2. CONTENTS
INTRODUCTION
THE ROLE OF MICROFLUIDICS
MICROFABRICATION
PUMPING,VALVING&MIXING
ADVANTAGES OF MICROFLUIDICS
USES
MODEL &INVENTED OF MICROFLUIDICS
FUTURE OF MICROFLUIDIES
APPLICATIONS
CONCLUSION
REFERENCES
3. INTRODUCTION
The micro fluidics involves the use of micro structured
device.
Featuring dimensions typically on the order of tens to hundreds
of micro meters that allow the precise handling of low volumes
(usually nano liters or less)of fluids within them.
First micro fluidic device was developed in 1970’s,it not until the
early 1990’s that micro fluidic came to “LAB-ON-A-CHIP”.
Devices originally focoused on aspects of analytical chemistry but micro
fluidics has since expanded into many areas ,particularly in chemistry&
biology.
Flow within micro fluidics devices is almost always laminar.
5. THE ROLE OF MICROFLUIDICS
Microfluidic technology has the potential to be used
as a platform to investigate interactions between drug
carriers and cells.
And also treatment effects of active compounds and
drugs.
The platform can be helpful for filling gap between
animal studies and human clinical trials.
6. MICRO FABRICATION
Microfluidic devices can be fabricated from a range
different method
In research lab now-a-days the most common chip
material is flexible elastomer ,
poly(dimethylsiloxane)(PDMS),which is well suited to
rapid prototyping.
And also developed the
paper microfluidic devices.
paper microfluidic
7. PUMPING,VALVING &MIXING
Two methods are available for pumping solutions.
Hydrodynamic pumping &
electro osmotic flow(EOF).
Hydrodynamic pumping:
It involves the application of pressure ,for example via a
syringe pump ¢rifugal forces and characterized by a
parabolic flow profile.
EOF –based pumping:
pumping occurs when a voltage difference is applied
across a micro channel that features charged surface
&the flow profile being almost completely flat.
8. ADVANTAGES
The low cost savings .
Increased precision .
Shortened time of experiments.
Flexible application.
Use less volume of samples in chemical reagents.
Micro fluidics allow the analysis the use of less volume
of samples , chemicals &reagents reducing the global
fees of applications.
9. USES
Micro fluidic systems are used in procedures such
as
sample injection in mass spectrometry.
PCR amplification.
DNA analysis.
Separation &manipulation of cells &cell patterning.
10. MODEL OF MICROFLUIDICS
Micro fluidic models allow including all the main
elements involved in the process of extravasation.
Ex: geometry of the blood vessel, presence of a 3D
environment ,etc.
INVENTED MICROFLUIDICS
Frederick stanley kipping, the british chemist
considered the father of silicon chemistry. The first
microfluidic devices were usually made of silicon from
micro electronics.
11. FUTURE OF MICROFLUIDICS
The future of microfluidic devices is likely to involve
their direct integration with human body.
It poses some challenges , not incompatibility between
electrial components &the flexible,dynamic nature of
tissue.
DEVELOPED BY
In late 1990’s the george white sides group of harvard
university introduced a new concept of low-cost micro
fluidics.
12. APPLICATIONS
“LAB-ON-CHIP” Technology can be applied to a wide
variety of chemical and biological process.
Micro fluidic devices can be employed for the
monitoring of every day concerns such as
enverinomental &food analysis, as well as in forensic
science. Where only small amount of samples may be
available.
Microfluidics has becomes of particular important for
clinical dignostics & DNA analysis.
Microfluidic technology has been developing more
and more towards integrated systems.
13. CONCLUSION
I concluded that the Microfluidics are easy to use in
laboratory ,
Also it give the type of flow .
And also used in DNA analysis.
14. REFERENCES
o Haeberle , S.; Zengerle , R. Lab Chip 2007, 7(9), 1094–1110; (b) Livak-Dahl, E.;
Sinn, I.; Burns, M. Ann. Rev. Chem. Biomol . Eng. 2011, 2(1), 325–353; (c) Nge, P.
o Rogers, C. I.; Woolley, A. T. Chem. Rev. 2013, 113(4), 2550–2583; (d) Mark, D.;
Haeberle , S.; Roth, G.; von Stetten , F.; Zengerle , R. Chem. Soc. Rev. 2010,
39(3), 1153–1182.
o Ohla, S.; Belder, D. Curr. Opin. Chem. Biol. 2012, 16(3–4), 453–459.