Scientists long ago discovered that a class of naturally-occurring pigments called carotenoids held powerful antioxidant properties that are crucial for eye health. This carotenoid is called astaxanthin. Astaxanthin is produced by the microalgae Haematococcus pluvialis when its water supply dries up, forcing it to protect itself from ultraviolet radiation. Astaxanthin is leaps and bounds more powerful than beta-carotene, alpha-tocopherol, lycopene, and lutein--other members of its chemical family. Astaxanthin exhibits very strong free radical scavenging activity, and protects eyes from oxidative damage. Astaxanthin is by far the most powerful carotenoid antioxidant when it comes to free radical scavenging: it is 65 times more powerful than vitamin C, 54 times more powerful than beta-carotene, and 14 times more powerful than vitamin E. Astaxanthin is far more effective than other carotenoids at "singlet oxygen quenching," which is a particular type of oxidation. The damaging effects of sunlight and various organic materials are caused by this less-stable form of oxygen. Astaxanthin is 550 times more powerful than vitamin E and 11 times more powerful than beta-carotene at neutralizing this singlet oxygen. Astaxanthin crosses the blood-brain barrier and the blood-retinal barrier which has huge implications for the health of eyes.
This document describes a study that investigated the neuroprotective effects of carnosine and cyclosporine-A against oxidative brain damage following closed head injury in immature rats. The study found that closed head injury significantly increased markers of oxidative stress, inflammation, apoptosis and brain damage in rats. Treatment with either carnosine or cyclosporine-A helped reduce these biomarkers, with the combination treatment having the strongest protective effects. The results suggest that carnosine and cyclosporine-A exert synergistic neuroprotective effects following traumatic brain injury by reducing oxidative stress, inflammation and apoptosis.
This document discusses research on the neuroprotective properties of natural astaxanthin. It summarizes studies showing that astaxanthin protects brain cells by preventing DNA damage and supporting mitochondrial function. Specifically, human research found that astaxanthin improved markers of dementia and cognitive function in elderly subjects. Additional pre-clinical research substantiated these findings. The document also discusses astaxanthin's strong antioxidant and anti-inflammatory activities, and how these contribute to its neuroprotective effects. It concludes that astaxanthin is a promising nutrient for maintaining brain health with age due to its ability to cross the blood-brain barrier and its demonstrated neuroprotective activities.
This document summarizes research on the anti-aging benefits of astaxanthin. It discusses several human clinical studies that have shown astaxanthin to have benefits for eye health including reducing eye fatigue, strain, and improving accommodation at doses of 4-12mg per day. Studies also found improved visual acuity, depth perception, and retinal blood flow. The document suggests astaxanthin addresses many aging-related health concerns and that most people over age 40 should supplement with at least 4mg daily to protect cells, DNA, mitochondria, and reduce inflammation.
Astashine capsules: an excellent choice for skin aging defenceSriramNagarajan18
Astashine capsules contain 2mg of naturally derived astaxanthin from algae extract to protect skin from aging. Clinical trials show astaxanthin reduces wrinkles and improves skin elasticity and moisture. Its strong antioxidant properties allow it to protect skin cells from damage caused by UV radiation and reactive oxygen species 10 times stronger than other antioxidants. Both oral and topical application of astaxanthin have demonstrated skin benefits with no safety concerns reported.
Excessive exposure of unprotected skin to sunlight results in sunburn and can also lead to photo-induced oxidation, inflammation, immunosuppression, aging and even carcinogenesis of skin cells. A pre-clinical study shows that typical dietary antioxidant, could reduce such damages. Astaxanthin is believed to protect the skin against UV-light photo-oxidation and the in vitro protective effect of Astaxanthin against UV-induced photooxidation was stronger when compared with β-carotene and lutein.
Astaxanthin is a potent antioxidant derived primarily from microalgae. It has many health benefits including reducing inflammation and oxidative stress. As a carotenoid, it has antioxidant properties much higher than other carotenoids and vitamins. It shows promise in reducing risk of heart disease, diabetes, macular degeneration and cancer. Absorption is optimized when taken with oils and bioavailability ranges from 10-20%. Recommended dosage is 2-4mg daily and it is generally well tolerated with no known toxicity.
This document discusses natural astaxanthin as the most versatile nutrient for eye health. It begins by summarizing the early research on astaxanthin's protective effects for the eyes conducted in France in the 1940s-1950s. It then discusses how astaxanthin is quantitatively and qualitatively a much stronger antioxidant than other nutrients like lutein, zeaxanthin, beta-carotene, and vitamin E based on numerous studies. Specifically, astaxanthin has been shown to be over 500 times stronger than vitamin E and over 10 times stronger than beta-carotene at eliminating singlet oxygen. The document also notes that astaxanthin has anti-inflammatory properties and can cross the blood-brain
Live Longer, Stay healthy, Feel better with AstashinecapsulesSriramNagarajan19
ASTASHINE capsule contains natural astaxanthin from Haematococcus pluvialis Astaxanthin has exceptional antioxidant activity to combat singlet oxygen when compared to other antioxidants. In particular, Astaxanthin can be used to defend against singlet oxygen damage, which are especially susceptible to aging effects.
In this study, Astaxanthin extracted from Haematococcus microalgae powerfully quenched singlet oxygen. Results show that the quenching effect of Astaxanthin is 800 times greater than coenzyme Q10. Astaxanthin was also about 75 times greater than alpha lipoic acid, about 550 times greater than green tea catechins and about 6000 times greater than Vitamin C.the present Article reviews the role of ASTASHINE capsules as World’s most powerful Antioxidant and Anti-aging Nutrient.
This document describes a study that investigated the neuroprotective effects of carnosine and cyclosporine-A against oxidative brain damage following closed head injury in immature rats. The study found that closed head injury significantly increased markers of oxidative stress, inflammation, apoptosis and brain damage in rats. Treatment with either carnosine or cyclosporine-A helped reduce these biomarkers, with the combination treatment having the strongest protective effects. The results suggest that carnosine and cyclosporine-A exert synergistic neuroprotective effects following traumatic brain injury by reducing oxidative stress, inflammation and apoptosis.
This document discusses research on the neuroprotective properties of natural astaxanthin. It summarizes studies showing that astaxanthin protects brain cells by preventing DNA damage and supporting mitochondrial function. Specifically, human research found that astaxanthin improved markers of dementia and cognitive function in elderly subjects. Additional pre-clinical research substantiated these findings. The document also discusses astaxanthin's strong antioxidant and anti-inflammatory activities, and how these contribute to its neuroprotective effects. It concludes that astaxanthin is a promising nutrient for maintaining brain health with age due to its ability to cross the blood-brain barrier and its demonstrated neuroprotective activities.
This document summarizes research on the anti-aging benefits of astaxanthin. It discusses several human clinical studies that have shown astaxanthin to have benefits for eye health including reducing eye fatigue, strain, and improving accommodation at doses of 4-12mg per day. Studies also found improved visual acuity, depth perception, and retinal blood flow. The document suggests astaxanthin addresses many aging-related health concerns and that most people over age 40 should supplement with at least 4mg daily to protect cells, DNA, mitochondria, and reduce inflammation.
