Full presentation summarize the relationship between Arsenic and it is presence in food

1. Arsenic and food
Sondos Almomani

2. rice is not the
only food or
beverage that
contains
arsenic.
It’s also found
in vegetables,
fruits, and
many other
foods.
FDA.2016

3. How does arsenic get in your food?
Crops absorb arsenic as they grow. That’s how
it gets into foods and beverages – it’s not an
additive or ingredient – and it cannot be
completely eliminated.
element in the
Earth’s crust water soil air
Industries
(release into
environment )
mining smelting
FDA.2016

4. There are two forms of arsenic, organic and
inorganic, with inorganic being the more toxic. The
term “organic” in this case has nothing to do with
types of farming. It’s about chemical elements. If
arsenic atoms bond with carbon, the compound is
organic. If there’s no carbon present, it’s inorganic.
organic
chemical
elements
arsenic
atoms bond
with carbon
inorganic
more toxic
no carbon
present
DRUGS FOR
TRYPANOSOMIASIS
Melarsoprol
This drug is an organic
arsenical that inhibits enzyme
sulfhydryl groups. Because it
enters the CNS, melarsoprol is
the drug of choice in African
sleeping sickness.
Anthony J. Trevor.et.al.2013

5. What about arsenic in rice?
infants
consume about
three times
more rice than
adults
Rice is a staple
of the global
diet
leading dietary
source of
inorganic
arsenic
FDA.2016

6. What are the potential health effects?
Nigel Bruce.et.al.2013
Contaminants in coal, including arsenic, present
additional risk.
WHO estimated that coal used for cooking was
responsible for 36 000 lung cancer deaths in
2004.

7. exposure to inorganic
arsenic in rice and rice
products causes an
additional four cases of
lung and bladder cancer
over the lifetime for
every 100,000 people in
the United States.
This estimate would account for far less than 1
percent of the nation’s lung and bladder cancer cases.

8. The toxicity profiles of metals differ, but most
of their effects appear to result from
interaction with sulfhydryl groups of enzymes
and regulatory proteins.1
1.Anthony J. Trevor.et.al.2013
Arsine gas—Arsine gas (AsH3), an occupational
hazard, is formed during the refinement and
processing of certain metals and is used in the
semiconductor industry.
Arsine causes a unique form of toxicity
characterized by massive hemolysis.
Pigment overload from erythrocyte breakdown
can cause renal failure.
Arsenic levels - normal values
Normal whole blood
concentration is <10 mcg/L
(<130 nmol/L).2
2.http://patient.info/doctor/arsenic-poisoning

9. Anthony J. Trevor.et.al.2013
results
Treatment consists of
supportive therapy to
replace water and
electrolytes

10. Chronic
arsenic
poisoning
skin changes hair loss
chronic nausea and
gastrointestinal
disturbances
anemia
bone marrow
depression
Anthony J. Trevor.et.al.2013

11. Dimercaprol is
used in acute
arsenic
• Succimer is also
effective in arsenic and
mercury poisoning, if
given within a few
hours of exposure.

12. If you have an infant or are pregnant,
what should you do?
consume a variety of foods, including
varied grains (such as wheat, oats, and
barley), for good nutrition.
Published studies, including new research by
the FDA, indicate that cooking rice in excess
water (from six to 10 parts water to one part
rice), and draining the excess water, can
reduce from 40 to 60 percent of the
inorganic arsenic content, depending on the
type of rice—although this method may also
remove some key nutrients.

13. If you’re an adult, what should you do?
well-balanced diet
Eating a variety of foods is more nutritious and
if there are substances in food (like arsenic)
where reducing exposure is prudent, you’re
minimizing that exposure.