Spio cytokinejan28-2
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Spio cytokinejan28-2
- 1. Cytokine-SPIO Protocol â˘Purpose: To enhance macrophage homing to plaque and monitor it by SPIO. Compare the iron particles present in macrophages of apo E-deficient atherosclerotic plaques under baseline conditions (control group) and after the administration of the cytokines TNF-alpha and IL-1beta (influenza simulated group). â˘Protocol: Eight retired female breeders, approximately 12-month old were divided in 2 groups. Five received I.P. 0.2 Âľg each of mouse recombinant TNF- and IL-1Ă; the 3 control received 0.5 mL saline containing1% BSA. Three hours later, all the animals were I.V. injected with Feridex 1 mMol/kg of iron. Seven days later, the recipients were euthanized with CO2 and perfused under physiological pressure. The entire aorta up to the iliac bifurcation was formalin-fixed, serially sectioned transversally and stained for H&E and iron.
- 2. No cytokines C1Cx10 Apo E SPIO Injected Iron Staining H&E Staining
- 3. No cytokines C1Cx10 Apo E SPIO Injected Iron Staining H&E Staining
- 4. No cytokines C1Cx10 Apo E SPIO Injected Iron Staining H&E Staining
- 5. No cytokines SPIO Injected Apo E Only plaque with SPIO C3Ex40
- 6. No Cytokines SPIO Injected Apo E C3E SPIO Found in Circulating Monocytes Iron Staining H&E Staining
- 7. T2Fx10 TNFÎą/IL-1Ă SPIO Injected Apo E Iron Staining H&E Staining
- 8. T2Fx10 TNFÎą/IL-1Ă SPIO Injected Apo E H&E StainingH&E Staining
- 15. TNFÎą/IL-1Ă T4B
- 16. TNFÎą/IL-1Ă T4F
- 21. Infarct and coronary involvement T4F
- 28. TNFÎą/IL-1Ă T4E