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Dr. Babasaheb Ambedkar
Technological University
Shree Mahavir Education Society’
SHREE MAHAVIR EDUCATION SOCIETY’
DTE CODE - 5281
‱ B-Pharmacy
Approved by AICTE, PCI New Delhi, DTE, Govt. Of Maharashtra
Affiliated to MSBTE, Mumbai, DBATU, Lonere
Course structure and contains for
PRACTICE SCHOOL
(BP706PS)
B. Pharm Final Year (SEM VII)
DOMAIN – 17
PATHOLOGY
PATHOLOGY OF BREAST CANCER
A Review Article By:
POOJA NARENDRA PATIL
Final Year B. Pharmacy
(1952811823023)
Guided By:
Prof. Soniya S. Satpute
 Content
Introduction
Types of cancer
Breast cancer
Etiology
Types of Brest cancer
Pathogesis
symptoms, prevention
Treatment
⚫ Introduction
 Cancer
Cancer is a group of disease involving
abnormal cell growth
With the potential to spread to other parts of the body.
Not all Tumors are cancerous
Bening Tumors do not Spread to other
part of the body
* Possible signs and symptoms
‱ Abnormal bleeding
‱ unexplained weight loss And change in bowel Moments
‱ Swelling or lumps anywhere such as in the neck, underarm,
stomach, and groin.
 These disease are characterized By cellular Malfunction.
Healthy cells are programmed To know, What to do And
when to do it. And cancerous cells do not have This programing
And therefore Replicate and Grow out of control.
 When cancerous cells are together it is called as Neoplasm
⚫ Morphological difference between Normal
cells and Cancer cells
Normal cells
 Large cytoplasm
 Single nucleus
 Single nucleolus
 fine chromatine
Cancer cells
 Small cytoplasm
 Multiple nuclei
 Multiple And large nucleoli
 Coarse Chromatine
⚫Basic stages of cancer cell
⚫ Types of cancer
 Most common Types of cancer:
‱ Lung Cancer
‱ Breast Cancer
‱ Prostate Cancer
‱ Throat Cancer
‱ Brain Cancer
‱ Bone Cancer
‱Kideney Cancer
 Breast Cancer
A cancer That forms in the cells of breast
Cancer is the deadfull.
* 80% To 90% of all cancers are the result Of the thing we do To
ourselves.
* Among women Breast cancer is the second most Common Cancer .
* Breast cancer is the most common malignant Condition of the Breast.
Breast Cancer
World Breast Cancer Day
 On October 19, World breast cancer day celebrated.
 It is called ‘Pink October’ as a people around the world adopt the pink colour and
display a pink ribbon to raise the awareness about breast health and importance of
screening for the early diagnosis of breast cancer
⚫ Etiology
‱ AGE
‱ GENETIC FACTORS
‱ GENDER
‱ GEOGRAPHICAL
‱ DIETARY FACTORS
‱ MENARCHE & MENOPAUSE
‱ ENDOCRINE FACTORS
‱ RADIATION
‱ CHILD BEARING & FERTILITY
‱ BREAST FEEDING
‱ BENIGN DUCT DISEASES
⚫Types of Breast cancer
 ∆ Ductal Carcinoma
‱ Invasive Ductal Carcinoma
‱ Non-invasive
 ∆ Inflammatory Breast cancer
 ∆ Lobular Carcinoma
‱ Invasive lobular Carcinoma
‱ Non-invasive
⚫Symptoms
 Bloody nipple discharge
 DiscomFort Inverted nipple
 Lump formation near breast
# Genetic changes
familial syndromes (BRCA genes)
Sporadic breast cancer : e.g. overexpression of the
HER2/NEU proto-oncogene (an epithelial growth factor receptor)( 30% of cases)
# Hormonal Influences
increased exposure to estrogen
# Environmental variables
⚫ prevention
 Keep weight in check And be physically fit.
 Avoid alcohol and smoking.
 Avoid birth control pills
 Limite dose And Duration Of harmone therapy
⚫ Treatment
 Cancer can be treated in following ways
* Surgery
Surgery , when used to treat cancer Is a procedure in which
surgeon remove Cancer cells from the patients body.
* Radiation therapy
It is the type of cancer treatment that uses High doses of
radiation to kill cancer Cells and shrink Tumors.
* Chemotherapy
It is the type of cancer treatment that uses drugs to kill
cancer cell.
* Immunotherapy
It is the type of cancer treatment that helps to immune
system fight cancer.
⚫ Conclusion
Indian women need to be aware of both modifiable and non-modifiable risk factors for breast cancer to
adopt appropriate practices for prevention. There is an urgent call for more effective nation- and state-wide
cancer literacy programmes, as well as engagements with community-level organisations and the health
system With wide variations in the state-level burden, a coordinated, intensive health promotion intervention
programme on risk factors, prevention, screening and management for breast cancer is prudent. Training
on the latest evidence regarding breast cancer risk factors should be offered to healthcare providers and
community workers to raise their cancer literacy so they can then transmit this knowledge to other sections
of the society. Continuing medical education programmes with enhanced emphasis on breast cancer in the
curricula of nursing at institutional level and other healthcare training institutions should be a priority for
women’s health in the country.
1) https://www.sciencedirect.com/science/article/pii/S221464741630054X
2) https://amp-cancer-
org.cdn.ampproject.org/v/s/amp.cancer.org/cancer/breast-
cancer/treatment/targeted-therapy-for-breast-
cancer.html?amp_gsa=1&amp_js_v=a9&usqp=mq331AQ
KKAFQArABIIACAw%3D%3D#amp_tf=From%20%251%
24s&aoh=16643119609458&csi=1&referrer=https%3A%2
F%2Fwww.google.com&ampshare=https%3A%2F%2Fww
w.cancer.org%2Fcancer%2Fbreast-
cancer%2Ftreatment%2Ftargeted-therapy-for-breast-
cancer.html
3) https://www.cancer.gov/about-
cancer/treatment/drugs/breast
4) https://www.omicsonline.org/breast-cancer.php
BIBLIOGRAPHY
5)https://www.cdc.gov/cancer/breast/basic_info/symptoms.htm
6) https://www.cancer.org/cancer/breast-cancer/screening-
tests-and-early-detection/breast-cancer-signs-and-
symptoms.html
7)https://www.cdc.gov/cancer/dcpc/resources/features/bre
astcancerawareness/index.htm
8) https://breastcancernow.org/information-support/have-
i-got-breast-cancer/signs-symptoms-breast-cancer
9)https://my.clevelandclinic.org/health/diseases/3986-
breast-cancer
10)https://www.cancer.gov/about-
cancer/treatment/drugs/breast
11)https://www.googleadservices.com/pagead/aclk?sa=L&ai=DChcSEwjFhKTCiNr7AhXUDSsKHTvnBZIYA
BAAGgJzZg&ae=2&dsh=1&agsac=WXcd81DBUFc&cit=CkQKCAiAvqGcBhAREjQAHCV6dI14VbU1uhYASn
AfMBYn-ZVRpSNAvU3nhLhn9dK4W4d-
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Thank you 🙏

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Breast cancer