Stem Cell Banking is a process of preserving your stem cells for future use. Dental stem cell banking in India is pioneered by Stemade Biotech. Dental Stem Cells / Mesenchymal Stem Cells (MSCs) are harvested from the milk teeth of children in the age group of 6 -12 years and wisdom teeth of young adults. Stem cell therapy is the new realm of regenerative medicine for Diabetes Type 1, Wound Healing, Parkinson's, Spinal Cord Injury, MI, MS, and Osteoarthritis and for many more ailments.

1. How do you see your children living their life ahead of them? 1

2. The answer lies somewhere in the anxiety you felt…when she took those fragile first steps. 2

3. 3 Answer lies in the panic his first fall from the cycle created…

4. 4 Answer lies in the wrinkles on your forehead and smile on your face when she came home with a bruise and a trophy.

5. 5 The fact is…despite the fear of accidents and injuries you want your child to be walking tall, running faster and jumping higher than before.

6. 6 Injuries happen… if there is a cure for them, your child will live their life the way you want them to live…

7. 7 …SECURE and FEARLESS.. And get best Quality of Life.

8. Did You Know? Average life expectancy in India is increasing by 5 years every decade… A child who is 10 years old today is expected to live up to age of 85yrs! 8

9. With increasing incidences of lifestyle diseases will this long life be of QUALITY… 9 We Wonder…

10. 10 Leon Eldred once said - “If I'd known I was going to live so long, I'd have taken better care of myself.”

11. What we do to ensure better quality of life? Vaccination Health Insurance Improved Diet & Nutrition Sport & Exercise … and for some fortunate children ‘Banking Stem Cells’ 11

12. Stem Cells are those master cells of the body that can be transformed into any other cell of the body. 12 What are Stem Cells?

13. Types of Stem Cells? Stem Cell Sources in Body Umbilical Cord Blood Bone Marrow Dental Pulp 13

15. Can be used to become tissue or organ specific cells.

16. Are responsible for repair of body

17. Can be stored for long term and can remain undifferentiated for a long time. 14

18. 15 What is Stem Cells Banking? Stem cell banking is the process of preserving your stem cells at temperatures several degrees below freezing point (Cryopreservation).

19. 16 Stem cell banking today is a worldwide phenomenon. In many countries it is now mandatory for doctors to inform parents about stem cell banking when they give birth to babies so that the stem cells can be extracted from the umbilical cord.

20. 17 Conventionally stem cells are extracted at the time of birth of a child from the umbilical cord. This timing is critical and so is the awareness of parents.

21. 18 Why Stem Cell Banking? You don’t want to use them, like you don’t want to visit the doctor. But if need be, these stem cells can possibly provide a cure for many conditions and offer opportunities for improved quality of life.

22. “ I was upset when I couldn’t bank umbilical cord stem cells for my elder 6 year old. It was a miserable feeling.” 19

23. Have you too missed the opportunity? Has your child missed the bus too? 20

24. 21 Good news is you can still avail the benefits of stem cells therapy, by banking your and your child’s Dental Stem Cells!

25. Dental stem cells can be preserved from milk teeth of children of age group 6 – 12 years and healthy wisdom teeth of young adults of age 30 years or more. 22

26. Dental pulp is a “cell-rich” zone, home to mesenchymal stem cells (MSC) - STEM CELLS THAT MAKE THE SOLID TISSUE OF THE BODY… 23

27. Dental Stem Cells For Improved Quality of Life In condition where cell damage is involved - e.g.Osteoarthritis, Diabetes, Heart Attack, Eye Care, Parkinson's, Spinal Cord Injury, Hair Loss, wounds, etc. dental stem cells can be used to repair and/or generate brand new healthy cells; without invasive procedures. 24

28. As we talk here today, many more applications of stem cells driven re-generative therapy are being researched. Soon stem cell will be available for cosmetic applications such as hair growth, skin, etc. 25

29. India is slated to be one of the leaders in stem cell research.. Government of India alone has invested significantly for such studies and trials… India is emerging as Research Hub for stem cells. Cardiac Corneal / Limbal Mesenchymal Neural Mesenchymal Mesenchymal Hematopoietic Corneal 26

30. Here Dental stem cell are extracted from the pulp of a tooth, and stored at a temperature of -156oC. It is an amazingly simple non invasive pain free method of tooth collection. You come to the clinic around the time your tooth was about to fall. And in a couple of minutes we send you back with the simple prescription of an ice cream. 27 What is Dental Stem Banking?

