1. Preclinical Imaging Centre
Centrum voor preklinische imaging van het Radboud UMC
Prof. dr. Otto C. Boerman
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

2. RTM: Radboud Translational Medicine
Discovery
Screening
preclinical testing
Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands

3. RTM: Radboud Translational Medicine
Discovery
Screening
preclinical testing
Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands

4. Radboudumc Technology Centres
Alain van Gool
Bioinformatics
Flow
cytometry
Preclinical
pharmacology
Proteomics
Metabolomics
Glycomics
Genetics
Otto Boerman
Preclinical
Imaging
Radboudumc
Technology
Centers
Big Data
Robotic
operations
Microscopy
Clinical
trials
Cleanrooms
Malaria lab
Neuroscience
unit
Biobank

5. PRIME: Preclinical Imaging Centre
microSPECT
Radboud University Nijmegen Medical Centre, The Netherlands

6. From human imaging to small animal imaging

7. From human imaging to small animal imaging
Mouse
Human
Uptake of 123I-IBF
by D2 receptors
Neurology
Dopamine w/ 99mTc-TRODAT
99mTc-MIBI
Cardiovascular
Stress 99mTc-MIBI
[99mTc] Minigastrin
Oncology
*functional imaging
Renal Cell Carcinoma

8. Radboud University Nijmegen Medical Centre, The Netherlands

9. Radboud University Nijmegen Medical Centre, The Netherlands

10. Radboud University Nijmegen Medical Centre, The Netherlands

11. Radboud University Nijmegen Medical Centre, The Netherlands

12. Radboud University Nijmegen Medical Centre, The Netherlands

13. PRIME
Preclinical Imaging Centre
microSPECT
PET imaging in PRIME
Radboud University Nijmegen Medical Centre, The Netherlands

14. Annihilation
Radboud University Nijmegen Medical Centre, The Netherlands

15. FDG-PET: imaging cancer
Normal FDG-PET
Metastasized Melanoma

16. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

17. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment
1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

18. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment
1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre

19. microPET/CT scanner
Radboud University Nijmegen Medical Centre, The Netherlands

20. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day
Radboud University Nijmegen Medical Center, The Netherlands

21. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day
1 day
Radboud University Nijmegen Medical Center, The Netherlands

22. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day
1 day
3 days
Radboud University Nijmegen Medical Center, The Netherlands

23. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day
1 day
3 days
7 days
Radboud University Nijmegen Medical Center, The Netherlands

24. PRIME
Preclinical Imaging Centre
microSPECT
SPECT imaging in PRIME
Radboud University Nijmegen Medical Centre, The Netherlands

25. Small animal SPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands

26. Radboud University Nijmegen Medical Centre, The Netherlands
26

27. microSPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands

28. Imaging transplated islets of Langerhans
Diabetes type 1: autoimmune destruction of insulin producing beta cells
Islet transplantation is a promising treatment for patients with type1 diabetes
AIM: Non-invasive in vivo determination of beta cell mass after islet transplantation.
In-111-DTPA-Exendin
islets
Radboud University Nijmegen Medical Centre, The Netherlands

29. Imaging transplated islets of Langerhans
Radboud University Nijmegen Medical Centre, The Netherlands

30. Imaging transplated islets of Langerhans
2D
3W
In-111-Exendin
6W
8W
11W
Radboud University Nijmegen Medical Centre, The Netherlands

31. PRIME
Preclinical Imaging Centre
microSPECT
Intravital fluorescence imaging in PRIME
Radboud University Nijmegen Medical Centre, The Netherlands

32. Multi-photon fluorescence microscopy
Radboud University Nijmegen Medical Centre, The Netherlands

33. Multi-photon fluorescence microscopy
Monitoring of tumor development using the dorsal skinfold chamber model
Radboud University Nijmegen Medical Centre, The Netherlands

34. Multi-photon fluorescence microscopy
Tumor cells
Extracellular
matrix, collagen,
muscle fibers
Fat cells, nerves
Blood vessels,
immune cells
Radboud University Nijmegen Medical Centre, The Netherlands

35. Multi-photon fluorescence microscopy
Tumor cells
Extracellular matrix,
collagen, muscle fibers
Fat cells, nerves
Blood vessels, immune
cells
Radboud University Nijmegen Medical Centre, The Netherlands

36. Immunofluorescence Guided Surgery
Radboud University Nijmegen Medical Center, The Netherlands

37. Immunofluorescence Guided Surgery
Radboud University Nijmegen Medical Center, The Netherlands

38. Multi-modality Imaging
Fluorescence imaging
MRI
PET
Multiphoton imaging
Radboud University Nijmegen Medical Centre, The Netherlands

39. Drug development Research
Hoffmann La Roche
Novartis
Sanofi
Fuji Biotechnology
Future Chemistry
Immunomedics Inc.
Synaffix
Wilex
Milabs
Radboud University Nijmegen Medical Centre, The Netherlands