Astashine capsules: an excellent choice for skin aging defenceSriramNagarajan18
Astashine capsules contain 2mg of naturally derived astaxanthin from algae extract to protect skin from aging. Clinical trials show astaxanthin reduces wrinkles and improves skin elasticity and moisture. Its strong antioxidant properties allow it to protect skin cells from damage caused by UV radiation and reactive oxygen species 10 times stronger than other antioxidants. Both oral and topical application of astaxanthin have demonstrated skin benefits with no safety concerns reported.
Excessive exposure of unprotected skin to sunlight results in sunburn and can also lead to photo-induced oxidation, inflammation, immunosuppression, aging and even carcinogenesis of skin cells. A pre-clinical study shows that typical dietary antioxidant, could reduce such damages. Astaxanthin is believed to protect the skin against UV-light photo-oxidation and the in vitro protective effect of Astaxanthin against UV-induced photooxidation was stronger when compared with β-carotene and lutein.
Astaxanthin is a potent antioxidant derived primarily from microalgae. It has many health benefits including reducing inflammation and oxidative stress. As a carotenoid, it has antioxidant properties much higher than other carotenoids and vitamins. It shows promise in reducing risk of heart disease, diabetes, macular degeneration and cancer. Absorption is optimized when taken with oils and bioavailability ranges from 10-20%. Recommended dosage is 2-4mg daily and it is generally well tolerated with no known toxicity.
This document discusses natural astaxanthin as the most versatile nutrient for eye health. It begins by summarizing the early research on astaxanthin's protective effects for the eyes conducted in France in the 1940s-1950s. It then discusses how astaxanthin is quantitatively and qualitatively a much stronger antioxidant than other nutrients like lutein, zeaxanthin, beta-carotene, and vitamin E based on numerous studies. Specifically, astaxanthin has been shown to be over 500 times stronger than vitamin E and over 10 times stronger than beta-carotene at eliminating singlet oxygen. The document also notes that astaxanthin has anti-inflammatory properties and can cross the blood-brain
Live Longer, Stay healthy, Feel better with AstashinecapsulesSriramNagarajan19
ASTASHINE capsule contains natural astaxanthin from Haematococcus pluvialis Astaxanthin has exceptional antioxidant activity to combat singlet oxygen when compared to other antioxidants. In particular, Astaxanthin can be used to defend against singlet oxygen damage, which are especially susceptible to aging effects.
In this study, Astaxanthin extracted from Haematococcus microalgae powerfully quenched singlet oxygen. Results show that the quenching effect of Astaxanthin is 800 times greater than coenzyme Q10. Astaxanthin was also about 75 times greater than alpha lipoic acid, about 550 times greater than green tea catechins and about 6000 times greater than Vitamin C.the present Article reviews the role of ASTASHINE capsules as World’s most powerful Antioxidant and Anti-aging Nutrient.
Astaxanthin - Strongest & Highest Quality Antioxidant white paperAlgaeHealthSciences
This document discusses astaxanthin as the world's strongest natural antioxidant. It begins by explaining how modern life has increased oxidative stress in the body beyond what can be handled by endogenous and dietary antioxidants alone. It then reviews studies that have found astaxanthin to be a much more powerful antioxidant than other carotenoids like beta-carotene and lutein, as well as vitamins C and E. Specifically, one study found astaxanthin was 550 times stronger than vitamin E at eliminating singlet oxygen. The document argues the qualitative properties of astaxanthin, such as its ability to cross the blood-brain barrier, make it the highest quality antioxidant available to support health and longevity.
1. Antioxidants like vitamin E, vitamin C, and carotenoids help neutralize harmful free radicals in the body.
2. Free radicals can damage cells, DNA, and other important molecules if left unchecked and have been linked to diseases such as cancer and heart disease.
3. Antioxidants donate an electron to free radicals without becoming unstable themselves, which stops the free radical chain reaction and prevents oxidative damage throughout the body.
The document discusses antioxidants and their role in reducing oxidative stress and free radicals in the body. It provides information on various antioxidants like vitamins A, C, E, carotenoids such as astaxanthin and lutein. Astaxanthin is highlighted as a powerful antioxidant found in marine organisms that is more effective than vitamins C and E. It has anti-inflammatory properties and can protect cells from damage caused by reactive oxygen species. Studies show astaxanthin may help reduce the risk of diseases like cardiovascular disease and dementia by lowering oxidative stress.
The document summarizes information about stem cells and stem cell enhancement products. It discusses embryonic stem cells, adult stem cells from bone marrow, and stem cells from umbilical cords. It then describes a company called CoSTEMTech that produces a stem cell enhancer product called StemEnhance made from algae that grows in Klamath Lake, Oregon. The document provides details on the health benefits and components of StemEnhance and outlines the business opportunity to become a distributor.
This document discusses the benefits of natural astaxanthin for athletes and active individuals. It begins by outlining 10 human clinical trials and 25 supporting animal studies that demonstrate astaxanthin's ability to improve recovery from exercise, enhance energy levels, and increase strength and endurance. The document then analyzes astaxanthin's powerful antioxidant effects and anti-inflammatory properties, both of which help promote faster recovery from exercise. Studies show astaxanthin is the strongest natural antioxidant, significantly more potent than other carotenoids and vitamins like vitamin E. Its anti-inflammatory effects also help prevent muscle and joint soreness after exercise.
Free radicals are electron missing atoms or molecules. It is very unstable and react quickly with other compounds, trying to capture the needed electron to gain stability.
Generally, free radicals attack the nearest stable molecule, "stealing" its electron.
When the "attacked" molecule loses its electron, it becomes a free radical itself, beginning a chain reaction like snowball.
Once the process is started, it can cascade, finally resulting in the disruption of a living cell. The rule of antioxidants is to give electrons to free radicals and neutralize its destructive effects especially on the DNA.
Osteomed is a calcium-containing osteoprotector that was found to promote bone consolidation after fractures. A study of 300 patients with fractures compared those taking Osteomed, those taking a different calcium preparation, and those not taking calcium. Patients taking Osteomed saw callus formation within 3 weeks, allowing rehabilitation to begin earlier and a return to work after a month. Those taking the other calcium began rehabilitation at 4 weeks and returned to work after 1.5 months. Patients not taking calcium began rehabilitation at 1.5 months and returned to work after 2 months. Osteomed reduced immobilization periods after fractures.
Resveratrol Supplementation May Boost Eye HealthNutricap Labs
Looking for ways to support the health of your eyes? Our document discusses the benefits associated with adding resveratrol or red wine extract to your diet and how you can even start your own resveratrol supplement line!!
The document discusses several radical new medical treatments that could help heal and protect major organs in the human body. Bionic retinas may restore sight to blind patients. Drugs are being researched to slow or reverse Alzheimer's disease and reduce Parkinson's symptoms. Scientists are working on growing replacement teeth, vaccines to prevent tooth decay, and "smart fillings". Gene therapy and new drugs show promise for treating lung cancer, diabetes, paralysis, leukemia, overactive bladders, heart disease, and more. Researchers are developing treatments for knees, bones, foot ulcers, and breast cancer detection as well. While progress is being made, prevention is emphasized as better than cure.
ASTASHINE Capsule: A Potential Therapeutic Agent in Removing Body’s Toxins fr...IIJSRJournal
ASTASHINE capsule contains natural astaxanthin from Haematococcuspluvialis. Astaxanthin has exceptional antioxidant activity to combat singlet oxygen when compared to other antioxidants. In particular, Astaxanthin can be used to defend against singlet oxygen damage, which is especially susceptible to aging effects. In this study, Astaxanthin extracted from Haematococcus microalgae powerfully quenched singlet oxygen. Results show that the quenching effect of Astaxanthin is 800 times greater than coenzyme Q10. Astaxanthin was also about 75 times greater than alpha lipoic acid, about 550 times greater than green tea catechins and about 6000 times greater than Vitamin C. the present Article reviews the role of ASTASHINE capsule, A Potential Therapeutic Agent in Liver Health and Disease.
