Professor Serge Jurasunas N.D., M.D. (Hon.) addresses the use of antioxidants in the treatment of cancer, given in Paris, France 2008, at the Anti-Aging Medicine World Congress. This was a workshop for the participants. For further information: www.sergejurasusas .com

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More Natural Approaches to Cancer Treatment
Workshop
Speaker: Serge Jurasunas

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Serge Jurasunas N.D. MD (Hom)
- 40 years of practice, research and
development of innovative medicine
and alternative therapies in cancer.
Speciality: Nutrition, orthomolecular medicine, oxidative stress and
antioxidant therapy, stem cells therapy, detoxification, mitochondrial
repair, peripheral blood analysis.
Holiterapias Institute of Integrative Medicine
Lisbon - Portugal
Member: Society of Integrative Oncology (USA), AAAA Medicine (USA),
International delegate WOSAM

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More natural therapies in
the treatment of cancer
1 – Adjuvant clinical nutrition – Nutritherapy
2 – Targeting cancer through natural angiogenic inhibitor

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Some common characteristics of cancer patients
- Antioxidants-vitamins, enzymes deficiency accentuated by chemotherapy.
- Wrong food diet.
- Poor appetite, poor digestion, malabsorption.
- Anorexia, malnutrition, decreasing quality of life, increasing mortality.
- Immune cells cannot function without vitamins, acidic milieu, poor oxygen.
- Negatively affected or damaged GUT system (bacteria or yeast movement
into blood stream).

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Our body needs for an healthy function and life survival
Daily needs of 50 essential nutritional factors
- 8 aminoacids (11 in premature child born)
- 13 vitamins (100 milligrams)
- 20 minerals (10 grams)
- 20 trace elements (60 milligrams)
- 12 to 15 grams of 2 eventual fatty-acids
- 1 source of energy (carbohydrates, 400 grams)
Water - Oxygen - Light
Parallel source of substances normally produced by the body but beneficial
for our health:
- Glutathione, coenzyme Q10, SOD, N-cysteine, orotic acid, choline, inositol
and nucleic acids.

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Peripheral Blood Analysis (nutritional and antioxidants deficiency)
- Abnormal, damages shape red cells
- Platelets aggregation
- Lipid ribbon and plaque
- Fragile and disintegrate WBC’s
- Red cells in rouleau
- Bacterial/fungal invasion
- Microclots
- Liver stress
- Kidney failure
Serge Jurasunas 2008
Health status – Before and after chemotherapy

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Photo 1 – vitamins-antioxidants
deficiency.
Photo 2 – Large lipid ribbon after chemotherapy (colon cancer.
Dr. Serge Jurasunas – Holiterapias 2006

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Photo 3 - Red cells with strong
rouleau (drug intoxication after
chemotherapy)
Photo 4 – large compact lipid
plaques – yeast form like candida
invasion – after chemotherapy
Photo 5 – large colony of yeast-
form like candida (PLFs) with
compacted microclots.
Photo 6 – large colony of yeast
form like budding sphere
(overgrowth) impaired immune
system – oxygen deficiency – bad
cancer case
Dr. Serge Jurasunas – Holiterapias 2006

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Photo 7 - Advanced liver cancer
treated by chemotherapy. Broken’s
RBC’s – rouleau – Platelets
aggregation – yeast-form like candida
invasion spread everywhere.
Photo 8 – Agglutinate red cells and
platelets to form a thrombus (cancer).
Dr. Serge Jurasunas – Holiterapias 2006

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Enzyme Yeast Cells preparation as anticancer food supplementation
36 years of experience
Attribution: Natural composition
Biological sources
Orthomolecular composition
High bioavailability
Rich in active enzymes
Developed by Dr. Siegfried Wolz – Co-worker Nobel Prize Prof. Lunnen (Germany)
- Immunonutrition -

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Enzyme Yeast Cells Process
Enzyme Yeast cells is a pure liquid
strain made from a fermentation
process at low temperature (32º) using
saccharomyces cerevisiaie, fresh fruit
juices, essential fatty acid, oxygen to
enhance the formation of krebs cycle
substrate and respiratory chain
enzymes in the mitochondria of the
yeast cells.
Enzyme yeast cells preparation contain
several billions of enzymatic
mitochondria.
Each 10ml contain 100 billions of active yeast cells.

