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Lifecycle of malarial parasite

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The life cycle of malarial parasite power point presentation.

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Lifecycle of malarial parasite

  1. 1. LIFECYCLE OFLIFECYCLE OF MALARIAL PARASITEMALARIAL PARASITE Soorej Jaiboi KSoorej Jaiboi K
  2. 2. MALARIAMALARIA MalariaMalaria is a mosquito borne infectiousis a mosquito borne infectious disease affecting humans and otherdisease affecting humans and other animals caused by parasitic protozoans (aanimals caused by parasitic protozoans (a group of single-celled microorganisms)group of single-celled microorganisms) belonging to thebelonging to the Plasmodium typePlasmodium type..
  3. 3. LIFECYCLELIFECYCLE In the life cycle ofIn the life cycle of PlasmodiumPlasmodium, a female, a female AnophelesAnopheles mosquito (the definitive host)mosquito (the definitive host) transmits a motile infective form (calledtransmits a motile infective form (called the sporozoite) to a vertebrate host suchthe sporozoite) to a vertebrate host such as a human (the secondary host), thusas a human (the secondary host), thus acting as a transmission vector.acting as a transmission vector.
  4. 4. The malaria parasite life cycle involves twoThe malaria parasite life cycle involves two hosts.hosts. During a blood meal, a malaria-infected femaleDuring a blood meal, a malaria-infected female AnophelesAnopheles mosquito inoculates sporozoitesmosquito inoculates sporozoites into the human host .into the human host . 1)Sporozoites infect liver cells.1)Sporozoites infect liver cells. 2)Mature into schizonts.2)Mature into schizonts.
  5. 5. 3) Which rupture and release merozoites.3) Which rupture and release merozoites. 4) After this initial replication in the liver ,the4) After this initial replication in the liver ,the parasites undergo asexual multiplication inparasites undergo asexual multiplication in the erythrocytes .Merozoites infect red bloodthe erythrocytes .Merozoites infect red blood cells.cells. 5) The ring stage trophozoites mature into5) The ring stage trophozoites mature into schizonts, which rupture releasingschizonts, which rupture releasing merozoites.merozoites.
  6. 6. 6) Some parasites differentiate into sexual6) Some parasites differentiate into sexual erythrocytic stages (gametocytes).erythrocytic stages (gametocytes). 7) Blood stage parasites are responsible for the7) Blood stage parasites are responsible for the clinical manifestations of the disease.clinical manifestations of the disease. 8) The gametocytes, male (microgametocytes)8) The gametocytes, male (microgametocytes) and female (macrogametocytes), are ingestedand female (macrogametocytes), are ingested by anby an AnophelesAnopheles mosquito during a bloodmosquito during a blood meal.meal.
  7. 7. C) The parasites multiplication in the mosquitoC) The parasites multiplication in the mosquito is known as the sporogonic cycle.is known as the sporogonic cycle. 9) While in the mosquito's stomach, the9) While in the mosquito's stomach, the microgametes penetrate the macrogametesmicrogametes penetrate the macrogametes generating zygotes.generating zygotes. 10) The zygotes in turn become motile and10) The zygotes in turn become motile and elongated (ookinetes).elongated (ookinetes).
  8. 8. 11) Which invade the midgut wall of the11) Which invade the midgut wall of the mosquito where they develop into oocysts.mosquito where they develop into oocysts. 12) The oocysts grow, rupture, and release12) The oocysts grow, rupture, and release sporozoites.sporozoites. 13) Which make their way to the mosquito's13) Which make their way to the mosquito's salivary glands. Inoculation of the sporozoitessalivary glands. Inoculation of the sporozoites into a new human host perpetuates the malariainto a new human host perpetuates the malaria life cycle.life cycle.
  9. 9. Only female mosquitoes feed on blood,maleOnly female mosquitoes feed on blood,male mosquitoes feed on plant nectar, and do notmosquitoes feed on plant nectar, and do not transmit the disease.transmit the disease. Malaria parasites can also be transmitted byMalaria parasites can also be transmitted by blood transfusions, although this is rare.blood transfusions, although this is rare.

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