Age related macular degeneration (AMD) is a leading cause of vision loss among older adults that results from the degeneration of photoreceptors in the macula. While there is no cure for AMD, studies have found that increasing intake of the carotenoids lutein and zeaxanthin through diet or supplementation can help delay progression of the disease and potentially reverse visual impairment. The average American consumes only 1-3mg of lutein and zeaxanthin per day, but increasing intake to 10mg daily has been shown to be beneficial. Lutein and zeaxanthin accumulate in the macula and help protect against light-induced damage by reducing oxidative stress.
Age related macular degeneration (AMD) is a leading cause of vision loss among older adults that results from the degeneration of photoreceptors in the macula. While there is no cure for AMD, studies have found that increasing intake of the carotenoids lutein and zeaxanthin through diet or supplementation can help delay progression of the disease and potentially reverse visual impairment. The average American consumes only 1-3mg of lutein and zeaxanthin per day, but increasing intake to 10mg daily has been shown to benefit AMD prevention and treatment. Lutein and zeaxanthin accumulate in high concentrations in the macula where they help protect against light damage and reduce oxidative stress.
This document discusses antioxidants, what they are, how they work, and why they are important. It defines antioxidants as molecules that prevent oxidation and free radical damage by donating or accepting electrons from free radicals. Various categories of antioxidants are described, along with tests used to measure antioxidant capacity. The document emphasizes that antioxidants play an important role in health by reducing free radical damage linked to diseases, and recommends including antioxidant-rich foods like fruits and vegetables in the diet.
11 health benefits of resveratrol supplementsWisePowder123
https://www.wisepowder.com/11-health-benefits-of-resveratrol-supplements/https://www.wisepowder.com/product-details/501-36-0/Resveratrol is a natural polyphenol plant compound that acts as an antioxidant.Resveratrol sources include red wine, grapes, berries, peanuts, and dark chocolate. This compound seems to be highly concentrated in the seeds and skins of berries and grapes. Seeds and skins of grape are applied in the fermentation of resveratrol wine, and that’s why red wine is highly concentrated in resveratrol. Resveratrol uses in health and wellness include the management of a wide range of age-related health challenges, such as heart disease, Alzheimer’s.
Globally, Diabetes Mellitus and its complications is the third largest killer. At the current rate, the diabetic population of 171 million will increase to 366 million by 2030. One of the most common complications associated with DM is nephropathy or kidney damage. Diabetes is strongly linked to oxidative stress as either a consequence of increased ROS production, reduced antioxidant status, or both. Oxidative stress in diabetes is brought on by consistent hyperglycemia (high blood sugar levels) from a very high carbohydrate diet, reduced cell carbohydrate uptake, and/or low insulin output from the pancreas. Astaxanthin could lessen oxidative stress in pancreatic beta cells (the cells in body that produce insulin) caused by chronic high blood sugar levels. In turn, this improves the body’s ability to manage blood glucose levels by allowing the pancreatic cells to make the right amount of insulin when needed. Astaxanthin was found to improve pancreatic beta cell function and protect these cells from glucose toxicity, cell breakdown and death. This article reviews the current available scientific literature regarding the effect of astaxanthin from the algae Haematoccus pluvialis as Antidiabetic and kidney protector.
Glutathione and Carnosine are naturally occurring antioxidants in the human body that help protect cells. They decline with age and supplementation has been shown to increase levels by 300% or more. Raising levels of glutathione and carnosine through supplementation may lead to benefits like improved immune function, brain health, skin health, athletic performance, and longevity.
Glutathione and Carnosine are naturally occurring antioxidants in the human body that help protect cells. They decline with age and supplementation has been shown to increase levels by 300% or more. Raising levels of glutathione and carnosine through supplementation may lead to benefits like improved immune function, brain health, skin health, athletic performance, and longevity.
Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canariu...AI Publications
The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.
The document discusses using chitosan nanoparticles as a delivery system for flavonoids extracted from Moringa oleifera leaves to treat Alzheimer's disease. Chitosan was chosen as the nanoparticle material due to its mucoadhesivity and ability to enhance penetration across mucosal surfaces. The flavonoids would provide antioxidants to combat oxidative stress in Alzheimer's. The nanoparticles could be prepared using a bottom-up approach by dissolving the extract in chitosan solution before adding TPP. This nose-to-brain delivery system using mucoadhesive nanoparticles is expected to maximize the therapeutic effects of the active components in Moringa oleifera by enhancing transport across the blood-brain barrier.
A new RP -HPLC method development and validation for simultaneous estimation ...SriramNagarajan19
A simple, accurate, precise method was developed for the simultaneous estimation of the Aspirin and Omeprazole in Tablet dosage form. Chromatogram was run through Discovery 250 x 4.6 mm, 5m. Mobile phase containing Buffer and Acetonitrile in the ratio of 70:30 v/v was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Aspirin and Omeprazole was 241 nm. Retention time of Aspirin and Omeprazole were found to be 2.454 min and 3.168 min %RSD of the Aspirin and Omeprazole were and found to be 1.1 and 0.8 respectively. Percentage recovery was obtained as 99.50% and 99.57%for Aspirin and Omeprazole. LOD, LOQ values were obtained from regression equations of Aspirin and Omeprazole were 0.26ppm, 0.80ppm and 0.06ppm, 0.17ppm respectively. Regression equation of Aspirin is y = 3524x + 3853, and of Omeprazole is y = 10438x+542.2.
Nutrease powder; a natural plant based nutritional shake with co-factors & co...SriramNagarajan19
Nutrease powder is an effective natural vitamin and minerals Nutritional supplementation to improve metabolism. Nutrease powder just ½ serving (1 scoop) Provides 150 calories,18 grams of protein, 12 grams of fiber, and 1 gram of sugar per day. Nutrease powder Supports effective weight management, Reduces hunger and cravings, Promotes energy and positive mood, Promotes loss of fat and preservation of lean body mass, Improves metabolism and insulin sensitivity. This article reviews the current available scientific literature regarding the effect of nutrease powder as an effective supplementation for daily energy needs.
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Astaxanthin - Strongest & Highest Quality Antioxidant white paperAlgaeHealthSciences
This document discusses astaxanthin as the world's strongest natural antioxidant. It begins by explaining how modern life has increased oxidative stress in the body beyond what can be handled by endogenous and dietary antioxidants alone. It then reviews studies that have found astaxanthin to be a much more powerful antioxidant than other carotenoids like beta-carotene and lutein, as well as vitamins C and E. Specifically, one study found astaxanthin was 550 times stronger than vitamin E at eliminating singlet oxygen. The document argues the qualitative properties of astaxanthin, such as its ability to cross the blood-brain barrier, make it the highest quality antioxidant available to support health and longevity.
1. Antioxidants like vitamin E, vitamin C, and carotenoids help neutralize harmful free radicals in the body.
2. Free radicals can damage cells, DNA, and other important molecules if left unchecked and have been linked to diseases such as cancer and heart disease.
3. Antioxidants donate an electron to free radicals without becoming unstable themselves, which stops the free radical chain reaction and prevents oxidative damage throughout the body.