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Oxygen
E
B2
B12
B1
< 32ºC
17 vitamins – 14 minerals
16 amino acids, enzymes of
the redox system,
biocatalysors
Proteins – 46/50g for 100g
of dried yeast
Particularly rich in vitamin B
complex
B1, B2, B3, B5, B6, B12.
Iodine, potassium,
magnesium, copper,
selenium, zinc, iron,
chromium, phosphoric acid.
-Activation of Krebs cycle
-Stimulation immune
defense
-Activation metallic
enzymes
-Against infection
Enzyme Yeast Cells contain a balanced combination

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Food
Aerobic Anaerobic
Glycolysis Glycolysis
Mitochondria
Cellular
respiration
Pyruvate
Oxidation
Citric Acid
cyle
Respiratory chain
Complete oxidation
waste products H2O
36 moles ATP
80% Energy
672 calories
Fermentation
reaction
cytosol
Blockage of the
respiratory chain
Incomplete oxidation
Waste products = carbon
compound (lactic acid, CO2
2 moles ATP
20% energy
35 calories
Acetyl
Coenzyme A
Oxphos
Complex I
II
III
IV
Complex V
ATP synthase

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Nutritional elements found in Enzyme Yeast Cells
Dr. Moerman (Nederland ) isolate the particular nutritional elements responsible
for building the immune system and activate the respiratory chain in the
mitochondria.
1 – Vitamina A
2 – Vit. B complex
3 – Vitamin C
4 – Vitamin E
5 – Citric acid
6 - Iodine
7 – Iron
8 – Sulphur
Vitamin A 50,000 U To 100,000 I.U.
B Complex 2 tablets per day (10g per day)
Vitamin C 1.250 mg 5-10g per day
Vitamin E 400 I.U. 2,200 I.U.
Citric acid 3 tablespoons solution 2,200 I.U.
Iodine 3 teaspoons solution 2,200 I.U.
Iron 3 teaspoons solution 2,200 I.U.

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Enzyme Yeast Cells contain
Particularly high in active glutathione (10mg/100ml of yeast preparation)
methionine Detox – antioxidant – redox value
cysteine
Particularly high in Q10 – critical to mitochondria
– Booster of energy
– Powerful liposoluble antioxidant
Cytochrome oxidase, coenzyme A, NADH, Superoxide dismutase (SOD)
Rich in nucleic acid, nucleus building substances: adenine nucleotides,
ribonucleic acids – Nucleotides repair damaged DNA and enhance T-cell
maturation, function, enhance NK cell activity.

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Enzyme Yeast Cells enhance immune system
Membrane contain defined polyssacharide 1-3D-glucan. (29-64%) – (1-6)40% mannan)
1 – macrophages (bind to macrophage beta-glucan receptors)
2 – Lymphocytes
3 – Natural Killer cells (N.K)
- Support the production of cytokines
- Tumor necrosis factor alpha (TNFa)
- Interleukine 1 – beta (Il-1-B)
Potent macrophages activator
A strong Biological
Response Modifier
Activate the regranulation of NK
cells and restore their function.
Significantly reduce the infection related mortality rate in
cancer patients (4.8% vs 30% control group from studies
in Japan)
Immunomodulating effects –
anti-inflammatory and bacterial property.

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Activation of macrophage cells by Beta 1-3-D - glucans
Y
Y Interferon – Gamma (IFN)
T.N.F.a
Interleukine 1 – Beta (1L-1B)
T-cells Activating a specific
response building
special antibody
communication
Macrophages (big eater)
Receptors
Dextin 1
Complement
3 receptor
Destroy foreign
bodies, bacterias,
fungi, necrotic
tissues, dead tumor
cells
Activate Natural Killer cells

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Application in cancer
1 – Combination Beta-glucan + antineoplasic agent
Potentialize the anti-tumor effect
2 – Contreact chemotherapy-induced immunosuppression
Resulting in higher mortality
3 – Protect cancer patients from 5 – Fluorouracil induced leukocytopenia
4 – Contreact corticosteroid hormones induced immunosuppressive effects in
cancer patients.
5 – Beta-glucans can affect biological responsed to bacterial
lipopolyssacharide (LPS) inducing pro-inflammatory mediators –
immunosuppressor – angiogenesis – P53 down-regulation.

