Presentation about food drug interaction

1. Food Drug Interaction
The presentator
Pharmasict
Mohammed malk jassim

2. Learning Objectives :
Know what a food-drug interaction
Know common foods and drugs interactions
Know the effect of the interaction on the body
Know how to help avoid food-drug interactions

3. Introduction:
A food-drug interaction is a situation when
active chemicals in drug reacts to a nutrient
or food item and causes the drug to be
 Less effective than expected
 More effective than expected
 May cause an effect in the body that could be
extremely harmful to the person.

4. Why are food-drug interaction
important ?
 Impact how effective a drug is, or its efficacy
 Increased metabolism can cause less of the
drug effective
 decreased metabolism can cause high
levels of drug in the body which can be toxic
and cause unwanted side effects

5. Introduction:
Food is either restricted or provided at a time
before or after the medication has been given
to prevent any food-drug interactions.

6. common foods and drugs interactions:
Grapefruit

7. Grapefruit
The grapefruit is a
subtropical citrus tree known for its
relatively large, sour to semi-sweet,
somewhat bitter fruit. The interior
flesh is segmented and varies in
color from pale yellow to dark pink.

8. Grapefruit
Grapefruit and grapefruit juice have been
found to interact with numerous drugs and
in many cases, to result in adverse direct
and/or side effects (if dosage is not
carefully adjusted).
inhibit the CYP3A4 enzyme, including
the P450 enzyme family responsible for
metabolizing 90% of drugs.

9. Grapefruit
 The effect on statins
 Statins are broken down by enzymes in the
liver
 The Grapefruit can block the action of this
enzymes which would cause more of the
statins to enter the body than intended
 Ex of statins drugs
 Atorvastatin
 Rosovastatin

10. Grapefruit
 The effect on calcium channel blocker
 Calcium channel blockers are medicines that
relax the muscles that make up the walls of
your arteries.
 They're used as part of the treatment of
conditions such as high blood pressure and
coronary heart diseases
 Grapefruit juice interacts with some calcium
channel blockers and increases the level of
the medicine in your blood.

11. Grapefruit
 Potential side effects
 Muscle damage
 Liver dame
 Digestive problems
 Neurological side effects

12. Licorice

13. Licorice
 Licorice is extracted from the roots of the tree,
which is sweeter than sugar, and extracted
from the roots of the tree, as a sweetener.
 In the year (1955-1960) a citroid compound
was separated and called glycerrhysic acid
from the roots of the licorice plant. It was
found that this acid is similar in its chemical
structure to cortisone.

14. Licorice
 Noting that continuing to use it for a long time
or increasing the dose has negative effects
such as headache, high blood pressure, fluid
retention and potassium deficiency.

15. Licorice
 The effect of licorice on the HT drugs
 Common interaction with ACEi,
ARBs,CCB,Diurretics.
 It decrease the HT drugs effect by block the
activity of 11hydroxysteroid-dehydrogenase
causing salt and water retention than
increase in HT

16. Licorice
 The effect of licorice on the HEART drugs
 The intake of Licorice with Digoxin can cause
irregular heartbeat and heart attack.
 It can decease the level of potassium

17. Syzygium cumini

18. Syzygium cumini
 Syzygium Cumini (Jamun): Jamun fruit also
called as sIndian blackberry. Syzygium
cumini at a dose level of 50 mg/kg also
showed significant decrease in blood glucose
level.

19. Syzygium cumini
 Jamun traditionally used as anti-diabetic
agent; so that it should be avoided and
contraindicated during the treatment of
diabetes because the administration of oral
hypoglycemic agents along with Jamun may
leads to severe hypoglycemia

20. Momordica Charantia

21. Momordica Charantia
 Momordica Charantia (Karela): Bitter Melon :
is a Tropical vegetable and common food in
Indian cuisine and has been used extensively
in folk medicine as a remedy for diabetes. It
has also been shown to have hypoglycaemic
properties in the animal as well as effective in
humans. It has been reported that intake
increases the number of beta cells in the
pancreas thereby improving the body’s ability
to produce insulin..

22. Momordica Charantia
 The fruit has also shown the ability to
promote insulin release by enhancing cells
uptake of glucose and potentiate the effect of
insulin.

23. Momordica Charantia
 Extremely high doses of the juice of Karela
(bitter melon) can cause diarrhoea and
abdominal pain. Bitter melon should not be
used and avoided for small children or
anyone with hypoglycemia, as it may trigger
or worsen low blood glucose or
hypoglycemia..

24. Momordica Charantia
 The use of KARELA should be avoided in
pregnant women as it stimulates the uterus
and may cause premature birth

25. Garlic

26. Garlic
 Garlic has been widely used for reducing the
high cholesterol. Garlic has also been used
for treating or myriad other disorders (such as
atherosclerosis, diabetes, fungal infections,
cancer, hypertension, myocardial infarction
and peripheral vascular disease)

27. Garlic
 Garlic oil shown hypoglycemic effect in
diabetic animals as well as in humans has
also been reported. Co-administered of
glimepiride with garlic resulted in tight
glycaemic control due to the hypoglycemic
properties of garlic as well as glimepiride

28. how to help avoid food-drug
interactions
 Counsel patients to
 Read drug labels
 Learn about the warning for the drug they
take
 Check with doctor or pharmacist before
taking an OTC drug if they are taking any
prescription medications
 Inform all healthcare professionals about all
medications and supplements they are taking

29. 
Drug Interactions Checker - For Drugs, Food
& Alcohol