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11/14/2015 1
BIOENGINEERED NANOROBOTICS
FOR CANCER THERAPY
11/14/2015 2
OVERVIEW
 Introduction
 Nanorobots
 Nanorobot Core
 Power Supply
 Propulsion
 Sensing and Actuation
 Control and Decision Making
 Integration
 Advantages
 Disadvantages
 Application
 Conclusion
11/14/2015 3
Introduction
Cancer
Uncontrolled Growth Of Cells
Spread all over the body
It Cause death
11/14/2015 4
Treatment
Kills Healthy Cells
Fatigue
Hair Loss
 Radiation Therapy
 Chemotherapy
11/14/2015 5
NanoRobots
The technology of creating machines or robots
at or close to the microscopic scale of a
nanometer (10−9 meters).
Nanorobots are devices made from DNA that
are so small they can be injected into the
bloodstream and carry a payload of drugs to
specific cells.
11/14/2015 6
Cure Using Nanorobots
 Inject nanorobots into
patient
 Detect cancer Cells
 Destroy Cells
 Do not affect on
Healthy Cells
11/14/2015 7
Contd.
Nano
Infinitesimally Small
Scale of Manufacturing
And Fabricating Materials
NanoRobot
Tiny machine
Perform specific task
11/14/2015 8
Nanorobot Core
The core is a polysaccharide-based nanoparticle or cyclic
peptide nanotube
Cyclic peptide has ability to self-assemble into
monodisperse nanotubes, are well suited to the core
Capable of carrying a payload
Allow the incorporation of propulsive, sensing and
actuating components
Float freely inside the body
Detect the tumor effectively
11/14/2015 9
Core of Nanorobots
11/14/2015 10
 Cant use conventional sources
 ATP released from core
 Production of heat in the human body
 Inclusion of electrodes in nanorobots and
electrolytes in human blood will act as battery
 Combination of chemical reactions in human
blood and chemicals in nanorobots will lead to the
formation of fuel source
Power Supply
11/14/2015 11
Propulsion
Fully functional flagella isolated from E.coli
Artificial bacterial flagella(ABF) to move in 3D
ABF are often fabricated from helical nanobelts with soft
magnetic heads composed of Cr/Ni/Au
It has ability to drive the nanorobots into the tumor tissue
11/14/2015 12
Sensing and Actuation
 Capable of sensing and recognizing the targeted
cancer cells
 Chemical sensors which detect the target molecules
 Aptamers (derived from the latin aptus, meaning to
fit) are artificial nucleic acid (DNA or RNA)
 Biomarkers can be specific cells, molecules, or genes,
gene products, enzymes, or hormones.
11/14/2015 13
Schematic of the cyclic peptide nanorobot core
with the aptamers designed for closing and
locking the nanotube.
11/14/2015 14
Aptamer-target interaction
11/14/2015 15
Control and Decision Making
 Use directional control, which is necessary for tumor
targeting
 Phototactic control to direct the nanorobot to the tumor
location
11/14/2015 16
Integration
First step is fabrication of power supply(ATP
containing nanoparticle)
Second step is load the power supply into the core
Final step is attachment of propulsion system to the
core
11/14/2015 17
Nanorobots can be used in blood cell to
detect pathogens.
11/14/2015 18
Advantages
Small Size
Inexpensive(if mass produced)
No maintenance
Automated
Painless Treatment
Easily Disposable
Affect only cancer cells
Rapid elimination of disease.
11/14/2015 19
Disadvantage
Initial Design Cost high
Very complicate design
11/14/2015 20
Applications
 Breaking up blood clots
 Fighting cancer
 Parasite Removal
 Breaking up kidney stones
2011/14/2015
Conclusion
With the introduction of nanorobots, humans can
overcome many type of diseases
It can also helpful in the detection of diseases
Decision making nanorobots are the future of
nanorobotic technology
11/14/2015 22
References
 R. Baum, “Nanotechnology: Drexler and Smalley make the case for
and against ‘molecular assemblers’,” Chem. Eng. News, vol. 81, pp.
37–42, 2003.