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Litterature
Beta-Glucan, a specific biologic response modifier that uses antibodies to target tumors –
J.Immunol.1999.
The beta-Glucan receptor, dectin 1, is predominantly expressed on the surface of cells of
the J. Immunol.2002.
Abel G., Czop I.K. (1992) stimulation of human monocyte B-glucan receptors by glucan
particules induces production of TNFa and IL 1B. Int.J. Immunopharmacol. 14-1363-1373.
Mansell P.W.A., ichinose H., Reed R.J. Krementz E.T., Mc Names R., Di Luzio N.R.
(1975) Macrophages – mediated destruction of human malignant cells in vivo – J. Natl
Cancer Institute 54-571-580.
Williams D-L Ha-T-Li C. Kalbfleish J.H., Laffan JJ, Ferguson D.A. (1999) Inhibiting early
activation of the tissue nuclear factor – KB and nuclear factor Interleukin 6 with (1→3) – B-
D glucan increases long-term survival in polymicrobial sepsis – Surgery 126-54-65.
Duan X, Acherly M., Vivier E, Anderson P. (1994) Evidence for involvement of beta-glucan
– binding cell surface lectins in human natural killer cell function – cell immunol. 157: 393-
402.
Lee D.Y., Ji I.H., Chang H.I., Kim C.W. (2002) High Level TNF alpha secretion and
macrophage activity with soluble beta-glucans from saccaromyces cerevisae – Biosci –
Biotechnol – Biochem 66: 233.238.

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NK cells are able to destroy cancer cells by attaching to the cell’s
membrane and injecting cytoplasmic granules. A NK cell destroy in 5
minutes time a cancer cell and move to another.
A single NK cell can repeat this process with up to 27 cells in its
lifetime.
Regranulation of NK cells by
beta-glucan retore their ability
to destroy cancer cells.
However, when the NK
cell is weak, the cancer
cell can also destroy
white cells.
Therefore it needs to be
activated and addition of
Enzyme Yeast Cells may
increase their activity.

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One activate NK cell attacking 3 cancer cells

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Results of the Freiburg university
study
Myoglobin
ug/l
1 h post
560
194
- 65 %
Before the intake of Enyzme Yeast Cells
After six weeks of Enyzme Yeast Cells intake

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Results of the Freiburg university
study
Muscle stress
Total-Creatinkinasis U/l
1 h post
Fibrinogen mg/dl
1 d post
Before the intake of Enzyme Yeast Cells
After six weeks of Enzyme Yeast cells intake
253
135
199
314
- 64 % - 27 %

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Enzyme Yeast Cells
Protection of DNA and cell membrane
Protection of mitochondria
Repair damaged DNA
Increase cell respiration
Yeast cells are identical to the human
body cell by 70% with the same repair
mechanism.
Enzyme yeast cell
Human cell
SOD
Catalase
Glutathione
Cytochrome
Oxidase
NADH
Coenzyme A
Mitochondria

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Enzyme Yeast Cells Preparation
-Contain thiny and fragile walled young
oxygen yeast cells.
- Uniformly formed cells – clearly cells
wall on which light is reflected.
Orally administered enzyme yeast cells
reach the small intestine, open, release
billions of enzymes, including natural
vitamins, minerals etc. for fast
absorption, body’s nourishment.
Total Biological Rejuvenation
Photo taken from a drop of the liquid enzyme
yeast cells preparation
Serge Jurasunas 2008

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Indication of Enzyme Yeast cells
Enzyme
Yeast
Cells
-Restore nutritional status
-Improve oxygen supply to tissue
-Restore damaged intestine – Regulation of bowel function
-Strengthen the immune system
-Anti-inflammatory effect – Reduce excessive fibrogenesis –
prevent thrombosis
-Increase energy level and prevent fatigue (during chemo)
-Stimulation of the nerve resistance – Reduce depression
-Promote detoxification
-Increase cellular respiration
-Prevent or counteract anorexia
Overall
increase
Quality of
Life