The document discusses antioxidants and their role in reducing oxidative stress and free radicals in the body. It provides information on various antioxidants like vitamins A, C, E, carotenoids such as astaxanthin and lutein. Astaxanthin is highlighted as a powerful antioxidant found in marine organisms that is more effective than vitamins C and E. It has anti-inflammatory properties and can protect cells from damage caused by reactive oxygen species. Studies show astaxanthin may help reduce the risk of diseases like cardiovascular disease and dementia by lowering oxidative stress.
The document summarizes information about stem cells and stem cell enhancement products. It discusses embryonic stem cells, adult stem cells from bone marrow, and stem cells from umbilical cords. It then describes a company called CoSTEMTech that produces a stem cell enhancer product called StemEnhance made from algae that grows in Klamath Lake, Oregon. The document provides details on the health benefits and components of StemEnhance and outlines the business opportunity to become a distributor.
This document discusses the benefits of natural astaxanthin for athletes and active individuals. It begins by outlining 10 human clinical trials and 25 supporting animal studies that demonstrate astaxanthin's ability to improve recovery from exercise, enhance energy levels, and increase strength and endurance. The document then analyzes astaxanthin's powerful antioxidant effects and anti-inflammatory properties, both of which help promote faster recovery from exercise. Studies show astaxanthin is the strongest natural antioxidant, significantly more potent than other carotenoids and vitamins like vitamin E. Its anti-inflammatory effects also help prevent muscle and joint soreness after exercise.
Free radicals are electron missing atoms or molecules. It is very unstable and react quickly with other compounds, trying to capture the needed electron to gain stability.
Generally, free radicals attack the nearest stable molecule, "stealing" its electron.
When the "attacked" molecule loses its electron, it becomes a free radical itself, beginning a chain reaction like snowball.
Once the process is started, it can cascade, finally resulting in the disruption of a living cell. The rule of antioxidants is to give electrons to free radicals and neutralize its destructive effects especially on the DNA.
Osteomed is a calcium-containing osteoprotector that was found to promote bone consolidation after fractures. A study of 300 patients with fractures compared those taking Osteomed, those taking a different calcium preparation, and those not taking calcium. Patients taking Osteomed saw callus formation within 3 weeks, allowing rehabilitation to begin earlier and a return to work after a month. Those taking the other calcium began rehabilitation at 4 weeks and returned to work after 1.5 months. Patients not taking calcium began rehabilitation at 1.5 months and returned to work after 2 months. Osteomed reduced immobilization periods after fractures.
Resveratrol Supplementation May Boost Eye HealthNutricap Labs
Looking for ways to support the health of your eyes? Our document discusses the benefits associated with adding resveratrol or red wine extract to your diet and how you can even start your own resveratrol supplement line!!
The document discusses several radical new medical treatments that could help heal and protect major organs in the human body. Bionic retinas may restore sight to blind patients. Drugs are being researched to slow or reverse Alzheimer's disease and reduce Parkinson's symptoms. Scientists are working on growing replacement teeth, vaccines to prevent tooth decay, and "smart fillings". Gene therapy and new drugs show promise for treating lung cancer, diabetes, paralysis, leukemia, overactive bladders, heart disease, and more. Researchers are developing treatments for knees, bones, foot ulcers, and breast cancer detection as well. While progress is being made, prevention is emphasized as better than cure.
ASTASHINE Capsule: A Potential Therapeutic Agent in Removing Body’s Toxins fr...IIJSRJournal
ASTASHINE capsule contains natural astaxanthin from Haematococcuspluvialis. Astaxanthin has exceptional antioxidant activity to combat singlet oxygen when compared to other antioxidants. In particular, Astaxanthin can be used to defend against singlet oxygen damage, which is especially susceptible to aging effects. In this study, Astaxanthin extracted from Haematococcus microalgae powerfully quenched singlet oxygen. Results show that the quenching effect of Astaxanthin is 800 times greater than coenzyme Q10. Astaxanthin was also about 75 times greater than alpha lipoic acid, about 550 times greater than green tea catechins and about 6000 times greater than Vitamin C. the present Article reviews the role of ASTASHINE capsule, A Potential Therapeutic Agent in Liver Health and Disease.
Age related macular degeneration (AMD) is a leading cause of vision loss among older adults that results from the degeneration of photoreceptors in the macula. While there is no cure for AMD, studies have found that increasing intake of the carotenoids lutein and zeaxanthin through diet or supplementation can help delay progression of the disease and potentially reverse visual impairment. The average American consumes only 1-3mg of lutein and zeaxanthin per day, but increasing intake to 10mg daily has been shown to be beneficial. Lutein and zeaxanthin accumulate in the macula and help protect against light-induced damage by reducing oxidative stress.
Age related macular degeneration (AMD) is a leading cause of vision loss among older adults that results from the degeneration of photoreceptors in the macula. While there is no cure for AMD, studies have found that increasing intake of the carotenoids lutein and zeaxanthin through diet or supplementation can help delay progression of the disease and potentially reverse visual impairment. The average American consumes only 1-3mg of lutein and zeaxanthin per day, but increasing intake to 10mg daily has been shown to benefit AMD prevention and treatment. Lutein and zeaxanthin accumulate in high concentrations in the macula where they help protect against light damage and reduce oxidative stress.
This document discusses antioxidants, what they are, how they work, and why they are important. It defines antioxidants as molecules that prevent oxidation and free radical damage by donating or accepting electrons from free radicals. Various categories of antioxidants are described, along with tests used to measure antioxidant capacity. The document emphasizes that antioxidants play an important role in health by reducing free radical damage linked to diseases, and recommends including antioxidant-rich foods like fruits and vegetables in the diet.
11 health benefits of resveratrol supplementsWisePowder123
https://www.wisepowder.com/11-health-benefits-of-resveratrol-supplements/https://www.wisepowder.com/product-details/501-36-0/Resveratrol is a natural polyphenol plant compound that acts as an antioxidant.Resveratrol sources include red wine, grapes, berries, peanuts, and dark chocolate. This compound seems to be highly concentrated in the seeds and skins of berries and grapes. Seeds and skins of grape are applied in the fermentation of resveratrol wine, and that’s why red wine is highly concentrated in resveratrol. Resveratrol uses in health and wellness include the management of a wide range of age-related health challenges, such as heart disease, Alzheimer’s.
Globally, Diabetes Mellitus and its complications is the third largest killer. At the current rate, the diabetic population of 171 million will increase to 366 million by 2030. One of the most common complications associated with DM is nephropathy or kidney damage. Diabetes is strongly linked to oxidative stress as either a consequence of increased ROS production, reduced antioxidant status, or both. Oxidative stress in diabetes is brought on by consistent hyperglycemia (high blood sugar levels) from a very high carbohydrate diet, reduced cell carbohydrate uptake, and/or low insulin output from the pancreas. Astaxanthin could lessen oxidative stress in pancreatic beta cells (the cells in body that produce insulin) caused by chronic high blood sugar levels. In turn, this improves the body’s ability to manage blood glucose levels by allowing the pancreatic cells to make the right amount of insulin when needed. Astaxanthin was found to improve pancreatic beta cell function and protect these cells from glucose toxicity, cell breakdown and death. This article reviews the current available scientific literature regarding the effect of astaxanthin from the algae Haematoccus pluvialis as Antidiabetic and kidney protector.
