Basic research.ppt

1. Design research study
•Study designs …(not exhaustive)
•Case series
•Cross-sectional
•Case-control
•Cohort:
(Observational study)
•Randomized controlled clinical trials
Research study design is a framework, or the set of methods
and procedures used to collect and analyse data on variables
specified in a particular research problem.

2. The Next Step
•Formally test the identified hypotheses in a
research study
•The study should follow a specific plan or
protocol (the study design)
•Study designs direct how the investigation
is conducted and allows for the translation
of a conceptual hypothesis into an
operational one

3. Clinical Research
• Research conducted on humans or
human tissues that makes use of
patient data.
• Includes study of disease mechanisms,
therapeutic interventions,
epidemiology, and clinical trials.
• Aimed at understanding human
disease and improving human health.
• Interaction between researchers and
patient data is a key feature.
Basic Scientific Research
• Fundamental theoretical or
experimental investigative research to
advance knowledge without a
specifically envisaged or immediately
practical application.
• It is the quest for new knowledge and
the exploration of the unknown.
• Takes many years for the results of
basic research to find some practical
utility.
• Output based research through
research articles and patents

4. Basic and Clinical Research are Interdependent
Translation from
basic science to
human studies
Translation of
new knowledge
into clinical practice
Basic
Research
Clinical
Research
Improved
Health
Adapted from Sung et al. (2003) JAMA, 289, 1278-89.
Copyright © (2003) American Medical Association. All Rights reserved.

5. “Disappointment is when a
beautiful hypothesis is
destroyed by an ugly fact”
“Sir, Isaac
Newton”
Thank you…