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Histophysiology of muscle
tissues
The structural unit of muscle
tissue is muscle fibre
Muscle as organ
Skeletal muscles
Myofibril
Myofibril
Sarcomere
Myofilamentes
Mechanism of contraction
http://www.youtube.com/watch?v=ELyoJZom5N0
Myofilaments sliding theory
Targets of calcium
Look inside
T- and L-systems
Look inside
Filaments arrangement




http://www.mechanobio.info/Home/essential-info/What-are-Motor-Proteins/myosin-role-in-contraction
Dystrophin   Dystrophin stabilizes the
             sarcolemma and protects
             muscle fibres from long-term
             contraction-induced damage
             and necrosis.
             Dystrophin serves to link the
             intracellular microfilament
             network of actin to a complex
             series of linking proteins in the
             cell membrane, and hence to
             the extracellular matrix
How to get energy during
contraction
Fitness
Physical training and ANS
Physical training and resistence
to stress


                   Physical
                   training
Will be discussed during circulatory system
lecture
Smooth muscle tissue
Significance of smooth
   myocytes




Gastro-Intestinal smooth myocytes:

- Contractile type - Tone of gut, gut motility
- pacemaker (Interstitial cells of Cajal) – tone control, generation of electrical
slow waves
Significance of smooth
  myocytes




Vascular smooth myocytes:
-Tcontractile type - tone of vessel – resistence – blood pressure
- secretory rype – matrix production
Types of smooth myocytes
News about smooth muscles
   miRNA-mediated SMC remodelling
Contraction of of smooth
myocyte
Filamentes arrangement in smooth
myocyte
Molecular organisation of
filaments in smooth myocyte
Caveolae of smooth myocyte
Caveolae nature
Caveolae significance
Regulation of smooth
  myocytes

Neural



                         Paracrine




Humoral
Diagnostics

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Muscle tissues