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Presented by
Dr. Sudhakar Kokate
Director PPRC, India
What is memory ??
 Memory is a natural complex phenomenon which is
controlled by the Central Nervous System

 The ability to think logically
 To learn
 To store and retrieve the information

PPRC/INDIA 01
Human Brain

PPRC/INDIA 02
Central Nervous System

PPRC/INDIA 03
Central Nervous System

PPRC/INDIA 04
Cerebral cortex
 Cerebral cortex ….a part of CNS
 Concerned with functions like

….Judgement
MEMORY

PPRC/INDIA 05
 If CNS is undeveloped
Or
 If CNS is impaired for any reason

 Fine control of movements
 Memory
Is first to be affected

PPRC/INDIA 06
Ayurvedic drugs
 Ancient
 From plant sources
 Effective

 Less side effects

 Easy to prepare or

handle

 Known in traditional
practices
 If excess no side effect
PPRC/INDIA 07
Ayurvedic drugs

PPRC/INDIA 08
When Ayurvedic drugs..Effective??
 Regular intake initially minimum for 40 days
 Diet, intake procedure, exercises, psycho-health to be

followed / maintained strictly
 Positive attitude towards life

PPRC/INDIA 09
Memory enhancement is needed for??
 For everybody, anytime, to all human beings on the globe
 All categories MUST
 Student, professional, farmer, worker, household women
and others
 If not – work, career everything gets AFFECTED :

stunted growth
PPRC/INDIA 10
Ideal diet plan
 Liquid, nutritious diet
 Avoid excess sweet, oil, carbohydrate, salt, spicy,

non- veg, roadside food, tea, coffee, cold drinks,
chocolate, etc
 Stop smoking and drinking

PPRC/INDIA 11
Avoid….

PPRC/INDIA 12
Stop….

PPRC/INDIA 13
 Consume daily milk, yoghurt, fruit juice, lemon, ginger,
garlic, tomato, salad, sprouted pulses
 Also intake of green leafy vegetables, fruits esp.

oranges, moringa pods is beneficial
 Be positive, happy and help others
 Maintain psychological health

PPRC/INDIA 14
Consume daily….

PPRC/INDIA 15
Consume daily….

PPRC/INDIA 16
Memory degeneration….
 Patients suffering from Alzheimer’s disease
 Loss of short memory and permanent memory

 In case of Accidents where memory suddenly gets
disturbed
 Persons suffering from mental retardation
PPRC/INDIA 17
Memory enhancing plants
General name

Botanical name

Part used

Vacha

Acorus calamus

Rhizome

Shatavari

Asparagus racemus

Root

Brahmi

Bacopa monnieri

Herb, leaf

Sankha pushpi

Canscora decussata

Herb

Kanguai

Celastrus paniculatus

Seeds

Mandukaparni

Centella asiatica

Herb, leaf

Aparajita

Clitoria ternatia

Root, bark
PPRC/INDIA 18
Vacha

Acorus calamus

PPRC/INDIA 19
Vacha
 Semi-aquatic perennial plant cultivated in damp
marshy places in India
 The rhizome, strong smelling acrid and bitter useful in
cleaning speech and for treating epilepsy, delirium,
hysteria and loss of memory
 4 mg / gm rhizome powder in female rats improved

learning performance (Choudhari 1996)
PPRC/INDIA 20
Vacha
 According to Dr. Jain 1968, Vacha oil from the rhizome
is good nervine stimulant
 Essential oil free alcoholic extract showed marked
sedative and analgesic properties

PPRC/INDIA 21
Brahmi

Bacopa monnieri

PPRC/INDIA 22
Brahmi
 Plant grows throughout India in wet damp marshy
places
 Major constituents are:
- saponins
- monnierin
- hersaponin
- baccoside A

- baccoside B

R & D work on alcoholic extract of Brahmi
Commercial preparation of drugs available in market
PPRC/INDIA 23
Brahmi
 Effective in anxiety neurosis (Singh et. al 1970)
Revitalizing intellectual faculty (Sharma et. al 1987)
Treatment of this extract for 30 days brought about
reduction in anxiety, adjustment disability leading to
improved mental functions (Rastogi & Mehrotra 1995)
 10 mg / kg oral administration for 24 days showed

maximum improvement of albino rats (Day et. al 1976)
PPRC/INDIA 24
Mandukaparni

Centella asiatica

PPRC/INDIA 25
Mandukaparni
 Occurs throughout India in marshy places
 It is considered as a tonic in nerve and blood diseases

(Chopra et. al 1956)
 In India spl. status in the treatment of amnesia and

hysteria, behaviour learning and memory
 In the west it is recognised as anti-dermal and wound
healing effect

PPRC/INDIA 26
Mandukaparni
 Contains 2 saponins with sedative effect
 Leaf powder of C. asiatica + equal quantity of cow’s

milk daily will strengthen brain nerves and promote
memory power (Kirtikar & Basu 1998)

 Appa Rao (1967) conducted a double blind clinical trial
on 30 mentally retarded children who were free from
epilepsy and neuro-disorders