32. Bones shrink in size and density

34. Kidney and liver functions begin to decrease… You age… your organs age… because the cells inside them age.

35. 29 Why Now? Stem Cells too experience changes with aging. They become larger and are less able to divide and reproduce. Mostcells lose there ability to function or they begin to function abnormally. If you want to utilize the full potential of stem cells … you have to bank them NOW…

36. 30 Once collected and preserved your stem cells last for an entire lifetime!

37. Stemade is pioneering dental stem cell banking in India. With its trademark Smile Clinics established in all the major cities of India. Stemade is also the first private dental stem cell bank and undoubtedly the most advanced when it comes to technology. 31

39. ISO Certification

40. US FDA ApprovedThe technology was established in 2008. Stemadegot this to India within two years of discovery 32

42. presence of mesenchymal stem cells

43. viability of the cells

44. Serology test

45. Sterility testCryopreservation of viable stem cells at -150 O C in liquid nitrogen Preservation Certificate The extraction of the tooth would done by the dentist, ensuring the dental pulp is intact Specifically formulated and imported preservative medium is used to ensure sterility of the dental pulp The extracted tooth is transported to the lab in a specially designed dental sampling kit to ensure controlled temperature Trained paramedics would collect the blood sample for serology testing 33

46. “When we walked out of the Stemade Clinic, as a mother I felt an instinct, which told me that I just did the right thing. A feeling I would describe as… FEARLESS maybe...” 34

47. Parents experiences about taking their first step in securing a healthy future for their loved ones. The concept is very innovative. I went for dental stem cell banking to secure future of my son. My experience of dealing with Stemade Team was very good. I am hoping more stem cell researches are successful. Mrs. Urvi Kothari We feel stem cell banking would be beneficial in future. And now-a-days we do not know what we have in our hands so might be it will be of some help to Vardan in future. The process was very helpful & the people involved were very friendly. Mrs. AparnaVelu 35

48. When our daughter was born umbilical cord banking was not available hence this is useful for us. It may benefit for Nitya if she requires it at any time in future. Also my husband is suffering from kidney disorder and with the breakthroughs in medicine maybe in future it would be of some help to him also.It was very easy and the service with timelines was prompt as also the callbacks. Mrs. Aarti K. My dentist recommended it to me. My experience of dental stem cell banking with Stemade was pretty good. You should be creating more awareness campaigns especially at pediatric dentists. Mr. Rajesh M. 36

49. It is the right thing; using science & technology diseases can be cured. I went for dental stem cell banking because it was the most appropriate thing to do & the best investment for securing my child's future. I have spoken with many people regarding the concept. Mr. Shailesh Dhuri Dental Stem Cell banking is unique as a technology and I am glad that I could encash on the opportunity this time around. Unfortunately, my child Pranav had lost all his milk tooth by then. However, the experts at stemade suggested that Pranav's MOLARS could also be banked. As a parent I am content that I took this decision to bank the MOLAR of my child.I have taken it as an insurance of my child and it does not cost much looking at the benefits it can offer. Mrs. Roli Gupta 37

50. I strongly think or rather I must say that Stemade came forward as a REAL tooth fairy for my daughter's future security health assurance. I think instead of putting our child's tooth under pillow for tooth fairy, consider how dental stem cells could one day help protect health of our family. Mrs. Kanwal & Capt.A.S.Sethy When our children were born umbilical cord banking was not known to us. The concept of dental stem cell banking is new and hopefully would be able to cure diseases in future. We decided to bank dental stem cell for our twins as insurance. The milk teeth are anyway going to fall, why not preserve them. I have already spoken to some of friends about the concept. Mr. A. Srinivas & Mrs. A. Padma 38

51. Grow an Entire Healthy Life Time From a Single Tooth! 39