Short Presentation , presentation style of ocular Drug delivery system

1. Presented by,
Pallab Kumar Pal
M.Pharm, 1st year(Pharmaceutics)
Roll no. 10
Under the guidance of,
Dr. Somasree Ray
Astt. Professor (Department of Pharmaceutics)
Gupta College of Technological Sciences

2. Introduction
Ocular administration of drug is primarily associated with the treatment
Of ocular disease
Eye is most accessible site for topical administration

3. Ideal characteristics of ocular DDS
Delivery of drug to right place
Reduced drainage of drug by tear flow
Should posses more local activity than systemic
Dose frequency less
Easy to self administration
Sterilizable on large-scale

4. Formulations
A. Ophthalmic solutions of drug resinates
B. Viscous solutions, hydrogel and mucoadhesive formulations
C. Dispersed system
D. Solid dosage form-Inserts

5. A.Ophthalmic solutions of drug resinates
Increase
residence time
+ + CarbomerAmberlite resin Drug

6. B. Viscous solutions, hydrogel and mucoadhesive formulations
Hydrocolloid
Aqueous drug
solution+
Viscous solution
and hydrogel
Mucoadhesive --------------------------
Hydrogen bond
Mucous
Improve drug absorption
and
prolong action

7. C. Dispersed system
i. Liposome
ii. Nano capsule
iii. Nano-sphere

8. D. Solid dosage form-Inserts
ii. Erodible ophthalmic insert
iii. Bioadhesive ophthalmic insert,
i. Non-erodible ocular insert
Tear fluid ->Penetrate to
drug reservoir->Dissolved
drug release
Medicated or non-medicated mini-
rod of soluble polymer(HPMC)
Adhesive rods based on mixture of
hydroxy propyl cellulose, ethyl
cellulose, polyarylic acid

9. New ophthalmic drug delivery system
Objectives:
Provide a sterile, preservative free, water-soluble, drug loaded
Film on eye
Serve unit dosage form precsely
Basic design:
Water soluble drug loaded film
Water soluble membrane film
Water-soluble handle film