 M. Sitti, “Microscale and nanoscale robotics systems [grand
challenges of robotics],” IEEE Robot. Autom. Mag., vol. 14, no. 1,
pp. 53–60, Mar. 2007.
 https://en.wikipedia.org/wiki/Nanorobotics
 http://hansmalab.physics.ucsb.edu/phys150/nanotech.pdf
 http://nano-bio.ehu.es/files/nanorobots_work.pdf
 http://www.roboticsbible.com/power-sources-of-nanorobots.html
 http://icmr.nic.in/ijmr/2010/august/0803.pdf
11/14/2015 23
Thank You
11/14/2015 24

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BIOENGINEERED NANOROBOTICS FOR CANCER THERAPY

  • 3. OVERVIEW  Introduction  Nanorobots  Nanorobot Core  Power Supply  Propulsion  Sensing and Actuation  Control and Decision Making  Integration  Advantages  Disadvantages  Application  Conclusion 11/14/2015 3
  • 4. Introduction Cancer Uncontrolled Growth Of Cells Spread all over the body It Cause death 11/14/2015 4
  • 5. Treatment Kills Healthy Cells Fatigue Hair Loss  Radiation Therapy  Chemotherapy 11/14/2015 5
  • 6. NanoRobots The technology of creating machines or robots at or close to the microscopic scale of a nanometer (10−9 meters). Nanorobots are devices made from DNA that are so small they can be injected into the bloodstream and carry a payload of drugs to specific cells. 11/14/2015 6
  • 7. Cure Using Nanorobots  Inject nanorobots into patient  Detect cancer Cells  Destroy Cells  Do not affect on Healthy Cells 11/14/2015 7
  • 8. Contd. Nano Infinitesimally Small Scale of Manufacturing And Fabricating Materials NanoRobot Tiny machine Perform specific task 11/14/2015 8
  • 9. Nanorobot Core The core is a polysaccharide-based nanoparticle or cyclic peptide nanotube Cyclic peptide has ability to self-assemble into monodisperse nanotubes, are well suited to the core Capable of carrying a payload Allow the incorporation of propulsive, sensing and actuating components Float freely inside the body Detect the tumor effectively 11/14/2015 9
  • 11.  Cant use conventional sources  ATP released from core  Production of heat in the human body  Inclusion of electrodes in nanorobots and electrolytes in human blood will act as battery  Combination of chemical reactions in human blood and chemicals in nanorobots will lead to the formation of fuel source Power Supply 11/14/2015 11
  • 12. Propulsion Fully functional flagella isolated from E.coli Artificial bacterial flagella(ABF) to move in 3D ABF are often fabricated from helical nanobelts with soft magnetic heads composed of Cr/Ni/Au It has ability to drive the nanorobots into the tumor tissue 11/14/2015 12
  • 13. Sensing and Actuation  Capable of sensing and recognizing the targeted cancer cells  Chemical sensors which detect the target molecules  Aptamers (derived from the latin aptus, meaning to fit) are artificial nucleic acid (DNA or RNA)  Biomarkers can be specific cells, molecules, or genes, gene products, enzymes, or hormones. 11/14/2015 13
  • 14. Schematic of the cyclic peptide nanorobot core with the aptamers designed for closing and locking the nanotube. 11/14/2015 14
  • 16. Control and Decision Making  Use directional control, which is necessary for tumor targeting  Phototactic control to direct the nanorobot to the tumor location 11/14/2015 16
  • 17. Integration First step is fabrication of power supply(ATP containing nanoparticle) Second step is load the power supply into the core Final step is attachment of propulsion system to the core 11/14/2015 17
  • 18. Nanorobots can be used in blood cell to detect pathogens. 11/14/2015 18
  • 19. Advantages Small Size Inexpensive(if mass produced) No maintenance Automated Painless Treatment Easily Disposable Affect only cancer cells Rapid elimination of disease. 11/14/2015 19
  • 20. Disadvantage Initial Design Cost high Very complicate design 11/14/2015 20
  • 21. Applications  Breaking up blood clots  Fighting cancer  Parasite Removal  Breaking up kidney stones 2011/14/2015
  • 22. Conclusion With the introduction of nanorobots, humans can overcome many type of diseases It can also helpful in the detection of diseases Decision making nanorobots are the future of nanorobotic technology 11/14/2015 22
  • 23. References  R. Baum, “Nanotechnology: Drexler and Smalley make the case for and against ‘molecular assemblers’,” Chem. Eng. News, vol. 81, pp. 37–42, 2003.  M. Sitti, “Microscale and nanoscale robotics systems [grand challenges of robotics],” IEEE Robot. Autom. Mag., vol. 14, no. 1, pp. 53–60, Mar. 2007.  https://en.wikipedia.org/wiki/Nanorobotics  http://hansmalab.physics.ucsb.edu/phys150/nanotech.pdf  http://nano-bio.ehu.es/files/nanorobots_work.pdf  http://www.roboticsbible.com/power-sources-of-nanorobots.html  http://icmr.nic.in/ijmr/2010/august/0803.pdf 11/14/2015 23