This a presentation that was developed alongside the summer research program, Summer Institute in Math and Science (SIMS) at UCSB. The program duration was two weeks and also included students taking rigorous mock classes. SIMS was designed for incoming science students to help them succeed in the difficult path of science and engineering.

1. Nanostructured Materials Controlling Biological Processes Team: Adrian Gusland, Basil Perkins, Diego Herrera, and Namgyal Sherpa Mentor: Dr. Won Hyuk Suh Advisor: Prof. Galen Stucky

4. Ultrasonic Spray Pyrolysis vacuum humidifier temp. regulator furnace cooling system bubbler flow meter airflow filter Ultrasonic fountain Suh, W. H.; Suslick, K. S. J. Am. Chem. Soc. 2005, 127 , 12007-12010.

7. Scanning Electron Microscopy 25 m 2 /g 53 m 2 /g Before etching After Etching SiO 2 pores

8. Average diameter of microspheres = 1.1µm 2 µm

10. Particle Internalization Optical Microscopy Analysis 20 x 100 x Microglia cells incubated with porous TiO 2 microspheres

11. Particle Internalization SEM analysis almost internalized internalization in progress Microglia cell grown with porous TiO 2 for 12h

12. Particle Internalization Fluorescent Microscopy Analysis arrow : cell undergoing mitosis (doubling) BV2 cell grown with porous TiO 2 for 12 hours Fixed using formaldehyde (HCHO) and DAPI nucleus stained