PPRC/INDIA 27
Memory enhancing plants
General name

Botanical name

Part used

Vishukranti

Evolvulus alasinoides

Herb, leaf

Yashti madhu

Glycyrrhiza glabra

Root

Jatamanasi

Nardostachys jatamansi

Root

Pippali

Piper langum

Fruit

Kushtha shilajit

Saussurea lappa

Root

Ashwagandha

Withania somnifera

Root

Convolvulus pluricaulis

Herb
PPRC/INDIA 28
Ashwagandha

Withania somnifera

PPRC/INDIA 29
Ashwagandha
 Occurs in dry regions of India
 The plant is extensively studied

 Root: Used in nervous exhaustion, brain fatigue and loss
of memory (Nadkarni 1976)

PPRC/INDIA 30
Ashwagandha
 Highly esteemed Ayurvedic drug capable of imparting
long life, youthful vigour and intellectual powers
 It is a good tonic for brain
 Effective in anxiety neurosis (Singh & Tripathi 1982)

PPRC/INDIA 31
Shilajit

Saussurea lappa

PPRC/INDIA 32
Shilajit
 Shilajit – a panacea of oriental medicine
Exudate from rocks of the Himalayas & hills of
Afghanistan
 Considered as an anxiolytic and to improve memory

 Used as restorative and geriatric tonic

PPRC/INDIA 33
Shilajit
 Contains number of organic constituents, minerals and
trace elements
 Major constituents:
- albumin

- benzoic acid

- hippuric acid - fulvic acid
- gums
PPRC/INDIA 34
Maidenhair tree

Ginkgo biloba Linn.

PPRC/INDIA 35
Maidenhair tree
 Ancient Chinese medicinal plant
 Now well cultivated in India
 Scientific and popular vast literature available about this
plant

 Leaves contain 24% flavonoids – flavonoid glycosides
and quercetin and 6% terpenes - ginkgolides
PPRC/INDIA 36
Maidenhair tree
 It increases cerebral blood flow in geriatric patients
suffering from short term memory loss (Tyler 1993)
 Dr. Racogini 1996 showed stimulation of brain beta
drenergic receptors in albino rats
 Short term memory loss improved in normal women one
hour after taking 600 mg of Ginkgo biloba extract

(Hindmarch 1986)
PPRC/INDIA 37
Memory enhancing drugs in market
Brand Name

Botanical name

Memory + Capsule

Bacopa monnieri extr

TECA Capsule
Menrat Tablets

Brain Tab. tonic
Shankhapushpi tonic

Company
Nirvan Herbal
Pvt. Ltd.
Juggat Pharma

Brahmi Leaf Powder
Brahmi, Mandukaparni,
Himalaya Drug
Vishnukrant, Jatamanasi, ext
Co.
powders
Brahmi, Shankhapushpi,
Baidyanath
Bhringaraj

Shankhapushpi

Baidyanath
PPRC/INDIA 38
Thank You !!
“BE WITH US”

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Phytodrugs for Memory enhancement