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Conclusion
-Enzyme yeast cells preparation is not a simply mixed combination
ingredients but are simply integrated in the cells with high
bioavailability.
-Enzyme yeast cells natural ingredients work in synergy with each
other and as an “Whole food” to increase the body’s defense
resistance and inhibit some factors of tumor growth.
Enzyme yeast cells are the perfect anticancer food

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A new approach to cancer: Angiogenesis
-Angiogenic agents to target
proangiogenic factors.
-Inhibit vascularization of the
tumor and destroy by apoptosis
existing vessels.
-Selective therapy to
tumor
-Result reduced tumor
resistance
-Overall increasing
effectiveness of
standard chemo-
regimen

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Abnormal vessels make trouble

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1 - The effect of the liquid cartilage extract (LCE) as an
angiogenic inhibitor
-A concentrate hydrosoluble extract of liquid cartilage using special patented
technique.
-Contain biologically active mucopolysacharides and proteins with strong
antiangiogenic property.
-Orally taken shown to be biovailable and non-toxic on long term administration
on the contrary of Avastin or Thialidomide.
LCE targets many different aspects of the angiogenic cascade
Interfere with VEGF binding and signaling to VEGF receptor.
Inhibit MMP’s – 2.9.12 activity.
Stimulate apoptosis of endothelial cells.
Promote angiostatin production in the vicinity of tumor.

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Tumor
Liquid Cartilage Extract Inhibit
Angiogenic Cascade
MMP’S
Inhibition of MMP’S
(L.C.E.)
Apoptosis of
existing vessels
L.C.E.
MMP’S
Receptor
Inhibition of the VEGF receptor
VEGF
L.C.E.
Angiogenic
factors
COX2 Activity
Inhibition by
Antioxidants
Inflammation
Decreasing
Macrophages
Increased Oxidative Stress
Increase Signals to
Cancer Cells
Conjointly
Professor Serge Jurasunas 2008
Promote
angiostatin
production
in vicinity of
tumor

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Does antiangiogenic therapy enhance the effectiveness
of cytotoxic drugs?
Yes, it does!
1 – Animal studies show that radiotherapy is enhanced by
antiangiogenic therapy (1).
2 – Experimental animal studies show that cytotoxic chemotherapy can
be enhanced by combining it with antiangiogenic therapy (2).
3 -Anti-angiogenesis therapy increase flow and oxygen delivery as well
as a drug delivery to a tumor (3)
(1) Teicher BA, Dupuis N., Kusumuto T, Robinson MF, Liu F, menon K, - Antiangiogenic agents can
increase tumor oxygenation and response to radiation therapy – Radiation Oncology Investigation 2 –
269 – 276 – 1995.
(2) Teicher BA, Holden AS, Ara G, Sotomayor EA, Huang ZD – Potentiation of cytotoxic cancer therapies
by TNP – 470 alone and with other anti-angiogenic agents – Int. J. Cancer 57.920-925.1994.
(3) Teicher BA, Dufins NP, Robinson MF, Emi Y. Golff D. Antiangiogenic treatment (TNP –
470/Minocyline) increases tissue levels of anticancer drugs in mice L.L.C. lung carcinoma – Oncol
Res 27:237.243 - 1995

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Comparable effects of chemotherapy with a direct targeting
of cancer by a antiangiogenic therapy
Chemotherapy Radiation
60 days30 90
days30 60 90
Antiangiogenic therapy
Cancer cells recover
increase their resistance
make more vascularization
Less vascularization
inhibition - starving

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Clinical application of L.C.E. at Holiterapias Institute with
successful response in cancer patient during a 12 years
period.
This include a wide variety of different cancer types such: prostate, multiple
myeloma, lung, colorectal, breast, ovaries, melanoma pancreas.
-Benefit survival extension.
-Significative reduction of tumor size.
-Decrease of metastasis specially bone metastasis.
-Elimination of secondary nodules.
-Our patients take L.C.E. during several years without
toxicity.
-Suggested in anti-cancer dormancy therapy

