To my students

1. Hypo & Hyperthyroidism Dr. Salman Pharmacology LMDC

3. Antihyperthyroid Drugs

4. The synthesis of thyroid hormone and action and effects of antithyroid agents

5. Inhibited by propranolol, and propylthioiracil Conversion of T 4 to T 3 via 5’ deiodinase in peripheral tissues 6 Inhibited by high doses of iodide Proteolytic release of T 3 and T 4 from thyroglobulin 5 4 3 2 1 Inhibited by thioamides Coupling of MIT and MIT to form T 3 and T 4 Inhibited by thioamides Iodination of tyrosyl residues on thyroglobulin from MIT and DIT Inhibited by thioamides Oxidation of iodide by peroxidases Basis for selective cell destruction of 131I Active accumulation of iodide into the gland Effects of antithyroid agents Thyroid hormone synthesis and action