The document discusses experimental and computational methods for protein structure prediction. Experimental methods like NMR, X-ray crystallography, and cryo-EM can accurately determine protein structure but require isolating and crystallizing the protein. Computational methods like homology modeling, ab initio modeling, and threading/folding predict structure from sequence alone and are less accurate but do not require crystallization. Computational methods work best when a template structure is available from experimental data. While experimental methods are very accurate, they are also costly and difficult for large numbers of proteins, making computational methods a useful complement despite being less accurate.