GLA University mathura up

1. AQUASOMES
Presentedby -
SHUBHAM SINGH
GLA UNIVERSITY
MATHURA

2. CONTENT –
1.Introduction
2.Preparation
3.Evaluation
4.Application

3. INTRODUCTION
Aquasomes are first discovered by Nir Kossovsky.
These are nanoparticulate carrier systems with
three layered self assembled structures
These comprises of central solid nanocrystalline core
coated with polyhydroxy oligomers onto
which biochemically active molecules are adsorbed.

4. Aquasomes are also called as “bodies of water” and
their water like properties protect and preserve fragile
biological molecules,
This property of maintaining conformational
integrity as well as high degree of surface exposure
made it as a successful carrier system for bioactive
molecules like peptide, protein, hormones, antigens
and genes to specific sites, that is for targeting.

5. PROPERTIES –
1. Provide sustain release
2. Protection from external environment
3. Suitable for temperature sensitive material.

6. Method of preparation
By using the principle of self assembly Aquasomes
can be prepared by three method.
(1) Preparation of core.
(2) coating of core.
(3) Immobilization of drug molecule.

7. 1) Preparation of core.
This stage mainly depends on the-
selection of material for core.
-its physical chemical properties
This can be fabricated by the
-Sonication
-Colloidal precipitation..
For the core material material ceramic material widely
used ,as they are structurally to be known..

8. Commonly used ceramic core are tin oxide, and
calcium phosphate.
Example:
synthesis of nanocrystalline tin oxide core material.

9. Purified Tin is sputtered in
High pressure gas mixture of argon and oxygen.
The ultra fine particle form in gas phase are collect on
copper tube and cool at 70oK with liquid nitrogen

10. (2) Carbohydrate coating
 The second step involves coating by carbohydrate
on the surface of ceramic cores.
 There are number of processes to enable the
carbohydrate (polyhydroxy oligomers) coating to
adsorb on to the surface of the Nanocrystalline
ceramic cores.

11. Process -
Addition ofpoly hydroxy oligomer
To a dispersion of core in ultra pure water.
Lyophilization
Excess of carbohydrate is removed by
ultrafilteration.

12. Commonly used coating material
Cellobiose
Citrate
Sucrose
Trihalose
(3) Immobilization of drug
 Drug can be loaded by partial adsorption

14. Characterization -
1. For morphological characterization and size
distribution analysis,scanning electron
microscopy (SEM) and transmission electron
microscopy (TEM) are generally used.
2.In vitro drug release

15. APPLICATIONS OF AQUASOMES
Aquasomes has got a quite versatile application potential
as a carrier for delivery of
vaccines, hemoglobin, drugs, dyes, enzymes.

16. REFERENCES-
Jain N.K. “Advances in controlled and novel
Drug Delivery”, CBS publisher & Distributers,
Edition 1st 2001, Pg. 408