dopamine, play a
key role in regulating appetite. It has been
observed that low serotonin and dopamine
levels trigger carbohydrate cravings and
increased consumption of calories.

9. PRECAUTIONS AND CONTRAINDICATIONS
AppTrim is contraindicated in an extremely small number of patients with hypersensitivity to any of the nutritional components of AppTrim.
ADVERSE REACTIONS
Ingestion of L-Tryptophan or Choline at high doses of up to 15 grams daily is generally well tolerated. The most common adverse reactions of
higher doses — from 15 to 30 grams daily — are nausea, abdominal cramps, and diarrhea. AppTrim contains less than 1 gram per dose of
amino acids however, some patients may experience these symptoms at lower doses. The total combined amount of amino acids in each
AppTrim capsule does not exceed 300 mg.
DRUG INTERACTIONS
AppTrim does not directly influence the pharmacokinetics of prescription drugs. Clinical experience has shown that administration of AppTrim
may allow for lowering the dose of co-administered drugs under physician supervision.
OVERDOSE
There is a negligible risk of overdose with AppTrim as the total amount of amino acids in a one month supply (120 capsules) is less than 30
grams. Overdose symptoms may include diarrhea, weakness, and nausea.
09
Safety Information

10. 1. Kaidar-Person Orit; Person Benjamin; Szomstein Samuel; Rosenthal Raul J. “Nutritional Deficiencies in Morbidly Obese Patients: A New Form of Malnutrition Part A:
Vitamins. Obesity Surgery 2008, vol. 18 No. 7 pp. 870-876
2. Toh SY, Zarshenas N, Jorgensen J. “Prevalence of Nutrient Deficiencies in Bariatric Patients” Nutrition 2009; 25(11-12): 150-6
3. Moize V, Deulofeu R, Torres F, de Ossaba JM, Vidal J. “Nutritional Intake and Prevalence of Nutritional Deficiencies Prior to Surgery in a Spanish Morbidly Obese Population”
Obes Surg 2011; 21(9): 1382-8
4. Antje Damms-Machado, Gesine Weser, Stephan C. Bischoff, “Micronutrient Deficiency in Obese Subjects Undergoing low calorie diet” Nutr J. 2012; 11:34
5. Balthasar N, Dalgaard LT, Lee CE, Yu J, Fumahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, et al. “Divergence of Melanocortin Pathways in the Control of
Food Intake and Energy Expenditure” Cell 2005; 123:493-505
6. Xu Y, Tong Q. “Expanding Neurotransmitters in the hypothalamic Neurocircuitry for Energy Balance Regulation” Protein Cell 2011; 2:800-813
7. Kabadi Shaum, Lui Longjian, “Increased Risk for Diabetes when Obesity and Low Vitamin D are Present” Diabetes Care
8. Adams, Sean “Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State” Adv Nutr Nov 2011 vol. 2: 445-456
9. Menge BA, Schrader H, Ritter PR, Ellrichmann M, Uhl W, Schmidt WE, Meier JJ “”Selective Amino Acid Deficiency in Patients with Impaired Glucose Tolerance and Type 2
Diabetes” Regul Pept 2010 Feb 25; 160 (1-3): 75-80
10. McClung JP, Karl JP “Iron Deficiency and Obesity: the Contribution of Inflammation and Diminished Iron Absorption” Nutr Rev. 2009; 67:100-104
11. Dibaise, JK, Frank, DN, Mathur, R “Impact of the gut microbiota on the development of obesity: current concepts” Am J Gastroenterol Suppl (2012) 1:22-27
12. Collado MC, Isolauri E, Laitinen K et al. “Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women” Am J Clin Nutr 2008; 88: 894-
899
13. Meister B. “Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight” Physiol Behav 2007; 92: 263-271
14. Breum L, Rasmussen MH, Hilsted J, Fernstrom JD “Twenty four hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not
normalized by substantial weight reduction” Am J Clin Nutr 2003 May; 77(5): 1112-8
15. Fernstrom MH “Depression, antidepressants, and body weight” Ann Ny Acad Sci 1989; 575: 31- 40
16. Wurtman RJ, Wurtman, JJ “Brain Serotonin, carbohydrate-craving, obesity and depression” Obesity Research Nov 1995 vol 3, Issue S4 pg 477S-480S
17. Reinholz J, Skopp O, Breitenstein, C, Bohr I, Wiinterhoff H, Knecht S “Compensatory weight gain due to dopaminergic hypofucntion: new evidence and own incidental
observations” Nutrition & Metabolism 2008, 5:35
10
Selected References
What Does the Science Say?

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For More Information
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