Glutathione and Carnosine are naturally occurring antioxidants in the human body that help protect cells. They decline with age and supplementation has been shown to increase levels by 300% or more. Raising levels of glutathione and carnosine through supplementation may lead to benefits like improved immune function, brain health, skin health, athletic performance, and longevity.
Glutathione and Carnosine are naturally occurring antioxidants in the human body that help protect cells. They decline with age and supplementation has been shown to increase levels by 300% or more. Raising levels of glutathione and carnosine through supplementation may lead to benefits like improved immune function, brain health, skin health, athletic performance, and longevity.
Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canariu...AI Publications
The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.
The document discusses using chitosan nanoparticles as a delivery system for flavonoids extracted from Moringa oleifera leaves to treat Alzheimer's disease. Chitosan was chosen as the nanoparticle material due to its mucoadhesivity and ability to enhance penetration across mucosal surfaces. The flavonoids would provide antioxidants to combat oxidative stress in Alzheimer's. The nanoparticles could be prepared using a bottom-up approach by dissolving the extract in chitosan solution before adding TPP. This nose-to-brain delivery system using mucoadhesive nanoparticles is expected to maximize the therapeutic effects of the active components in Moringa oleifera by enhancing transport across the blood-brain barrier.
A new RP -HPLC method development and validation for simultaneous estimation ...SriramNagarajan19
A simple, accurate, precise method was developed for the simultaneous estimation of the Aspirin and Omeprazole in Tablet dosage form. Chromatogram was run through Discovery 250 x 4.6 mm, 5m. Mobile phase containing Buffer and Acetonitrile in the ratio of 70:30 v/v was pumped through column at a flow rate of 1 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Aspirin and Omeprazole was 241 nm. Retention time of Aspirin and Omeprazole were found to be 2.454 min and 3.168 min %RSD of the Aspirin and Omeprazole were and found to be 1.1 and 0.8 respectively. Percentage recovery was obtained as 99.50% and 99.57%for Aspirin and Omeprazole. LOD, LOQ values were obtained from regression equations of Aspirin and Omeprazole were 0.26ppm, 0.80ppm and 0.06ppm, 0.17ppm respectively. Regression equation of Aspirin is y = 3524x + 3853, and of Omeprazole is y = 10438x+542.2.
Nutrease powder; a natural plant based nutritional shake with co-factors & co...SriramNagarajan19
Nutrease powder is an effective natural vitamin and minerals Nutritional supplementation to improve metabolism. Nutrease powder just ½ serving (1 scoop) Provides 150 calories,18 grams of protein, 12 grams of fiber, and 1 gram of sugar per day. Nutrease powder Supports effective weight management, Reduces hunger and cravings, Promotes energy and positive mood, Promotes loss of fat and preservation of lean body mass, Improves metabolism and insulin sensitivity. This article reviews the current available scientific literature regarding the effect of nutrease powder as an effective supplementation for daily energy needs.
Analytical method development and validation for the estimation of quinapril ...SriramNagarajan19
A simple and selective LC method is described for the determination of Quinapril and Tolcapone tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a Mixed Phosphate buffer (KH2PO4 +K2HPO4): Acetonitrile 40:60, with detection of 239 nm. Linearity was observed in the range 50 - 150 µg /ml for Quinapril (r2 =0.995) and 62.5- 187.5µg /ml for Tolcapone (r2 =0.999) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.
The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
Method development and validation of simultaneous estimation of paracetamol &...SriramNagarajan19
A drug may be defined as a substance meant for diagnosis, cure, mitigation, prevention or treatment of diseases in human beings or animals or for alternating any structure or function of the body of human being or animals. Pharmaceutical chemistry is a science that makes use of general laws of chemistry to study drugs i.e. their preparation, chemical natures, composition, structure, influence on an organism and studies the physical and chemical properties of drugs, the methods of quality control and the conditions of their storage etc. the family of drugs may be broadly classified as.
1. Pharmacodynamic agents.
2. Chemotherapeutic agents.
It is necessary to find the content of each drug either in pure or single, combined dosage forms for purity testing. It is also essential to know the concentration of the drug and it’s metabolites in biological fluids after taking the dosage form for treatment.
The scope of developing and validating analytical methods is to ensure a suitable method for a particular analyte more specific, accurate and precise. The main objective for that is to improve the conditions and parameters, which should be followed in the development and validation.
WELLIA-R tablets; helps to protect brain tissue in cerebral edemaSriramNagarajan19
Boswellia serrate extract in Wellia- R gained significant importance in treatment of cerebral edema in patients with brain tumors, colon cancer, lung cancer, blood cancer, skin cancer, breast cancer, renal cancer, fibro sarcoma, prostate cancer and pancreatic cancer. The medicinal properties of Boswellia serrate extract in Wellia- R have been known and utilized since antiquity. Its current potential as an anti inflammatory and anticancer agent are being investigated and hold great promise. This article reviews the current available scientific literature regarding the effect of wellia-R tablets, from Boswellia serrate extract that Provides long lasting cerebral protection in brain tumor patients
Formulation and invivo evaluation of mucoadhesive microspheres embedded clero...SriramNagarajan19
In this study an attempt was made to prepare mucoadhesive microcapsules of Clerodendrum phlomidis extract using alginate polymers for prolonged release. Encapsulation of extract into sodium alginate polymer was done by ionic-gelation technique. In vivo testing of the mucoadhesive microcapsules in diabetic albino rats demonstrated significant antidiabetic effect of extract. The hypoglycemic effect obtained by mucoadhesive microcapsules was for more than 16 h whereas plain CP extract produced an antidiabetic effect for only 4 h suggesting that mucoadhesive microcapsules are a valuable system for the long term delivery of CP extract. In-vivo data obtained over a 120-h period indicate that CP extract loaded alginate microspheres from batch F7 showed the better glycemic control than control and a commercial brand of the drug.
Brian stroke memory impairment and treatment strategiesSriramNagarajan19
A brain stroke occurs when one of the brain parts are deprived form oxygen-rich blood due to various mechanism. Usually a brain stroke occurs when one of the arteries is blocked either because of narrowing of small arteries with in the brain or the hardening of the arteries that lead to atherosclerosis strokes can be either ischemic (85%) or Hemorrhagic (15%). Forget fullness is a common complaint among older people. Age –related memory changes are not the same thing as dementia. Preventing memory loss is by exercise regularly staying social, manage stress, get plenty of sleep and don’t smoke. Eat plenty of fruits and vegetable and take food contain antioxidant in abundance; will reduce your risk of stroke. Walking regularly is an easy to fight memory loss and also brain exercises to prevent loss and boost brainpower. Research is going no to enhance memory power in brain in patient with brain stroke.
A new analytical method development and validation for the estimation of lenv...SriramNagarajan19
A simple and selective LC method is described for the determination of Lenvatinib dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Phosphate buffer (KH2PO4): Acetonitrile (80:20) with detection of 240nm. Linearity was observed in the range 60-140 µg /ml for Lenvatinib (r2 =0.996) for the amount of drug estimated by the proposed methods was in good agreement with the label claim.
The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
A new analytical method development and validation for the simultaneus estima...SriramNagarajan19
A simple and selective LC method is described for the determination of LEDIPASVIR and SOFOSBUVIR in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Mixed Phosphate Buffer:ACN (55:45) with detection of 213 nm. Linearity was observed in the range 60-140 µg/ml for LEDIPASVIR oxalate (r2 =0.999) and 6-14 µg /ml for SOFOSBUVIR (r2 =0.996) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.
