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Ipertensione Polmonare nelle malattie ematologiche
1. LâIpertensione Polmonare nelle Malattie Ematologiche Corso di aggiornamento sullâipertensione polmonare. Pavia 21 maggio 2011 Giovanni Barosi Laboratorio di Epidemiologia Clinica/Centro per lo Studio della Mielofibrosi. IRCCS Policlinico S. Matteo Foundation, Pavia, Italy
10. Barosi et al. Blood 2001 Barosi et al, BJH 2003 3. CD34+ hemopoietic stem cells constitutionally migrate from bone marrow to blood and to extramedullary organs Current Biological Paradigm of MMM CD34 + in PB CD34 + in Spleen
11. PERIPHERAL BLOOD HEMATOPOIESIS FIBROSIS BONE MARROW A Biological Model of MMM CD34+ CELLS HEMATOPOIESIS Anemia, thrombocytopenia SPLEEN Splenomegaly Blast transformation ANGIOGENESIS ANGIOGENESIS?
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13. PH in PMF (and MPNs) 36% TTE PMF or post ET/Post PV MF =36 Cortelezzi et al. (Leukemia, 2008) 48% TTE ET=9 PV=15 CML=3 Gupta et al. (J Natl Med Ass 2006) ET= 47.8% Reactive thrombocytosis=0% TTE ET=46 Reactive thrombocytosis=40 Altintas et al. (Leukemia & Lymphoma, 2007) Transthoracic Echo (TTE) Diagnosis of PH 41.7% PV =2 ET=14 PMF=6 CML=2 Garypidou et al. (Haematologica 2004) Incidence Disorders Author