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Published animated redox and antioxidant mechanisms
1.
E E E E E E E E E E E E E E E NOS1 CaMCaM Arg NO sGC MC NMDAr Neuron
2.
NOS2 Arg NO sGC MC Pro-inflammatory stimuli Astrocytes
3.
Blood Vessel VGEF-A VEFGR-2 NOS3 eNOS NONO VSMC relaxation Vaso- dilation sGC 5’ GMP cGMP cGMP-gated ion
channels Na+ Ca2+ NO sGC cGMP 5’ GMP cGMP-gated ion channels Na+ Ca2+
4.
C NOS1 Arg•NOO 2 • − C C C C C C ETC ONOO− SOD H2O2 •OH Fe2+ Fe3+ GPxGSR H2O GSH GSSG Neuron Formation and
elimination of ROS and RNS in neurons
5.
Astrocytes co-operate with
neurons for antioxidant GSH biosynthesis Cul3 GCL Nrf2 Keap1 Nrf2 GSH GlnGln GSH CysGlyCysGly X γGluX Glu γGluCys GCL GS GSH Neuron Astrocyte
6.
Neuronal glucose metabolism
supports antioxidant GSH Glucose G6P F6P 6PG R5P NADP+ NADPH GSSG GSH F1,6P2 Pyr NAD + NADH ADP ATP Pfk1 Pfkfb3 APC/C Cdh1 F2,6P2 + G6PD NADPH NADP+ GSSG GSH
7.
K K Astrocytes and neurons couple
glucose metabolism to antioxidant defense Neuron Astrocyte C C C C C Glucose G6P R5P G6P Pyr Pyr NADPH NADP+ GSSG GSH ROS Nrf2 GSH NAD+ NADH Lac APC/C Cdh 1 ATP CO2 s s s K K s s s ATP ADP
Hinweis der Redaktion
G6P- Glucose-6-phosphate, G6PD- glucose-6-phosphate dehydrogenase, 6PG-6-phosphogluconate, R5P-Ribulose-5-phosphate, GSSH-
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