New drug on way to beat dengue

1. New drug on way to
beat dengue
Pune-Based Firm In Process To Develop Therapy To Treat All
Strains Of Virus
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2. Contd..
Asia's largest vaccine maker, Pune-based Serum Institute, is in the process of
developing a biological therapy to treat all four strains of the dengue virus. It
will be applying to the ministry of science and technology for a “fast-track
approval“ to rollout the drug in the country . The biologic treatment
(monoclonal antibody) will be given as an injection to cure dengue and cost
between Rs 5,000-10,000 for a single dose.
Serum, which has tied up with US-based biotechnology company Visterra to
use its technology , hopes to commercialize the treatment within 1218
months of getting the regulatory approvals, Serum Institute CEO Adar
Poonawalla told TOI.
Apart from Serum, other biggies like Sanofi and Novartis are in the race to
launch a vaccine over the next few years.
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3. Contd..
“We hope that the government will give a fast-track approval to our
application as dengue has assumed alarming proportions and could become
apublic health crisis,“ said Poonawalla, adding that after getting the nod it
would initiate clinical trials on 100 to 1000 subjects to prove its safety and
effi cacy . If the trials are successful, Serum could perhaps become the first
company to offer a cure for the dreaded infection which has shown the
worst outbreak claiming several lives, with cases doubling this year.
The firm has an exclusive license to commercialize the treatment for the
Indian subcontinent, including India, Pakistan, Bangladesh, Nepal, Bhutan,
Maldives, and Sri Lanka. It has paid Visterra $5 million upfront and will give
an additional $34 million based on the achievement of certain development
and commercial milestones.
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4. Contd..
Serum Institute will fund and be responsible for the clinical development of
the monoclonal antibody VIS513 in the licensed territories, including filing of
regulatory applications. The companies will establish a joint steering commit
tee to coordinate the development for the Indian subcontinent.
VIS513 has reportedly worked to neutralize all four se rotypes of dengue
virus with the “animal model“ studies showing promising results Poonawalla
added. The US company is already running its own trials in Singapore. Serum
will need to do clinical studies on Indian subjects by import ing the clone.
The Pune-based company is also working on a dengue vac cine to be given as
a preventive drug. The development of a vaccine will take 3-4 years as it has
to be tested on a wide range and number of subjects.
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5. Contd..
Globally , amongst the vac cines, Sanofi has emerged as a frontrunner
having completed Phase-II trials, a company offi cial said. The market
for the vaccine could reach $400 mil lion in 2020, according to Glob
alData estimates. Others say it could be more than triple and bring in
$1.4 billion a year at its peak.
About half the world's pop ulation is at risk of contracting the virus
with no specific treat ment for dengue, but early de tection and access
to proper medical care lowers fatality rates below 1%, according to the
World Health Organization
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