The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
A new analytical method development and validation for the simultaneus estima...SriramNagarajan19
A simple and selective LC method is described for the determination of Ibuprofen and Tramadol in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 60 volumes of Triethylamine buffer, 40 volumes of acetonitrile with detection of 227 nm. Linearity was observed in the range 50-150 µg/ml for Ibuprofen (r2 =0.983) and 50-150 µg /ml for Tramadol (r2 =0.985) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.
The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
Method development and validation of escitalopram and estizolam in tablet dos...SriramNagarajan19
A simple and selective LC method is described for the determination of Escitalopram oxalate and Etizolam in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 30 volumes of ammonium acetate buffer, 40 volumes of acetonitrile and 30 volumes of Methanol with detection of 238 nm. Linearity was observed in the range 60-140 µg/ml for Escitalopram oxalate (r2 =0.999) and 6-14 µg /ml for Etizolam (r2 =0.996) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.
The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
Analytical method development and validation for the estimation of aspirin an...SriramNagarajan19
A simple and selective LC method is described for the determination of Aspirin and Omeprazole in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 30 volumes of ammonium acetate buffer, 40 volumes of acetonitrile and 30 volumes of Methanol with detection of 233 nm. Linearity was observed in the range 18-42 µg/ml for Aspirin (r2 =0.983) and 6-14 µg /ml for Omeprazole (r2 =0.970) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
A new analytical method development and validation for the simultaneus estima...SriramNagarajan19
A simple and selective LC method is described for the determination of Albuterol and Ipratropium Bromide in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 80 volumes of methanol and 20 volumes of water with detection of 239 nm. Linearity was observed in the range 36-84 µg /ml for Albuterol (r2 =0.996) and 6-14 µg /ml for Ipratropium Bromide (r2 =0.997) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.
The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.
Formulation and evaluation of rosiglitazone nanosuspensionSriramNagarajan19
The main aim of this study is to formulate and evaluate Rosiglitazone Nano suspension. Nano suspensions are colloidal dispersion of Nano sized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1micro meter in size. Rosiglitazone is an oral rapid and short –acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enter hepatic circulation. Rosiglitazone Nano suspension was prepared by precipitation technique. After preparation of Nano suspension various characterization studies were done such as drug content, %yield, FTIR, DSC, TEM, and Invitro drug release.PVPK30,polaxomer are used as stabilizers. From the dissolution study F4 formulation which containts PVPK30 as stabilizer was considered as optimized formulation. It showed maximum drug release at 30min.FTIR and DSC studies revealed that good stability in dispersion.
Effect of hydrophilic polymers on solubility of some antihypertentives drugs ...SriramNagarajan19
The main aim of the present study is to carried out to enhance solubility of Felodipine. Felodipine.was selected as model drug and different carriers like Vitamin-E, Polyethylene Glycol 8000, Polyvinyl pyrrolidone K-30 were used in drug to carrier ratio 1:1, 1:2, 1:4 by weight respectively. Solid dispersions were prepared by physical mixing method and solvent evaporation method. Solid dispersions were evaluated by drug content, in-vitro release, FT-IR, DSC and XRD. The obtained data of solid dispersion prepared by solvent evaporation method were compared with physical mixing method. The result showed decrease in melting point change from crystalline to amorphous form and improved dissolution rate as compared to physical mixing as well as pure Felodipine. The finding of present study proposes that solid dispersion approach is beneficial in enhancing solubility of drug and bioavailability as well.
A review on plants act on both antidiabetic and antihyperlipidemic plantsSriramNagarajan19
Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of diabetes mellitus especially in developing countries where resources are meager. Oral hypoglycemic agents like sulphonylureas and biguanides are still the major players in the management of the disease but there is growing interest in herbal remedies due to the side effects associated with the oral hypoglycemic agents. Herbal medicines have been the highly esteemed source of medicine throughout human history. Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Hyperlipidemia is a condition when abnormally high levels of lipids i.e. the fatty substances are found in the blood. Hypolipidemic drugs are extensively used as prophylactic agents to prevent such atherosclerosis induced disorders. But these hypolipidemic drugs are not free from adverse effects. Many plant derivatives and domestic remedies have been screened for their hypolipidemic action. More than 70 medicinal plants have been documented to have significant hypolipidemic action. During the last decade, an increase in the use of medicinal plants has been observed in metropolitan areas of developed countries. Medicinal plants play a major role in diabetes and hypolipidemic activity. The advantages of herbal medicines reported are effectiveness, safety, affordability and acceptability, this review focus on diabeties and hyperlipidemia and the role of plants used for the treatment of diabeties and hyperlipidemia.
FORMULATION AND CHARACTERISATION OF TRANSDERMAL PATCHES OF PERINDOPRILSriramNagarajan19
This document summarizes the formulation and characterization of transdermal patches containing perindopril. Five formulations of transdermal patches were prepared using different polymer ratios and evaluated for thickness, weight variation, folding endurance, moisture uptake and loss, and in vitro drug release. Formulation 5, containing HPMC 250 mg, Carbopol 971P 250 mg, and other excipients, showed the best drug release profile over 24 hours and was considered the optimized formulation.
Intercontinental journal of pharmaceutical Investigations and ResearchSriramNagarajan19
Anti-inflammatory activity of the ethanolic extract of Portulaca quadrifida Linn. was studied in wister rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (200 mg/kg, p.o.,) produced the inhibition of carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction on the pleural exudates as well as reduction on the granuloma weight in the cotton pellet granuloma method. The results indicated that the ethanolic extract produced significant (P<0.001) anti-inflammatory activity when compared with the standard and untreated control.
ANTI-BACTERIAL ACTIVITY OF EXTRACTS OF TACHYSPERMUM AMMI FRUITSSriramNagarajan19
This study was carried out with an objective to investigate the antibacterial activity of Tachyspermum ammi fruits extracts. In the present study, the anti-bacterial activity of aqueous and ethanolic extracts of Tachyspermum ammi fruits was evaluated for potential antimicrobial activity against medically important bacterial and fungal strains. The antimicrobial activity was determined using agar disc diffusion method. The antibacterial and antifungal activities of extracts were tested against Gram-positive—Staphylococcus aureus and Gram-negative—Escherichia coli human pathogenic bacteria. Zone of inhibition of extracts were compared with that of different standard drugs. The results showed that the remarkable inhibition of the bacterial growth was shown against the tested organisms. The phytochemical analyses of the plants were carried out. The antibacterial activity of the Tachyspermum ammi fruits was due to the presence of various secondary metabolites. Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities.
Anti bacterial activity of Derris indica leaf extractsSriramNagarajan19
Derris indica, family Fabaceae also known as Pongamia pinnata has various therapeutic properties. It shows activities like hepatoprotective, antirheumatic, hypoglycemic, anti bacterial etc. The plant leaves are is rich in flavanoids, alkaloids which are proved by phytochemical analysis. The aqueous, chloroform, methanolic and petroleum ether extracts were screened for anti bacterial activity using Bacillus subtilis and E. coli strain. The anti bacterial activity was performed using diffusion assay method using spread plate method. The study showed methanoilc and chloroform extracts have potent antibacterial activity. Thus Derris indica have abti bacterial activity along with other therapeutic activities.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
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Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.
