SHAPE Society

1. A
Figure 1. Periaortic iron in C57 Bl (A) and ApoE K/O (B) mice 6 days
following intravenous administration of SPIO (1 mmol/kg iron). Iron uptake
is much greater in the periaortic fat of ApoE K/O mice.
B

2. A
Figure 2. Periaortic Mac3 stain in C57 Bl (A) and ApoE K/O (B) mice. There
is greater positivity in the latter. Mac3 x10.
B

3. A B
Figure 3. Subcutaneous tissue iron in C57 Bl (A) and ApoE K/O (B) 6 days
following the intravenous administration of SPIO (1 mmol/kg. iron). There
is no significant difference in iron uptake.

4. A
Figure 4. Subendothelial and periaortic fat iron in WHHL rabbit (A) 6 days
following intravenous administration of SPIO. In this case, fat uptake was
greater than subendothelial. RAM-11 staining (B) shows positivity in the
plaque and periaortic fat.
B

5. A
Figure 5. A. Human atherosclerotic coronary
artery with prominent necrotic core and
macrophage infiltration. x4 B. CD68
demonstrates heavy macrophage
concentration in the plaque but also in the
pericoronary fat. C. Inset shows in higher
magnification the vascular-stroma positive
population.
C
B

6. A
Figure 5. A. Human atherosclerotic coronary
artery with prominent necrotic core and
macrophage infiltration. x4 B. CD68
demonstrates heavy macrophage
concentration in the plaque but also in the
pericoronary fat. C. Inset shows in higher
magnification the vascular-stroma positive
population.
C
B