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Therapy Posology Produced by
Enzyme Yeast Cells
Immunokomplex with
additional concentrate
wild fruits, vegetables
extracts, betacarotene
40 to 60ml per day (up to
600 billions of enzyme
yeast cells) mixed in
beetroot juice, apple
juice. Divided in 3 intake
per day.
Dr. Wolz. Zell Gmbh
Germany
Liquid Cartilage Extract Frozen vial of 30ml
concentrate
1 vial under the tongue
each morning before
breackfast
Atrium Biotechnologies
Quebec - Canada
The two natural products work with synergistic effects with
various therapeutic options. The anticancer diet by Serge
Jurasunas is suggested to combine more effectiveness.

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Example of clinical improvement of a patient with liver metastasis
and chemotherapy doing our anticancer food treatment including
Enzyme Yeast Cells
2/12/08
3/26/08
Dr. Serge Jurasunas – Holiterapias 2006

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Patient female –50 years old with a metastasic recurrency from breast
cancer (2000) in 2004 with multiple lesions dissiminated in the skeleton.
Strong pains and after one year of a new protocol of chemotherapy a new
bone scan (May 2005) showed more lesions disseminated in comparaition
of 2004. Poor response and evolution of the disease.
The complete case fully illustrated is available in English and French.
X ray of the spine
After 3 months of
combined therapy +
chemotherapy.
Total elimination of the
very large lesions in the
illium and spine.
Dr. Serge Jurasunas – Holiterapias 2006

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10/11/2005 – bad physical condition – metastases to bone skeleton – PSA 354 nl/ml
Treatment – L.C.E. (Comitris) – Antioxidant compound (Anoxe) 18g per day –
Enzyme Yeast cells.
12/01/2006 - PSA 53.6 nl/ml - after 3 months PSA 1.4 nl/ml
After 5 months elimination of almost all the bone metastases.
Patient male – 73 years old – Prostate Cancer
clinical story: adenocarcinoma of the prostate – Gleason 7 (3+4) -
Advanced case – No surgery or chemotherapy/radiation.
Dr. Serge Jurasunas – Holiterapias 2006

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Patient female – 62 years old
Clinical story: carcinoma left breast 1988
Partial resection– chemotherapy
2005 – Recurrence: Lung metastasis – However the patient refuse
more chemotherapy with the alternative option of CAM.
22/11/2005 - CA 15.3 – 617-U/ml - ACE – 1.25 ng/ml
15/09/2005 – CA.15.3 – 446 U/ml - ACE – 1.23 ng/ml
25/09/2006 – CA 15.3 – 50.2 U/ml - RBC - 5.16 – Hemo 14.9 – WBC’s 4700
06/02/2007 – CA 15.3 – 32 U/ml - RBC - 5.16 – Hemo 14.9

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Female 52 years (pharmacist)
Clinical story: February 2004 -
Pancreatic cancer with abdominal
large metastasis, multiple liver
metastasis.
Under chemotherapy: Follow our strategy program including L.C.E.,
Enzyme Yeast Cells and antioxidants (no adverse effects).
3 April 2008: Good physical condition, good quality of life
New hospital check-up shown total elimination of
abdominal and liver metastasis and reduce pancreatic
tumor.

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For more information:
-Liquid Cartilage Extract as a natural nutritional adjuvant to conventional
therapies: Serge Jurasunas – 8th Congress for Nutri x Phytotherapy – March 2007
– Brussels – Belgium.
-The therapy of Enzyme Yeast Cells in cancer disease, CFS and Aging process.
Serge Jurasunas – Booklet.
-Mitochondria and Cancer – Townsend letter – August/Sept 2006 – Serge
Jurasunas.
-A new combination therapy as support to conventional treatment – Townsend
Letter – Special issue “Alternative Therapies for cancer”
-More clinical cases.
Holiterapias Institute
Rua da Misericórdia, 137 – 1º - Lisbon – Portugal
Tel: 00351 213471117 – Fax: 00351 213471119
Email: info@sergejurasunas.com
www.sergejurasunas.com