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It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
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NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdf
Astashine capsules: an excellent choice for eye fatique relieve
1. Govind S et al, ICJPIR 2016, 3(3), 142-147
www.icjpir.com
~142~
Available online at www.icjpir.com ISSN: 2349-5448
Intercontinental journal of pharmaceutical
Investigations and Research
ICJPIR |Volume 3 | Issue 3 | July – Sep- 2016 Research Article
Astashine capsules: an excellent choice for eye fatique relieve.
Govind Shukla, Nagalakshmi Yaparthy, Jyothika Vanamali, G.Santosh Kumar, C.J.
Sampath Kumar
Lactonova Nutripharm (P) Ltd, Makers of ASTASHINE capsules, 81/3, IDA Mallapur, Hyderabad,
Telangana, India-500 076.
Corresponding Author: Govind Shukla
ABSTRACT
Scientists long ago discovered that a class of naturally-occurring pigments called carotenoids held powerful
antioxidant properties that are crucial for eye health. This carotenoid is called astaxanthin. Astaxanthin is produced
by the microalgae Haematococcus pluvialis when its water supply dries up, forcing it to protect itself from ultraviolet
radiation. Astaxanthin is leaps and bounds more powerful than beta-carotene, alpha-tocopherol, lycopene, and lutein--
other members of its chemical family. Astaxanthin exhibits very strong free radical scavenging activity, and protects
eyes from oxidative damage. Astaxanthin is by far the most powerful carotenoid antioxidant when it comes to free
radical scavenging: it is 65 times more powerful than vitamin C, 54 times more powerful than beta-carotene, and 14
times more powerful than vitamin E. Astaxanthin is far more effective than other carotenoids at "singlet oxygen
quenching," which is a particular type of oxidation. The damaging effects of sunlight and various organic materials
are caused by this less-stable form of oxygen. Astaxanthin is 550 times more powerful than vitamin E and 11 times
more powerful than beta-carotene at neutralizing this singlet oxygen. Astaxanthin crosses the blood-brain barrier and
the blood-retinal barrier which has huge implications for the health of eyes.
INTRODUCTION
It is similar to beta-carotene but a slight
difference in the structure, and causes a radical
difference in biological activity. It is ten times
stronger than beta-carotene and up to 500 times
stronger than vitamin E as an antioxidant. Unique
aspects of the astaxanthin structure allow it to pass
the "blood brain barrier", meaning it can deliver
antioxidant activity benefits directly to the brain,
eyes and nervous system.
Astaxanthin kills free radicals, staving off age
related diseases like macular degeneration, by
preventing these unstable molecules from
damaging cells. It also boosts the functioning of
your immune system by increasing the number and
activity of T cells and macrophages, two kinds of
protective cells that fight infection. Unlike other
antioxidants, astaxanthin is available both within
and without the cell wall which allows it to fight
free radicals both inside and outside the cell wall.
2. Govind S et al, ICJPIR 2016, 3(3), 142-147
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Figure 1
Mechanism of action of Astashine on Eye
health
Certain carotenoids have been shown to help
protect the retina of the eye from oxidative damage.
The lens of the eye focuses incoming light onto the
photosensitive retina, which then transmits visual
signals to the brain. In the central area of the retina
lies the macula, which has the highest density of
photoreceptors that provides visual acuity.
Oxidation, as from sunlight exposure, degrades the
retinal membranes and likely leads to damage or
destruction of photoreceptor cells.
A recent study indicates that astaxanthin is able
to cross the blood retinal barrier and exert
antioxidant effects to stop retinal destruction by
staving off light induced oxidation and protect
photoreceptors from degeneration.
Astaxanthin’s ability to protect the eye from
Light-induced damage
Photoreceptor cell damage
Ganglion cell damage
Neuronal damage
Composition of Astashine capsule
Astaxanthin - 2mg (Naturally derived from
Haematococcus pulvialis algae extract, which is
microencapsulated)
Figure 2
CLINICAL STUDY REPORTS ON ASTASHINE CAPSULES
The possible role of antioxidants in alleviating oxidation stress and other oxidative damages to the eye has
been extensively reviewed [1].
3. Govind S et al, ICJPIR 2016, 3(3), 142-147
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Figure 3
A 2011 review of previous and on-going research
points to the wide range of benefits of this potent
antioxidant with excellent tolerability and safety
factors as well. It has been found to lower levels
of free radicals in people who are smokers or
overweight; blocked oxidative damage to DNA,
acted as an anti-inflammatory agent, supported
tuberculin immunity, lowered triglycerides,
increased blood flow and good HDL cholesterol,
supported brain functioning with improved
cognition and nerve stem cell growth, improved
visual acuity, reproductive health and more.
As one of nature's most effective antioxidants
with the ability to cross the blood-brain barrier,
astaxanthin's potential benefits for the health of
the eye and the nervous system are very
promising.
The eye is potentially one of the organs that is the
most exposed to oxidation, because it is exposed
to air and UV-light as well as being fed by a very
large number of small capillaries capable of
bringing many of the metabolic oxidative
residues through the blood.
The eye also contains high levels of
polyunsaturated fatty acids and pigments that are
sensitive to oxidation. Recently, a research group
demonstrated increased superoxide and peroxide
formation following UV irradiation of a lens
protein. Photoxidation of the lens proteins have
been associated to the development of cataracts.
4. Govind S et al, ICJPIR 2016, 3(3), 142-147
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Lutein and zeaxanthin, the carotenoids naturally
found in the human retina, are closely related to
astaxanthin. There is abundant evidence that
certain carotenoids can help protect the retina
from oxidative damage.
Investigations of the antioxidant effectiveness of
astaxanthin in the eye are just beginning but are
already very promising. A recent study with rats
indicates that astaxanthin can be effective at
ameliorating retinal injury, and that it is also
effective at protecting photoreceptors from
degeneration.
Other carotenoids have begun to attain a certain
level of fame for having beneficial properties for
the eyes. There is no doubt that lutein and
zeaxanthin are wonderful products to support and
protect the eyes, and there is credible evidence that
they can help prevent age related macular
degeneration and other degenerative conditions.
But due to Natural Astaxanthin’s superior
antioxidant and anti-inflammatory properties,
indications are that it will prove to be superior to
all other nutraceuticals for eye and brain health.
Scientists believe that something may cause
people’s internal antioxidant defense system to
malfunction or wear out as we age. Our bodies may
lose the ability to produce high levels of the
antioxidants that are normally produced internally
such as superoxide dismutase, catalase and
glutathione peroxidase. Also, our bodies are now
subjected to unprecedented levels of oxidation
caused by environmental factors such as pollution,
containments, processed food and the high levels of
stress in modern life. All of these lead to an assault
on our vital organs as we age, particularly our
brains and eyes. The eye, in particular is now
subjected to much higher levels of oxidation than
our ancestors’ experienced. The depletion of the
ozone layer is causing more intense sunlight than
ever before, which directly affects the eyes and
skin. Excessive exposures to sunlight and to the
highly oxygenated environment cause free radicals
to be generated in the eye. A condition called
―ischemia‖ which is a type of blockage that
deprives the eye of nutrition and oxygen is a
common cause of increased oxidation in the eye.
Another cause of increased oxidation in the eye
happens when the ischemic blockages are removed.