  • 1. Presented by Dr. Sudhakar Kokate Director PPRC, India
  • 2. What is memory ??  Memory is a natural complex phenomenon which is controlled by the Central Nervous System  The ability to think logically  To learn  To store and retrieve the information PPRC/INDIA 01
  • 6. Cerebral cortex  Cerebral cortex ….a part of CNS  Concerned with functions like ….Judgement MEMORY PPRC/INDIA 05
  • 7.  If CNS is undeveloped Or  If CNS is impaired for any reason  Fine control of movements  Memory Is first to be affected PPRC/INDIA 06
  • 8. Ayurvedic drugs  Ancient  From plant sources  Effective  Less side effects  Easy to prepare or handle  Known in traditional practices  If excess no side effect PPRC/INDIA 07
  • 10. When Ayurvedic drugs..Effective??  Regular intake initially minimum for 40 days  Diet, intake procedure, exercises, psycho-health to be followed / maintained strictly  Positive attitude towards life PPRC/INDIA 09
  • 11. Memory enhancement is needed for??  For everybody, anytime, to all human beings on the globe  All categories MUST  Student, professional, farmer, worker, household women and others  If not – work, career everything gets AFFECTED : stunted growth PPRC/INDIA 10
  • 12. Ideal diet plan  Liquid, nutritious diet  Avoid excess sweet, oil, carbohydrate, salt, spicy, non- veg, roadside food, tea, coffee, cold drinks, chocolate, etc  Stop smoking and drinking PPRC/INDIA 11
  • 15.  Consume daily milk, yoghurt, fruit juice, lemon, ginger, garlic, tomato, salad, sprouted pulses  Also intake of green leafy vegetables, fruits esp. oranges, moringa pods is beneficial  Be positive, happy and help others  Maintain psychological health PPRC/INDIA 14
  • 18. Memory degeneration….  Patients suffering from Alzheimer’s disease  Loss of short memory and permanent memory  In case of Accidents where memory suddenly gets disturbed  Persons suffering from mental retardation PPRC/INDIA 17
  • 19. Memory enhancing plants General name Botanical name Part used Vacha Acorus calamus Rhizome Shatavari Asparagus racemus Root Brahmi Bacopa monnieri Herb, leaf Sankha pushpi Canscora decussata Herb Kanguai Celastrus paniculatus Seeds Mandukaparni Centella asiatica Herb, leaf Aparajita Clitoria ternatia Root, bark PPRC/INDIA 18
  • 21. Vacha  Semi-aquatic perennial plant cultivated in damp marshy places in India  The rhizome, strong smelling acrid and bitter useful in cleaning speech and for treating epilepsy, delirium, hysteria and loss of memory  4 mg / gm rhizome powder in female rats improved learning performance (Choudhari 1996) PPRC/INDIA 20
  • 22. Vacha  According to Dr. Jain 1968, Vacha oil from the rhizome is good nervine stimulant  Essential oil free alcoholic extract showed marked sedative and analgesic properties PPRC/INDIA 21
  • 24. Brahmi  Plant grows throughout India in wet damp marshy places  Major constituents are: - saponins - monnierin - hersaponin - baccoside A - baccoside B R & D work on alcoholic extract of Brahmi Commercial preparation of drugs available in market PPRC/INDIA 23
  • 25. Brahmi  Effective in anxiety neurosis (Singh et. al 1970) Revitalizing intellectual faculty (Sharma et. al 1987) Treatment of this extract for 30 days brought about reduction in anxiety, adjustment disability leading to improved mental functions (Rastogi & Mehrotra 1995)  10 mg / kg oral administration for 24 days showed maximum improvement of albino rats (Day et. al 1976) PPRC/INDIA 24
  • 27. Mandukaparni  Occurs throughout India in marshy places  It is considered as a tonic in nerve and blood diseases (Chopra et. al 1956)  In India spl. status in the treatment of amnesia and hysteria, behaviour learning and memory  In the west it is recognised as anti-dermal and wound healing effect PPRC/INDIA 26
  • 28. Mandukaparni  Contains 2 saponins with sedative effect  Leaf powder of C. asiatica + equal quantity of cow’s milk daily will strengthen brain nerves and promote memory power (Kirtikar & Basu 1998)  Appa Rao (1967) conducted a double blind clinical trial on 30 mentally retarded children who were free from epilepsy and neuro-disorders PPRC/INDIA 27
  • 29. Memory enhancing plants General name Botanical name Part used Vishukranti Evolvulus alasinoides Herb, leaf Yashti madhu Glycyrrhiza glabra Root Jatamanasi Nardostachys jatamansi Root Pippali Piper langum Fruit Kushtha shilajit Saussurea lappa Root Ashwagandha Withania somnifera Root Convolvulus pluricaulis Herb PPRC/INDIA 28
  • 31. Ashwagandha  Occurs in dry regions of India  The plant is extensively studied  Root: Used in nervous exhaustion, brain fatigue and loss of memory (Nadkarni 1976) PPRC/INDIA 30
  • 32. Ashwagandha  Highly esteemed Ayurvedic drug capable of imparting long life, youthful vigour and intellectual powers  It is a good tonic for brain  Effective in anxiety neurosis (Singh & Tripathi 1982) PPRC/INDIA 31
  • 34. Shilajit  Shilajit – a panacea of oriental medicine Exudate from rocks of the Himalayas & hills of Afghanistan  Considered as an anxiolytic and to improve memory  Used as restorative and geriatric tonic PPRC/INDIA 33
  • 35. Shilajit  Contains number of organic constituents, minerals and trace elements  Major constituents: - albumin - benzoic acid - hippuric acid - fulvic acid - gums PPRC/INDIA 34
  • 36. Maidenhair tree Ginkgo biloba Linn. PPRC/INDIA 35
  • 37. Maidenhair tree  Ancient Chinese medicinal plant  Now well cultivated in India  Scientific and popular vast literature available about this plant  Leaves contain 24% flavonoids – flavonoid glycosides and quercetin and 6% terpenes - ginkgolides PPRC/INDIA 36
  • 38. Maidenhair tree  It increases cerebral blood flow in geriatric patients suffering from short term memory loss (Tyler 1993)  Dr. Racogini 1996 showed stimulation of brain beta drenergic receptors in albino rats  Short term memory loss improved in normal women one hour after taking 600 mg of Ginkgo biloba extract (Hindmarch 1986) PPRC/INDIA 37
  • 39. Memory enhancing drugs in market Brand Name Botanical name Memory + Capsule Bacopa monnieri extr TECA Capsule Menrat Tablets Brain Tab. tonic Shankhapushpi tonic Company Nirvan Herbal Pvt. Ltd. Juggat Pharma Brahmi Leaf Powder Brahmi, Mandukaparni, Himalaya Drug Vishnukrant, Jatamanasi, ext Co. powders Brahmi, Shankhapushpi, Baidyanath Bhringaraj Shankhapushpi Baidyanath PPRC/INDIA 38
  • 40. Thank You !! “BE WITH US”