The reoxygenation of the tissue after blockage is
called ―reperfusion,‖ and the end result is another
attack on the eye’s normal oxidative balance. Even
normal enzymatic processes cause increased
generation of free radicals and singlet oxygen such
as hydrogen peroxide, superoxide and hydroxyl in
the eyes. Free radicals and singlet oxygen oxidize
the polyunsaturated fatty acids in the retina which
leads to functional impairment of the retinal cell
membranes, causing temporary and permanent
damage to the retinal cells. Once the retina is
damaged, it cannot be replaced. Antioxidants that
can reach the inner eye by crossing the blood-brain
and blood-retinal barriers are essential because they
protect the eye from these damaging conditions.
The carotenoids lutein and zeaxanthin are normally
found in the eyes.
Dr. Mark Tso of the University of Illinois
extensively worked on Astaxanthin’s benefits on
the eyes. Dr. Tso was the first person who proved
that Astaxanthin could cross the blood-brain and
blood-retinal barriers. He took laboratory rats and
tested their eyes for Astaxanthin. He fed the rats
Astaxanthin and proved that Astaxanthin could
cross first the blood-brain barrier and get into the
brain, and then once in the brain it could reach the
retina and the macula by crossing through the
blood-retinal barrier. Through an extensive series
of tests, Dr. Tso went on to prove that Astaxanthin
has many protective properties once it reaches the
eyes.
In a double blind study performed in Japan,
after four weeks of supplementation with 5 mg of
Astaxanthin per day (extracted from
Haematococcus algae meal) the authors reported a
46% reduction in the number of eye strain subjects.
They also found higher accommodation amplitude
(the adjustment in the lens of the eye that allows it
to focus) in subjects who used visual display
terminals. The mechanism of action is most likely
due to Astaxanthin’s potent antioxidant properties
[3].
Additional research in the area of eye fatigue
has been carried out. In fact, there are now nine
different positive human clinical studies that have
been published in this area. Two different dosage
levels were tested for eye fatigue by a group led by
Dr. Nakamura in 2004. They found positive effects
at 4 mg per day, but found a better result at 12 mg
per day [4].
5. Govind S et al, ICJPIR 2016, 3(3), 142-147
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Another group of Japanese researchers found
similar results in another human clinical study.
This double blind study was done to evaluate
Astaxanthin’s effect on eye fatigue and visual
accommodation. Forty subjects were divided into
placebo and treatment groups, with the treatment
group receiving 6 mg of Astaxanthin for four
weeks. The results were that three separate visual
parameters were found to have statistically
significant benefits from Astaxanthin
supplementation. This research established an
optimum daily dose for eye fatigue at 6 mg per day
[5].
Additional studies showing that 6 mg per day of
Natural Astaxanthin supplementation for four
weeks can reduce eye soreness, dryness, tiredness
and blurred vision [2].
Astaxanthin may work in a preventative role for eye
fatigue as compared to a curative one that has already
been established. The other studies all centered on the
use of Astaxanthin to cure eye fatigue. A clinical
study was done on subjects whose eyes were healthy,
with no signs of fatigue or strain. Both the treatment
and the placebo groups were subjected to heavy visual
stimuli to induce eye fatigue, and it was found that the
treatment group recovered more quickly. This clearly
indicates that Natural Astaxanthin may serve to
prevent eye fatigue from occurring in healthy people
[10].
It is very important to have sufficient blood
flow to the eyes and the retina. A human clinical
study examined the ability of Astaxanthin to
improve retinal capillary blood flow. Eighteen
subjects were given 6 mg per day of Natural
Astaxanthin and another eighteen people were
given a placebo. After four weeks it was found that
the treatment group had improved retinal capillary
blood flow as compared to the placebo group [14].
The mechanisms of action thought to enable
Astaxanthin to reduce or prevent eye fatigue are
diverse. Of course, Astaxanthin’s role as an
antioxidant and anti-inflammatory must play a part. A
study conducted at the Hokkaido University Graduate
School of Medicine determined that Astaxanthin
inhibited inflammation in the eye by blocking nitric
oxide synthase [6]. Astaxanthin was also found to
have potent antioxidant effects in the prevention of
cataracts in rats’ eyes [13].
Human clinical studies on Natural
Astaxanthin’s effects on the eyes has also yielded
positive results. This study was done in Japan with
subjects comprised of twenty year old men. The
treatment group was given 6 mg of Natural
Astaxanthin per day for four weeks. Different
visual parameters were measured, with statistically
significant improvement found in two different
parameters for visual acuity. The greatest
enhancement was seen in depth perception which
improved by 46% in the group supplementing with
Natural Astaxanthin [7].
(Pre-clinical animal studies and in-vitro
experiments on Astaxanthin and eye health. One
such study took the lens from the eyes of pigs and
tested the ability of Astaxanthin to protect them
from induced oxidative damage. This experiment
found that Astaxanthin was capable of protecting
the lens proteins from oxidative damage. In fact,
Astaxanthin performed better than the antioxidant
glutathione which is produced by the pig’s own
body [12].
A study done in rats was very helpful in that it
measured the effect of Astaxanthin on three
important inflammatory markers in the uvea (the
middle layer of the eye including the iris).
Inflammation in the uvea was induced, after which
nitric oxide; tumor necrosis factor alpha and
prostaglandin E-2 were measured. The rats that had
been injected with Astaxanthin had lower levels of
all three inflammatory markers. The researchers
concluded that Astaxanthin is effective in reducing
ocular inflammation [9].
A previous study done on inflammation of the
eye of rats yielded similar results, but also
demonstrated that the effects of Astaxanthin
worked in a dose- dependent fashion. Additionally,
this study proved these anti-inflammatory
mechanisms in-vitro [6].
SAFETY OF ASTASHINE CAPSULES
Astaxanthin has demonstrated safety in
numerous human clinical trials. In one open-label
clinical study on subjects with metabolic syndrome
(n=17), astaxanthin (16 mg/day, for three months)
significantly raised blood bilirubin (p≤0.05),
potassium (p≤0.05), and creatine kinase (p≤0.01),
although all three values remained within normal
range. Also, astaxanthin significantly lowered the
liver enzyme gamma-glutamyl transpeptidase
(GGTP; p≤0.05). Since the researchers noted this
enzyme was abnormally elevated in 11 of the 17
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~147~
subjects at baseline, this astaxanthin effect may
have been beneficial. Animal experiments have
investigated astaxanthin at levels well over 120
mg/day in human equivalents, without causing
apparent harm. Hoffman-La Roche confirmed its
safety with extensive tests, including acute toxicity,
mutagenicity, teratogenicity, embryotoxicity, and
reproductive toxicity.
Suggested Dosage
The doses of astaxanthin used in clinical trials have
ranged from 1 mg/day to 40 mg/day (with the
majority in the 6-12 mg range); single-dose
pharmacokinetic studies used up to 100 mg per dose.
As a dietary supplement, astaxanthin should be taken
along with fats, with or immediately prior to meals, to
ensure its optimal absorption.
CONCLUSION
Astaxanthin may work in a preventative role for
eye fatigue as compared to a curative one that has
already been established. The studies all centered
on the use of Astaxanthin to cure eye fatigue. Both
the treatment and the placebo groups were
subjected to heavy visual stimuli to induce eye
fatigue, and it was found that the treatment group
recovered more quickly. This clearly indicates that
Natural Astaxanthin may serve to prevent eye
fatigue from occurring in healthy people
Astaxanthin has great benefits for the eyes, and in
fact, may be the best choice for eye health among
all nutraceutical products.
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